Formoterol (BioDeep_00000001989)

 

Secondary id: BioDeep_00000405828

human metabolite blood metabolite


代谢物信息卡片


3-formylamino-4-Hydroxy-alpha-(N-1-methyl-2-P-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate

化学式: C19H24N2O4 (344.1735984)
中文名称: 酒石酸福莫特罗
谱图信息: 最多检出来源 Homo sapiens(blood) 28.57%

分子结构信息

SMILES: CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
InChI: InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)

描述信息

Formoterol is a long-acting (12 hours) beta2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease (COPD). Inhaled formoterol works like other beta2-agonists, causing bronchodilatation through relaxation of the smooth muscle in the airway so as to treat the exacerbation of asthma.
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

19 个代谢物同义名

3-formylamino-4-Hydroxy-alpha-(N-1-methyl-2-P-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate; N-[2-Hydroxy-5-(1-hydroxy-2-{[2-(4-methoxyphenyl)-1-methylethyl]amino}ethyl)phenyl]formamide; N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide; N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide; 2-Hydroxy-5-(1-hydroxy-2-((p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide; 2-Hydroxy-5-{1-hydroxy-2-[(p-methoxy-alpha-methylphenethyl)amino]ethyl}formanilide; 2-Hydroxy-5-(1-hydroxy-2-((p-methoxy-a-methylphenethyl)amino)ethyl)formanilide; 2-Hydroxy-5-(1-hydroxy-2-((p-methoxy-α-methylphenethyl)amino)ethyl)formanilide; 2-Hydroxy-5-{1-hydroxy-2-[(p-methoxy-a-methylphenethyl)amino]ethyl}formanilide; 2-Hydroxy-5-{1-hydroxy-2-[(p-methoxy-α-methylphenethyl)amino]ethyl}formanilide; Formoterol fumarate, ((r*,r*)-(+-))-isomer; Formoterol, ((r*,r*)-(+-))-isomer; Formoterol fumarate; Arformoterol; Eformoterol; formoterol; Foradil; BD 40a; Oxis



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sanna H Loppi, Marco A Tavera-Garcia, Natalie E Scholpa, Boaz K Maiyo, Danielle A Becktel, Helena W Morrison, Rick G Schnellmann, Kristian P Doyle. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316632. [PMID: 38068955]
  • Yiwen Gong, Zichao Sui, Yinghua Lv, Qingshan Zheng, Lujin Li. LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data. European journal of clinical pharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00228-023-03543-y. [PMID: 37507595]
  • Christiana J Raymond-Pope, Alec M Basten, Angela S Bruzina, Jennifer McFaline-Figueroa, Thomas J Lillquist, Jarrod A Call, Sarah M Greising. Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism. The Journal of physiology. 2023 02; 601(4):743-761. doi: 10.1113/jp283959. [PMID: 36536512]
  • Piotr Kuna, Joanna Jerzynska, Matteo Martini, Andrea Vele, Irene Barneschi, Fabrizia Mariotti, George Georges, Giorgia Ciurlia. Pharmacokinetics of extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide in adolescent and adult patients with asthma. Pharmacology research & perspectives. 2022 08; 10(4):e980. doi: 10.1002/prp2.980. [PMID: 35733414]
  • Zhu Luo, Germano Lucci, Luigi Santoro, Eva Topole, Fabrizia Mariotti. Pharmacokinetic profile of beclometasone dipropionate/formoterol fumarate administered through a novel dry-powder inhaler in Chinese healthy volunteers. Pulmonary pharmacology & therapeutics. 2022 06; 73-74(?):102129. doi: 10.1016/j.pupt.2022.102129. [PMID: 35525480]
  • Glenn A Jacobson, Morten Hostrup. The salmeterol anomaly and the need for a urine threshold. Drug testing and analysis. 2022 Jun; 14(6):997-1003. doi: 10.1002/dta.2810. [PMID: 32314556]
  • Hong Zhang, Sami Z Daoud, Michael S Gillen, Natalia Calderon, Maria Heijer, Eduard Molins, Esther Garcia-Gil, Hong Chen, Qianqian Li, Chengjiao Liu, Yanhua Ding. An Evaluation of the Pharmacokinetics, Safety, and Tolerability of Aclidinium/Formoterol Fixed-Dose Combination Administered in Chinese Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease. Drugs in R&D. 2022 Mar; 22(1):35-42. doi: 10.1007/s40268-021-00374-z. [PMID: 35133636]
  • Qing Kong, Yuxue Cao, Zhen Gao, Jing Sun, Hongying Zhang, Yijie Du, Yubao Lv, Sihan Zhou, Zihui Tang, Baojun Liu, Jingcheng Dong. Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD: study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial. Trials. 2022 Feb; 23(1):143. doi: 10.1186/s13063-022-06057-7. [PMID: 35164853]
  • Yiwen Gong, Yinghua Lv, Hongxia Liu, Qingshan Zheng, Lujin Li. Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD. Therapeutic advances in respiratory disease. 2022 Jan; 16(?):17534666211066068. doi: 10.1177/17534666211066068. [PMID: 35001708]
  • F D Richard Hobbs, Ly-Mee Yu, Benjamin R Saville, Mona Bafadhel, Christopher C Butler. High-dose budesonide for early COVID-19 - Authors' reply. Lancet (London, England). 2021 12; 398(10317):2147-2148. doi: 10.1016/s0140-6736(21)02449-1. [PMID: 34895528]
  • Massimo Cella, Jörg Täubel, Irisz Delestre-Levai, Anne Tulard, Andrea Vele, George Georges. Ethnic Sensitivity Study of the Extrafine, Single-Inhaler, Triple Therapy Beclomethasone Dipropionate, Formoterol Fumarate, and Glycopyrronium Bromide Pressurized Metered Dose Inhaler in Japanese and Caucasian Healthy Individuals: A Randomized, Double-Blind, Single-Dose Crossover Study. Clinical therapeutics. 2021 11; 43(11):1934-1947.e4. doi: 10.1016/j.clinthera.2021.09.001. [PMID: 34600734]
  • Yun Shi, Jason Pizzini, Hanzhou Wang, Falguni Das, Parveez Ahamed Abdul Azees, Goutam Ghosh Choudhury, Jeffrey L Barnes, Mengwei Zang, Susan T Weintraub, Chih-Ko Yeh, Michael S Katz, Amrita Kamat. β2-Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states. American journal of physiology. Endocrinology and metabolism. 2021 07; 321(1):E90-E104. doi: 10.1152/ajpendo.00651.2020. [PMID: 34029162]
  • Sanjay Ramakrishnan, Mona Bafadhel. Inhaled budesonide for early treatment of COVID-19 - Authors' reply. The Lancet. Respiratory medicine. 2021 07; 9(7):e61. doi: 10.1016/s2213-2600(21)00212-5. [PMID: 33991509]
  • Ernest L Vallorz, Karen Blohm-Mangone, Rick G Schnellmann, Heidi M Mansour. Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules. The AAPS journal. 2021 06; 23(4):88. doi: 10.1208/s12248-021-00619-4. [PMID: 34169439]
  • Dietrich Reinhardt. Title Not Available. MMW Fortschritte der Medizin. 2021 04; 163(8):27-28. doi: 10.1007/s15006-021-9864-0. [PMID: 33904080]
  • Kristan H Cleveland, Frank C Brosius, Rick G Schnellmann. Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β2-adrenergic receptor agonist formoterol. American journal of physiology. Renal physiology. 2020 11; 319(5):F773-F779. doi: 10.1152/ajprenal.00427.2020. [PMID: 32954853]
  • Ying Huang, Pryseley Nkouibert Assam, Cong Feng, Rong Su, Paul Dorinsky, Michael Gillen. Ethnic pharmacokinetic comparison of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) between Asian and Western healthy subjects. Pulmonary pharmacology & therapeutics. 2020 10; 64(?):101976. doi: 10.1016/j.pupt.2020.101976. [PMID: 33152467]
  • Yang Lee, Tony Warne, Rony Nehmé, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Madhu Chaturvedi, Patricia C Edwards, Javier García-Nafría, Andrew G W Leslie, Arun K Shukla, Christopher G Tate. Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor. Nature. 2020 07; 583(7818):862-866. doi: 10.1038/s41586-020-2419-1. [PMID: 32555462]
  • Lisa Joy Juergens, Heinrich Worth, Uwe R Juergens. New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach. Advances in therapy. 2020 05; 37(5):1737-1753. doi: 10.1007/s12325-020-01279-0. [PMID: 32200535]
  • Chao Hu, Jia Miao, Shiqing Shu, Ying Wang, Xiaohong Zhu, Zhu Luo. Pharmacokinetics, pharmacodynamics and safety of a novel extrafine BDP/FF/GB combination delivered via metered-dose inhaler in healthy Chinese subjects. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Mar; 144(?):105198. doi: 10.1016/j.ejps.2019.105198. [PMID: 31862312]
  • Leonard J Dunn, Edward M Kerwin, Kiernan DeAngelis, Patrick Darken, Michael Gillen, Paul Dorinsky. Pharmacokinetics of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler formulated using co-suspension delivery technology after single and chronic dosing in patients with COPD. Pulmonary pharmacology & therapeutics. 2020 02; 60(?):101873. doi: 10.1016/j.pupt.2019.101873. [PMID: 31841699]
  • Pallavi Bhargava, Jaroslav Janda, Rick G Schnellmann. Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney. American journal of physiology. Renal physiology. 2020 02; 318(2):F322-F328. doi: 10.1152/ajprenal.00533.2019. [PMID: 31841384]
  • Alessia Vignoli, Giuseppe Santini, Leonardo Tenori, Giuseppe Macis, Nadia Mores, Francesco Macagno, Francesco Pagano, Tim Higenbottam, Claudio Luchinat, Paolo Montuschi. NMR-Based Metabolomics for the Assessment of Inhaled Pharmacotherapy in Chronic Obstructive Pulmonary Disease Patients. Journal of proteome research. 2020 01; 19(1):64-74. doi: 10.1021/acs.jproteome.9b00345. [PMID: 31621329]
  • Donald P Tashkin. Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease. International journal of chronic obstructive pulmonary disease. 2020; 15(?):3105-3122. doi: 10.2147/copd.s273497. [PMID: 33273813]
  • Omar Usmani, Nicolas Roche, Jonathan Marshall, Helen Danagher, David Price. An innovative corticosteroid/long-acting β2-agonist breath-triggered inhaler: facilitating lung delivery of fluticasone propionate/formoterol fumarate for the treatment of asthma. Expert opinion on drug delivery. 2019 12; 16(12):1367-1380. doi: 10.1080/17425247.2019.1689957. [PMID: 31752560]
  • Ehtesham Arif, Ashish K Solanki, Pankaj Srivastava, Bushra Rahman, Wayne R Fitzgibbon, Peifeng Deng, Milos N Budisavljevic, Catalin F Baicu, Michael R Zile, Judit Megyesi, Michael G Janech, Sang-Ho Kwon, Justin Collier, Rick G Schnellmann, Deepak Nihalani. Mitochondrial biogenesis induced by the β2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney international. 2019 09; 96(3):656-673. doi: 10.1016/j.kint.2019.03.023. [PMID: 31262488]
  • Glenn A Jacobson, Morten Hostrup, Christian K Narkowicz, David S Nichols, E Haydn Walters. Enantioselective disposition of (R,R)-formoterol, (S,S)-formoterol and their respective glucuronides in urine following single inhaled dosing and application to doping control. Drug testing and analysis. 2019 Jul; 11(7):950-956. doi: 10.1002/dta.2587. [PMID: 30865387]
  • Morten Hostrup, Christian K Narkowicz, Sajad Habib, David S Nichols, Glenn A Jacobson. Beta2 -adrenergic ligand racemic formoterol exhibits enantioselective disposition in blood and skeletal muscle of humans, and elicits myocellular PKA signaling at therapeutic inhaled doses. Drug testing and analysis. 2019 Jul; 11(7):1048-1056. doi: 10.1002/dta.2580. [PMID: 30836453]
  • Robert B Cameron, Whitney S Gibbs, Siennah R Miller, Tess V Dupre, Judit Megyesi, Craig C Beeson, Rick G Schnellmann. Proximal Tubule β 2-Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function after Ischemia-Reperfusion Injury. The Journal of pharmacology and experimental therapeutics. 2019 04; 369(1):173-180. doi: 10.1124/jpet.118.252833. [PMID: 30709866]
  • Andrea Maes, Paolo DePetrillo, Shahid Siddiqui, Colin Reisner, Paul Dorinsky. Pharmacokinetics of Co-Suspension Delivery Technology Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate (BGF MDI) and Budesonide/Formoterol Fumarate Dihydrate (BFF MDI) Fixed-Dose Combinations Compared With an Active Control: A Phase 1, Randomized, Single-Dose, Crossover Study in Healthy Adults. Clinical pharmacology in drug development. 2019 02; 8(2):223-233. doi: 10.1002/cpdd.585. [PMID: 29901860]
  • Colin Reisner, Joel Miller, Paolo DePetrillo, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin. Pharmacokinetics and safety of a single dose of the novel LAMA/LABA fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler, formulated using co-suspension delivery technology, in Japanese healthy subjects. Pulmonary pharmacology & therapeutics. 2018 12; 53(?):33-38. doi: 10.1016/j.pupt.2018.09.005. [PMID: 30218695]
  • Warisara Parichatikanond, Akiyuki Nishimura, Motohiro Nishida, Supachoke Mangmool. Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells. Journal of pharmacological sciences. 2018 Nov; 138(3):184-191. doi: 10.1016/j.jphs.2018.09.007. [PMID: 30322801]
  • Ana Isabel Martín, Ana Belén Gómez-SanMiguel, Teresa Priego, Asunción López-Calderón. Formoterol treatment prevents the effects of endotoxin on muscle TNF/NF-kB, Akt/mTOR, and proteolytic pathways in a rat model. Role of IGF-I and miRNA 29b. American journal of physiology. Endocrinology and metabolism. 2018 10; 315(4):E705-E714. doi: 10.1152/ajpendo.00043.2018. [PMID: 29969314]
  • Paul Dorinsky, Paolo DePetrillo, Shahid Siddiqui, Andrea Maes, Colin Reisner. Safety and pharmacokinetics of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler (BGF MDI) in healthy adult subjects of Japanese descent. Pulmonary pharmacology & therapeutics. 2018 08; 51(?):18-25. doi: 10.1016/j.pupt.2018.05.001. [PMID: 29763659]
  • Patrick Darken, Paolo DePetrillo, Colin Reisner, Earl St Rose, Paul Dorinsky. The pharmacokinetics of three doses of budesonide/glycopyrronium/formoterol fumarate dihydrate metered dose inhaler compared with active controls: A Phase I randomized, single-dose, crossover study in healthy adults. Pulmonary pharmacology & therapeutics. 2018 06; 50(?):11-18. doi: 10.1016/j.pupt.2018.03.001. [PMID: 29544728]
  • Faisal Fakih, Selwyn Spangenthal, Barry Sigal, Patrick Darken, Andrea Maes, Shahid Siddiqui, Michael Gillen, Colin Reisner, Ubaldo J Martin. Randomized study of the effects of Aerochamber Plus® Flow-Vu® on the efficacy, pharmacokinetics and safety of glycopyrronium/formoterol fumarate dihydrate metered dose inhaler in patients with chronic obstructive pulmonary disease. Respiratory medicine. 2018 05; 138(?):74-80. doi: 10.1016/j.rmed.2018.03.033. [PMID: 29724397]
  • Ole D Wolthers, Sabine Mersmann, Sanjeeva Dissanayake. A Pilot Study of the Normative Range of Overnight Urinary Free Cortisol Corrected for Creatinine in Children. Clinical drug investigation. 2018 Apr; 38(4):313-318. doi: 10.1007/s40261-017-0609-x. [PMID: 29256049]
  • Gary T Ferguson, Roberto Rodriguez-Roisin, Colin Reisner, Andrea Maes, Shahid Siddiqui, Ubaldo J Martin. Pharmacokinetics of glycopyrronium/formoterol fumarate dihydrate delivered via metered dose inhaler using co-suspension delivery technology in patients with moderate-to-very severe COPD. International journal of chronic obstructive pulmonary disease. 2018; 13(?):945-953. doi: 10.2147/copd.s154988. [PMID: 29606861]
  • Yong Zou, Jian Xiao, Xiao Xiao Lu, Zi An Xia, Bin Xie, Jun Li, Qiong Chen. Tiotropium plus formoterol versus tiotropium alone for stable moderate-to-severe chronic obstructive pulmonary disease: A meta-analysis. The clinical respiratory journal. 2018 Jan; 12(1):269-278. doi: 10.1111/crj.12526. [PMID: 27402142]
  • Robert B Cameron, Yuri K Peterson, Craig C Beeson, Rick G Schnellmann. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol. Scientific reports. 2017 09; 7(1):10578. doi: 10.1038/s41598-017-11030-5. [PMID: 28874749]
  • Johan Onslev, Glenn Jacobson, Christian Narkowicz, Vibeke Backer, Anders Kalsen, Michael Kreiberg, Søren Jessen, Jens Bangsbo, Morten Hostrup. Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men. European journal of applied physiology. 2017 Sep; 117(9):1907-1915. doi: 10.1007/s00421-017-3679-9. [PMID: 28702809]
  • Si Yan, Duncan E Shaw, Linhong Yang, David A Sandham, Mark P Healy, John Reilly, Bing Wang. Interactions between β2-Adrenoceptor Ligands and Membrane: Atomic-Level Insights from Magic-Angle Spinning NMR. Journal of medicinal chemistry. 2017 08; 60(16):6867-6879. doi: 10.1021/acs.jmedchem.7b00205. [PMID: 28703592]
  • Fabrizia Mariotti, Giorgia Ciurlia, Luca Spaccapelo, Annamaria Muraro, Daniela Acerbi. A Two-Period Open-Label, Single-Dose Crossover Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Between Cimetidine and Inhaled Extrafine CHF 5993. European journal of drug metabolism and pharmacokinetics. 2017 Apr; 42(2):269-279. doi: 10.1007/s13318-016-0345-2. [PMID: 27209586]
  • H A Inal, Z H Ozturk Inal, N Yilmaz, H Timur, A S Oruc, M N Kalem, O Han. The effects of formoterol on the serum, peritoneal VEGF, MDA, and VEGF levels in the ovaries and endometrium of rats with OHSS. Clinical and experimental obstetrics & gynecology. 2017; 44(1):122-128. doi: . [PMID: 29714880]
  • Glenn A Jacobson, J Paul Fawcett. Beta2-Agonist Doping Control and Optical Isomer Challenges. Sports medicine (Auckland, N.Z.). 2016 Dec; 46(12):1787-1795. doi: 10.1007/s40279-016-0547-4. [PMID: 27164986]
  • Andrzej Emeryk, Rabih Klink, Tammy McIver, Prashant Dalvi. A 12-week open-label, randomized, controlled trial and 24-week extension to assess the efficacy and safety of fluticasone propionate/formoterol in children with asthma. Therapeutic advances in respiratory disease. 2016 08; 10(4):324-37. doi: 10.1177/1753465816646320. [PMID: 27185164]
  • Renata D Belfort-DeAguiar, Sarita Naik, Janice Hwang, Barbara Szepietowska, Robert S Sherwin. Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes. Diabetes care. 2015 Sep; 38(9):1736-41. doi: 10.2337/dc14-2472. [PMID: 26153273]
  • Piotr Kuna, Mirco Govoni, Germano Lucci, Mario Scuri, Daniela Acerbi, Iwona Stelmach. Pharmacokinetics and pharmacodynamics of an extrafine fixed pMDI combination of beclometasone dipropionate/formoterol fumarate in adolescent asthma. British journal of clinical pharmacology. 2015 Sep; 80(3):569-80. doi: 10.1111/bcp.12640. [PMID: 25808292]
  • Lori Weisfeld, Youyi Shu, Tushar P Shah. Bioequivalence of budesonide plus formoterol (BF) Spiromax® and BF Turbohaler® (with and without charcoal block) in healthy volunteers. International journal of clinical pharmacology and therapeutics. 2015 Jul; 53(7):593-602. doi: 10.5414/cp202238. [PMID: 26042485]
  • Yuan-Hua Liu, Song-Ze Wu, Gang Wang, Ni-Wen Huang, Chun-Tao Liu. A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype‑3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Molecular medicine reports. 2015 Jun; 11(6):4121-8. doi: 10.3892/mmr.2015.3307. [PMID: 25672589]
  • Nikolaos Grekas, Katerina Athanassiou, Katerina Papataxiarchou, Simona Rizea Savu, Luigi Silvestro. Pharmacokinetic study for the establishment of bioequivalence of two inhalation treatments containing budesonide plus formoterol. The Journal of pharmacy and pharmacology. 2014 Dec; 66(12):1677-85. doi: 10.1111/jphp.12303. [PMID: 25109416]
  • Marti Antilla, Fábio Castro, Álvaro Cruz, Adalberto Rubin, Nelson Rosário, Rafael Stelmach. Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2014 Nov; 40(6):599-608. doi: 10.1590/s1806-37132014000600003. [PMID: 25610500]
  • A Kalsen, M Hostrup, J Bangsbo, V Backer. Combined inhalation of beta2 -agonists improves swim ergometer sprint performance but not high-intensity swim performance. Scandinavian journal of medicine & science in sports. 2014 Oct; 24(5):814-22. doi: 10.1111/sms.12096. [PMID: 23834392]
  • Saba Arshi, Morteza Fallahpour, Mohammad Nabavi, Mohammad Hasan Bemanian, Seyed Ali Javad-Mousavi, Marzieh Nojomi, Hossein Esmaeilzadeh, Rasool Molatefi, Mahsa Rekabi, Farhad Jalali, Nadieh Akbarpour. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2014 Oct; 113(4):404-9. doi: 10.1016/j.anai.2014.07.005. [PMID: 25091714]
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