Fludrocortisone (BioDeep_00000001976)
Secondary id: BioDeep_00000637526
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
化学式: C21H29FO5 (380.1999)
中文名称: 氟可的松-d5
谱图信息:
最多检出来源 Homo sapiens(urine) 75%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC1C3CCC(O)(C(=O)CO)C3(C)CC(O)C12F
InChI: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
描述信息
Fludrocortisone is only found in individuals that have used or taken this drug. It is a synthetic mineralocorticoid with anti-inflammatory activity. [PubChem]Fludrocortisone binds the mineralocorticoid receptor (aldosterone receptor). This binding (or activation of the mineralocorticoid receptor by fludrocortisone) in turn causes an increase in ion and water transport and thus raises extracellular fluid volume and blood pressure and lowers potassium levels.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
同义名列表
28 个代谢物同义名
(1R,2S,10S,11S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 9alpha-fluoro-11beta,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione; 9 alpha Fluoro 17 hydroxycorticosterone; 9 alpha-Fluoro-17-hydroxycorticosterone; Merck brand OF fludrocortisone; 9 alpha Fluorohydrocortisone; 9 alpha Fludrohydrocortisone; 9 alpha-Fluorohydrocortisone; 9 Fluoro 17 hydroxycortisone; 9-Fluoro-17-hydroxycortisone; 9 Fluorohydrocortisone; 9-Fluorohydrocortisone; 9ALPHA-FLUOROCORTISOL; 9a-FLUOROCORTISOL; 9Α-fluorocortisol; 9-Fluorocortisol; Fludrocortisonum; 9 Fluorocortisol; fludrocortisone; Fludrocortisona; SCHEMBL13026141; Merck, astonin; Astonin merck; Astonin-H; Astonin H; Astonin; FCOL; Fludrocortisone
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:50885
- KEGG: C07004
- KEGGdrug: D07967
- PubChem: 31378
- HMDB: HMDB0014825
- Metlin: METLIN2715
- DrugBank: DB00687
- ChEMBL: CHEMBL1201388
- Wikipedia: Fludrocortisone
- MeSH: Fludrocortisone
- chemspider: 29111
- CAS: 127-31-1
- PMhub: MS000001580
- PubChem: 9217
- LipidMAPS: LMST02030103
- PDB-CCD: ZK5
- NIKKAJI: J10.052H
- RefMet: Fludrocortisone
- KNApSAcK: 50885
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Osama A Gheith, Mohammed Dahab, Ayman Maher Nagib, Mohamed Adel, Nabil Elserwy, Islam Sobhy, Mohamed AbdelMonem, Hasaneen Abo Atya, Torki Al-Otaibi. Fludrocortisone Among Adult Renal Transplant Recipients With Persistent Hyperkalemia: Single-Center Experience.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2022 03; 20(Suppl 1):69-73. doi:
10.6002/ect.mesot2021.o27. [PMID: 35384810] - Busra Gurpinar Tosun, Yasemin Kendir Demirkol, Tuba Seven Menevse, Sare Betul Kaygusuz, Mehmet Nuri Ozbek, Selda Ayca Altincik, Jamala Mammadova, Atilla Cayir, Esra Doger, Elvan Bayramoglu, Ozlem Nalbantoglu, Gul Yesiltepe Mutlu, AghaRza Aghayev, Serap Turan, Abdullah Bereket, Tulay Guran. Catch-up Growth and Discontinuation of Fludrocortisone Treatment in Aldosterone Synthase Deficiency.
The Journal of clinical endocrinology and metabolism.
2022 01; 107(1):e106-e117. doi:
10.1210/clinem/dgab619. [PMID: 34415991] - Rouvick M Gama, David Makanjuola, Mona Wahba, Virginia Quan, Mysore Phanish. Fludrocortisone Is an Effective Treatment for Hyperkalaemic Metabolic Acidosis in Kidney Transplant Recipients on Tacrolimus: A Case Series.
Nephron.
2022; 146(2):190-196. doi:
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Pediatric nephrology (Berlin, Germany).
2021 09; 36(9):2731-2737. doi:
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Pediatric transplantation.
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2018 10; 27(5):304-312. doi:
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Pediatric transplantation.
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Pediatric transplantation.
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BMJ case reports.
2015 Jun; 2015(?):. doi:
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The American journal of the medical sciences.
2015 Jun; 349(6):526-9. doi:
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Rheumatology (Oxford, England).
2015 May; 54(5):933-9. doi:
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Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2015 May; 27(3):361-8. doi:
10.1177/1040638715583530. [PMID: 25901003] - Haroon Younas, Omer Sabir, Ilyas Baig, Nauman Tarif. Cerebral salt wasting: a report of three cases.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2015 Jan; 25(1):73-5. doi:
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Best practice & research. Clinical endocrinology & metabolism.
2015 Jan; 29(1):17-24. doi:
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2015; 62(1):101-6. doi:
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Clinical endocrinology.
2014 Dec; 81(6):871-5. doi:
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Journal of molecular medicine (Berlin, Germany).
2014 Nov; 92(11):1201-8. doi:
10.1007/s00109-014-1193-7. [PMID: 25088215] - Svetlana Pavleska-Kuzmanovska, Zivko Popov, Ognen Ivanovski, Vesna Ristovska, Jelka Masin-Spasovska, Irena Rambabova-Busljetic, Ninoslav Ivanovski. Cyclosporine nephrotoxicity and early posttransplant hyperkalemia in living-donor renal recipients: report of 4 cases.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2014 Oct; 12(5):479-83. doi:
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Pediatric nephrology (Berlin, Germany).
2014 Oct; 29(10):2061-4. doi:
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Journal of veterinary internal medicine.
2014 Sep; 28(5):1471-8. doi:
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2014 Aug; 99(8):2745-53. doi:
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2014 Jun; 63(6):1212-8. doi:
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2014 Apr; 43(4 Pt 1):438-43. doi:
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Indian journal of pediatrics.
2014 Feb; 81(2):178-85. doi:
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Fundamental & clinical pharmacology.
2014 Feb; 28(1):53-64. doi:
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2014 Jan; 25(1):149-51. doi:
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Journal of veterinary internal medicine.
2013 Nov; 27(6):1493-9. doi:
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Journal of feline medicine and surgery.
2013 Oct; 15(10):941-4. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2013 May; 420(?):109-13. doi:
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2013 Apr; 98(4):1409-16. doi:
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Cardiology clinics.
2013 Feb; 31(1):123-9. doi:
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Psychoneuroendocrinology.
2013 Jan; 38(1):115-21. doi:
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2013; 35(2):131-7. doi:
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American journal of physiology. Renal physiology.
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