Thromboxane A2 (BioDeep_00000019510)

 

Secondary id: BioDeep_00000004866

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoic acid

化学式: C20H32O5 (352.225)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 28.18%

分子结构信息

SMILES: CCCCCC(C=CC1C(C2CC(O2)O1)CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1

描述信息

Thromboxane A2 is an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.

同义名列表

36 个代谢物同义名

7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoic acid; 7-[3-(3-Hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-[1S-[1alpha,3alpha(1E,3R*),4beta(Z),5alpha]]-5-heptenoate; (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-heptenoic acid; (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-heptenoate; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,6-dioxabicyclo[3.1.1]heptan-4-yl]hept-5-enoic acid; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-Hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoic acid; (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-Hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxy-thromboxa-5,13-dien-1-Oic acid; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxy-thromboxa-5,13-dien-1-Oate; (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,13E)-(15S)-9-alpha,11-alpha-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,9Α,11α,13E,15S)-9,11-epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,9a,11a,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oic acid; (5Z,13E)-(15S)-9-alpha,11-alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,9a,11a,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,9Α,11α,13E,15S)-9,11-epoxy-15-hydroxythromboxa-5,13-dien-1-Oate; (5Z,13E)-(15S)-9a,11a-Epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9Α,11α-epoxy-15-hydroxythromboxa-5,13-dienoic acid; (5Z,13E)-(15S)-9a,11a-Epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9,11-Epoxy-15-hydroxythromba-5,13-dienoic acid; (5Z,13E)-(15S)-9Α,11α-epoxy-15-hydroxythromboxa-5,13-dienoate; (5Z,13E)-(15S)-9,11-Epoxy-15-hydroxythromba-5,13-dienoate; 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid; 9S,11S-Epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-Oate; Rabbit aorta contracting substance; a2, Thromboxane; Thromboxane A2; Thromboxane; TXA-2; TXA2; RCS; Cid; Thromboxane A2



数据库引用编号

17 个数据库交叉引用编号

分类词条

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, EDN1, PLA2G12A, PTGS1, PTGS2, TNK1, VEGFA
Peripheral membrane protein 4 AP1S2, PTGS1, PTGS2, TNK1
Endoplasmic reticulum membrane 3 PTGIS, PTGS1, PTGS2
Nucleus 4 ALB, PLCZ1, PTGIS, VEGFA
cytosol 4 ALB, AP1S2, PLCZ1, PRKCQ
centrosome 1 ALB
nucleoplasm 1 PLCZ1
Cell membrane 3 AGTR1, AGTR2, P2RY12
Cytoplasmic side 1 AP1S2
Multi-pass membrane protein 5 AGTR1, AGTR2, CACNA1I, P2RY12, RHO
cell surface 3 ITGA2B, P2RY12, VEGFA
Golgi apparatus 5 ALB, AP1S2, PTGS1, RHO, VEGFA
Golgi membrane 2 AP1S2, RHO
lysosomal membrane 1 AP1S2
plasma membrane 10 AGTR1, AGTR2, CACNA1I, ITGA2B, KNG1, P2RY12, PRKCQ, REN, RHO, TNK1
Membrane 8 AGTR1, CACNA1I, ITGA2B, P2RY12, REN, RHO, TNK1, VEGFA
caveola 2 PTGIS, PTGS2
extracellular exosome 5 ALB, ITGA2B, KNG1, PTGS1, VWF
endoplasmic reticulum 5 ALB, PTGIS, PTGS2, VEGFA, VWF
extracellular space 7 ALB, EDN1, KNG1, PTGIS, REN, VEGFA, VWF
perinuclear region of cytoplasm 1 PLCZ1
adherens junction 1 VEGFA
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 2 AP1S2, PTGS1
Microsome membrane 2 PTGS1, PTGS2
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ITGA2B
Secreted 6 ALB, EDN1, PLA2G12A, REN, VEGFA, VWF
extracellular region 7 ALB, EDN1, KNG1, PLA2G12A, REN, VEGFA, VWF
Single-pass membrane protein 1 PTGIS
basal part of cell 1 EDN1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 2 PTGS1, RHO
external side of plasma membrane 1 ITGA2B
Secreted, extracellular space, extracellular matrix 2 VEGFA, VWF
nucleolus 1 PLCZ1
Early endosome 1 AP1S2
Membrane, clathrin-coated pit 1 AP1S2
apical part of cell 1 REN
cell-cell junction 1 RHO
clathrin-coated pit 1 AP1S2
Cytoplasm, perinuclear region 1 PLCZ1
focal adhesion 1 ITGA2B
extracellular matrix 2 VEGFA, VWF
collagen-containing extracellular matrix 2 KNG1, VWF
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 RHO
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 3 ALB, ITGA2B, KNG1
sperm midpiece 1 RHO
Endomembrane system 2 AP1S2, PTGS1
Cytoplasmic vesicle membrane 1 AP1S2
Golgi-associated vesicle membrane 1 RHO
platelet alpha granule 1 VWF
trans-Golgi network membrane 1 AP1S2
endoplasmic reticulum lumen 3 ALB, KNG1, PTGS2
platelet alpha granule lumen 4 ALB, KNG1, VEGFA, VWF
voltage-gated calcium channel complex 1 CACNA1I
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 EDN1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
AP-1 adaptor complex 1 AP1S2
platelet alpha granule membrane 1 ITGA2B
integrin complex 1 ITGA2B
photoreceptor disc membrane 1 RHO
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 2 EDN1, VWF
integrin alphaIIb-beta3 complex 1 ITGA2B
rod photoreceptor outer segment 1 RHO
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB


文献列表

  • Shuai Yan, Yuanyang Wang, Bei Wang, Shengkai Zuo, Ying Yu. Thromboxane A2 Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14-3-3γ/StAR Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 May; 11(18):e2307926. doi: 10.1002/advs.202307926. [PMID: 38460156]
  • Yufeng Dai, Ruijie Xu, Jinxiang Chen, Jialong Fang, Hao Zhang, Haitao Li, Wei Chen. Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease. British journal of pharmacology. 2023 Sep; ?(?):. doi: 10.1111/bph.16238. [PMID: 37940413]
  • E Prakash, S Pavithra, D G Kishor Kumar, Manjit Panigrahi, Thakur Uttam Singh, Dinesh Kumar, Subhashree Parida. TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106736. doi: 10.1016/j.prostaglandins.2023.106736. [PMID: 37062326]
  • Amel Bouhadoun, Hasanga D Manikpurage, Catherine Deschildre, Sara Zalghout, Marc Dubourdeau, Valérie Urbach, Benoît Ho-Tin-Noe, Lydia Deschamps, Jean-Baptiste Michel, Dan Longrois, Xavier Norel. DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE2. Prostaglandins & other lipid mediators. 2022 Dec; 165(?):106700. doi: 10.1016/j.prostaglandins.2022.106700. [PMID: 36528331]
  • Elisa Villa-Martínez, Selma Romina López-Vaquera, Lesvia Karina Alvarado-Coutiño, Ana María Gámez-Méndez, Amelia Ríos, Bruno Escalante. Thromboxane-dependent coronary vasoconstriction in obese mice: Role of peroxynitrite. Prostaglandins & other lipid mediators. 2022 06; 160(?):106631. doi: 10.1016/j.prostaglandins.2022.106631. [PMID: 35272056]
  • Heike Braun, Michael Hauke, Robert Eckenstaler, Markus Petermann, Anne Ripperger, Niklas Kühn, Edzard Schwedhelm, Beatrice Ludwig-Kraus, Frank Bernhard Kraus, Virginie Dubourg, Alma Zernecke, Barbara Schreier, Michael Gekle, Ralf A Benndorf. The F2-isoprostane 8-iso-PGF2α attenuates atherosclerotic lesion formation in Ldlr-deficient mice - Potential role of vascular thromboxane A2 receptors. Free radical biology & medicine. 2022 05; 185(?):36-45. doi: 10.1016/j.freeradbiomed.2022.04.010. [PMID: 35470061]
  • Anna Michno, Katarzyna Grużewska, Anna Ronowska, Sylwia Gul-Hinc, Marlena Zyśk, Agnieszka Jankowska-Kulawy. Resveratrol Inhibits Metabolism and Affects Blood Platelet Function in Type 2 Diabetes. Nutrients. 2022 Apr; 14(8):. doi: 10.3390/nu14081633. [PMID: 35458194]
  • Robert Eckenstaler, Anne Ripperger, Michael Hauke, Markus Petermann, Sandra A Hemkemeyer, Edzard Schwedhelm, Süleyman Ergün, Maike Frye, Oliver Werz, Andreas Koeberle, Heike Braun, Ralf A Benndorf. A Thromboxane A2 Receptor-Driven COX-2-Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis. Arteriosclerosis, thrombosis, and vascular biology. 2022 04; 42(4):444-461. doi: 10.1161/atvbaha.121.317380. [PMID: 35236104]
  • Shin-Sook Yoon, Hyuk-Woo Kwon, Jung-Hae Shin, Man Hee Rhee, Chang-Eun Park, Dong-Ha Lee. Anti-Thrombotic Effects of Artesunate through Regulation of cAMP and PI3K/MAPK Pathway on Human Platelets. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031586. [PMID: 35163507]
  • Maeve Kiely, Ginger L Milne, Tsion Z Minas, Tiffany H Dorsey, Wei Tang, Cheryl J Smith, Francine Baker, Christopher A Loffredo, Clayton Yates, Michael B Cook, Stefan Ambs. Urinary Thromboxane B2 and Lethal Prostate Cancer in African American Men. Journal of the National Cancer Institute. 2022 01; 114(1):123-129. doi: 10.1093/jnci/djab129. [PMID: 34264335]
  • Pankaj Bhatia, Nirmal Singh. Thromboxane A2 synthase inhibition ameliorates endothelial dysfunction, memory deficits, oxidative stress and neuroinflammation in rat model of streptozotocin diabetes induced dementia. Physiology & behavior. 2021 11; 241(?):113592. doi: 10.1016/j.physbeh.2021.113592. [PMID: 34534530]
  • Juan Hu, Zhenzhen Yang, Xueqin Chen, Sujuan Kuang, Zhiwen Lian, Guibao Ke, Ruyi Liao, Jianchao Ma, Sijia Li, Li Zhang, Zhuo Li, Zhonglin Feng, Huaban Liang, Ting Lin, Wei Dong, Ruizhao Li, Zhilian Li, Yuanhan Chen, Xinling Liang, Wei Shi, Chunyu Deng, Shuangxin Liu. Thromboxane A2 is involved in the development of hypertension in chronic kidney disease rats. European journal of pharmacology. 2021 Oct; 909(?):174435. doi: 10.1016/j.ejphar.2021.174435. [PMID: 34416239]
  • Anna Vogelsang, Susann Eichler, Niklas Huntemann, Lars Masanneck, Hannes Böhnlein, Lisa Schüngel, Alice Willison, Karin Loser, Bernhard Nieswandt, Beate E Kehrel, Alexander Zarbock, Kerstin Göbel, Sven G Meuth. Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189915. [PMID: 34576080]
  • Pankaj Bhatia, Nirmal Singh. Ameliorative effect of ozagrel, a thromboxane A2 synthase inhibitor, in hyperhomocysteinemia-induced experimental vascular cognitive impairment and dementia. Fundamental & clinical pharmacology. 2021 Aug; 35(4):650-666. doi: 10.1111/fcp.12610. [PMID: 33020931]
  • Michał Majewski, Adam Jurgoński. The Effect of Hemp (Cannabis sativa L.) Seeds and Hemp Seed Oil on Vascular Dysfunction in Obese Male Zucker Rats. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082575. [PMID: 34444734]
  • Jie V Zhao, Wai-Fung Yeung, Yap-Hang Chan, Dana Vackova, June Y Y Leung, Dennis K M Ip, Jiaxi Zhao, Wai-Kwan Ho, Hung-Fat Tse, Catherine Mary Schooling. Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082550. [PMID: 34444711]
  • Bingsheng Li, Ru Huang, Ruixiao Wang, Yuhan Liu, Christian G Stief, Martin Hennenberg. Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries. Pharmacology research & perspectives. 2021 05; 9(3):e00771. doi: 10.1002/prp2.771. [PMID: 33929093]
  • Patrizia Amadio, Benedetta Porro, Viviana Cavalca, Silvia Stella Barbieri, Sonia Eligini, Susanna Fiorelli, Alessandro Di Minno, Alessandra Gorini, Mattia Giuliani, Josè Pablo Werba, Nicola Cosentino, Paolo Olivares, Simone Barbieri, Fabrizio Veglia, Elena Tremoli, Daniela Trabattoni. Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Apr; 136(?):111259. doi: 10.1016/j.biopha.2021.111259. [PMID: 33450492]
  • Xiaolong Wu, Minghui Wei, Haifeng Zhang, Xiaomei Fan, Xiaochen Ma, Jiaming Liu, Mingming Xue. The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats. BioMed research international. 2021; 2021(?):2043415. doi: 10.1155/2021/2043415. [PMID: 33969115]
  • Miltan Chandra Roy, Kiwoong Nam, Jaesu Kim, David Stanley, Yonggyun Kim. Thromboxane Mobilizes Insect Blood Cells to Infection Foci. Frontiers in immunology. 2021; 12(?):791319. doi: 10.3389/fimmu.2021.791319. [PMID: 34987515]
  • Sara Alberti, Qianqian Zhang, Ilaria D'Agostino, Annalisa Bruno, Stefania Tacconelli, Annalisa Contursi, Simone Guarnieri, Melania Dovizio, Lorenza Falcone, Patrizia Ballerini, Götz Münch, Ying Yu, Paola Patrignani. The antiplatelet agent revacept prevents the increase of systemic thromboxane A2 biosynthesis and neointima hyperplasia. Scientific reports. 2020 12; 10(1):21420. doi: 10.1038/s41598-020-77934-x. [PMID: 33293599]
  • Gulsev Ozen, Khadija Aljesri, Zeynep Celik, Gulsum Turkyılmaz, Saygın Turkyılmaz, Onder Teskin, Xavier Norel, Gokce Topal. Mechanism of thromboxane receptor-induced vasoconstriction in human saphenous vein. Prostaglandins & other lipid mediators. 2020 12; 151(?):106476. doi: 10.1016/j.prostaglandins.2020.106476. [PMID: 32721526]
  • Tao-Fang Cheng, Jing Zhao, Qiu-Lin Wu, Hua-Wu Zeng, Yu-Ting Sun, Yu-Hao Zhang, Rui Mi, Xiao-Po Qi, Jing-Tao Zou, Ai-Jun Liu, Hui-Zi Jin, Wei-Dong Zhang. Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153330. doi: 10.1016/j.phymed.2020.153330. [PMID: 32932202]
  • Tatjana Majkić, Kristina Bekvalac, Ivana Beara. Plantain (Plantago L.) species as modulators of prostaglandin E2 and thromboxane A2 production in inflammation. Journal of ethnopharmacology. 2020 Nov; 262(?):113140. doi: 10.1016/j.jep.2020.113140. [PMID: 32736048]
  • Ajay Gupta, Kate Chander Chiang. Prostaglandin D2 as a mediator of lymphopenia and a therapeutic target in COVID-19 disease. Medical hypotheses. 2020 Oct; 143(?):110122. doi: 10.1016/j.mehy.2020.110122. [PMID: 32759007]
  • Juyu Cai, Bin Liu, Tingting Guo, Yingzhan Zhang, Xiangzhong Wu, Jing Leng, Ningxia Zhu, Jinwei Guo, Yingbi Zhou. Effects of thromboxane prostanoid receptor deficiency on diabetic nephropathy induced by high fat diet and streptozotocin in mice. European journal of pharmacology. 2020 Sep; 882(?):173254. doi: 10.1016/j.ejphar.2020.173254. [PMID: 32553735]
  • P Conti, Al Caraffa, C E Gallenga, R Ross, S K Kritas, I Frydas, A Younes, P Di Emidio, G Ronconi, E Toniato. IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra). Journal of biological regulators and homeostatic agents. 2020 Sep; 34(5):1623-1627. doi: 10.23812/20-34-4edit-65. [PMID: 32744052]
  • Yu-Lien Tsai, Chih-Wei Liu, Chien-Fu Hsu, Chia-Chang Huang, Ming-Wei Lin, Shiang-Fen Huang, Tzu-Hao Li, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Tzung-Yan Lee, Hsuan-Miao Liu, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin. Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by down-regulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway. Clinical science (London, England : 1979). 2020 08; 134(15):2055-2073. doi: 10.1042/cs20200452. [PMID: 32725149]
  • Jiang Zhang, Andreas Wieser, Hao Lin, Yuhui Fan, Hanwei Li, Tobias S Schiergens, Julia Mayerle, Alexander L Gerbes, Christian J Steib. Pretreatment with zinc protects Kupffer cells following administration of microbial products. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jul; 127(?):110208. doi: 10.1016/j.biopha.2020.110208. [PMID: 32417689]
  • Diva M Villalpando, Juan Gómez Rivas, Daniel Flynn, Fermín R de Bethencourt, Mercedes Ferrer. Gonadal function protects against organ culture-induced vascular damage. Involvement of prostanoids. Prostaglandins & other lipid mediators. 2020 06; 148(?):106406. doi: 10.1016/j.prostaglandins.2019.106406. [PMID: 31945460]
  • Meadhbh McCall, Aaron Peace, Anthony F Tedesco, David Foley, Ronán M Conroy, Dermot Cox. Weight as an assay-independent predictor of poor response to enteric aspirin in cardiovascular patients. Platelets. 2020 May; 31(4):530-535. doi: 10.1080/09537104.2019.1667495. [PMID: 31530207]
  • Masahiko Tachi, Naoko Yamaguchi, Shoshiro Okada. Thromboxane A2 in the paraventricular hypothalamic nucleus mediates glucoprivation-induced adrenomedullary outflow. European journal of pharmacology. 2020 May; 875(?):173034. doi: 10.1016/j.ejphar.2020.173034. [PMID: 32097659]
  • Marta Aleksandrowicz, Katarzyna Klapczynska, Ewa Kozniewska. Dysfunction of the endothelium and constriction of the isolated rat's middle cerebral artery in low sodium environment in the presence of vasopressin. Clinical and experimental pharmacology & physiology. 2020 05; 47(5):759-764. doi: 10.1111/1440-1681.13242. [PMID: 31876005]
  • Xiao Tang, David Fuchs, Shuai Tan, Mette Trauelsen, Thue W Schwartz, Craig E Wheelock, Nailin Li, Jesper Z Haeggström. Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4. Journal of thrombosis and haemostasis : JTH. 2020 04; 18(4):976-984. doi: 10.1111/jth.14734. [PMID: 31930602]
  • S Rangarajan, G Rezonzew, P Chumley, H Fatima, M Y Golovko, W Feng, P Hua, E A Jaimes. COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease. American journal of physiology. Renal physiology. 2020 02; 318(2):F475-F485. doi: 10.1152/ajprenal.00407.2019. [PMID: 31841390]
  • Chengcheng Yang, Yan Zhao, Daoyuan Ren, Xingbin Yang. Protective Effect of Saponins-Enriched Fraction of Gynostemma pentaphyllum against High Choline-Induced Vascular Endothelial Dysfunction and Hepatic Damage in Mice. Biological & pharmaceutical bulletin. 2020; 43(3):463-473. doi: 10.1248/bpb.b19-00805. [PMID: 32115504]
  • Mei-Chi Chang, Bei-En Chang, Yu-Hwa Pan, Bor-Ru Lin, Yun-Chia Lian, Ming-Shu Lee, Sin-Yuet Yeung, Li-Deh Lin, Jiiang-Huei Jeng. Antiplatelet, antioxidative, and anti-inflammatory effects of hydroquinone. Journal of cellular physiology. 2019 08; 234(10):18123-18130. doi: 10.1002/jcp.28444. [PMID: 30843219]
  • Tatjana M Majkić, Ljilja D Torović, Marija M Lesjak, Dragana D Četojević-Simin, Ivana N Beara. Activity profiling of Serbian and some other European Merlot wines in inflammation and oxidation processes. Food research international (Ottawa, Ont.). 2019 07; 121(?):151-160. doi: 10.1016/j.foodres.2019.03.033. [PMID: 31108736]
  • Dongshuai Shen, Ning Ma, Yajun Yang, Xiwang Liu, Zhe Qin, Shihong Li, Zenghua Jiao, Xiaojun Kong, Jianyong Li. UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats. Molecules (Basel, Switzerland). 2019 Jun; 24(13):. doi: 10.3390/molecules24132380. [PMID: 31252591]
  • Giovanna Petrucci, Francesco Zaccardi, Alberto Giaretta, Viviana Cavalca, Esmeralda Capristo, Carmine Cardillo, Dario Pitocco, Benedetta Porro, Francesca Schinzari, Gianna Toffolo, Elena Tremoli, Bianca Rocca. Obesity is associated with impaired responsiveness to once-daily low-dose aspirin and in vivo platelet activation. Journal of thrombosis and haemostasis : JTH. 2019 06; 17(6):885-895. doi: 10.1111/jth.14445. [PMID: 30933424]
  • Debashree Das, Suryanarayan Biswal, Kalpana Kumari Barhwal, Pushpender Bhardwaj, Ashish Kumar, Sunil Kumar Hota, Om Prakash Chaurasia, Bhuvnesh Kumar. Methanolic root extract of Codonopsis clematidea prevents hypoxia induced procoagulant state by inhibition of GPIb receptor regulated Lyn kinase activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152903. doi: 10.1016/j.phymed.2019.152903. [PMID: 30981188]
  • Yukihito Nakano, Yoshihisa Nakatani, Masahiro Takami, Yoshihiro Taniyama, Shuji Arima. Diverse associations between oxidative stress and thromboxane A2 in hypertensive glomerular injury. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 04; 42(4):450-458. doi: 10.1038/s41440-018-0162-x. [PMID: 30542084]
  • Sikai Li, Tsugunobu Andoh, Qun Zhang, Daisuke Uta, Yasushi Kuraishi. β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4 and thromboxane A2) are involved in chronic renal failure-associated itch-associated responses in mice. European journal of pharmacology. 2019 Mar; 847(?):19-25. doi: 10.1016/j.ejphar.2019.01.017. [PMID: 30659825]
  • Johanna Ebmeyer, Jessica Behrend, Mario Lorenz, Georgia Günther, Raymond Reif, Jan G Hengstler, Albert Braeuning, Alfonso Lampen, Stefanie Hessel-Pras. Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. Chemico-biological interactions. 2019 Jan; 298(?):104-111. doi: 10.1016/j.cbi.2018.11.007. [PMID: 30465738]
  • Helga Helgadóttir, Ísleifur Ólafsson, Karl Andersen, Sveinbjörn Gizurarson. Stability of thromboxane in blood samples. Vascular health and risk management. 2019; 15(?):143-147. doi: 10.2147/vhrm.s204925. [PMID: 31239692]
  • Li Li, Hongwei Chen, Aling Shen, Qiongyu Li, Youqin Chen, Jianfeng Chu, Liya Liu, Jun Peng, Keji Chen. Ligustrazine inhibits platelet activation via suppression of the Akt pathway. International journal of molecular medicine. 2019 Jan; 43(1):575-582. doi: 10.3892/ijmm.2018.3970. [PMID: 30387814]
  • A Kij, K Kus, M Smeda, A Zakrzewska, B Proniewski, K Matyjaszczyk, A Jasztal, M Stojak, M Walczak, S Chlopicki. Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2018 Dec; 69(6):. doi: 10.26402/jpp.2018.6.05. [PMID: 30802213]
  • Daniele Pastori, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Marta Novo, Vittoria Cammisotto, Silvia Piconese, Maria Santulli, Fortunata Vasaturo, Francesco Violi, Pasquale Pignatelli. Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study. Journal of the American Heart Association. 2018 11; 7(22):e009509. doi: 10.1161/jaha.118.009509. [PMID: 30571484]
  • Yun-Yi Yan, Lu-Yao Ao, Lin Zhou, Cheng-Yuan Li, Wei-Rong Fang, Wei-Yang Shen, Bing-Wen Liang, Xiong Zhu, Yun-Man Li. Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):805-812. doi: 10.1016/j.biopha.2018.07.023. [PMID: 29990874]
  • Marta Zarà, Ilaria Canobbio, Caterina Visconte, Jessica Canino, Mauro Torti, Gianni Francesco Guidetti. Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells. Cellular signalling. 2018 Aug; 48(?):45-53. doi: 10.1016/j.cellsig.2018.04.008. [PMID: 29705335]
  • Aleksander Falkowski, Iwona Gorący, Mariusz Kaczmarczyk, Marcin Szemitko, Hubert Bogacki, Julia Kostka. Lipid derivatives of arachidonic acid used as markers of atherosclerotic plaque instability: a pilot study. International angiology : a journal of the International Union of Angiology. 2018 Aug; 37(4):286-292. doi: 10.23736/s0392-9590.18.03862-2. [PMID: 29509372]
  • Huanjun Xu, Hong Lu, Xiaocui Zhu, Wei Wang, Zhoumiao Zhang, Huizheng Fu, Shuangcheng Ma, Yuehua Luo, Jianjiang Fu. Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro. International journal of molecular medicine. 2018 Jul; 42(1):615-624. doi: 10.3892/ijmm.2018.3634. [PMID: 29693158]
  • Zeming Zhang, Zheng Li, Lu Chen, Yancun Wang. The effects of inhaled NO on plasma vasoactive factor and CTnI level in rabbits with acute massive pulmonary embolism1. Acta cirurgica brasileira. 2018 Jul; 33(7):577-587. doi: 10.1590/s0102-865020180070000003. [PMID: 30110059]
  • Karolina Serhan, Allison Gartung, Dipak Panigrahy. Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer. Prostaglandins & other lipid mediators. 2018 07; 137(?):40-45. doi: 10.1016/j.prostaglandins.2018.06.001. [PMID: 29933028]
  • Longfei Wang, Yong Li, Shenglan Lin, Zhiqiang Pu, Haiping Li, Zhili Tang. Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats. Brazilian journal of cardiovascular surgery. 2018 Jul; 33(4):384-390. doi: 10.21470/1678-9741-2018-0059. [PMID: 30184036]
  • Dermot Cox, Desmond J Fitzgerald. Lack of Bioequivalence Among Low-dose, Enteric-coated Aspirin Preparations. Clinical pharmacology and therapeutics. 2018 06; 103(6):1047-1051. doi: 10.1002/cpt.874. [PMID: 28905988]
  • Eneida S Oliveira, Stella G Colombarolli, Camila S Nascimento, Izabella C A Batista, Jorge G G Ferreira, Daniele L R Alvarenga, Laís O B de Sousa, Rafael R Assis, Marcele N Rocha, Érica A R Alves, Carlos E Calzavara-Silva. Increased Levels of Txa₂ Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue. Viruses. 2018 02; 10(3):. doi: 10.3390/v10030104. [PMID: 29495587]
  • Harvey G Roweth, Ruoling Yan, Nader H Bedwani, Alisha Chauhan, Nicole Fowler, Alice H Watson, Jean-Daniel Malcor, Stewart O Sage, Gavin E Jarvis. Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport. Scientific reports. 2018 02; 8(1):3494. doi: 10.1038/s41598-018-21348-3. [PMID: 29472624]
  • Nina S McCarthy, Ciara Vangjeli, Praveen Surendran, Achim Treumann, Cathy Rooney, Emily Ho, Peter Sever, Simon Thom, Alun D Hughes, Patricia B Munroe, Philip Howard, Toby Johnson, Mark Caulfield, Denis C Shields, Eoin O'Brien, Desmond J Fitzgerald, Alice V Stanton. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis. 2018 02; 269(?):42-49. doi: 10.1016/j.atherosclerosis.2017.12.013. [PMID: 29258006]
  • H Chen. Role of thromboxane A2 signaling in endothelium-dependent contractions of arteries. Prostaglandins & other lipid mediators. 2018 01; 134(?):32-37. doi: 10.1016/j.prostaglandins.2017.11.004. [PMID: 29180071]
  • Salim M A Bastaki, Ireneusz T Padol, Naheed Amir, Richard H Hunt. Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels in the anaesthetized rats in vivo. Molecular and cellular biochemistry. 2018 Jan; 438(1-2):25-34. doi: 10.1007/s11010-017-3110-1. [PMID: 28766164]
  • Jianjun Ren, Changfa Li, Yan Liu, Haitao Liu, Zhenming Dong. Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. Acta cirurgica brasileira. 2018 Jan; 33(1):22-30. doi: 10.1590/s0102-865020180010000003. [PMID: 29412230]
  • Jianjiang Fu, Xiaocui Zhu, Wei Wang, Hong Lu, Zhoumiao Zhang, Ting Liu, Huanjun Xu, Huizheng Fu, Shuangcheng Ma, Yuehua Luo. 1, 6-di-O-caffeoyl-β-D-glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Dec; 36(?):273-282. doi: 10.1016/j.phymed.2017.10.012. [PMID: 29157825]
  • Nikolaos Kakouros, Tyler J Gluckman, John V Conte, Thomas S Kickler, Katherine Laws, Bruce A Barton, Jeffrey J Rade. Differential Impact of Serial Measurement of Nonplatelet Thromboxane Generation on Long-Term Outcome After Cardiac Surgery. Journal of the American Heart Association. 2017 Nov; 6(11):. doi: 10.1161/jaha.117.007486. [PMID: 29097390]
  • Michal Bijak, Joanna Saluk-Bijak. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC complementary and alternative medicine. 2017 Aug; 17(1):396. doi: 10.1186/s12906-017-1897-7. [PMID: 28797264]
  • Sudharsana Sundarrajan, Mohanapriya Arumugam. A systems pharmacology perspective to decipher the mechanism of action of Parangichakkai chooranam, a Siddha formulation for the treatment of psoriasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Apr; 88(?):74-86. doi: 10.1016/j.biopha.2016.12.135. [PMID: 28095356]
  • Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. PloS one. 2017; 12(9):e0184345. doi: 10.1371/journal.pone.0184345. [PMID: 28880908]
  • Ivana Hegeduš, Jakov Milić, Anita Ćosić, Krunoslav Buljan, Ines Drenjančević. Cerebrovascular reactivity in acute hyperoxia in patients with acute ischaemic stroke. Brain injury. 2017; 31(4):560-566. doi: 10.1080/02699052.2017.1280853. [PMID: 28287282]
  • Xingyang Yi, Jing Lin, Hua Luo, Chun Wang, Yingying Liu. Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. PloS one. 2017; 12(7):e0180704. doi: 10.1371/journal.pone.0180704. [PMID: 28704403]
  • Guimei Ran, Yixuan Wang, Haochen Liu, Chunxiang Wei, Tao Zhu, Haidong Wang, Hua He, Xiaoquan Liu. A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk. Disease markers. 2017; 2017(?):9506527. doi: 10.1155/2017/9506527. [PMID: 28630527]
  • Hyuk-Woo Kwon, Jung-Hae Shin, Deok Hwi Lim, Woo Jeong Ok, Gi Suk Nam, Min Ji Kim, Ho-Kyun Kwon, Jun-Hee Noh, Je-Young Lee, Hyun-Hong Kim, Jong-Lae Kim, Hwa-Jin Park. Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro. BMC complementary and alternative medicine. 2016 Dec; 16(1):508. doi: 10.1186/s12906-016-1463-8. [PMID: 27927214]
  • Mariangela Scavone, Eti Alessandra Femia, Vera Caroppo, Marco Cattaneo. Inhibition of the platelet P2Y12 receptor for adenosine diphosphate does not impair the capacity of platelet to synthesize thromboxane A2. European heart journal. 2016 Nov; 37(44):3347-3356. doi: 10.1093/eurheartj/ehv551. [PMID: 26516174]
  • Amira Mira, Wael Alkhiary, Qinchang Zhu, Toshinori Nakagawa, Hai-Bang Tran, Yhiya M Amen, Kuniyoshi Shimizu. Improved Biological Activities of Isoepoxypteryxin by Biotransformation. Chemistry & biodiversity. 2016 Oct; 13(10):1307-1315. doi: 10.1002/cbdv.201600049. [PMID: 27449560]
  • Agnieszka Kij, Lukasz Mateuszuk, Barbara Sitek, Kamil Przyborowski, Agnieszka Zakrzewska, Krystyna Wandzel, Maria Walczak, Stefan Chlopicki. Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):148-154. doi: 10.1016/j.jpba.2016.06.050. [PMID: 27424195]
  • Francesco Fracassi, Giampaolo Niccoli, Giancarla Scalone, Giuseppe Di Gioia, Micaela Conte, Jozef Bartunek, Gregory A Sgueglia, Bernard De Bruyne, Rocco A Montone, William Wijns, Filippo Crea, Emanuele Barbato. Prognostic role of multiple biomarkers in stable patients undergoing fractional flow reserve-guided coronary angioplasty. Journal of cardiovascular medicine (Hagerstown, Md.). 2016 Sep; 17(9):687-93. doi: 10.2459/jcm.0000000000000342. [PMID: 26627500]
  • Callum N Watson, Steven W Kerrigan, Dermot Cox, Ian R Henderson, Steve P Watson, Mònica Arman. Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets. 2016 Sep; 27(6):535-40. doi: 10.3109/09537104.2016.1148129. [PMID: 27025455]
  • Hideki Amano, Masaki Nakamura, Yoshiya Ito, Hiroki Kakutani, Koji Eshima, Hidero Kitasato, Shuh Narumiya, Masataka Majima. Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia. The Journal of surgical research. 2016 07; 204(1):153-63. doi: 10.1016/j.jss.2016.04.011. [PMID: 27451882]
  • Ning Ma, Xi-Wang Liu, Ya-Jun Yang, Dong-Shuai Shen, Xiao-Le Zhao, Isam Mohamed, Xiao-Jun Kong, Jian-Yong Li. Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF1α and blood biochemistry in rat model. BMC veterinary research. 2016 Jun; 12(1):108. doi: 10.1186/s12917-016-0738-0. [PMID: 27296110]
  • T Lhermusier, S Severin, J Van Rothem, C Garcia, J Bertrand-Michel, P Le Faouder, B Hechler, C Broccardo, P Couvert, G Chimini, P Sié, B Payrastre. ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1. Journal of thrombosis and haemostasis : JTH. 2016 Mar; 14(3):585-95. doi: 10.1111/jth.13247. [PMID: 26749169]
  • Francesco Zaccardi, Alessandro Rizzi, Giovanna Petrucci, Flavia Ciaffardini, Luigi Tanese, Francesca Pagliaccia, Viviana Cavalca, Angela Ciminello, Aida Habib, Isabella Squellerio, Paola Rizzo, Elena Tremoli, Bianca Rocca, Dario Pitocco, Carlo Patrono. In Vivo Platelet Activation and Aspirin Responsiveness in Type 1 Diabetes. Diabetes. 2016 Feb; 65(2):503-9. doi: 10.2337/db15-0936. [PMID: 26470782]
  • Ana Cavka, Anita Cosic, Ivana Jukic, Bojan Jelakovic, Julian H Lombard, Shane A Phillips, Vatroslav Seric, Ivan Mihaljevic, Ines Drenjancevic. The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans. The Journal of physiology. 2015 Dec; 593(24):5313-24. doi: 10.1113/jp271631. [PMID: 26498129]
  • Pasquale Pignatelli, Daniele Pastori, Alessio Farcomeni, Cristina Nocella, Simona Bartimoccia, Tommasa Vicario, Tommaso Bucci, Roberto Carnevale, Francesco Violi. Mediterranean diet reduces thromboxane A2 production in atrial fibrillation patients. Clinical nutrition (Edinburgh, Scotland). 2015 Oct; 34(5):899-903. doi: 10.1016/j.clnu.2014.09.011. [PMID: 25288566]
  • Xuan Dang, Jing-Jing Miao, An-Qi Chen, Peng Li, Lin Chen, Jin-Ru Liang, Ren-Ming Xie, Ye Zhao. The antithrombotic effect of RSNK in blood-stasis model rats. Journal of ethnopharmacology. 2015 Sep; 173(?):266-72. doi: 10.1016/j.jep.2015.06.030. [PMID: 26216512]
  • Hideki Amano, Yoshiya Ito, Koji Eshima, Shintaro Kato, Fumihiro Ogawa, Kanako Hosono, Kazuhito Oba, Hideaki Tamaki, Hiroyuki Sakagami, Masabumi Shibuya, Shuh Narumiya, Masataka Majima. Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions. Cardiovascular research. 2015 Sep; 107(4):509-21. doi: 10.1093/cvr/cvv139. [PMID: 25935870]
  • Elodie Gautier-Veyret, Laetitia Van Noolen, Patrick Lévy, Jean Louis Pepin, Françoise Stanke-Labesque. Could the thromboxane A2 pathway be a therapeutic target for the treatment of obstructive sleep apnea-induced atherosclerosis?. Prostaglandins & other lipid mediators. 2015 Sep; 121(Pt A):97-104. doi: 10.1016/j.prostaglandins.2015.05.005. [PMID: 26026712]
  • Katharina Mederle, Manuel Meurer, Hayo Castrop, Klaus Höcherl. Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice. American journal of physiology. Renal physiology. 2015 Aug; 309(4):F332-40. doi: 10.1152/ajprenal.00567.2014. [PMID: 26017977]
  • Xiao-ying Zheng, Jing Yao, Jia-mei Zhu, Mei Li, Shu-qiong Qiu, Zhao-xia Zhu, Ming Zhang. [Effect of Magnesium Sulfate, Nifedipine Tablet Combined Salvia Injection on ET-1/NO, TXA2/PGI2 and Hemorheology of Preeclampsia Patients]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2015 Aug; 35(8):962-5. doi: . [PMID: 26485911]
  • Tao Liu, Denise Garofalo, Chunli Feng, Juying Lai, Howard Katz, Tanya M Laidlaw, Joshua A Boyce. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. Journal of immunology (Baltimore, Md. : 1950). 2015 Jun; 194(11):5061-8. doi: 10.4049/jimmunol.1402959. [PMID: 25904552]
  • Yun Wang, Shao-Hua Cao, Ying-Jie Cui, Le-Kai Kong, Hua Tian, Hong-Xin Cai, Ya-Ping Wu, Ji-Ju Han, Xiao-Min Zhao, Zuo-Li Xia. Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats. The Tohoku journal of experimental medicine. 2015 06; 236(2):155-62. doi: 10.1620/tjem.236.155. [PMID: 26074502]
  • Tanya M Laidlaw, Joshua A Boyce. Platelets in patients with aspirin-exacerbated respiratory disease. The Journal of allergy and clinical immunology. 2015 Jun; 135(6):1407-14; quiz 1415. doi: 10.1016/j.jaci.2015.02.005. [PMID: 26051947]
  • Leman G Erkan, Burcin Altinbas, Gokcen Guvenc, Selim Alcay, Mehmed Berk Toker, Burcu Ustuner, Duygu Udum Kucuksen, Murat Yalcin. Brain thromboxane A2 via arachidonic acid cascade induces the hypothalamic-pituitary-gonadal axis activation in rats. Autonomic neuroscience : basic & clinical. 2015 May; 189(?):50-5. doi: 10.1016/j.autneu.2015.02.005. [PMID: 25784152]
  • Hitoshi Kashiwagi, Koh-Ichi Yuhki, Fumiaki Kojima, Shima Kumei, Osamu Takahata, Yoshiki Sakai, Shuh Narumiya, Fumitaka Ushikubi. The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice. The Journal of pharmacology and experimental therapeutics. 2015 May; 353(2):269-78. doi: 10.1124/jpet.115.222612. [PMID: 25740898]
  • Valérie Capra, G Enrico Rovati, Paolo Mangano, Carola Buccellati, Robert C Murphy, Angelo Sala. Transcellular biosynthesis of eicosanoid lipid mediators. Biochimica et biophysica acta. 2015 Apr; 1851(4):377-82. doi: 10.1016/j.bbalip.2014.09.002. [PMID: 25218301]
  • Francesca Santilli, Domenico Lapenna, Sara La Barba, Giovanni Davì. Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus. Free radical biology & medicine. 2015 Mar; 80(?):101-10. doi: 10.1016/j.freeradbiomed.2014.12.010. [PMID: 25530150]
  • Dong-Ha Lee, Hyuk-Woo Kwon, Hyun-Hong Kim, Deok Hwi Lim, Gi Suk Nam, Jung-Hae Shin, Yun-Yi Kim, Jong-Lae Kim, Jong-Jin Lee, Ho-Kyun Kwon, Hwa-Jin Park. Cordycepin-enriched WIB801C from Cordyceps militaris inhibits ADP-induced [Ca(2+)] i mobilization and fibrinogen binding via phosphorylation of IP 3R and VASP. Archives of pharmacal research. 2015 Jan; 38(1):81-97. doi: 10.1007/s12272-014-0436-z. [PMID: 25001901]
  • Mao-Jie Wang, Yu Huang, Run-Yue Huang, Xiu-Min Chen, Ying-Yan Zhou, Wan-Lin Yu, Yong-Liang Chu, Qing-Chun Huang. Determination of role of thromboxane A2 in rheumatoid arthritis. Discovery medicine. 2015 Jan; 19(102):23-32. doi: . [PMID: 25636958]
  • E M Faioni, C Razzari, A Zulueta, E A Femia, L Fenu, M Trinchera, G M Podda, M Pugliano, F Marongiu, M Cattaneo. Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency. Thrombosis and haemostasis. 2014 Dec; 112(6):1182-9. doi: 10.1160/th14-04-0352. [PMID: 25102815]
  • Viginie Voisin, Anne-Emilie Declèves, Virginie Hubert, Vanessa Colombaro, Laetitia Giordano, Isabelle Habsch, Nadine Bouby, Denis Nonclercq, Nathalie Caron. Protection of Wistar-Furth rats against postischaemic acute renal injury: role for nitric oxide and thromboxane?. Clinical and experimental pharmacology & physiology. 2014 Nov; 41(11):911-20. doi: 10.1111/1440-1681.12298. [PMID: 25115485]
  • Chiang-Ting Chien, Shih-Chen Fan, Shao-Chieh Lin, Chang-Chih Kuo, Chih-Hui Yang, Tzu-Ying Yu, Shih-Pin Lee, Dai-Yu Cheng, Ping-Chia Li. Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis-induced arteriovenous fistula failure in chronic kidney disease. Thrombosis and haemostasis. 2014 Nov; 112(5):1051-64. doi: 10.1160/th14-03-0258. [PMID: 25030617]