Thromboxane A2 (BioDeep_00000019510)

 

Secondary id: BioDeep_00000004866

human metabolite Endogenous blood metabolite


代谢物信息卡片


7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoic acid

化学式: C20H32O5 (352.2249622)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.8%

分子结构信息

SMILES: CCCCCC(C=CC1C(C2CC(O2)O1)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1

描述信息

Thromboxane A2 is an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.

同义名列表

35 个代谢物同义名

7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoic acid; 7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoate; (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-heptenoic acid; (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-heptenoate; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-Hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoic acid; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-Hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxy-thromboxa-5,13-dien-1-Oic acid; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxy-thromboxa-5,13-dien-1-Oate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,13E)-(15S)-9-alpha,11-alpha-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,9Α,11α,13E,15S)-9,11-epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,9a,11a,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,13E)-(15S)-9-alpha,11-alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,9a,11a,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,9Α,11α,13E,15S)-9,11-epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,13E)-(15S)-9a,11a-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9Α,11α-epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9a,11a-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9,11-Epoxy-15-hydroxythromba-5,13-dienoic acid; (5Z,13E)-(15S)-9Α,11α-epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9,11-Epoxy-15-hydroxythromba-5,13-dienoate; 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid; 9S,11S-Epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-Oate; Rabbit aorta contracting substance; a2, Thromboxane; Thromboxane A2; Thromboxane; TXA-2; TXA2; RCS; Cid



数据库引用编号

15 个数据库交叉引用编号

分类词条

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuai Yan, Yuanyang Wang, Bei Wang, Shengkai Zuo, Ying Yu. Thromboxane A2 Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14-3-3γ/StAR Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 May; 11(18):e2307926. doi: 10.1002/advs.202307926. [PMID: 38460156]
  • Yufeng Dai, Ruijie Xu, Jinxiang Chen, Jialong Fang, Hao Zhang, Haitao Li, Wei Chen. Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease. British journal of pharmacology. 2023 Sep; ?(?):. doi: 10.1111/bph.16238. [PMID: 37940413]
  • E Prakash, S Pavithra, D G Kishor Kumar, Manjit Panigrahi, Thakur Uttam Singh, Dinesh Kumar, Subhashree Parida. TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106736. doi: 10.1016/j.prostaglandins.2023.106736. [PMID: 37062326]
  • Amel Bouhadoun, Hasanga D Manikpurage, Catherine Deschildre, Sara Zalghout, Marc Dubourdeau, Valérie Urbach, Benoît Ho-Tin-Noe, Lydia Deschamps, Jean-Baptiste Michel, Dan Longrois, Xavier Norel. DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE2. Prostaglandins & other lipid mediators. 2022 Dec; 165(?):106700. doi: 10.1016/j.prostaglandins.2022.106700. [PMID: 36528331]
  • Elisa Villa-Martínez, Selma Romina López-Vaquera, Lesvia Karina Alvarado-Coutiño, Ana María Gámez-Méndez, Amelia Ríos, Bruno Escalante. Thromboxane-dependent coronary vasoconstriction in obese mice: Role of peroxynitrite. Prostaglandins & other lipid mediators. 2022 06; 160(?):106631. doi: 10.1016/j.prostaglandins.2022.106631. [PMID: 35272056]
  • Heike Braun, Michael Hauke, Robert Eckenstaler, Markus Petermann, Anne Ripperger, Niklas Kühn, Edzard Schwedhelm, Beatrice Ludwig-Kraus, Frank Bernhard Kraus, Virginie Dubourg, Alma Zernecke, Barbara Schreier, Michael Gekle, Ralf A Benndorf. The F2-isoprostane 8-iso-PGF2α attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A2 receptors. Free radical biology & medicine. 2022 05; 185(?):36-45. doi: 10.1016/j.freeradbiomed.2022.04.010. [PMID: 35470061]
  • Anna Michno, Katarzyna Grużewska, Anna Ronowska, Sylwia Gul-Hinc, Marlena Zyśk, Agnieszka Jankowska-Kulawy. Resveratrol Inhibits Metabolism and Affects Blood Platelet Function in Type 2 Diabetes. Nutrients. 2022 Apr; 14(8):. doi: 10.3390/nu14081633. [PMID: 35458194]
  • Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A Hemkemeyer, Edzard Schwedhelm, Süleyman Ergün, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A Benndorf. A Thromboxane A2 Receptor-Driven COX-2-Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis. Arteriosclerosis, thrombosis, and vascular biology. 2022 04; 42(4):444-461. doi: 10.1161/atvbaha.121.317380. [PMID: 35236104]
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  • Juan Hu, Zhenzhen Yang, Xueqin Chen, Sujuan Kuang, Zhiwen Lian, Guibao Ke, Ruyi Liao, Jianchao Ma, Sijia Li, Li Zhang, Zhuo Li, Zhonglin Feng, Huaban Liang, Ting Lin, Wei Dong, Ruizhao Li, Zhilian Li, Yuanhan Chen, Xinling Liang, Wei Shi, Chunyu Deng, Shuangxin Liu. Thromboxane A2 is involved in the development of hypertension in chronic kidney disease rats. European journal of pharmacology. 2021 Oct; 909(?):174435. doi: 10.1016/j.ejphar.2021.174435. [PMID: 34416239]
  • Anna Vogelsang, Susann Eichler, Niklas Huntemann, Lars Masanneck, Hannes Böhnlein, Lisa Schüngel, Alice Willison, Karin Loser, Bernhard Nieswandt, Beate E Kehrel, Alexander Zarbock, Kerstin Göbel, Sven G Meuth. Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189915. [PMID: 34576080]
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  • Michał Majewski, Adam Jurgoński. The Effect of Hemp (Cannabis sativa L.) Seeds and Hemp Seed Oil on Vascular Dysfunction in Obese Male Zucker Rats. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082575. [PMID: 34444734]
  • Jie V Zhao, Wai-Fung Yeung, Yap-Hang Chan, Dana Vackova, June Y Y Leung, Dennis K M Ip, Jiaxi Zhao, Wai-Kwan Ho, Hung-Fat Tse, Catherine Mary Schooling. Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082550. [PMID: 34444711]
  • Bingsheng Li, Ru Huang, Ruixiao Wang, Yuhan Liu, Christian G Stief, Martin Hennenberg. Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries. Pharmacology research & perspectives. 2021 05; 9(3):e00771. doi: 10.1002/prp2.771. [PMID: 33929093]
  • Patrizia Amadio, Benedetta Porro, Viviana Cavalca, Silvia Stella Barbieri, Sonia Eligini, Susanna Fiorelli, Alessandro Di Minno, Alessandra Gorini, Mattia Giuliani, Josè Pablo Werba, Nicola Cosentino, Paolo Olivares, Simone Barbieri, Fabrizio Veglia, Elena Tremoli, Daniela Trabattoni. Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Apr; 136(?):111259. doi: 10.1016/j.biopha.2021.111259. [PMID: 33450492]
  • Xiaolong Wu, Minghui Wei, Haifeng Zhang, Xiaomei Fan, Xiaochen Ma, Jiaming Liu, Mingming Xue. The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats. BioMed research international. 2021; 2021(?):2043415. doi: 10.1155/2021/2043415. [PMID: 33969115]
  • Miltan Chandra Roy, Kiwoong Nam, Jaesu Kim, David Stanley, Yonggyun Kim. Thromboxane Mobilizes Insect Blood Cells to Infection Foci. Frontiers in immunology. 2021; 12(?):791319. doi: 10.3389/fimmu.2021.791319. [PMID: 34987515]
  • Sara Alberti, Qianqian Zhang, Ilaria D'Agostino, Annalisa Bruno, Stefania Tacconelli, Annalisa Contursi, Simone Guarnieri, Melania Dovizio, Lorenza Falcone, Patrizia Ballerini, Götz Münch, Ying Yu, Paola Patrignani. The antiplatelet agent revacept prevents the increase of systemic thromboxane A2 biosynthesis and neointima hyperplasia. Scientific reports. 2020 12; 10(1):21420. doi: 10.1038/s41598-020-77934-x. [PMID: 33293599]
  • Gulsev Ozen, Khadija Aljesri, Zeynep Celik, Gulsum Turkyılmaz, Saygın Turkyılmaz, Onder Teskin, Xavier Norel, Gokce Topal. Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein. Prostaglandins & other lipid mediators. 2020 12; 151(?):106476. doi: 10.1016/j.prostaglandins.2020.106476. [PMID: 32721526]
  • Tao-Fang Cheng, Jing Zhao, Qiu-Lin Wu, Hua-Wu Zeng, Yu-Ting Sun, Yu-Hao Zhang, Rui Mi, Xiao-Po Qi, Jing-Tao Zou, Ai-Jun Liu, Hui-Zi Jin, Wei-Dong Zhang. Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153330. doi: 10.1016/j.phymed.2020.153330. [PMID: 32932202]
  • Tatjana Majkić, Kristina Bekvalac, Ivana Beara. Plantain (Plantago L.) species as modulators of prostaglandin E2 and thromboxane A2 production in inflammation. Journal of ethnopharmacology. 2020 Nov; 262(?):113140. doi: 10.1016/j.jep.2020.113140. [PMID: 32736048]
  • Ajay Gupta, Kate Chander Chiang. Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease. Medical hypotheses. 2020 Oct; 143(?):110122. doi: 10.1016/j.mehy.2020.110122. [PMID: 32759007]
  • Juyu Cai, Bin Liu, Tingting Guo, Yingzhan Zhang, Xiangzhong Wu, Jing Leng, Ningxia Zhu, Jinwei Guo, Yingbi Zhou. Effects of thromboxane prostanoid receptor deficiency on diabetic nephropathy induced by high fat diet and streptozotocin in mice. European journal of pharmacology. 2020 Sep; 882(?):173254. doi: 10.1016/j.ejphar.2020.173254. [PMID: 32553735]
  • P Conti, Al Caraffa, C E Gallenga, R Ross, S K Kritas, I Frydas, A Younes, P Di Emidio, G Ronconi, E Toniato. IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra). Journal of biological regulators and homeostatic agents. 2020 Sep; 34(5):1623-1627. doi: 10.23812/20-34-4edit-65. [PMID: 32744052]
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