MG(O-18:0/0:0/0:0) (BioDeep_00000019325)

Main id: BioDeep_00000230841

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S)-3-(octadecyloxy)propane-1,2-diol

化学式: C21H44O3 (344.329)
中文名称: 甘油单酯, 鲨肝醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCOCC(CO)O
InChI: InChI=1S/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3

描述信息

MG(O-18:0/0:0/0:0) belongs to the family of monoradyglycerols, which are glycerolipids lipids containing a common glycerol backbone to which at one fatty acyl group is attached. Their general formula is [R1]OCC(CO[R2])O[R3]. MG(O-18:0/0:0/0:0) is made up of one octadecyl(R1).
1-Octadecyl-sn-glycerol is an intermediate in ether lipid metabolism. Ether lipids are lipids in which one or more of the carbon atoms on glycerol is bonded to an alkyl chain via an ether linkage, as opposed to the usual ester linkage. [HMDB]
C26170 - Protective Agent > C797 - Radioprotective Agent
3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite.

同义名列表

22 个代谢物同义名

(2S)-3-(octadecyloxy)propane-1,2-diol; (S)-3-(Octadecyloxy)-1,2-propanediol; (2S)-3-Octadecoxypropane-1,2-diol; 3-octadecoxypropane-1,2-diol; 1-O-octadecyl-sn-glycerol; (S)-1-O-Octadecylglycerol; Glycerol octadecyl ether; 1-Octadecyl-sn-glycerol; (S)-Octadecylglycerol; 1-O-octadecylglycerol; 1-Octadecylglycerol; MAG(O-18:0/0:0/0:0); MG(O-18:0/0:0/0:0); MG(18:0E/0:0/0:0); (S)-Batyl alcohol; LysoMG(O-18:0); Batyl alcohol; LysoMG(18:0E); MG(O-18:0); MG O-18:0; Batilol; 1-O-Octadecyl-sn-glycerol



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, APOE, AXIN2, GPX1, PEX7, PLA2G12A, RAC1
Peripheral membrane protein 1 GNPAT
Endoplasmic reticulum membrane 3 CD4, MFSD2A, RAC1
Mitochondrion membrane 1 ABCG2
Nucleus 3 APOE, AXIN2, RAC1
cytosol 6 AXIN2, GNPAT, GPX1, LEP, PEX7, RAC1
dendrite 2 APOE, RAC1
mitochondrial membrane 2 ABCG2, GNPAT
trans-Golgi network 1 RAC1
centrosome 1 AXIN2
nucleoplasm 1 ABCG2
Cell membrane 7 ABCB1, ABCG2, CD4, CD86, MFSD2A, RAC1, TNF
Lipid-anchor 1 RAC1
Cytoplasmic side 1 RAC1
lamellipodium 1 RAC1
ruffle membrane 1 RAC1
Multi-pass membrane protein 3 ABCB1, ABCG2, MFSD2A
Synapse 1 RAC1
cell cortex 1 RAC1
cell surface 5 ABCB1, ADIPOQ, CD86, EPO, TNF
glutamatergic synapse 2 APOE, RAC1
Golgi apparatus 1 APOE
Golgi membrane 1 INS
neuronal cell body 2 APOE, TNF
postsynapse 1 RAC1
Cytoplasm, cytosol 1 PEX7
plasma membrane 9 ABCB1, ABCG2, APOE, AXIN2, CD4, CD86, MFSD2A, RAC1, TNF
Membrane 7 ABCB1, ABCG2, APOE, CD86, GNPAT, MFSD2A, RAC1
apical plasma membrane 2 ABCB1, ABCG2
extracellular exosome 5 ABCB1, APOE, CD86, EPO, RAC1
endoplasmic reticulum 2 ADIPOQ, APOE
extracellular space 8 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, TNF
mitochondrion 1 GPX1
Single-pass type I membrane protein 2 CD4, CD86
Secreted 9 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, PLA2G12A, RAC1
extracellular region 10 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, PLA2G12A, RAC1, TNF
mitochondrial matrix 1 GPX1
centriolar satellite 1 CD86
external side of plasma membrane 3 CD4, CD86, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 RAC1
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 RAC1
Early endosome 2 APOE, CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ABCG2
Cell projection, lamellipodium 1 RAC1
Matrix side 1 GNPAT
Membrane raft 3 ABCG2, CD4, TNF
focal adhesion 1 RAC1
extracellular matrix 1 APOE
Peroxisome 2 GNPAT, PEX7
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 PEX7
peroxisomal matrix 2 GNPAT, PEX7
peroxisomal membrane 2 GNPAT, PEX7
collagen-containing extracellular matrix 2 ADIPOQ, APOE
phagocytic cup 1 TNF
cytoskeleton 1 RAC1
cytoplasmic ribonucleoprotein granule 1 RAC1
Secreted, extracellular space 1 APOE
brush border membrane 1 ABCG2
blood microparticle 1 APOE
Recycling endosome membrane 1 RAC1
Endomembrane system 1 GNPAT
endosome lumen 1 INS
Cell projection, dendrite 1 RAC1
Melanosome 2 APOE, RAC1
cell body 1 EPO
Peroxisome membrane 1 GNPAT
exocytic vesicle 1 IGF1
secretory granule lumen 2 EPO, INS
secretory granule membrane 1 RAC1
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 APOE, CD4, INS
platelet alpha granule lumen 1 IGF1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 APOE, CD4
synaptic cleft 1 APOE
ficolin-1-rich granule membrane 1 RAC1
external side of apical plasma membrane 2 ABCB1, ABCG2
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
NADPH oxidase complex 1 RAC1
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fabian Dorninger, Frédéric M Vaz, Hans R Waterham, Jan B van Klinken, Gerhard Zeitler, Sonja Forss-Petter, Johannes Berger, Christoph Wiesinger. Ether lipid transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters. Brain research bulletin. 2022 10; 189(?):69-79. doi: 10.1016/j.brainresbull.2022.08.006. [PMID: 35981629]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny Y Y Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 Mar; 1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. [PMID: 29217479]
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  • Nancy E Braverman, Ann B Moser. Functions of plasmalogen lipids in health and disease. Biochimica et biophysica acta. 2012 Sep; 1822(9):1442-52. doi: 10.1016/j.bbadis.2012.05.008. [PMID: 22627108]
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  • Pedro Brites, Ana Sofia Ferreira, Tiago Ferreira da Silva, Vera F Sousa, Ana R Malheiro, Marinus Duran, Hans R Waterham, Myriam Baes, Ronald J A Wanders. Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice. PloS one. 2011; 6(12):e28539. doi: 10.1371/journal.pone.0028539. [PMID: 22163031]
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