Pioglitazone (BioDeep_00000002072)

 

Secondary id: BioDeep_00000397572

human metabolite blood metabolite


代谢物信息卡片


(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

化学式: C19H20N2O3S (356.119457)
中文名称: 匹格列酮
谱图信息: 最多检出来源 Homo sapiens(blood) 13.33%

分子结构信息

SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)

描述信息

Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BG - Thiazolidinediones
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D007004 - Hypoglycemic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research[2][3][4].

同义名列表

12 个代谢物同义名

(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione; 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; Pioglitazone Hydrochloride; Poglitazone hydrochloride; Pioglitazone HCl; Pioglitazonum; Pioglitazona; Pioglitazone; Actos; U 72107



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Soo Lim, Seung-Hwan Lee, Kyung-Wan Min, Chang Beom Lee, Sang Yong Kim, Hye Jin Yoo, Nan Hee Kim, Jae Hyeon Kim, Seungjoon Oh, Jong Chul Won, Hyuk Sang Kwon, Mi Kyung Kim, Jung Hwan Park, In-Kyung Jeong, Sungrae Kim. A multicentre, double-blind, placebo-controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add-on therapy in type 2 diabetic patients treated with metformin and dapagliflozin. Diabetes, obesity & metabolism. 2024 Jun; 26(6):2188-2198. doi: 10.1111/dom.15526. [PMID: 38425186]
  • Fatemeh Amin, Arghavan Memarzia, Hamideh Kazemi Rad, Hamid Reza Kazerani, Seyedeh Zahra Ghasemi, Mohammad Hossein Boskabady. Inhaled paraquat-induced lung injury in rat, improved by the extract of Zataria multiflora boiss and PPARγ agonist, pioglitazone. Legal medicine (Tokyo, Japan). 2024 Mar; 67(?):102335. doi: 10.1016/j.legalmed.2023.102335. [PMID: 37951808]
  • Lim Shern Kwok, Shim Siang Yian, Layla Qasim Ismael, Yvonne Tee Get Bee, Gam Lay Harn, Khoo Boon Yin. Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions. Molecular biology reports. 2024 Feb; 51(1):317. doi: 10.1007/s11033-024-09269-z. [PMID: 38381204]
  • Yang Shaojun, M A Yanhua, Bai Zhouxia, Y U Ye, Fang Buwu, Zhang Li, Wang Li. Intervention effect of Cigu Xiaozhi prescription on ceramide lipoapoptosis in non-alcoholic fatty liver disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):63-69. doi: 10.19852/j.cnki.jtcm.20231215.002. [PMID: 38213240]
  • Kwazi Gabuza, Thendo I Mabuda, Oelfah Patel, Noxolo Khuboni, Ruzayda van Aarde, Sylvia Riedel, Nonhlakanipho F Sangweni, Shantal Windvogel, Rabia Johnson, Christo J F Muller. Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD. PloS one. 2024; 19(4):e0297572. doi: 10.1371/journal.pone.0297572. [PMID: 38630788]
  • Laya Hooshmand Gharabagh, Ali Shargh, Mohammad Reza Mohammad Hosseini Azar, Ayda Esmaeili. Comparison between the effect of Empagliflozin and Pioglitazone added to metformin in patients with type 2 diabetes and nonalcoholic fatty liver disease. Clinics and research in hepatology and gastroenterology. 2023 Dec; 48(3):102279. doi: 10.1016/j.clinre.2023.102279. [PMID: 38159676]
  • Shankar Gupta, Gurkaran Singh Baweja, Shamsher Singh, Mehdi Irani, Rajveer Singh, Vivek Asati. Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2,4-diones: Design, synthesis and in vivo studies. European journal of medicinal chemistry. 2023 Dec; 261(?):115826. doi: 10.1016/j.ejmech.2023.115826. [PMID: 37793328]
  • Batool Zamani, Seyyed Mashaalah Tabatabizadeh, Hamidreza Gilasi, Shadi Yazdani. Effects of pioglitazone and linagliptin on glycemic control, lipid profile and hs-CRP in metformin-treated patients with type 2 diabetes: a comparative study. Hormone molecular biology and clinical investigation. 2023 Dec; 44(4):385-391. doi: 10.1515/hmbci-2022-0070. [PMID: 38143260]
  • Johanna M Melin, Maria Forslund, Simon J Alesi, Terhi Piltonen, Daniela Romualdi, Poli M Spritzer, Chau Thien Tay, Alexia S Pena, Selma F Witchel, Aya Mousa, Helena J Teede. Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis. Clinical endocrinology. 2023 Nov; ?(?):. doi: 10.1111/cen.14983. [PMID: 37933831]
  • Ahmad H Alhowail. Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. Behavioural brain research. 2023 Oct; ?(?):114714. doi: 10.1016/j.bbr.2023.114714. [PMID: 37838244]
  • Arghavan Memarzia, Seyedeh Zahra Ghasemi, Sepideh Behrouz, Mohammad Hossein Boskabady. The effects of Crocus sativus extract on inhaled paraquat-induced lung inflammation, oxidative stress, pathological changes and tracheal responsiveness in rats. Toxicon : official journal of the International Society on Toxinology. 2023 Oct; ?(?):107316. doi: 10.1016/j.toxicon.2023.107316. [PMID: 37827264]
  • F de Zegher, M Díaz, L Ibáñez. Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone. Journal of endocrinological investigation. 2023 Oct; ?(?):. doi: 10.1007/s40618-023-02206-0. [PMID: 37805962]
  • Moumita Nath, Kasturi Bhattacharjee, Yashmin Choudhury. The antidiabetic drug pioglitazone ameliorates betel-nut-induced carcinogenesis in mice by restoring normal lipid metabolism, reducing oxidative stress, and inducing apoptosis. Journal of cancer research and therapeutics. 2023 Oct; 19(7):1967-1974. doi: 10.4103/jcrt.jcrt_844_22. [PMID: 38376305]
  • Rasool Haddadi, Mohammad Cheraghi-Poor. Peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand, pioglitazone, increases analgesic and anti-inflammatory effects of naproxen. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02715-y. [PMID: 37698622]
  • Y Pei, Y-Y Liu, M Sun, J Zheng, T-T Zhou, B Wang, H Hu, Z-L Wang. Beneficial effects of pioglitazone and α-lipoic acid in patients with polycystic ovaries syndrome. European review for medical and pharmacological sciences. 2023 Aug; 27(15):7118-7126. doi: 10.26355/eurrev_202308_33285. [PMID: 37606122]
  • Jieying Liu, Dongmei Wang, Ziyan Xie, Lu Ding, Shunhua Li, Xuemei Ma, Jing Liu, Jing Ren, Cheng Xiao, Chunru Yang, Xinhua Xiao. Combination of Pioglitazone and Metformin Actions on Liver Lipid Metabolism in Obese Mice. Biomolecules. 2023 07; 13(8):. doi: 10.3390/biom13081199. [PMID: 37627267]
  • Yanmei Zhong, Yingying Xu, Yongzhen Tan, Xuanxuan Zhang, Ruolun Wang, Danmin Chen, Zhaotao Wang, Xunlong Zhong. Lipidomics of the erythrocyte membrane and network pharmacology to explore the mechanism of mangiferin from Anemarrhenae rhizoma in treating type 2 diabetes mellitus rats. Journal of pharmaceutical and biomedical analysis. 2023 Jun; 230(?):115386. doi: 10.1016/j.jpba.2023.115386. [PMID: 37044004]
  • Silvia Botrous, Ayaat Elmaghraby, Samar El-Achy, Yehia Mustafa, Effat Badr, Amany Haggag, Salah Abdel-Rahman. Inhibition of TNF-α Oncogene Expression by Artemisia Annua L. Extract Against Pioglitazone Side Effects in Male Albino Mice. Molecular biotechnology. 2023 May; ?(?):. doi: 10.1007/s12033-023-00762-7. [PMID: 37179253]
  • Azza A Ali, Eman B Saad, Rana H Abd El-Rhman, Ola M Abd El-Raouf, Amany M Gad. Impact of peroxisome proliferator activated receptor agonist drugs in a model of nephrotoxicity in rats. Journal of biochemical and molecular toxicology. 2023 Mar; ?(?):e23350. doi: 10.1002/jbt.23350. [PMID: 36988379]
  • Mohd Imran, Sahaya Mercy Jaquline Robert, Manju Sharma, Vidhu Aeri. Evaluation of Sida cordifolia and Sida rhombifolia extracts in a rat model of streptozotocin-induced diabetic nephropathy. Polimery w medycynie. 2023 Mar; ?(?):. doi: 10.17219/pim/156847. [PMID: 36975210]
  • Seyedeh Zahra Ghasemi, Sima Beigoli, Arghavan Memarzia, Sepideh Behrouz, Zahra Gholamnezhad, Majid Darroudi, Fatemeh Amin, Mohammad Hossein Boskabady. Paraquat-induced systemic inflammation and oxidative stress in rats improved by Curcuma longa ethanolic extract, curcumin and a PPAR agonist. Toxicon : official journal of the International Society on Toxinology. 2023 Mar; 227(?):107090. doi: 10.1016/j.toxicon.2023.107090. [PMID: 36965712]
  • Han Zhao, Dongxu Wang, Chuan Xing, Bo Lv, Xiaochen Wang, Bing He. Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α. The Journal of steroid biochemistry and molecular biology. 2023 Feb; 229(?):106265. doi: 10.1016/j.jsbmb.2023.106265. [PMID: 36737028]
  • Jihyun An, Joo Hyun Sohn. Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials. Clinical and molecular hepatology. 2023 02; 29(Suppl):S268-S275. doi: 10.3350/cmh.2022.0437. [PMID: 36537018]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Thomas J McClelland, Alexander J Fowler, Thomas W Davies, Rupert Pearse, John Prowle, Zudin Puthucheary. Can pioglitazone be used for optimization of nutrition in critical illness? A systematic review. JPEN. Journal of parenteral and enteral nutrition. 2023 Jan; ?(?):. doi: 10.1002/jpen.2481. [PMID: 36700419]
  • L N Tamimi, Z Zakaraya, M Hailat, W Abu Dayyih, E Daoud, A Abed, M J Saadh, B Majeed, H Abumansour, A Aburumman, J M Majeed, M Hamad. Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats. European review for medical and pharmacological sciences. 2023 01; 27(1):325-332. doi: 10.26355/eurrev_202301_30879. [PMID: 36647881]
  • Fu Jianfang, Xiao Wanxia, Gao Xiling, Xu Jing, Yang Wenjuan, Liu Jianrong, He Qingzhen, Ma Kaiyan, Lian Jingxuan, Chen Taixiong, Xu Qian, Li Mengying, Ming Jie, Ji Qiuhe. Effect and Safety of Pioglitazone-Metformin Tablets in the Treatment of Newly Diagnosed Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease in Shaanxi Province: A Randomized, Double-Blinded, Double-Simulated Multicenter Study. Journal of diabetes research. 2023; 2023(?):2044090. doi: 10.1155/2023/2044090. [PMID: 37305429]
  • Xuehui Zhang, Xue Chen, Zhe Liang, Maoxiao Nie, Yunfeng Yan, Quanming Zhao. Pioglitazone combined with atorvastatin promotes plaque stabilization in a rabbit model. Vascular. 2022 Dec; 30(6):1205-1212. doi: 10.1177/17085381211040992. [PMID: 34470532]
  • Gary N Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S Bell, John Tower. A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects. Fly. 2022 12; 16(1):397-413. doi: 10.1080/19336934.2022.2149209. [PMID: 36412257]
  • Liudan Chen, Yangu Tao, Jianjun Li, Mengru Kang. Pioglitazone use is associated with reduced risk of Parkinson's disease in patients with diabetes: A systematic review and meta-analysis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2022 Dec; 106(?):154-158. doi: 10.1016/j.jocn.2022.10.023. [PMID: 36335768]
  • Yan Zhao, Wenli Zhao, Hongwu Wang, Ye Zhao, Huaien Bu, Hirokazu Takahashi. Pioglitazone on nonalcoholic steatohepatitis: A systematic review and meta-analysis of 15 RCTs. Medicine. 2022 Nov; 101(46):e31508. doi: 10.1097/md.0000000000031508. [PMID: 36401449]
  • Hager H Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G Aly, Ahmed F El-Yazbi, Ahmed Wahid. Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms. Life sciences. 2022 Nov; 308(?):120956. doi: 10.1016/j.lfs.2022.120956. [PMID: 36103959]
  • Bruno Vergès. Intestinal lipid absorption and transport in type 2 diabetes. Diabetologia. 2022 10; 65(10):1587-1600. doi: 10.1007/s00125-022-05765-8. [PMID: 35908083]
  • Seung Hyun Lee, Nayoung Kim, Minkyu Kim, Sang-Ho Woo, Inhee Han, Jisu Park, Kyeongdae Kim, Kyu Seong Park, Kibyeong Kim, Dahee Shim, Sang-Eun Park, Jing Yu Zhang, Du-Min Go, Dae-Yong Kim, Won Kee Yoon, Seung-Pyo Lee, Jongsuk Chung, Ki-Wook Kim, Jung Hwan Park, Seung Hyun Lee, Sak Lee, Soo-Jin Ann, Sang-Hak Lee, Hyo-Suk Ahn, Seong Cheol Jeong, Tae Kyeong Kim, Goo Taeg Oh, Woong-Yang Park, Hae-Ock Lee, Jae-Hoon Choi. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia. Nature communications. 2022 09; 13(1):5461. doi: 10.1038/s41467-022-33202-2. [PMID: 36115863]
  • Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi. Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study. Diabetes & metabolism journal. 2022 09; 46(5):689-700. doi: 10.4093/dmj.2021.0183. [PMID: 35295073]
  • Yousef Baghcheghi, Farimah Beheshti, Mahmoud Hosseini, Arezoo Gowhari-Shabgah, Mohammad Ali-Hassanzadeh, Mahdiyeh Hedayati-Moghadam. Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress. Clinical and experimental hypertension (New York, N.Y. : 1993). 2022 Aug; 44(6):539-547. doi: 10.1080/10641963.2022.2079669. [PMID: 35722928]
  • Ricardo J Samms, Christine C Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew C Adams, Muhammad A Abdul-Ghani, Ralph A DeFronzo, Luke Norton. FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes. American journal of physiology. Endocrinology and metabolism. 2022 08; 323(2):E123-E132. doi: 10.1152/ajpendo.00050.2022. [PMID: 35723225]
  • Muneera Waheed Alfarhan, Heba Al-Hussaini, Narayana Kilarkaje. Role of PPAR-γ in diabetes-induced testicular dysfunction, oxidative DNA damage and repair in leptin receptor-deficient obese type 2 diabetic mice. Chemico-biological interactions. 2022 Jul; 361(?):109958. doi: 10.1016/j.cbi.2022.109958. [PMID: 35472412]
  • Xiran Lin, Xianmin Meng, Zhiqi Song, Jingrong Lin. Peroxisome proliferator-activator receptor γ and psoriasis, molecular and cellular biochemistry. Molecular and cellular biochemistry. 2022 Jul; 477(7):1905-1920. doi: 10.1007/s11010-022-04417-0. [PMID: 35348980]
  • Pierre-Axel Monternier, Jaspreet Singh, Parveen Parasar, Pierre Theurey, Sheila DeWitt, Vincent Jacques, Eric Klett, Navtej Kaur, Tavarekere N Nagaraja, David E Moller, Sophie Hallakou-Bozec. Therapeutic potential of deuterium-stabilized (R)-pioglitazone-PXL065-for X-linked adrenoleukodystrophy. Journal of inherited metabolic disease. 2022 07; 45(4):832-847. doi: 10.1002/jimd.12510. [PMID: 35510808]
  • Christian Setz, Maximilian Große, Janina Auth, Maria Fröba, Pia Rauch, Alexander Bausch, Matthew Wright, Ulrich Schubert. Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126830. [PMID: 35743273]
  • Baran Ghezelbash, Nader Shahrokhi, Mohammad Khaksari, Gholamreza Asadikaram, Maryam Shahrokhi, Sara Shirazpour. Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. Chinese journal of integrative medicine. 2022 Jun; 28(6):531-537. doi: 10.1007/s11655-022-3307-3. [PMID: 35258780]
  • Kusuma Kumari Garikapati, Ravi Kiran Ammu V V V, Praveen Thaggikuppe Krishnamurthy, Narenderan S T, Babu B, Krishnaveni Nagappan. Quantification of rosiglitazone in rat plasma and tissues via LC-MS/MS: Method development, validation, and application in pharmacokinetic and tissue distribution studies. Biomedical chromatography : BMC. 2022 May; 36(5):e5326. doi: 10.1002/bmc.5326. [PMID: 34993979]
  • Olga Lavynenko, Muhammad Abdul-Ghani, Mariam Alatrach, Curtiss Puckett, John Adams, Siham Abdelgani, Naim Alkhouri, Curtis Triplitt, Geoffrey D Clarke, Juan A Vasquez, Jinqi Li, Eugenio Cersosimo, Amalia Gastaldelli, Ralph A DeFronzo. Combination therapy with pioglitazone/exenatide/metformin reduces the prevalence of hepatic fibrosis and steatosis: The efficacy and durability of initial combination therapy for type 2 diabetes (EDICT). Diabetes, obesity & metabolism. 2022 05; 24(5):899-907. doi: 10.1111/dom.14650. [PMID: 35014145]
  • Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan P Jastrzębski, Karol G Makowczenko, Monika Golubska, Iwona Bogacka. PPARγ regulates the expression of genes involved in the DNA damage response in an inflamed endometrium. Scientific reports. 2022 03; 12(1):4026. doi: 10.1038/s41598-022-07986-8. [PMID: 35256739]
  • Hend A Hamouda, Suzan M Mansour, Mohammed F Elyamany. Vitamin D Combined with Pioglitazone Mitigates Type-2 Diabetes-induced Hepatic Injury Through Targeting Inflammation, Apoptosis, and Oxidative Stress. Inflammation. 2022 Feb; 45(1):156-171. doi: 10.1007/s10753-021-01535-7. [PMID: 34468908]
  • Hyejin Ko, Seungchan An, Sungjin Ahn, In Guk Park, Junpyo Gong, Seok Young Hwang, Soyeon Oh, Min Won Ki, Sun Hee Jin, Won Jun Choi, Minsoo Noh. Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist. Toxicology letters. 2022 Feb; 355(?):141-149. doi: 10.1016/j.toxlet.2021.12.001. [PMID: 34864131]
  • Chihiro Ebihara, Megumi Aizawa-Abe, Mingming Zhao, Valentino Gumbilai, Ken Ebihara. Different sites of actions make different responses to thiazolidinediones between mouse and rat models of fatty liver. Scientific reports. 2022 01; 12(1):449. doi: 10.1038/s41598-021-04036-7. [PMID: 35013417]
  • Bhavimani Guru, Akhilesh K Tamrakar, Subhankar P Mandal, Prashantha B R Kumar, Aditya Sharma, Santhepete Nanjundaiah Manjula. A Novel Partial PPARγ Agonist Has Weaker Lipogenic Effect in Adipocytes and Stimulates GLUT4 Translocation in Skeletal Muscle Cells via AMPK-Dependent Signaling. Pharmacology. 2022; 107(1-2):90-101. doi: 10.1159/000519331. [PMID: 34736259]
  • Zainab Z Zakaraya, Lina AlTamimi, Mohammad Hailat, Mousa N Ahmad, Nidal A Qinna, Bayan Y Ghanim, Mohamed J Saadh, Nisreen Al-Dmour, Wael Abu Dayyih. Ameliorative effect of selenium yeast in combination with pioglitazone on diabetes outcomes in streptozotocin-induced. Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique. 2022; 29(4):e202-e210. doi: 10.47750/jptcp.2022.1003. [PMID: 36579951]
  • Jerry R Colca, Philipp E Scherer. The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease. Molecular metabolism. 2022 01; 55(?):101409. doi: 10.1016/j.molmet.2021.101409. [PMID: 34863942]
  • Chao-Chung Ho, Yi-Sun Yang, Chien-Ning Huang, Shih-Chang Lo, Yu-Hsun Wang, Edy Kornelius. The efficacy of pioglitazone for renal protection in diabetic kidney disease. PloS one. 2022; 17(2):e0264129. doi: 10.1371/journal.pone.0264129. [PMID: 35176115]
  • Karem H Alzoubi, Omar F Khabour, Mahmoud Alfaqih, Murad Tashtoush, Sayer I Al-Azzam, Nizar M Mhaidat, Nasr Alrabadi. The Protective Effects of Pioglitazone Against Cognitive Impairment Caused by L-methionine Administration in a Rat Model. CNS & neurological disorders drug targets. 2022; 21(1):77-84. doi: 10.2174/1871527320666210809122523. [PMID: 34370649]
  • Hobby Aggarwal, Priya Pathak, Yashwant Kumar, Kumaravelu Jagavelu, Madhu Dikshit. Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010195. [PMID: 35008623]
  • Xingming Hou, Clemens Malainer, Atanas G Atanasov, Elke H Heiß, Verena M Dirsch, Limei Wang, KeWei Wang. Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice. Journal of natural products. 2021 12; 84(12):3110-3116. doi: 10.1021/acs.jnatprod.1c00881. [PMID: 34902249]
  • Jian-Ta Wang, Jin-Gang Peng, Jing Xia, Ji-Quan Zhang, Chu-Jiao Hu, Gao-Feng Zhu, Bing Guo, Lei Tang. Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists. Bioorganic & medicinal chemistry letters. 2021 11; 52(?):128410. doi: 10.1016/j.bmcl.2021.128410. [PMID: 34626784]
  • Szu-Yu Liu, Chia-Chang Huang, Shiang-Fen Huang, Tsai-Ling Liao, Nai-Rong Kuo, Ying-Ying Yang, Tzu-Hao Li, Chih-Wei Liu, Ming-Chih Hou, Han-Chieh Lin. Pioglitazone Ameliorates Acute Endotoxemia-Induced Acute on Chronic Renal Dysfunction in Cirrhotic Ascitic Rats. Cells. 2021 11; 10(11):. doi: 10.3390/cells10113044. [PMID: 34831270]
  • Sevil Cayli, Ebru Alimogullari, Ilkay Piskin, Ayca Bilginoglu, Hilal Nakkas. Effect of pioglitazone on the expression of ubiquitin proteasome system and autophagic proteins in rat pancreas with metabolic syndrome. Journal of molecular histology. 2021 Oct; 52(5):929-942. doi: 10.1007/s10735-021-10013-1. [PMID: 34410563]
  • Gábor Kökény, Laurent Calvier, Georg Hansmann. PPARγ and TGFβ-Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910431. [PMID: 34638771]
  • Sheryar Afzal, Munavvar Abdul Sattar, Edward James Johns, Olorunfemi A Eseyin. Peroxisome proliferator-activated receptor agonist (pioglitazone) with exogenous adiponectin ameliorates arterial stiffness and oxidative stress in diabetic Wistar Kyoto rats. European journal of pharmacology. 2021 Sep; 907(?):174218. doi: 10.1016/j.ejphar.2021.174218. [PMID: 34111396]
  • Camila Pires Mendes, Bárbara Graziela Postal, Marisa Jádna Silva Frederico, Rui Gonçalves Marques Elias, Veronica Aiceles de Medeiros Pinto, Cristiane da Fonte Ramos, Patrícia Devantier Neuenfeldt, Ricardo José Nunes, Fátima Regina Mena Barreto Silva. Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats. Bioorganic chemistry. 2021 09; 114(?):105157. doi: 10.1016/j.bioorg.2021.105157. [PMID: 34328855]
  • Hiroshi Hasegawa, Kenji Yatomi, Yumiko Mitome-Mishima, Nobukazu Miyamoto, Ryota Tanaka, Hidenori Oishi, Hajime Arai, Nobutaka Hattori, Takao Urabe. Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal Ischemia in Type 2 Diabetes. Neuroscience research. 2021 Sep; 170(?):314-321. doi: 10.1016/j.neures.2020.09.004. [PMID: 33309864]
  • Ying-Yiu Lam, Sheng-Feng Tsai, Pei-Chun Chen, Yu-Min Kuo, Yun-Wen Chen. Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111734. doi: 10.1016/j.biopha.2021.111734. [PMID: 34022606]
  • Giuseppe Della Pepa, Marco Russo, Marilena Vitale, Fabrizia Carli, Claudia Vetrani, Maria Masulli, Gabriele Riccardi, Olga Vaccaro, Amalia Gastaldelli, Angela A Rivellese, Lutgarda Bozzetto. Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial. Diabetes research and clinical practice. 2021 Aug; 178(?):108984. doi: 10.1016/j.diabres.2021.108984. [PMID: 34311022]
  • Valquíria Mariane Oliveira Póvoa, Jeany Delafiori, Flávia Luísa Dias-Audibert, Arthur Noin de Oliveira, Ana Beatriz Pascoal Lopes, Erich Vinícius de Paula, Katia Borgia Barbosa Pagnano, Rodrigo Ramos Catharino. Metabolic shift of chronic myeloid leukemia patients under imatinib-pioglitazone regimen and discontinuation. Medical oncology (Northwood, London, England). 2021 Jul; 38(9):100. doi: 10.1007/s12032-021-01551-5. [PMID: 34302533]
  • Atsuo Tahara. Effects of SGLT2 inhibitor ipragliflozin alone and combined with pioglitazone on fluid retention in type 2 diabetic mice with NASH. European journal of pharmacology. 2021 Jun; 901(?):174076. doi: 10.1016/j.ejphar.2021.174076. [PMID: 33798599]
  • Jiann-Horng Yeh, Kuo-Ching Wang, Asuka Kaizaki, Jonathan W Lee, Han-Chi Wei, Michelle A Tucci, Norma B Ojeda, Lir-Wan Fan, Lu-Tai Tien. Pioglitazone Ameliorates Lipopolysaccharide-Induced Behavioral Impairment, Brain Inflammation, White Matter Injury and Mitochondrial Dysfunction in Neonatal Rats. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126306. [PMID: 34208374]
  • Benjamin Schröder, Sabine Kahl, Michael Roden. Non-alcoholic fatty liver disease in type 2 diabetes - A specific entity?. Liver international : official journal of the International Association for the Study of the Liver. 2021 06; 41 Suppl 1(?):105-111. doi: 10.1111/liv.14846. [PMID: 34155798]
  • Yi Zhu, Jing-Jing Ji, Xiao-Dong Wang, Xue-Jiao Sun, Min Li, Qin Wei, Li-Qun Ren, Nai-Feng Liu. Periostin promotes arterial calcification through PPARγ-related glucose metabolism reprogramming. American journal of physiology. Heart and circulatory physiology. 2021 06; 320(6):H2222-H2239. doi: 10.1152/ajpheart.01009.2020. [PMID: 33834866]
  • Hoda E Mohamed, Mervat E Asker, Mohamed A Shaheen, Rana G Eissa, Nahla N Younis. Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract. Journal of food biochemistry. 2021 05; 45(5):e13715. doi: 10.1111/jfbc.13715. [PMID: 33782984]
  • Keiko Imamura, Yasuteru Sakurai, Takako Enami, Ran Shibukawa, Yohei Nishi, Akira Ohta, Tsugumine Shu, Jitsutaro Kawaguchi, Sayaka Okada, Thomas Hoenen, Jiro Yasuda, Haruhisa Inoue. iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility. FEBS open bio. 2021 05; 11(5):1452-1464. doi: 10.1002/2211-5463.13153. [PMID: 33822489]
  • Hui-Li Lin, Pei-Wen Cheng, Yi-Chen Tu, Bor-Chun Yeh, Bin-Nan Wu, Kuo-Ping Shen. The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR. The Journal of pharmacy and pharmacology. 2021 Apr; 73(6):835-845. doi: 10.1093/jpp/rgab029. [PMID: 33779726]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Ken-Ichi Izutsu, Kazuki Matsui, Shinji Yamashita. In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration. Molecular pharmaceutics. 2021 04; 18(4):1711-1719. doi: 10.1021/acs.molpharmaceut.0c01207. [PMID: 33629861]
  • Joost Boeckmans, Alessandra Natale, Matthias Rombaut, Karolien Buyl, Brent Cami, Veerle De Boe, Anja Heymans, Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Robim M Rodrigues. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. Cell biology and toxicology. 2021 04; 37(2):293-311. doi: 10.1007/s10565-020-09544-2. [PMID: 32613381]
  • May A Abd El Fattah, Yasmine A Abdelhamid, Mohammed F Elyamany, Osama A Badary, Ola A Heikal. Rice Bran Extract Protected against LPS-Induced Neuroinflammation in Mice through Targeting PPAR-γ Nuclear Receptor. Molecular neurobiology. 2021 Apr; 58(4):1504-1516. doi: 10.1007/s12035-020-02196-7. [PMID: 33205365]
  • Brian S Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L Confides, Hemendra J Vekaria, Riham H El Khouli, Zachary R Johnson, Philip M Westgate, Jianzhong Chen, Andrew J Morris, Patrick G Sullivan, Esther E Dupont-Versteegden, Philip A Kern. Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism. JCI insight. 2021 03; 6(6):. doi: 10.1172/jci.insight.143650. [PMID: 33571166]
  • Guozhu Ye, Bi-Cheng Yang, Han Gao, Zeming Wu, Jinsheng Chen, Xiao-Yan Ai, Qiansheng Huang. Metabolomics Insights into Oleate-Induced Disorders of Phospholipid Metabolism in Macrophages. The Journal of nutrition. 2021 03; 151(3):503-512. doi: 10.1093/jn/nxaa411. [PMID: 33571370]
  • Salwa A Ibrahim, Mervat Z Mohamed, Nashwa F El-Tahawy, Aly M Abdelrahman. Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats. Canadian journal of physiology and pharmacology. 2021 Mar; 99(3):313-320. doi: 10.1139/cjpp-2020-0159. [PMID: 32721217]
  • Anjul Sharma, Raymond E Bourey, John C Edwards, David S Brink, Stewart G Albert. Nephrotic range proteinuria associated with focal segmental glomerulosclerosis reversed with pioglitazone therapy in a patient with Dunnigan type lipodystrophy. Diabetes research and clinical practice. 2021 Feb; 172(?):108620. doi: 10.1016/j.diabres.2020.108620. [PMID: 33316307]
  • Aya A Gbr, Nayira A Abdel Baky, Eman A Mohamed, Heba S Zaky. Cardioprotective effect of pioglitazone and curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus: impact on CaMKII/NF-κB/TGF-β1 and PPAR-γ signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2021 02; 394(2):349-360. doi: 10.1007/s00210-020-01979-y. [PMID: 32984914]
  • Ali M Alshabi, Saad A Alkahtani, Ibrahim A Shaikh, Mohammed S Habeeb. Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics. Saudi medical journal. 2021 Feb; 42(2):151-160. doi: 10.15537/smj.2021.2.25695. [PMID: 33563733]
  • Karol Mierzejewski, Łukasz Paukszto, Aleksandra Kurzyńska, Zuzanna Kunicka, Jan Paweł Jastrzębski, Iwona Bogacka. Transcriptome analysis of porcine endometrium after LPS-induced inflammation: effects of the PPAR-gamma ligands in vitro†. Biology of reproduction. 2021 01; 104(1):130-143. doi: 10.1093/biolre/ioaa200. [PMID: 33112378]
  • H M Al-Muzafar, F S Alshehri, K A Amin. The role of pioglitazone in antioxidant, anti-inflammatory, and insulin sensitivity in a high fat-carbohydrate diet-induced rat model of insulin resistance. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021; 54(8):e10782. doi: 10.1590/1414-431x2020e10782. [PMID: 34037093]
  • Jingxuan Lian, Jianfang Fu. Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis. Frontiers in endocrinology. 2021; 12(?):615409. doi: 10.3389/fendo.2021.615409. [PMID: 33995271]
  • Eman D Mohammed, Zechuan Zhang, Wenfang Tian, Venkatanarayana Gangarapu, A A Al-Gendy, Jun Chen, Jifu Wei, Beicheng Sun. Modulation of IR as a therapeutic target to prevent NASH using NRF from Diceratella elliptica (DC.) jonsell. Strong Nrf2 and leptin inducer as well as NF-kB inhibitor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 80(?):153388. doi: 10.1016/j.phymed.2020.153388. [PMID: 33113501]
  • Vivien Telek, Luca Erlitz, Ibitamuno Caleb, Tibor Nagy, Mónika Vecsernyés, Bálint Balogh, György Sétáló, Péter Hardi, Gábor Jancsó, Ildikó Takács. Effect of Pioglitazone on endoplasmic reticulum stress regarding in situ perfusion rat model. Clinical hemorheology and microcirculation. 2021; 79(2):311-325. doi: 10.3233/ch-211163. [PMID: 33867357]
  • Yuma Ito, Megumi Yamamoto, Shohei Furukawa, Masaki Fukui, Ko Morishita, Tatsuya Kitao, Hiroaki Shirahase. Effects of KY-903, a Novel Tetrazole-Based Peroxisome Proliferator-Activated Receptor γ Modulator, in Male Diabetic Mice and Female Ovariectomized Rats. Biological & pharmaceutical bulletin. 2021; 44(5):659-668. doi: 10.1248/bpb.b20-01002. [PMID: 33952822]
  • Fatemeh Amin, Arghavan Memarzia, Ali Roohbakhsh, Farzaneh Shakeri, Mohammad Hossein Boskabady. Zataria multiflora and Pioglitazone Affect Systemic Inflammation and Oxidative Stress Induced by Inhaled Paraquat in Rats. Mediators of inflammation. 2021; 2021(?):5575059. doi: 10.1155/2021/5575059. [PMID: 34054344]
  • Oelfah Patel, Christo J F Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe. Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice. PloS one. 2021; 16(5):e0251069. doi: 10.1371/journal.pone.0251069. [PMID: 33983968]
  • Sietse J Koopmans, Heleen M M van Beusekom, F Josef van der Staay, Gisabeth Binnendijk, Marcel Hulst, Zlaw Mroz, Mariette T Ackermans, Lambertus Benthem. Beneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet. PloS one. 2021; 16(10):e0257299. doi: 10.1371/journal.pone.0257299. [PMID: 34669714]
  • Ayako Nagayama, Kenji Ashida, Miki Watanabe, Kanoko Moritaka, Aya Sonezaki, Yoichiro Kitajima, Hirokazu Takahashi, Satoko Yoshinobu, Shimpei Iwata, Junichi Yasuda, Nao Hasuzawa, Shuichi Ozono, Seiichi Motomura, Masatoshi Nomura. Case Report: Metreleptin and SGLT2 Inhibitor Combination Therapy Is Effective for Acquired Incomplete Lipodystrophy. Frontiers in endocrinology. 2021; 12(?):690996. doi: 10.3389/fendo.2021.690996. [PMID: 34135866]
  • Ursula White, Mark D Fitch, Robbie A Beyl, Marc K Hellerstein, Eric Ravussin. Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial. Diabetologia. 2021 01; 64(1):159-167. doi: 10.1007/s00125-020-05281-7. [PMID: 33001232]
  • Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong. Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators. Journal of medicinal chemistry. 2020 12; 63(24):16012-16027. doi: 10.1021/acs.jmedchem.0c01874. [PMID: 33325691]
  • Aryendu Kumar Saini, Rakesh Saini, Shubham Singh. Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects. Molecular medicine (Cambridge, Mass.). 2020 12; 26(1):128. doi: 10.1186/s10020-020-00246-3. [PMID: 33308138]
  • Kristina Bardova, Jiri Funda, Radek Pohl, Tomas Cajka, Michal Hensler, Ondrej Kuda, Petra Janovska, Katerina Adamcova, Ilaria Irodenko, Lucie Lenkova, Petr Zouhar, Olga Horakova, Pavel Flachs, Martin Rossmeisl, Jerry Colca, Jan Kopecky. Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue. Nutrients. 2020 Dec; 12(12):. doi: 10.3390/nu12123737. [PMID: 33291653]
  • Niki Katsiki, Ele Ferrannini. Anti-inflammatory properties of antidiabetic drugs: A 'promised land' in the COVID-19 era?. Journal of diabetes and its complications. 2020 12; 34(12):107723. doi: 10.1016/j.jdiacomp.2020.107723. [PMID: 32900588]
  • Nour-Mounira Z Bakkar, Nahed Mougharbil, Ali Mroueh, Abdullah Kaplan, Ali H Eid, Souha Fares, Fouad A Zouein, Ahmed F El-Yazbi. Worsening baroreflex sensitivity on progression to type 2 diabetes: localized vs. systemic inflammation and role of antidiabetic therapy. American journal of physiology. Endocrinology and metabolism. 2020 11; 319(5):E835-E851. doi: 10.1152/ajpendo.00145.2020. [PMID: 32865011]
  • Guizhen Chang, Jin Wang, Jingxin Song, Zhilong Zhang, Litao Zhang. Efficacy and safety of pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials. The Journal of dermatological treatment. 2020 Nov; 31(7):680-686. doi: 10.1080/09546634.2019.1610552. [PMID: 31116619]