Oxycodone (BioDeep_00000002107)
Secondary id: BioDeep_00000397513
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
化学式: C18H21NO4 (315.1470506)
中文名称: 羟可待酮
谱图信息:
最多检出来源 Homo sapiens(blood) 5.71%
分子结构信息
SMILES: CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)OC)O4)O
InChI: InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
描述信息
Oxycodone is only found in individuals that have used or taken this drug. It is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AA - Natural opium alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
26 个代谢物同义名
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one; 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; 4,5a-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; 4,5Α-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; Purdue frederick brand OF oxycodone; (-)-14-Hydroxydihydrocodeinone; Dihydro-14-hydroxycodeinone; Dihydrohydroxycondeinone; Dihydrohydroxycodeinone; oxycodone hydrochloride; Dihydroxycodeinone; Oxycodeinon; Oxycodonum; Dihydrone; Pancodine; Oxicodona; oxycodone; Theocodin; Oxycontin; Oxiconum; Dinarkon; Oxycone; Eucodal; PTI-821; Oxicone
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:7852
- KEGG: C08018
- KEGGdrug: D05312
- PubChem: 5284603
- PubChem: 4635
- HMDB: HMDB0014640
- Metlin: METLIN43292
- DrugBank: DB00497
- ChEMBL: CHEMBL656
- Wikipedia: Oxycodone
- MeSH: Oxycodone
- chemspider: 4447649
- CAS: 76-42-6
- PMhub: MS000001843
- PubChem: 10218
- PDB-CCD: OOX
- NIKKAJI: J9.316E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3469 Papaver somniferum: 10.1016/J.JPBA.2008.06.022
- 3469 Papaver somniferum: 10.1016/J.JPBA.2008.06.022
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jack E Henningfield, Joseph V Rodricks, Aaron M Magnuson, Marilyn A Huestis. Respiratory effects of oral mitragynine and oxycodone in a rodent model.
Psychopharmacology.
2022 Dec; 239(12):3793-3804. doi:
10.1007/s00213-022-06244-z. [PMID: 36308562] - Srikanth C Nallani, Wenjing Li, Silvia N Calderon, Ellen Fields, Rigoberto A Roca, Yun Xu, Liang Zhao, Lanyan Fang, Chandrahas G Sahajwalla, Issam Zineh. Concentration-Response Model of Immediate Release Oxycodone Drug Liking by Different Routes of Abuse.
Pain medicine (Malden, Mass.).
2022 Jul; 23(7):1311-1322. doi:
10.1093/pm/pnab339. [PMID: 34865125] - Vlad Radoi, Gerd Jakobsson, Vinko Palada, Andrej Nikosjkov, Henrik Druid, Lars Terenius, Eva Kosek, Vladana Vukojević. Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation.
Molecules (Basel, Switzerland).
2022 Apr; 27(7):. doi:
10.3390/molecules27072350. [PMID: 35408749] - Nicole Arguelles, Janielle Richards, Ahmed A El-Sherbeni, Sharon Miksys, Rachel F Tyndale. Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia.
Biochemical pharmacology.
2022 04; 198(?):114949. doi:
10.1016/j.bcp.2022.114949. [PMID: 35143755] - Zhi-Bing You, Eliot L Gardner, Ewa Galaj, Allamar R Moore, Tristram Buck, Chloe J Jordan, Bree A Humburg, Guo-Hua Bi, Zheng-Xiong Xi, Lorenzo Leggio. Involvement of the ghrelin system in the maintenance of oxycodone self-administration: converging evidence from endocrine, pharmacologic and transgenic approaches.
Molecular psychiatry.
2022 04; 27(4):2171-2181. doi:
10.1038/s41380-022-01438-5. [PMID: 35064236] - Matthew J Blitz, Burton Rochelson, Lakha Prasannan, Guillaume J Stoffels, Karalyn Pappas, Greg T Palleschi, Harvey Marchbein. Scheduled versus as-needed postpartum analgesia and oxycodone utilization.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2022 Mar; 35(6):1054-1062. doi:
10.1080/14767058.2020.1742318. [PMID: 32193961] - Minna Guo, Shijiang Liu, Jian Gao, Chuanbao Han, Chun Yang, Cunming Liu. The effects of fentanyl, oxycodone, and butorphanol on gastrointestinal function in patients undergoing laparoscopic hysterectomy: a prospective, double-blind, randomized controlled trial.
BMC anesthesiology.
2022 02; 22(1):53. doi:
10.1186/s12871-022-01594-9. [PMID: 35209847] - Michael T Truver, Gerd Jakobsson, Maria D Chermà, Madeleine J Swortwood, Henrik Gréen, Robert Kronstrand. The Quantification of Oxycodone and Its Phase I and II Metabolites in Urine.
Journal of analytical toxicology.
2022 Feb; 46(1):55-63. doi:
10.1093/jat/bkaa186. [PMID: 33270113] - The Lancet. Managing the opioid crisis in North America and beyond.
Lancet (London, England).
2022 02; 399(10324):495. doi:
10.1016/s0140-6736(22)00200-8. [PMID: 35122752] - You Liang, Xiuyun Xu, Xiaona Sun, Chuanmin Song. Application of oxycodone combined with intravenous inhalation anesthesia in PFNA internal fixation of femoral intertrochanteric fracture in the elderly.
Minerva surgery.
2022 02; 77(1):90-92. doi:
10.23736/s2724-5691.21.08953-x. [PMID: 34160179] - Guang-Dan Zhu, Penn Whitley, Leah LaRue, Brandon Adkins, Eric Dawson, Angela Huskey, Edmund V Capparelli, Andria L Del Tredici. Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests.
The pharmacogenomics journal.
2022 02; 22(1):25-32. doi:
10.1038/s41397-021-00253-5. [PMID: 34480108] - Grzegorz Kowalski, Bogumił Olczak, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Danuta Szkutnik-Fiedler, Michał Adamski, Katarzyna Wieczorowska-Tobis. Analgesic Efficacy and Safety of Spinal Oxycodone in Total Hip Arthroplasty: A Preliminary Study.
Current medicinal chemistry.
2022; 29(21):3806-3814. doi:
10.2174/0929867329666220126125256. [PMID: 35081884] - Xian Bing Hou, Dan Dan Chen, Tong Fei Cheng, Dan Wang, Xiao Jun Dai, Yao Wang, Bi Xian Cui, Yuan Yuan Wang, Hui Xu, Hong Zhou Chen. Meta-analysis of efficacy and safety of sustained release oxycodone hydrochloride rectal administration for moderate to severe pain.
PloS one.
2022; 17(6):e0266754. doi:
10.1371/journal.pone.0266754. [PMID: 35759471] - Nicole Arguelles, Sharon Miksys, Rachel F Tyndale. Sex and Estrous Cycle Differences in Analgesia and Brain Oxycodone Levels.
Molecular neurobiology.
2021 Dec; 58(12):6540-6551. doi:
10.1007/s12035-021-02560-1. [PMID: 34581987] - James D Morse, Milan Sundermann, Jacqueline A Hannam, Hannu Kokki, Merja Kokki, Brian J Anderson. Population pharmacokinetics of oxycodone: Premature neonates to adults.
Paediatric anaesthesia.
2021 Dec; 31(12):1332-1339. doi:
10.1111/pan.14283. [PMID: 34469607] - Patrick Y Joynt, George Sam Wang. Fentanyl contaminated 'M30' pill overdoses in pediatric patients.
The American journal of emergency medicine.
2021 12; 50(?):811.e3-811.e4. doi:
10.1016/j.ajem.2021.05.035. [PMID: 34030905] - Monique M Cherrier, Danny D Shen, Laura Shireman, Andrew J Saxon, Tracy Simpson, Alex Men, Preetma Kooner, Gregory W Terman. Elevated customary alcohol consumption attenuates opioid effects.
Pharmacology, biochemistry, and behavior.
2021 12; 211(?):173295. doi:
10.1016/j.pbb.2021.173295. [PMID: 34742948] - Tao Feng, Si Zeng, Jie Ding, Gong Chen, Bin Wang, Daguo Wang, Xueli Li, Kunfeng Wang. Comparative analysis of the effects of opioids in angiogenesis.
BMC anesthesiology.
2021 10; 21(1):257. doi:
10.1186/s12871-021-01475-7. [PMID: 34702181] - Aymen A Al-Qurain, Desmond B Williams, Lorraine Mackenzie, Michael S Roberts, Michael D Wiese. Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 203(?):114171. doi:
10.1016/j.jpba.2021.114171. [PMID: 34087551] - Louise Ladebo, Ahmad Y Abuhelwa, David J R Foster, Jens P Kroustrup, Grzegorz J Pacyk, Kenneth T Kongstad, Asbjørn M Drewes, Lona L Christrup, Anne E Olesen. Effect of Roux-en-Y gastric bypass on the pharmacokinetic-pharmacodynamic relationships of liquid and controlled-release formulations of oxycodone.
Basic & clinical pharmacology & toxicology.
2021 Sep; 129(3):232-245. doi:
10.1111/bcpt.13634. [PMID: 34228875] - Louise Ladebo, Lars Vinter-Jensen, Johanne Hestvang, Maja Schjønning Mikkelsen, Henrik Højgaard Rasmussen, Lona Louring Christrup, Asbjørn Mohr Drewes, Anne Estrup Olesen. Oral absorption of oxycodone in patients with short bowel syndrome.
Scandinavian journal of gastroenterology.
2021 09; 56(9):1023-1029. doi:
10.1080/00365521.2021.1944299. [PMID: 34196257] - Saeid Raofi, Minori Kinjo, Dajun Sun, Zhichuan Li, Heather Boyce, Karthika Natarajan, Mitchell Frost, Liang Zhao, Markham Luke, Robert Lionberger, Debra Kelsh, Myong-Jin Kim. Particle size affects pharmacokinetics of milled oxycodone hydrochloride tablet products following nasal insufflation in nondependent, recreational opioid users.
Clinical and translational science.
2021 09; 14(5):1977-1987. doi:
10.1111/cts.13053. [PMID: 33982418] - Donald Fedrigon, Anna Faris, Naveen Kachroo, Rajat Jain, Marlie Elia, Lamont Wilkins, Jianbo Li, Smita De, Mark Noble, Manoj Monga, Sri Sivalingam. SKOPE-Study of Ketorolac vs Opioid for Pain after Endoscopy: A Double-Blinded Randomized Control Trial in Patients Undergoing Ureteroscopy.
The Journal of urology.
2021 Aug; 206(2):373-381. doi:
10.1097/ju.0000000000001772. [PMID: 33819072] - April M Huseby Kelcher, Carly A Baehr, Fatima A Hamid, Geoffrey T Hart, Marco Pravetoni. Contribution of Antibody-Mediated Effector Functions to the Mechanism of Efficacy of Vaccines for Opioid Use Disorders.
Journal of immunology (Baltimore, Md. : 1950).
2021 08; 207(3):860-867. doi:
10.4049/jimmunol.2100204. [PMID: 34281999] - Mohamed Abou El Hassan, David Colantonio, Sergei Likhodii, Bassam A Nassar. The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard.
Clinical biochemistry.
2021 Jul; 93(?):99-103. doi:
10.1016/j.clinbiochem.2021.04.003. [PMID: 33844982] - Anna Dari, Stefan Buller, Michael Gautrois, Hans-Jürgen Stahlberg, Jens Rengelshausen, Jan Freijer. Oxycodone Effect on Pupil Constriction in Recreational Opioid Users: A Pharmacokinetic/Pharmacodynamic Meta-Analysis Approach.
Clinical pharmacokinetics.
2021 06; 60(6):785-794. doi:
10.1007/s40262-020-00980-1. [PMID: 33515201] - Lieselot L G Carrette, Giordano de Guglielmo, Marsida Kallupi, Lisa Maturin, Molly Brennan, Brent Boomhower, Dana Conlisk, Sharona Sedighim, Lani Tieu, McKenzie J Fannon, Nathan Velarde, Angelica R Martinez, Jenni Kononoff, Adam Kimbrough, Sierra Simpson, Lauren C Smith, Kokila Shankar, Francisco J Ramirez, Apurva S Chitre, Bonnie Lin, Oksana Polesskaya, Leah C Solberg Woods, Abraham A Palmer, Olivier George. The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction.
eNeuro.
2021 May; 8(3):. doi:
10.1523/eneuro.0033-21.2021. [PMID: 33875455] - John Mach, XiaoSuo Wang, Sarah N Hilmer. Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy.
Fundamental & clinical pharmacology.
2021 Apr; 35(2):410-422. doi:
10.1111/fcp.12602. [PMID: 32813878] - Giulia Zanni, Patrese A Robinson-Drummer, Ashlee A Dougher, Hannah M Deutsch, Matthew J DeSalle, David Teplitsky, Aishwarya Vemulapalli, Regina M Sullivan, Amelia J Eisch, Gordon A Barr. Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function.
Drug and alcohol dependence.
2021 04; 221(?):108628. doi:
10.1016/j.drugalcdep.2021.108628. [PMID: 33761428] - Zhengzuo Wan, Chunhua Chu, Rong Zhou, Bin Que. Effects of Oxycodone Combined With Flurbiprofen Axetil on Postoperative Analgesia and Immune Function in Patients Undergoing Radical Resection of Colorectal Cancer.
Clinical pharmacology in drug development.
2021 03; 10(3):251-259. doi:
10.1002/cpdd.818. [PMID: 32567233] - F Plass, C Nicolle, M Zamparini, G Al Issa, A L Fiant, Y Le Roux, J L Gérard, M O Fischer, A Alvès, J-L Hanouz. Effect of intra-operative intravenous lidocaine on opioid consumption after bariatric surgery: a prospective, randomised, blinded, placebo-controlled study.
Anaesthesia.
2021 Feb; 76(2):189-198. doi:
10.1111/anae.15150. [PMID: 32564365] - Hossein Khosropour, Behzad Rezaei, Hossein A Alinajafi, Ali A Ensafi. Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone.
Mikrochimica acta.
2021 01; 188(1):1. doi:
10.1007/s00604-020-04655-3. [PMID: 33386503] - Elina Ashirova, Natalina H Contoreggi, Megan A Johnson, Fatima J Al-Khayat, Gabriela A Calcano, Batsheva R Rubin, Emma M O'Cinneide, Yong Zhang, Yan Zhou, Lennox Gregoire, Bruce S McEwen, Mary Jeanne Kreek, Teresa A Milner. Oxycodone injections not paired with conditioned place preference have little effect on the hippocampal opioid system in female and male rats.
Synapse (New York, N.Y.).
2021 01; 75(1):e22182. doi:
10.1002/syn.22182. [PMID: 32654187] - Shuo Qiu, Sachinder Vasudeva. A case report of satisfactory post-left knee replacement pain control after switching from oxycodone to buprenorphine.
Journal of opioid management.
2021; 17(7):179-182. doi:
10.5055/jom.2021.0656. [PMID: 34520040] - Andrew M McDonald, Sharon A Spencer, Christopher D Willey, James A Bonner, Michael C Dobelbower, Thomas A Swain, Lisle Nabell, Susan McCammon, William R Carroll, Gerald McGwin, Smita Bhatia, Eddy S Yang. Lipid microsphere bound oxycodone for pain management in patients receiving radiotherapy for head and neck cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2021 Jan; 29(1):263-269. doi:
10.1007/s00520-020-05474-1. [PMID: 32350670] - Ashish Kumar, Susy Kim, Yixin Su, Mitu Sharma, Pawan Kumar, Sangeeta Singh, Jingyun Lee, Cristina M Furdui, Ravi Singh, Fang-Chi Hsu, Jeongchul Kim, Christopher T Whitlow, Michael A Nader, Gagan Deep. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone.
EBioMedicine.
2021 Jan; 63(?):103192. doi:
10.1016/j.ebiom.2020.103192. [PMID: 33418508] - Alysabeth G Phillips, Dillon J McGovern, Soo Lee, Kyu Ro, David T Huynh, Sophie K Elvig, Katelynn N Fegan, David H Root. Oral prescription opioid-seeking behavior in male and female mice.
Addiction biology.
2020 11; 25(6):e12828. doi:
10.1111/adb.12828. [PMID: 31489746] - Payel J Roy, Melanie Weltman, Laura M Dember, Jane Liebschutz, Manisha Jhamb. Pain management in patients with chronic kidney disease and end-stage kidney disease.
Current opinion in nephrology and hypertension.
2020 11; 29(6):671-680. doi:
10.1097/mnh.0000000000000646. [PMID: 32941189] - Yelizaveta Sher, Beatrice Rabkin, José R Maldonado, Paul Mohabir. COVID-19-Associated Hyperactive Intensive Care Unit Delirium With Proposed Pathophysiology and Treatment: A Case Report.
Psychosomatics.
2020 Sep; 61(5):544-550. doi:
10.1016/j.psym.2020.05.007. [PMID: 32591212] - Chase R Brown, Zehang Chen, Fabliha Khurshan, Peter W Groeneveld, Nimesh D Desai. Development of Persistent Opioid Use After Cardiac Surgery.
JAMA cardiology.
2020 08; 5(8):889-896. doi:
10.1001/jamacardio.2020.1445. [PMID: 32584934] - Iván González, Stephen Roper. Elevated Lipase in an Infant with Altered Mental Status.
Laboratory medicine.
2020 Jul; 51(4):e38-e41. doi:
10.1093/labmed/lmz090. [PMID: 31833546] - Holly L Geyer, Halena Gazelka, Ruben Mesa. How I treat pain in hematologic malignancies safely with opioid therapy.
Blood.
2020 06; 135(26):2354-2364. doi:
10.1182/blood.2019003116. [PMID: 32352512] - Y Xie, C-L Ge, Z-Y Zhang, G-X Fei. Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA/ROCK1 signaling pathway.
European review for medical and pharmacological sciences.
2020 06; 24(11):6371-6379. doi:
10.26355/eurrev_202006_21535. [PMID: 32572934] - Jinli Zhang, Yixuan Zhang, Hongli Yan, Ke Zhang. Influence of Preemptive Analgesia with Oxycodone Hydrochloride on Stress Hormone Level of Geriatric Patients undergoing Gastrointestinal Surgery.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2020 May; 30(5):476-479. doi:
10.29271/jcpsp.2020.05.476. [PMID: 32580841] - Adam Kimbrough, Jenni Kononoff, Sierra Simpson, Marsida Kallupi, Sharona Sedighim, Kenia Palomino, Dana Conlisk, Jeremiah D Momper, Giordano de Guglielmo, Olivier George. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.
Psychopharmacology.
2020 May; 237(5):1545-1555. doi:
10.1007/s00213-020-05479-y. [PMID: 32114633] - Mari Kinnunen, Hannu Kokki, Heidi Hautajärvi, Kaisa Tuovinen, Merja Kokki. Oxycodone for pain management in the latent phase of labour - A pragmatic trial.
Acta anaesthesiologica Scandinavica.
2020 05; 64(5):685-690. doi:
10.1111/aas.13550. [PMID: 31950485] - Jian Zhang, Qing Tu, Jianhui Gan, Shuai Miao, Ying Zhou, Qiang Li, Chuandong Zheng. Preemptive Anti-Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement-A Randomized Controlled Trial.
Clinical pharmacology in drug development.
2020 04; 9(3):321-329. doi:
10.1002/cpdd.764. [PMID: 31820593] - Louise Ladebo, David J R Foster, Ahmad Y Abuhelwa, Richard N Upton, Kenneth T Kongstad, Asbjørn M Drewes, Lona L Christrup, Anne E Olesen. Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers.
Basic & clinical pharmacology & toxicology.
2020 Mar; 126(3):263-276. doi:
10.1111/bcpt.13330. [PMID: 31597014] - Jeffrey Gudin. Effect of physical manipulation on the oral pharmacokinetic profile of Xtampza® ER (oxycodone DETERx® formulation): A review of published studies.
Journal of opioid management.
2020 Mar; 16(2):127-139. doi:
10.5055/jom.2020.0559. [PMID: 32329888] - Zhu Luo, Jia Miao, Shiqing Shu, Ying Wang, Xiaohong Zhu, Chao Hu, Yali Shen. Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain.
Clinical drug investigation.
2020 Feb; 40(2):139-148. doi:
10.1007/s40261-019-00870-w. [PMID: 31679120] - Jiang Wu, Qi Gui, Jinlin Wang, Jingjing Ye, Zhongfang Xia, Shufen Wang, Feng Liu, Fanli Kong, Liang Zhong. Oxycodone preemptive analgesia after endoscopic plasma total adenotonsillectomy in children: A randomized controlled trial.
Medicine.
2020 Feb; 99(6):e19004. doi:
10.1097/md.0000000000019004. [PMID: 32028411] - John R Cashman, Mark Gohdes, Annelies de Kater, Grant Schoenhard. N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide.
Drug metabolism and disposition: the biological fate of chemicals.
2020 02; 48(2):106-115. doi:
10.1124/dmd.119.089300. [PMID: 31727673] - Jianhui Gan, Qing Tu, Shuai Miao, Tiantian Lei, Xiaoyan Cui, Jinyin Yan, Jian Zhang. Effects of oxycodone applied for patient-controlled analgesia on postoperative cognitive function in elderly patients undergoing total hip arthroplasty: a randomized controlled clinical trial.
Aging clinical and experimental research.
2020 Feb; 32(2):329-337. doi:
10.1007/s40520-019-01202-w. [PMID: 30993660] - Salimah H Meghani, William E Rosa, Jesse Chittams, April Hazard Vallerand, Ting Bao, Jun J Mao. Both Race and Insurance Type Independently Predict the Selection of Oral Opioids Prescribed to Cancer Outpatients.
Pain management nursing : official journal of the American Society of Pain Management Nurses.
2020 02; 21(1):65-71. doi:
10.1016/j.pmn.2019.07.004. [PMID: 31501079] - Ruping Fan, Lisa M Schrott, Stephen Snelling, John Felty, Derrel Graham, Patrick L McGauly, Thomas Arnold, Nadejda L Korneeva. Carbonyl-protein content increases in brain and blood of female rats after chronic oxycodone treatment.
BMC neuroscience.
2020 01; 21(1):4. doi:
10.1186/s12868-020-0552-2. [PMID: 31969118] - Jacques D Nguyen, Kevin M Creehan, Tony M Kerr, Michael A Taffe. Lasting effects of repeated ∆9 -tetrahydrocannabinol vapour inhalation during adolescence in male and female rats.
British journal of pharmacology.
2020 01; 177(1):188-203. doi:
10.1111/bph.14856. [PMID: 31478558] - Rebekah D Tenney, Steven Blake, Paul T Bremer, Bin Zhou, Candy S Hwang, Justin L Poklis, Kim D Janda, Matthew L Banks. Vaccine blunts fentanyl potency in male rhesus monkeys.
Neuropharmacology.
2019 11; 158(?):107730. doi:
10.1016/j.neuropharm.2019.107730. [PMID: 31369740] - Mari Kinnunen, Hannu Kokki, Heidi Hautajärvi, Juulia Lantto, Juha Räsänen, Hanna-Marja Voipio, Merja Kokki. Oxycodone concentrations in the central nervous system and cerebrospinal fluid after epidural administration to the pregnant ewe.
Basic & clinical pharmacology & toxicology.
2019 Nov; 125(5):430-438. doi:
10.1111/bcpt.13276. [PMID: 31222944] - P S Joshi, N Sanakkayala, L Kirkpatrick, P S Terse. Nonclinical safety assessment of PF614: A novel TAAP prodrug of oxycodone for chronic pain indication.
Regulatory toxicology and pharmacology : RTP.
2019 Nov; 108(?):104433. doi:
10.1016/j.yrtph.2019.104433. [PMID: 31362032] - Liang Zheng, Miao Xu, Shi-Wei Tang, Hao-Xin Song, Xue-Hua Jiang, Ling Wang. Physiologically Based Pharmacokinetic Modeling of Oxycodone in Children to Support Pediatric Dosing Optimization.
Pharmaceutical research.
2019 Oct; 36(12):171. doi:
10.1007/s11095-019-2708-2. [PMID: 31654287] - Brett Gall, Joe M El-Khoury. Unusual Drug Test Results for a Patient on Buprenorphine and Naloxone.
Clinical chemistry.
2019 10; 65(10):1332-1333. doi:
10.1373/clinchem.2019.309484. [PMID: 31570415] - Esben B Mark, Mark B Bødker, Debbie Grønlund, Lasse R Østergaard, Jens B Frøkjaer, Asbjørn M Drewes. MRI analysis of fecal volume and dryness: Validation study using an experimental oxycodone-induced constipation model.
Journal of magnetic resonance imaging : JMRI.
2019 09; 50(3):733-745. doi:
10.1002/jmri.26628. [PMID: 30609164] - Joseph S Gimbel, Richard L Rauck, Almasa Bass, Jacquelyn Wilson, Glenn Pixton, Bimal Malhotra, Gary Wilson, Gernot Wolfram. Effects of naltrexone exposure observed in two phase three studies with ALO-02, an extended-release oxycodone surrounding sequestered naltrexone.
Journal of opioid management.
2019 Sep; 15(5):417-427. doi:
10.5055/jom.2019.0530. [PMID: 31849032] - Michael N Kammer, Amanda Kussrow, Ilavarasi Gandhi, Rafal Drabek, Robert H Batchelor, George W Jackson, Darryl J Bornhop. Quantification of Opioids in Urine Using an Aptamer-Based Free-Solution Assay.
Analytical chemistry.
2019 08; 91(16):10582-10588. doi:
10.1021/acs.analchem.9b01638. [PMID: 31314489] - Panu Piirainen, Hannu Kokki, Brian Anderson, Jacqueline Hannam, Heidi Hautajärvi, Veli-Pekka Ranta, Merja Kokki. Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecological laparoscopy-A randomised, double blind, active control, double-dummy clinical comparison with intravenous administration.
British journal of clinical pharmacology.
2019 08; 85(8):1798-1807. doi:
10.1111/bcp.13971. [PMID: 31026086] - Lynn R Webster, Eric R Kinzler, Carmela Pantaleon, Matthew Iverson, Stefan Aigner. Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study.
Advances in therapy.
2019 07; 36(7):1730-1740. doi:
10.1007/s12325-019-00963-0. [PMID: 31065992] - Suresh Narayanasamy, Nageswara R Pilli, Lin Xu, Ashok Chockalingam, Katherine I Shea, Sharron Stewart, Vikram Patel, Rodney Rouse, Murali K Matta. An alternating polarity switching assay for quantification of oxycodone and topiramate: An application of LC-MS/MS method in support to PK/PD study in rodents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Jun; 1118-1119(?):93-100. doi:
10.1016/j.jchromb.2019.04.044. [PMID: 31030106] - Yi An, Lei Zhao, Tianlong Wang, Jiapeng Huang, Wei Xiao, Ping Wang, Lixia Li, Zhongjia Li, Xiaoxu Chen. Preemptive oxycodone is superior to equal dose of sufentanil to reduce visceral pain and inflammatory markers after surgery: a randomized controlled trail.
BMC anesthesiology.
2019 06; 19(1):96. doi:
10.1186/s12871-019-0775-x. [PMID: 31185942] - M Lamminsalo, P Piirainen, H Kokki, C A J Knibbe, V-P Ranta, P Välitalo, Merja Kokki. Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration.
Expert opinion on drug delivery.
2019 06; 16(6):649-656. doi:
10.1080/17425247.2019.1618267. [PMID: 31092024] - Hongming Pan, Peng Shen, Qijin Shu, Liqin Lu, Suying Qian, Yuefen Zhou, Feng Han, Qunyi Guo, Zhiping Yang, Jie Pan, Qing Xu, Peng Zhang, Kaifeng Wang. Efficacy and safety of sustained-release oxycodone compared with immediate-release morphine for pain titration in cancer patients: A multicenter, open-label, randomized controlled trial (SOCIAL).
Medicine.
2019 Jun; 98(24):e15505. doi:
10.1097/md.0000000000015505. [PMID: 31192908] - Lynn R Webster, Matthew Iverson, Carmela Pantaleon, Michael D Smith, Eric R Kinzler, Stefan Aigner. A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation.
Pain medicine (Malden, Mass.).
2019 04; 20(4):747-757. doi:
10.1093/pm/pny043. [PMID: 29608768] - Anne Leuppi-Taegtmeyer, Urs Duthaler, Felix Hammann, Yasmin Schmid, Michael Dickenmann, Patricia Amico, Andreas W Jehle, Stefan Kalbermatter, Christoph Lenherr, Henriette E Meyer Zu Schwabedissen, Manuel Haschke, Matthias E Liechti, Stephan Krähenbühl. Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 04; 34(4):692-702. doi:
10.1093/ndt/gfy285. [PMID: 30189012] - Douglas M McMillan, Sharon Miksys, Rachel F Tyndale. Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.
Addiction biology.
2019 03; 24(2):228-238. doi:
10.1111/adb.12590. [PMID: 29266563] - Mengyang Di, Jessica Bian, James N Butera. A new onset of thrombocytopenia and microangiopathic hemolytic anemia in the healthcare setting: A challenge for diagnosis.
American journal of hematology.
2019 01; 94(1):145-148. doi:
10.1002/ajh.25298. [PMID: 30264862] - Robert West, Charles Mikel, Doriane Hofilena, Maria Guevara. Positivity rates of drugs in patients treated for opioid dependence with buprenorphine: A comparison of oral fluid and urine using paired collections and LC-MS/MS.
Drug and alcohol dependence.
2018 12; 193(?):183-191. doi:
10.1016/j.drugalcdep.2018.07.023. [PMID: 30391868] - Malik Bechakra, Floor Moerdijk, Joost van Rosmalen, Birgit C P Koch, Carin C D van der Rijt, Peter A E Sillevis Smitt, Joost L M Jongen. Opioid responsiveness of nociceptive versus mixed pain in clinical cancer patients.
European journal of cancer (Oxford, England : 1990).
2018 12; 105(?):79-87. doi:
10.1016/j.ejca.2018.09.036. [PMID: 30439627] - Mari Kinnunen, Hannu Kokki, Heidi Hautajärvi, Heikki Huhta, Veli-Pekka Ranta, Juha Räsänen, Hanna-Marja Voipio, Merja Kokki. Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe.
Acta obstetricia et gynecologica Scandinavica.
2018 Oct; 97(10):1200-1205. doi:
10.1111/aogs.13378. [PMID: 29772054] - Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes. Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Sep; 122(?):77-84. doi:
10.1016/j.ejps.2018.06.018. [PMID: 29933077] - Yuan Ping, Chen Jing, Jia Qing. Comparison of the use of different analgesics in the course of anesthesia care based on pharmacoeconomics.
Pakistan journal of pharmaceutical sciences.
2018 Sep; 31(5(Special)):2241-2247. doi:
". [PMID: 30463819] - Xian-Hui Kang, Fang-Ping Bao, Hong-Gang Zhang, Dan-Jun Yu, Ke Ha, Qing Xie, Sheng-Mei Zhu. Gender Affects the Median Effective Dose and 95\% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naïve Adult Patients.
Chinese medical journal.
2018 Aug; 131(16):1958-1963. doi:
10.4103/0366-6999.238138. [PMID: 30082527] - Jacques D Nguyen, Candy S Hwang, Yanabel Grant, Kim D Janda, Michael A Taffe. Prophylactic vaccination protects against the development of oxycodone self-administration.
Neuropharmacology.
2018 08; 138(?):292-303. doi:
10.1016/j.neuropharm.2018.06.026. [PMID: 29936242] - Lin Zhou, Yahui Hu, Chengyuan Li, Yunyi Yan, Luyao Ao, Boyang Yu, Weirong Fang, Jihua Liu, Yunman Li. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway.
Neuropharmacology.
2018 06; 135(?):34-47. doi:
10.1016/j.neuropharm.2018.03.004. [PMID: 29518397] - Jari Kärkkäinen, Iina Saimanen, Tuomas Selander, Samuli Aspinen, Jukka Harju, Petri Juvonen, Matti Eskelinen. Gallstone Patients with Enhanced Oxidative Stress Biomarker Superoxide Dismutase (SOD1) Plasma Levels Have Significantly Lower Number of Postoperative Analgesic Oxycodone Doses: A Prospective Study with Special Reference to Cancer Patients.
Anticancer research.
2018 Jun; 38(6):3573-3578. doi:
10.21873/anticanres.12630. [PMID: 29848712] - Michael D Raleigh, Megan Laudenbach, Federico Baruffaldi, Samantha J Peterson, Michaela J Roslawski, Angela K Birnbaum, F Ivy Carroll, Scott P Runyon, Scott Winston, Paul R Pentel, Marco Pravetoni. Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.
The Journal of pharmacology and experimental therapeutics.
2018 05; 365(2):346-353. doi:
10.1124/jpet.117.247049. [PMID: 29535156] - Michele Protti, Maria Carmen Catapano, Boaz Gedaliahu Samolsky Dekel, James Rudge, Gilberto Gerra, Lorenzo Somaini, Roberto Mandrioli, Laura Mercolini. Determination of oxycodone and its major metabolites in haematic and urinary matrices: Comparison of traditional and miniaturised sampling approaches.
Journal of pharmaceutical and biomedical analysis.
2018 Apr; 152(?):204-214. doi:
10.1016/j.jpba.2018.01.043. [PMID: 29414014] - Megan Laudenbach, Federico Baruffaldi, Christine Robinson, Philipp Carter, Davis Seelig, Carly Baehr, Marco Pravetoni. Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose.
Scientific reports.
2018 04; 8(1):5508. doi:
10.1038/s41598-018-23777-6. [PMID: 29615715] - T Lilius, E Kangas, M Niemi, P Rauhala, E Kalso. Ketamine and norketamine attenuate oxycodone tolerance markedly less than that of morphine: from behaviour to drug availability.
British journal of anaesthesia.
2018 Apr; 120(4):818-826. doi:
10.1016/j.bja.2017.11.081. [PMID: 29576122] - Kristiina Cajanus, Mikko Neuvonen, Outi Koskela, Mari A Kaunisto, Pertti J Neuvonen, Mikko Niemi, Eija Kalso. Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?.
Clinical pharmacology and therapeutics.
2018 04; 103(4):653-662. doi:
10.1002/cpt.771. [PMID: 28643329] - Martin Purdy, Mari Kinnunen, Merja Kokki, Maarit Anttila, Matti Eskelinen, Heidi Hautajärvi, Marko Lehtonen, Hannu Kokki. A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy.
Medicine.
2018 Feb; 97(7):e9968. doi:
10.1097/md.0000000000009968. [PMID: 29443788] - Stephen P Mayock, Said Saim, Alison B Fleming. In Vitro Drug Release After Crushing: Evaluation of Xtampza® ER and Other ER Opioid Formulations.
Clinical drug investigation.
2017 Dec; 37(12):1117-1124. doi:
10.1007/s40261-017-0561-9. [PMID: 28940174] - Michael J Brennan, Ernest A Kopecky, Ann Marseilles, Melinda O'Connor, Alison B Fleming. The comparative pharmacokinetics of physical manipulation by crushing of Xtampza® ER compared with OxyContin®.
Pain management.
2017 Nov; 7(6):461-472. doi:
10.2217/pmt-2017-0030. [PMID: 29171358] - Naum Shaparin, Neel Mehta, Frank Kunkel, Richard Stripp, Damon Borg, Elizabeth Kolb. A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid.
Pain medicine (Malden, Mass.).
2017 Nov; 18(11):2162-2169. doi:
10.1093/pm/pnw335. [PMID: 28339737] - Bernhard Scheidel, Martina A Maritz, Yves J Gschwind, Kerstin Steigerwald, Volker Guth, Peter Kovacs, Helene Rey. Bioavailability of oxycodone after administration of a new prolonged-release once-daily tablet formulation in healthy subjects, in comparison to an established twice-daily tablet
.
International journal of clinical pharmacology and therapeutics.
2017 Nov; 55(11):881-890. doi:
10.5414/cp203005. [PMID: 28933336] - Elena G Shcherbakova, Ben Zhang, Samer Gozem, Tsuyoshi Minami, Peter Y Zavalij, Mariia Pushina, Lyle D Isaacs, Pavel Anzenbacher. Supramolecular Sensors for Opiates and Their Metabolites.
Journal of the American Chemical Society.
2017 10; 139(42):14954-14960. doi:
10.1021/jacs.7b06371. [PMID: 28820934] - Hiromichi Matsuoka, Junji Tsurutani, Yasutaka Chiba, Yoshihiko Fujita, Masato Terashima, Takeshi Yoshida, Kiyohiro Sakai, Yoichi Otake, Atsuko Koyama, Kazuto Nishio, Kazuhiko Nakagawa. Selection of opioids for cancer-related pain using a biomarker: a randomized, multi-institutional, open-label trial (RELIEF study).
BMC cancer.
2017 Oct; 17(1):674. doi:
10.1186/s12885-017-3664-z. [PMID: 28985716] - Kaoru Toyama, Naoki Kiyosawa, Kenji Watanabe, Hitoshi Ishizuka. Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment.
International journal of molecular sciences.
2017 Sep; 18(9):. doi:
10.3390/ijms18091991. [PMID: 28926935] - Kaoru Toyama, Hidetoshi Furuie, Kana Kuroda, Hitoshi Ishizuka. Pharmacokinetic Bioequivalence Studies of an Extended-Release Oxycodone Hydrochloride Tablet in Healthy Japanese Subjects Under Fasting and Fed Conditions Without an Opioid Antagonist.
Drugs in R&D.
2017 Sep; 17(3):363-370. doi:
10.1007/s40268-017-0184-x. [PMID: 28516342] - Roger W Byard, Michaela Kenneally. Body pushing, prescription drugs and hospital admission.
Forensic science, medicine, and pathology.
2017 Sep; 13(3):359-361. doi:
10.1007/s12024-017-9855-8. [PMID: 28299558] - Lu Yang, Cheng-Zhi Chai, Yan Yan, Ying-Dan Duan, Astrid Henz, Bo-Li Zhang, Anders Backlund, Bo-Yang Yu. Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27.
Molecules (Basel, Switzerland).
2017 Aug; 22(9):. doi:
10.3390/molecules22091392. [PMID: 28850076]