fludrocortisone (BioDeep_00000637526)
Main id: BioDeep_00000001976
代谢物信息卡片
化学式: C21H29FO5 (380.1998916)
中文名称: 氟可的松-d5
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC3C2(C(CC4(C3CCC4(C(=O)CO)O)C)O)F
InChI: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
描述信息
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:50885
- KEGG: C07004
- KEGGdrug: D07967
- PubChem: 31378
- DrugBank: DB00687
- ChEMBL: CHEMBL1201388
- LipidMAPS: LMST02030103
- MeSH: Fludrocortisone
- CAS: 127-31-1
- PubChem: 9217
- PDB-CCD: ZK5
- NIKKAJI: J10.052H
- RefMet: Fludrocortisone
- KNApSAcK: 50885
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Osama A Gheith, Mohammed Dahab, Ayman Maher Nagib, Mohamed Adel, Nabil Elserwy, Islam Sobhy, Mohamed AbdelMonem, Hasaneen Abo Atya, Torki Al-Otaibi. Fludrocortisone Among Adult Renal Transplant Recipients With Persistent Hyperkalemia: Single-Center Experience.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2022 03; 20(Suppl 1):69-73. doi:
10.6002/ect.mesot2021.o27
. [PMID: 35384810] - Busra Gurpinar Tosun, Yasemin Kendir Demirkol, Tuba Seven Menevse, Sare Betul Kaygusuz, Mehmet Nuri Ozbek, Selda Ayca Altincik, Jamala Mammadova, Atilla Cayir, Esra Doger, Elvan Bayramoglu, Ozlem Nalbantoglu, Gul Yesiltepe Mutlu, AghaRza Aghayev, Serap Turan, Abdullah Bereket, Tulay Guran. Catch-up Growth and Discontinuation of Fludrocortisone Treatment in Aldosterone Synthase Deficiency.
The Journal of clinical endocrinology and metabolism.
2022 01; 107(1):e106-e117. doi:
10.1210/clinem/dgab619
. [PMID: 34415991] - Rouvick M Gama, David Makanjuola, Mona Wahba, Virginia Quan, Mysore Phanish. Fludrocortisone Is an Effective Treatment for Hyperkalaemic Metabolic Acidosis in Kidney Transplant Recipients on Tacrolimus: A Case Series.
Nephron.
2022; 146(2):190-196. doi:
10.1159/000519670
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Pediatric nephrology (Berlin, Germany).
2021 09; 36(9):2731-2737. doi:
10.1007/s00467-021-05018-7
. [PMID: 33768328] - Muneera A Alabdulqader, Ahmad Azzam, Alanoud A Alshami. Incidence of hyperkalemic RTA in pediatric post-renal transplant patients and the role of fludrocortisone.
Pediatric transplantation.
2021 Sep; 25(6):e14029. doi:
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Journal of clinical research in pediatric endocrinology.
2021 08; 13(3):362-366. doi:
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Cell reports.
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Turkish journal of medical sciences.
2021 02; 51(1):231-237. doi:
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Rheumatology international.
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Clinical chemistry.
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Clinical journal of the American Society of Nephrology : CJASN.
2020 01; 15(1):16-24. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 01; 75(1):A15-A18. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Problemy endokrinologii.
2019 05; 65(1):39-45. doi:
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Archives of endocrinology and metabolism.
2019 Feb; 63(1):84-88. doi:
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. [PMID: 30864636] - Cenk Gökalp, Faruk Yildiz, Simge Tuzun, Gorkem Karadag, Ilhan Kurultak, Sedat Ustundag. Adrenal Insufficiency Secondary to Peritoneal Dialysis-Related Peritonitis: A Case Report.
Blood purification.
2019; 48(3):272-275. doi:
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. [PMID: 31291617] - Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner. The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2019 Jan; 20(1):1470320319827449. doi:
10.1177/1470320319827449
. [PMID: 30813831] - Zeng Guo, Marko Poglitsch, Brett C McWhinney, Jacobus P J Ungerer, Ashraf H Ahmed, Richard D Gordon, Martin Wolley, Michael Stowasser. Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism.
The Journal of clinical endocrinology and metabolism.
2018 11; 103(11):3965-3973. doi:
10.1210/jc.2018-01041
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The Journal of clinical endocrinology and metabolism.
2018 11; 103(11):4113-4124. doi:
10.1210/jc.2018-01394
. [PMID: 30239841] - Usha K Misra, Jayantee Kalita, Mritunjai Kumar. Safety and Efficacy of Fludrocortisone in the Treatment of Cerebral Salt Wasting in Patients With Tuberculous Meningitis: A Randomized Clinical Trial.
JAMA neurology.
2018 11; 75(11):1383-1391. doi:
10.1001/jamaneurol.2018.2178
. [PMID: 30105362] - Joanna Kanarek-Kucner, Adrian Stefański, Rufus Barraclough, Tomasz Gorycki, Jacek Wolf, Krzysztof Narkiewicz, Michał Hoffmann. Insufficiency of the zona glomerulosa of the adrenal cortex and progressive kidney insufficiency following unilateral adrenalectomy - case report and discussion.
Blood pressure.
2018 10; 27(5):304-312. doi:
10.1080/08037051.2018.1470460
. [PMID: 29742971] - Yukiko Yasuoka, Yuichiro Izumi, Takanori Nagai, Takashi Fukuyama, Yushi Nakayama, Hideki Inoue, Kahori Horikawa, Miho Kimura, Masayoshi Nanami, Kengo Yanagita, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu, Rui Yamamura, Noritada Kobayashi, Yoshitaka Shimada, Yasushi Nagaba, Takeshi Nakanishi, Tetsuro Yamashita, Masashi Mukoyama, Yuichi Sato, Katsumasa Kawahara, Hiroshi Nonoguchi. Fludrocortisone stimulates erythropoietin production in the intercalated cells of the collecting ducts.
Biochemical and biophysical research communications.
2018 09; 503(4):3121-3127. doi:
10.1016/j.bbrc.2018.08.102
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JCI insight.
2018 08; 3(16):. doi:
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Journal of medical case reports.
2018 Jul; 12(1):212. doi:
10.1186/s13256-018-1678-z
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Kidney international.
2018 07; 94(1):225-226. doi:
10.1016/j.kint.2017.12.009
. [PMID: 29933854] - Fredrik Erlandsson, Muna Albayaty, Ligia Chialda, Hans Ericsson, Carl Amilon, Karin Nelander, Rasmus Jansson-Löfmark, Linda Wernevik, Magnus Kjaer, Krister Bamberg, Judith Hartleib-Geschwindner. Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.
British journal of clinical pharmacology.
2018 07; 84(7):1486-1493. doi:
10.1111/bcp.13562
. [PMID: 29468715] - Juuso Tainio. Calcineurin inhibitor-associated electrolyte disturbances after pediatric renal transplantation: Could fludrocortisone therapy have a role?.
Pediatric transplantation.
2018 03; 22(2):. doi:
10.1111/petr.13097
. [PMID: 29222873] - S R Ali, I Shaheen, D Young, I Ramage, H Maxwell, D A Hughes, D Athavale, M G Shaikh. Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.
Pediatric transplantation.
2018 03; 22(2):. doi:
10.1111/petr.13134
. [PMID: 29345400] - Ying Song, Shumin Yang, Wenwen He, Jinbo Hu, Qingfeng Cheng, Yue Wang, Ting Luo, Linqiang Ma, Qianna Zhen, Suhua Zhang, Mei Mei, Zhihong Wang, Hua Qing, Dennis Bruemmer, Bin Peng, Qifu Li. Confirmatory Tests for the Diagnosis of Primary Aldosteronism: A Prospective Diagnostic Accuracy Study.
Hypertension (Dallas, Tex. : 1979).
2018 01; 71(1):118-124. doi:
10.1161/hypertensionaha.117.10197
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World neurosurgery.
2017 Dec; 108(?):529-533. doi:
10.1016/j.wneu.2017.09.013
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Chemistry and physics of lipids.
2017 10; 207(Pt B):271-278. doi:
10.1016/j.chemphyslip.2017.04.007
. [PMID: 28435101] - Anneke P Bech, Jack F M Wetzels, Tom Nijenhuis. Use of the Furosemide Fludrocortisone Test to Clinically Assess Distal Tubular Acidification.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 10; 70(4):589-591. doi:
10.1053/j.ajkd.2017.05.009
. [PMID: 28634085] - Nasser A Dhayat, Michael W Gradwell, Ganesh Pathare, Manuel Anderegg, Lisa Schneider, David Luethi, Cedric Mattmann, Orson W Moe, Bruno Vogt, Daniel G Fuster. Furosemide/Fludrocortisone Test and Clinical Parameters to Diagnose Incomplete Distal Renal Tubular Acidosis in Kidney Stone Formers.
Clinical journal of the American Society of Nephrology : CJASN.
2017 Sep; 12(9):1507-1517. doi:
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Sleep.
2017 08; 40(8):. doi:
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. [PMID: 28521050] - S J H Dobbin, J R Petrie, M E J Lean, G A McKay. Fludrocortisone therapy for persistent hyperkalaemia.
Diabetic medicine : a journal of the British Diabetic Association.
2017 07; 34(7):1005-1008. doi:
10.1111/dme.13359
. [PMID: 28375568] - Noureddine Hamitouche, Emmanuelle Comets, Mégane Ribot, Jean-Claude Alvarez, Eric Bellissant, Bruno Laviolle. Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers.
The AAPS journal.
2017 05; 19(3):727-735. doi:
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The Journal of steroid biochemistry and molecular biology.
2017 01; 165(Pt B):396-406. doi:
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British journal of clinical pharmacology.
2016 12; 82(6):1509-1516. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2016 11; 31(11):1870-1876. doi:
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Environmental science & technology.
2016 09; 50(18):10245-54. doi:
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Medicine.
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Diabetic medicine : a journal of the British Diabetic Association.
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Internal medicine (Tokyo, Japan).
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Pediatric emergency care.
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The American journal of the medical sciences.
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Rheumatology (Oxford, England).
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