Dichlorphenamide (BioDeep_00000002127)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

4,5-Dichloro-benzene-1,3-disulphonic acid diamide

化学式: C6H6Cl2N2O4S2 (303.9146056)
中文名称: 二氯苯甲酰胺, 双氯非那胺
谱图信息: 最多检出来源 Homo sapiens(blood) 95.24%

分子结构信息

SMILES: C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N
InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)

描述信息

Dichlorphenamide is only found in individuals that have used or taken this drug. It is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO^3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na⁺ and HCO^3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EC - Carbonic anhydrase inhibitors
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor

同义名列表

34 个代谢物同义名

4,5-Dichloro-benzene-1,3-disulphonic acid diamide; 4,5-Dichloro-benzene-1,3-disulfonic acid diamide; 4,5-Dichloro-benzene-1,3-disulphonate diamide; 4,5-Dichloro-benzene-1,3-disulfonate diamide; 3,4-Dichloro-5-sulphamylbenzenesulphonamide; 3,4-Dichloro-5-sulfamylbenzenesulfonamide; 4,5-Dicholorobenzene-1,3-disulfonamide; 4,5-DICHLOROBENZENE-1,3-disulphonamide; 4,5-Dichloro-1,3-benzenedisulphonamide; 4,5-Dichloro-1,3-benzenedisulfonamide; 4,5-DICHLOROBENZENE-1,3-disulfonamide; 4,5-Dichloro-m-benzenedisulphonamide; 4,5-Dichloro-1,3-disulphamoylbenzene; 1,3-Disulphamoyl-4,5-dichlorobenzene; 1,3-Disulphamyl-4,5-dichlorobenzene; 1,3-Disulfamoyl-4,5-dichlorobenzene; 4,5-Dichloro-1,3-disulfamoylbenzene; 4,5-Dichloro-m-benzenedisulfonamide; 1,3-Disulfamyl-4,5-dichlorobenzene; Llorens brand OF dichlorphenamide; Merck brand OF dichlorphenamide; Dichlorophenamide; dichlorphenamide; Dichlorphenamid; Dichlofenamide; Diclofenamidum; Diclofenamida; diclofenamide; Diclofenamid; Glauconide; Daranide; Keveyis; Dichlorphenamide; Dichlorphenamide

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:101085
KEGG: C07459
KEGGdrug: D00518
PubChem: 3038
HMDB: HMDB0015275
Metlin: METLIN3980
DrugBank: DB01144
ChEMBL: CHEMBL17
Wikipedia: Dichlorphenamide
MeSH: Dichlorphenamide
chemspider: 2930
CAS: 120-97-8
PMhub: MS000001884
PubChem: 9662
PDB-CCD: I7A
NIKKAJI: J8.589H
RefMet: Dichlorphenamide
KNApSAcK: 101085

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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Fredric Cohen. Open-Label, Dose-Escalation, Phase 1 Study of Safety and Single and Multiple-Dose Pharmacokinetics of Dichlorphenamide in Healthy Volunteers. Clinical pharmacology in drug development. 2019 01; 8(1):87-94. doi: 10.1002/cpdd.464. [PMID: 29762909]
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