cholesterol sulfate (BioDeep_00000229589)

Main id: BioDeep_00000012044

 

human metabolite natural product


代谢物信息卡片


cholesterol sulfate

化学式: C27H46O4S (466.3117)
中文名称: 胆甾醇硫酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OS(=O)(=O)O)C)C
InChI: InChI=1S/C27H46O4S/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30)/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
A steroid sulfate that is cholesterol substituted by a sulfoxy group at position 3.
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

cholesterol sulfate; Cholesterol sulfate



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 DOCK2, IVL, LORICRIN, SREBF2, SULT2B1
Peripheral membrane protein 3 CYP11A1, DOCK2, FDXR
Endosome membrane 1 LDLR
Endoplasmic reticulum membrane 4 HMGCR, SREBF2, STAR, STS
Mitochondrion membrane 1 CYP11A1
Nucleus 3 FLG, SREBF2, SULT2B1
cytosol 8 DOCK2, FLG, IVL, LORICRIN, PRKCQ, SREBF2, SULT2B1, TGM1
nuclear body 1 IVL
centrosome 1 IVL
nucleoplasm 2 LORICRIN, SREBF2
Cell membrane 3 CD8A, LDLR, STAR
Lipid-anchor 1 TGM1
Cytoplasmic granule 1 FLG
Multi-pass membrane protein 2 HMGCR, SREBF2
Golgi apparatus membrane 1 SREBF2
cell surface 2 LDLR, PLAU
glutamatergic synapse 1 FLG
Golgi apparatus 2 LDLR, STS
Golgi membrane 2 INS, SREBF2
mitochondrial inner membrane 2 CYP11A1, FDXR
postsynapse 1 FLG
Cytoplasm, cytosol 1 SULT2B1
Lysosome 2 LDLR, STS
endosome 1 STS
plasma membrane 10 CD8A, DOCK2, F2, FLG, LDLR, PLAU, PRKCQ, STAR, STS, TGM1
Membrane 7 CYP11A1, DOCK2, FLG, HMGCR, LDLR, STS, TGM1
basolateral plasma membrane 1 LDLR
extracellular exosome 7 DOCK2, F2, IVL, MMP7, PLAU, SULT2B1, TGM1
endoplasmic reticulum 4 HMGCR, SREBF2, STS, SULT2B1
extracellular space 4 F2, INS, MMP7, PLAU
mitochondrion 4 CYP11A1, FDX1, FDXR, STAR
intracellular membrane-bounded organelle 3 SREBF2, STS, SULT2B1
Single-pass type I membrane protein 3 CD8A, LDLR, STAR
Secreted 3 F2, INS, PLAU
extracellular region 7 CD8A, DOCK2, F2, FLG, INS, MMP7, PLAU
Single-pass membrane protein 1 LDLR
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 FDX1
mitochondrial matrix 4 CYP11A1, FDX1, FDXR, STAR
centriolar satellite 1 PRKCQ
external side of plasma membrane 3 CD8A, LDLR, PLAU
Secreted, extracellular space, extracellular matrix 1 MMP7
low-density lipoprotein particle 1 LDLR
cytoplasmic vesicle 1 FLG
Early endosome 1 LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
Mitochondrion inner membrane 2 CYP11A1, FDXR
Cytoplasm, cytoskeleton 1 DOCK2
focal adhesion 1 PLAU
extracellular matrix 1 MMP7
peroxisomal membrane 1 HMGCR
mitochondrial intermembrane space 1 STAR
collagen-containing extracellular matrix 2 F2, FLG
Late endosome 1 LDLR
receptor complex 3 CD8A, FLG, LDLR
chromatin 1 SREBF2
cytoskeleton 1 DOCK2
cytoplasmic ribonucleoprotein granule 1 FLG
blood microparticle 1 F2
Endomembrane system 2 DOCK2, LDLR
endosome lumen 1 INS
sorting endosome 1 LDLR
Cornified envelope 4 FLG, IVL, LORICRIN, TGM1
specific granule membrane 1 PLAU
tertiary granule membrane 1 PLAU
Peroxisome membrane 1 HMGCR
Microsome 1 SULT2B1
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 F2, INS, STS
specific granule lumen 1 DOCK2
transport vesicle 1 INS
serine-type endopeptidase complex 1 PLAU
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ER to Golgi transport vesicle membrane 1 SREBF2
clathrin-coated endocytic vesicle membrane 1 LDLR
endolysosome membrane 1 LDLR
SREBP-SCAP-Insig complex 1 SREBF2
[Isoform 1]: Cell membrane 1 CD8A
serine protease inhibitor complex 1 PLAU
somatodendritic compartment 1 LDLR
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF2
protein complex involved in cell-matrix adhesion 1 PLAU
PCSK9-LDLR complex 1 LDLR
T cell receptor complex 1 CD8A
keratohyalin granule 1 FLG
Cytoplasmic vesicle, secretory vesicle, microneme membrane 1 STS
microneme membrane 1 STS
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane 1 SREBF2
[Processed sterol regulatory element-binding protein 2]: Nucleus 1 SREBF2


文献列表

  • S Tokoro, T Ogawa, S Hayashi, K Igawa. High-resolution mass spectrometry imaging reveals skin lipid changes and the cholesterol sulphate cycle during keratinization. Journal of the European Academy of Dermatology and Venereology : JEADV. 2024 Jun; 38(6):e456-e458. doi: 10.1111/jdv.19621. [PMID: 37909310]
  • Yunling Wang, Jinyue Yang, Yuming Wang, Yaoguang Chang, Changhu Xue, Tiantian Zhang. Preparation and properties of fucoxanthin-loaded liposomes stabilized by sea cucumber derived cholesterol sulfate instead of cholesterol. Journal of bioscience and bioengineering. 2023 Feb; 135(2):160-166. doi: 10.1016/j.jbiosc.2022.11.004. [PMID: 36494249]
  • Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui. Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Frontiers in immunology. 2023; 14(?):1131146. doi: 10.3389/fimmu.2023.1131146. [PMID: 37006281]
  • Fumika Mi-Ichi, Hiroshi Tsugawa, Makoto Arita, Hiroki Yoshida. Pleiotropic Roles of Cholesteryl Sulfate during Entamoeba Encystation: Involvement in Cell Rounding and Development of Membrane Impermeability. mSphere. 2022 08; 7(4):e0029922. doi: 10.1128/msphere.00299-22. [PMID: 35943216]
  • Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Daiji Sakata, Yoshihiro Izumi, Tetsuya Sakurai, Yuko Hattori, Eiji Oki, Naoto Kubota, Koshiro Nishimoto, Masafumi Oyama, Kazufumi Kunimura, Takuto Ohki, Takeshi Bamba, Hideaki Tahara, Michiie Sakamoto, Masafumi Nakamura, Makoto Suematsu, Yoshinori Fukui. Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells. International immunology. 2022 04; 34(5):277-289. doi: 10.1093/intimm/dxac002. [PMID: 35094065]
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