Etoricoxib (BioDeep_00000001966)

   

human metabolite blood metabolite


代谢物信息卡片


5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulphonyl)phenyl)pyridine

化学式: C18H15ClN2O2S (358.054272)
中文名称: 依托考昔
谱图信息: 最多检出来源 Homo sapiens(blood) 4.92%

分子结构信息

SMILES: CC1=NC=C(C=C1)C1=C(C=C(Cl)C=N1)C1=CC=C(C=C1)S(C)(=O)=O
InChI: InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3

描述信息

Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2). This reduces the generation of prostaglandins (PGs) from arachidonic acid.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AH - Coxibs
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents

同义名列表

12 个代谢物同义名

5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulphonyl)phenyl)pyridine; 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine; 5-chloro-3-(4-methanesulfonylphenyl)-2-(6-methylpyridin-3-yl)pyridine; 5-Chloro-3-(4-methanesulphonyl-phenyl)-6-methyl-[2,3]bipyridinyl; 5-Chloro-3-(4-methanesulfonyl-phenyl)-6-methyl-[2,3]bipyridinyl; 5-Chloro-6-methyl-3-(p-(methylsulphonyl)phenyl)-2,3-bipyridine; 5-Chloro-6-methyl-3-(p-(methylsulfonyl)phenyl)-2,3-bipyridine; Etoricoxibum; Etoricoxib; Arcoxia; L791456; MK-663



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hao Wang, Si-Ting Chen, Xiao-Jie Ding, Le Kuai, Liang Hua, Xin Li, Yi-Fei Wang, Ming Zhang, Bin Li, Rui-Ping Wang, Mi Zhou. Efficacy and safety of Huzhang Granule, a compound Chinese herbal medicine, for acute gouty arthritis: A double-blind, randomized controlled trial. Journal of integrative medicine. 2024 May; 22(3):270-278. doi: 10.1016/j.joim.2024.03.008. [PMID: 38553375]
  • Eman Fs Taha, Noha Sayed Hamed, Sahar Khateeb. Etoricoxib nanostructured lipid carriers attenuate inflammation by modulating Cyclooxygenase-2 signaling and activation of nuclear factor-κB-p65 pathways in radiation-induced acute cardiotoxicity in rats. European journal of pharmacology. 2023 Aug; 957(?):176029. doi: 10.1016/j.ejphar.2023.176029. [PMID: 37648012]
  • Julia Steinmetz-Späh, Samsul Arefin, Karin Larsson, Jabin Jahan, Neja Mudrovcic, Lars Wennberg, Peter Stenvinkel, Marina Korotkova, Karolina Kublickiene, Per-Johan Jakobsson. Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease. British journal of pharmacology. 2022 04; 179(7):1433-1449. doi: 10.1111/bph.15729. [PMID: 34766335]
  • Natasja de Bruin, Ann-Kathrin Schneider, Philipp Reus, Sonja Talmon, Sandra Ciesek, Denisa Bojkova, Jindrich Cinatl, Imran Lodhi, Bruce Charlesworth, Simon Sinclair, Graham Pennick, William F Laughey, Philip Gribbon, Aimo Kannt, Susanne Schiffmann. Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031049. [PMID: 35162972]
  • Gaber Ali, Hany Omar, Fatema Hersi, Amira Abo-Youssef, Osama Ahmed, Wafaa Mohamed. The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling. Current molecular pharmacology. 2022; 15(1):252-262. doi: 10.2174/1874467214666210708103752. [PMID: 34238176]
  • Synne Jenum, Kristian Tonby, Corina S Rueegg, Morten Rühwald, Max P Kristiansen, Peter Bang, Inge Christoffer Olsen, Kjersti Sellæg, Kjerstin Røstad, Tehmina Mustafa, Kjetil Taskén, Dag Kvale, Rasmus Mortensen, Anne Ma Dyrhol-Riise. A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients. Nature communications. 2021 11; 12(1):6774. doi: 10.1038/s41467-021-27029-6. [PMID: 34811370]
  • Huocheng Liao, Suzhen Ou, Xiaoyan Dong, Jianping Liu, Chun Xiao. Association of Etoricoxib treatment and incident hypoxia in patients with aortic dissection undergoing endovascular aortic repair. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111625. doi: 10.1016/j.biopha.2021.111625. [PMID: 33895524]
  • Ruo Wang. Etoricoxib may inhibit cytokine storm to treat COVID-19. Medical hypotheses. 2021 May; 150(?):110557. doi: 10.1016/j.mehy.2021.110557. [PMID: 33730601]
  • Natasha C Brigham, Rebecca Nofsinger, Xin Luo, Nathan Z Dreger, Alexandra K Abel, Tiffany P Gustafson, Seth P Forster, Andre Hermans, Ru-Rong Ji, Matthew L Becker. Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management. Journal of controlled release : official journal of the Controlled Release Society. 2021 01; 329(?):316-327. doi: 10.1016/j.jconrel.2020.11.052. [PMID: 33278481]
  • Michael B Subhahar, Jaipaul Singh, Peter H Albert, Ahmed M Kadry. Detection and Pharmacokinetics of Etoricoxib in Thoroughbred Horses. Journal of equine veterinary science. 2020 May; 88(?):102942. doi: 10.1016/j.jevs.2020.102942. [PMID: 32303303]
  • Marwa Abd El-Kader, Reham Ismail Taha. Comparative nephroprotective effects of curcumin and etoricoxib against cisplatin-induced acute kidney injury in rats. Acta histochemica. 2020 May; 122(4):151534. doi: 10.1016/j.acthis.2020.151534. [PMID: 32151374]
  • Yong Sun, Changde Wang, Chunzhu Gong. Repairing effects of glucosamine sulfate in combination with etoricoxib on articular cartilages of patients with knee osteoarthritis. Journal of orthopaedic surgery and research. 2020 Apr; 15(1):150. doi: 10.1186/s13018-020-01648-z. [PMID: 32299482]
  • Jin Qiu, Mian Xie, Ronglan Qu. The Influence of Etoricoxib on Pain Control for Laparoscopic Cholecystectomy: A Meta-analysis of Randomized Controlled Trials. Surgical laparoscopy, endoscopy & percutaneous techniques. 2019 Jun; 29(3):150-154. doi: 10.1097/sle.0000000000000635. [PMID: 30855399]
  • Vivek Dave, Prarthana Srivastava, Kajal Tak, Swapnil Sharma. PEG-PLGA- hybrid nanoparticles loaded with etoricoxib - phospholipid complex for effective treatment of inflammation in rat model. Journal of microencapsulation. 2019 May; 36(3):236-249. doi: 10.1080/02652048.2019.1617362. [PMID: 31092089]
  • L Burgos Pratx, D Santoro, B Coca Mogro, V L Valiente, P Camino, W Scordo, H Salamone. Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure. Transfusion. 2019 05; 59(5):1657-1660. doi: 10.1111/trf.15226. [PMID: 30865300]
  • Xiaoran Zhang, Nan Guo, Wei Ji, Qing Wen. Rapid quantitative analysis of etoricoxib in human plasma by UPLC-MS/MS and application to a pharmacokinetic study in Chinese healthy volunteers. Biomedical chromatography : BMC. 2019 Feb; 33(2):e4414. doi: 10.1002/bmc.4414. [PMID: 30360014]
  • Christian Kirschneck, Erika Calvano Küchler, Ulrich Wahlmann, Peter Proff, Agnes Schröder. Effects of the highly COX-2-selective analgesic NSAID etoricoxib on the rate of orthodontic tooth movement and cranial growth. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2018 Nov; 220(?):21-28. doi: 10.1016/j.aanat.2018.07.001. [PMID: 30048759]
  • Giuseppe Di Stolfo, Pietro Palumbo, Stefano Castellana, Sandra Mastroianno, Tommaso Biagini, Orazio Palumbo, Maria Pia Leone, Giovanni De Luca, Domenico Rosario Potenza, Tommaso Mazza, Aldo A Russo, Massimo Carella. Sudden cardiac death in J wave syndrome with short QT associated to a novel mutation in Nav 1.8 coding gene SCN10A: First case report for a possible pharmacogenomic role. Journal of electrocardiology. 2018 Sep; 51(5):809-813. doi: 10.1016/j.jelectrocard.2018.06.005. [PMID: 30177317]
  • Paula Cíntia Machado Sampaio, Yan Garcia Lira, Hellen Yuki Umemura Ribeiro, Fernanda de Paula Moreira, Maitê Silva Martins Gadelha, Sérgio Ferreira Santos da Cruz. Poncet's disease after the intravesical instillation of Bacillus Calmette-Guérin (BCG): a case report. BMC research notes. 2017 Aug; 10(1):416. doi: 10.1186/s13104-017-2606-9. [PMID: 28821265]
  • Shan-Shan Li, Jin-We He, Wen-Zhen Fu, Yu-Juan Liu, Yun-Qiu Hu, Zhen-Lin Zhang. Clinical, Biochemical, and Genetic Features of 41 Han Chinese Families With Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results From a Six-Month Prospective Clinical Intervention. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 Aug; 32(8):1659-1666. doi: 10.1002/jbmr.3157. [PMID: 28425581]
  • Yi-Kai Yu, Fei Yu, Cong Ye, Gui-Fen Shen, Xiao-Mei Lei, Sheng-Tao Zhang, Shao-Xian Hu. Combination Therapies of Diacerein and Febuxostat Inhibit IL-1β Responses and Improve Clinical Symptoms in Patients With Refractory Gout. American journal of therapeutics. 2017 May; 24(3):e290-e297. doi: 10.1097/mjt.0000000000000284. [PMID: 26035033]
  • Christian Prebensen, Marius Trøseid, Thor Ueland, Anders Dahm, Per Morten Sandset, Ingeborg Aaberge, Kristian Waalen, Anne Ma Dyrhol-Riise, Kjetil Taskén, Dag Kvale. Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. PloS one. 2017; 12(5):e0176527. doi: 10.1371/journal.pone.0176527. [PMID: 28464042]
  • Marcella Goetz Moro, Paula Katherine Vargas Sanchez, Mayara Vitorino Gevert, Emeline Maria Baller, Ana Flávia Tostes, Ana Caroline Lupepsa, Sinvaldo Baglie, Gilson Cesar Nobre Franco. Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy. Brazilian oral research. 2016 Nov; 30(1):e127. doi: 10.1590/1807-3107bor-2016.vol30.0127. [PMID: 27901208]
  • Annika Piirainen, Merja Kokki, Heidi Hautajärvi, Marko Lehtonen, Hannu Miettinen, Kari Pulkki, Veli-Pekka Ranta, Hannu Kokki. The Cerebrospinal Fluid Distribution of Postoperatively Administred Dexketoprofen and Etoricoxib and Their Effect on Pain and Inflammatory Markers in Patients Undergoing Hip Arthroplasty. Clinical drug investigation. 2016 Jul; 36(7):545-55. doi: 10.1007/s40261-016-0400-4. [PMID: 27086319]
  • Aishwarya Balap, Bhagyashri Atre, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. Journal of ethnopharmacology. 2016 May; 183(?):9-17. doi: 10.1016/j.jep.2015.11.011. [PMID: 26593212]
  • Upasana Bilthariya, Nivrati Jain, Vaibhav Rajoriya, Ashish Kumar Jain. Folate-conjugated albumin nanoparticles for rheumatoid arthritis-targeted delivery of etoricoxib. Drug development and industrial pharmacy. 2015 Jan; 41(1):95-104. doi: 10.3109/03639045.2013.850705. [PMID: 24164469]
  • I A Zolotovskaya, I L Davydkin. [Effect of nonsteroidal anti-inflammatory drugs on the indicators of cardiovascular risk in patients with acute nonspecific back pain]. Terapevticheskii arkhiv. 2015; 87(12):18-25. doi: 10.17116/terarkh2015871218-25. [PMID: 26978413]
  • Bahadir Suleyman, Abdulmecit Albayrak, Nezahat Kurt, Elif Demirci, Cemal Gundogdu, Mehmet Aksoy. The effect of etoricoxib on kidney ischemia-reperfusion injury in rats: a biochemical and immunohistochemical assessment. International immunopharmacology. 2014 Nov; 23(1):179-85. doi: 10.1016/j.intimp.2014.06.042. [PMID: 25068826]
  • Kameran Daham, Anna James, David Balgoma, Maciej Kupczyk, Bo Billing, Agneta Lindeberg, Elisabeth Henriksson, Garret A FitzGerald, Craig E Wheelock, Sven-Erik Dahlén, Barbro Dahlén. Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma. The Journal of allergy and clinical immunology. 2014 Aug; 134(2):306-13. doi: 10.1016/j.jaci.2013.12.002. [PMID: 24461582]
  • Lisa Felden, Carmen Walter, Carlo Angioni, Yannick Schreiber, Nils von Hentig, Nerea Ferreiros, Gerd Geisslinger, Jörn Lötsch. Similar maximum systemic but not local cyclooxygenase-2 inhibition by 50 mg lumiracoxib and 90 mg etoricoxib: a randomized controlled trial in healthy subjects. Pharmaceutical research. 2014 Jul; 31(7):1813-22. doi: 10.1007/s11095-013-1285-z. [PMID: 24469906]
  • Tilman T Zittel, Dan Razavi, Andras Papp, Kjell Lundberg. Increased risk for complications after colorectal surgery with selective cyclo-oxygenase 2 inhibitor etoricoxib. Diseases of the colon and rectum. 2013 Jun; 56(6):761-7. doi: 10.1097/dcr.0b013e318285bb5a. [PMID: 23652751]
  • Beate Mayer, Ramona Genth, Rainer Dehner, Abdulgabar Salama. The first example of a patient with etoricoxib-induced immune hemolytic anemia. Transfusion. 2013 May; 53(5):1033-6. doi: 10.1111/j.1537-2995.2012.03843.x. [PMID: 22882551]
  • Klaus Schaffler, Peter Reeh, W Rachel Duan, Andrea E Best, Ahmed A Othman, Connie R Faltynek, Charles Locke, Wolfram Nothaft. An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UV(B)-inflamed and normal skin. British journal of clinical pharmacology. 2013 Feb; 75(2):404-14. doi: 10.1111/j.1365-2125.2012.04377.x. [PMID: 22775239]
  • Ting Li, Shun-le Chen, Qing Dai, Xing-Hai Han, Zhan-Guo Li, Dong-Hai Wu, Xiao Zhang, Jie-Ruo Gu, Nan-Ping Yang, Ling-Yun Sun, Miu-Jia Zhang, Xing-Fu Li, Chun-de Bao. Etoricoxib versus indometacin in the treatment of Chinese patients with acute gouty arthritis: a randomized double-blind trial. Chinese medical journal. 2013; 126(10):1867-71. doi: . [PMID: 23673101]
  • N Nadda, V Vaish, S Setia, S N Sanyal. Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2012 Sep; 66(6):474-83. doi: 10.1016/j.biopha.2012.04.002. [PMID: 22681911]
  • Jonathan L Marks, Désirée M van der Heijde, Alexandra N Colebatch, Rachelle Buchbinder, Christopher J Edwards. Pain pharmacotherapy in patients with inflammatory arthritis and concurrent cardiovascular or renal disease: a Cochrane systematic review. The Journal of rheumatology. Supplement. 2012 Sep; 90(?):81-4. doi: 10.3899/jrheum.120347. [PMID: 22942334]
  • B Renner, G Walter, J Strauss, M F Fromm, J Zacher, K Brune. Preoperative administration of etoricoxib in patients undergoing hip replacement causes inhibition of inflammatory mediators and pain relief. European journal of pain (London, England). 2012 Jul; 16(6):838-48. doi: 10.1002/j.1532-2149.2011.00062.x. [PMID: 22337568]
  • M A Radwan, N A A Baky, I Zaghloul, H Y Aboul-Enein. Pharmacokinetics and cardiovascular effect of etoricoxib in the absence or presence of St. John's Wort in rats. Arzneimittel-Forschung. 2012 Jul; 62(7):313-8. doi: 10.1055/s-0032-1309043. [PMID: 22549240]
  • B Walter, I Schrettenbrunner, M Vogelhuber, J Grassinger, K Bross, J Wilke, T Suedhoff, A Berand, W F Wieland, S Rogenhofer, R Andreesen, A Reichle. Pioglitazone, etoricoxib, interferon-α, and metronomic capecitabine for metastatic renal cell carcinoma: final results of a prospective phase II trial. Medical oncology (Northwood, London, England). 2012 Jun; 29(2):799-805. doi: 10.1007/s12032-011-9982-0. [PMID: 21607771]
  • Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar; 55(5):2287-300. doi: 10.1021/jm201528b. [PMID: 22263894]
  • Dinesh Kumar Dhull, Ankur Jindal, Rakesh K Dhull, Saurabh Aggarwal, Deepak Bhateja, Satyanarayana S V Padi. Neuroprotective effect of cyclooxygenase inhibitors in ICV-STZ induced sporadic Alzheimer's disease in rats. Journal of molecular neuroscience : MN. 2012 Jan; 46(1):223-35. doi: 10.1007/s12031-011-9583-6. [PMID: 21701788]
  • Mahasen A Radwan, Ghada A Bawazeer, Nouf M Aloudah, Bushra T AlQuadeib, Hassan Y Aboul-Enein. Determination of free and total warfarin concentrations in plasma using UPLC MS/MS and its application to a patient samples. Biomedical chromatography : BMC. 2012 Jan; 26(1):6-11. doi: 10.1002/bmc.1616. [PMID: 21374651]
  • I Doña, N Blanca-López, L R Jagemann, M J Torres, C Rondón, P Campo, A I Gómez, J Fernández, J J Laguna, A Rosado, M Blanca, G Canto. Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. Allergy. 2011 Nov; 66(11):1428-33. doi: 10.1111/j.1398-9995.2011.02684.x. [PMID: 21834936]
  • Jonathan L Marks, Alexandra N Colebatch, Rachelle Buchbinder, Christopher J Edwards. Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity. The Cochrane database of systematic reviews. 2011 Oct; ?(10):CD008952. doi: 10.1002/14651858.cd008952.pub2. [PMID: 21975789]
  • Anurag Maheshwari, Lohit Badgujar, Bonoranjan Phukan, Subhash Laxmanrao Bodhankar, Prasad Thakurdesai. Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. European journal of pharmacology. 2011 Sep; 667(1-3):230-7. doi: 10.1016/j.ejphar.2011.05.030. [PMID: 21635885]
  • R Andrew Moore, Helen Gaskell, Peter Rose, Jonathan Allan. Meta-analysis of efficacy and safety of intravenous ferric carboxymaltose (Ferinject) from clinical trial reports and published trial data. BMC blood disorders. 2011 Sep; 11(?):4. doi: 10.1186/1471-2326-11-4. [PMID: 21942989]
  • S Singh Kanwar, V Vaish, S Nath Sanyal. Altered membrane lipid dynamics and chemoprevention by non-steroidal anti inflammatory drugs during colon carcinogenesis. Nutricion hospitalaria. 2011 Sep; 26(5):1141-54. doi: 10.1590/s0212-16112011000500034. [PMID: 22072366]
  • Surender Singh, Vinod Nair, Y K Gupta. Antiarthritic activity of majoon suranjan (a polyherbal Unani formulation) in rat. The Indian journal of medical research. 2011 Sep; 134(?):384-8. doi: ". [PMID: 21985823]
  • Anke Olliges, Stefanie Wimmer, Rolf M Nüsing. Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors. British journal of pharmacology. 2011 Jul; 163(5):927-36. doi: 10.1111/j.1476-5381.2011.01313.x. [PMID: 21391980]
  • Elbio Leiguez, Juliana Pavan Zuliani, Aurora Marques Cianciarullo, Cristina Maria Fernandes, José Maria Gutiérrez, Catarina Teixeira. A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways. Journal of leukocyte biology. 2011 Jul; 90(1):155-66. doi: 10.1189/jlb.0510263. [PMID: 21478270]
  • Francisco Y B Macedo, Lívia T C Mourão, Raimundo C Palheta, Davi M Jucá, Roberto C P Lima, José de Sá C Neto, Pedro J C Magalhães, Armênio A Santos, Marcellus H L P Souza, Gerly A C Brito, Ronaldo A Ribeiro. Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. Cancer chemotherapy and pharmacology. 2011 Apr; 67(4):935-43. doi: 10.1007/s00280-010-1392-z. [PMID: 20602232]
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  • David R Lionberger, Michael J Brennan. Topical nonsteroidal anti-inflammatory drugs for the treatment of pain due to soft tissue injury: diclofenac epolamine topical patch. Journal of pain research. 2010 Nov; 3(?):223-33. doi: 10.2147/jpr.s13238. [PMID: 21197326]
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  • Maria Cecilia Anauate, Luce Maria Torres, Suzana Beatriz Veríssimo de Mello. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytotherapy research : PTR. 2010 Sep; 24(9):1365-9. doi: 10.1002/ptr.3124. [PMID: 20812280]
  • Swagata Tripathy, Suresh Chandra Dash. Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet. International journal of emergency medicine. 2010 Aug; 3(4):443-6. doi: 10.1007/s12245-010-0208-6. [PMID: 21373319]
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