Primidone (BioDeep_00000002214)

 

Secondary id: BioDeep_00000398791

human metabolite blood metabolite


代谢物信息卡片


5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione

化学式: C12H14N2O2 (218.1055)
中文名称: 扑米酮
谱图信息: 最多检出来源 Homo sapiens(blood) 15.11%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Primidone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/primidone (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002214). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(ccccc1)C2(C(=O)NCNC2=O)CC
InChI: InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

描述信息

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AA - Barbiturates and derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
EAWAG_UCHEM_ID 195; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 195
CONFIDENCE standard compound; INTERNAL_ID 4095
INTERNAL_ID 4095; CONFIDENCE standard compound
CONFIDENCE standard compound; INTERNAL_ID 8502
CONFIDENCE standard compound; INTERNAL_ID 1516
KEIO_ID P061

同义名列表

28 个代谢物同义名

5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione; 5-ethyl-5-phenyl-1,3-diazinane-4,6-dione; Sanofi-synthelabo brand OF primidone; AstraZeneca brand OF primidone; Desitin brand OF primidone; Holsten brand OF primidone; Zeneca brand OF primidone; Draxis brand OF primidone; Apotex brand OF primidone; Astra brand OF primidone; Xcel brand OF primidone; 2-Deoxyphenobarbital; Desoxyphenobarbital; Primidon holsten; Apo primidone; Apo-primidone; Primidonum; Mylepsinum; Primaclone; Liskantin; Primidona; Resimatil; primidone; Misodine; Mysoline; Mizodin; Sertan; Primidone



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ALB, CALCA, CYP2C19, CYP2C9, CYP2E1, CYP3A4, PHB1, TRAPPC11
Peripheral membrane protein 2 ACHE, CYP2E1
Endoplasmic reticulum membrane 4 CYP2C19, CYP2C9, CYP2E1, CYP3A4
Nucleus 3 ACHE, ALB, PHB1
cytosol 3 ALB, GPT, TRAPPC11
centrosome 1 ALB
nucleoplasm 2 PHB1, SCNN1G
Cell membrane 4 ABCB1, ACHE, PHB1, TRPM3
Multi-pass membrane protein 6 ABCB1, CACNA1I, CATSPER3, NPC1, SCNN1G, TRPM3
Synapse 1 ACHE
cell surface 3 ABCB1, ACHE, PHB1
Golgi apparatus 4 ACHE, ALB, NPC1, TRAPPC11
Golgi membrane 1 INS
lysosomal membrane 1 NPC1
mitochondrial inner membrane 2 CYP2E1, PHB1
neuromuscular junction 1 ACHE
neuronal cell body 1 CALCA
Lysosome 2 NPC1, NPC2
acrosomal vesicle 1 CATSPER3
plasma membrane 10 ABCB1, ACHE, CACNA1I, CATSPER3, CYP2C19, CYP2C9, NPC1, PHB1, SCNN1G, TRPM3
terminal bouton 1 CALCA
Membrane 7 ABCB1, ACHE, CACNA1I, CYP3A4, NPC1, PHB1, TRPM3
apical plasma membrane 2 ABCB1, SCNN1G
extracellular exosome 8 ABCB1, ALB, GPT, NPC1, NPC2, PHB1, SCNN1G, SERPINA7
Lysosome membrane 1 NPC1
endoplasmic reticulum 4 ALB, CATSPER3, NPC1, NPC2
extracellular space 7 ACHE, ALB, CALCA, INS, NPC2, PTH, SERPINA7
lysosomal lumen 1 NPC2
perinuclear region of cytoplasm 2 ACHE, NPC1
mitochondrion 1 PHB1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 4 CYP2C19, CYP2C9, CYP2E1, CYP3A4
Microsome membrane 3 CYP2C9, CYP2E1, CYP3A4
Secreted 5 ACHE, ALB, CALCA, INS, NPC2
extracellular region 8 ACHE, ALB, CALCA, INS, NPC1, NPC2, PTH, SERPINA7
hippocampal mossy fiber to CA3 synapse 1 CALCA
Extracellular side 1 ACHE
anchoring junction 1 ALB
motile cilium 1 CATSPER3
external side of plasma membrane 1 SCNN1G
Early endosome 1 PHB1
Apical cell membrane 2 ABCB1, SCNN1G
Mitochondrion inner membrane 2 CYP2E1, PHB1
Membrane raft 1 NPC1
basement membrane 1 ACHE
ciliary basal body 1 ALB
Late endosome membrane 1 NPC1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 NPC1
Endomembrane system 1 NPC1
endosome lumen 1 INS
Cell projection, cilium, flagellum membrane 1 CATSPER3
sodium channel complex 1 SCNN1G
side of membrane 1 ACHE
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
azurophil granule lumen 1 NPC2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 CALCA
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
Golgi apparatus, cis-Golgi network 1 TRAPPC11
TRAPP complex 1 TRAPPC11
TRAPPIII protein complex 1 TRAPPC11
[Isoform H]: Cell membrane 1 ACHE
mitochondrial prohibitin complex 1 PHB1
ciliary transition fiber 1 ALB
CatSper complex 1 CATSPER3


文献列表

  • Ramzi Shawahna, Lina Zaid. Concentrations of antiseizure medications in breast milk of lactating women with epilepsy: A systematic review with qualitative synthesis. Seizure. 2022 May; 98(?):57-70. doi: 10.1016/j.seizure.2022.03.017. [PMID: 35427849]
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  • Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer. Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 05; 158(5):856-867. doi: 10.1097/j.pain.0000000000000846. [PMID: 28106668]
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