Biperiden (BioDeep_00000001909)

 

Secondary id: BioDeep_00000408908

human metabolite blood metabolite


代谢物信息卡片


1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol

化学式: C21H29NO (311.2249)
中文名称: 比哌立登, 联哌啶
谱图信息: 最多检出来源 Homo sapiens(blood) 37.61%

分子结构信息

SMILES: c1ccc(cc1)C(CCN1CCCCC1)(C1CC2C=CC1C2)O
InChI: InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2

描述信息

A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. [PubChem]
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
N - Nervous system > N04 - Anti-parkinson drugs > N04A - Anticholinergic agents > N04AA - Tertiary amines
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

同义名列表

23 个代谢物同义名

1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol; alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol; alpha-Bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol; a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol; Α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol; alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol; Biperiden, 1S-(1 alpha,2 alpha(r*),4 alpha)-isomer; Biperiden, 1R-(1 alpha,2 alpha(r*),4 alpha)-isomer; Α-5-norbornen-2-yl-α-phenyl-1-piperidinepropanol; a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol; Hydrochloride, biperiden; Biperiden hydrochloride; Biperidenum; Biperidene; Biperideno; Biperidine; biperiden; Beperiden; Akineton; KL 373; Biperiden; Biperiden



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, BDNF, BICC1, CYP2D6, CYP3A4, GUCY1A1, MALT1, NTRK2, REL, UBR4
Peripheral membrane protein 1 ACHE
Endosome membrane 1 NTRK2
Endoplasmic reticulum membrane 5 CYP1A2, CYP2D6, CYP3A4, DRD1, SLC27A5
Nucleus 6 ACHE, ALB, DRD1, MALT1, REL, UBR4
cytosol 7 ALB, GUCY1A1, HEATR5B, MALT1, NTRK2, REL, UBR4
dendrite 4 BDNF, DRD2, HTR1A, NTRK2
centrosome 2 ALB, UBR4
nucleoplasm 3 REL, SCNN1G, UBR4
Cell membrane 6 ACHE, DRD1, DRD2, HTR1A, NTRK2, SLC27A5
Cell projection, axon 1 NTRK2
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 5 DRD1, DRD2, HTR1A, SCNN1G, SLC27A5
Golgi apparatus membrane 1 DRD2
Synapse 4 ACHE, DRD2, HTR1A, TAC1
cell surface 1 ACHE
glutamatergic synapse 3 DRD1, DRD2, GUCY1A1
Golgi apparatus 2 ACHE, ALB
Golgi membrane 1 DRD2
neuromuscular junction 1 ACHE
neuronal cell body 1 TAC1
presynaptic membrane 2 DRD1, DRD2
synaptic vesicle 1 BDNF
acrosomal vesicle 1 DRD2
endosome 1 UBR4
plasma membrane 9 ACHE, BCHE, DRD1, DRD2, HTR1A, NTRK2, SCNN1G, SLC27A5, UBR4
synaptic vesicle membrane 1 DRD2
terminal bouton 1 NTRK2
Membrane 8 ACHE, BDNF, CYP2D6, CYP3A4, HEATR5B, MALT1, NTRK2, UBR4
apical plasma membrane 1 SCNN1G
axon 4 BDNF, DRD2, NTRK2, TAC1
extracellular exosome 2 ALB, SCNN1G
endoplasmic reticulum 3 ALB, CYP2D6, SLC27A5
extracellular space 5 ACHE, ALB, BCHE, BDNF, TAC1
perinuclear region of cytoplasm 5 ACHE, BDNF, HEATR5B, MALT1, NTRK2
mitochondrion 1 CYP2D6
protein-containing complex 3 ALB, MALT1, SLC27A5
intracellular membrane-bounded organelle 4 CYP1A2, CYP2D6, CYP3A4, HEATR5B
Microsome membrane 3 CYP1A2, CYP2D6, CYP3A4
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 1 NTRK2
Secreted 4 ACHE, ALB, BCHE, BDNF
extracellular region 5 ACHE, ALB, BCHE, BDNF, TAC1
Single-pass membrane protein 1 CYP2D6
Extracellular side 1 ACHE
anchoring junction 1 ALB
ciliary membrane 2 DRD1, DRD2
external side of plasma membrane 1 SCNN1G
dendritic spine 3 DRD1, DRD2, NTRK2
perikaryon 1 DRD2
Early endosome 1 NTRK2
postsynaptic membrane 2 DRD1, DRD2
Apical cell membrane 1 SCNN1G
Cytoplasm, perinuclear region 3 HEATR5B, MALT1, NTRK2
Cytoplasm, cytoskeleton 1 UBR4
GABA-ergic synapse 3 DRD1, DRD2, GUCY1A1
basement membrane 1 ACHE
Cell projection, dendritic spine 1 DRD1
lateral plasma membrane 1 DRD2
nuclear speck 1 HEATR5B
receptor complex 1 NTRK2
ciliary basal body 1 ALB
cilium 2 DRD1, DRD2
chromatin 1 REL
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, BCHE
non-motile cilium 2 DRD1, DRD2
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
fibrillar center 1 MALT1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 3 DRD1, HTR1A, NTRK2
specific granule membrane 1 UBR4
tertiary granule membrane 1 UBR4
side of membrane 1 ACHE
basal plasma membrane 1 SLC27A5
clathrin-coated vesicle 1 HEATR5B
Microsome 1 SLC27A5
endoplasmic reticulum lumen 3 ALB, BCHE, BDNF
platelet alpha granule lumen 1 ALB
axon terminus 2 DRD2, NTRK2
Cytoplasmic vesicle, clathrin-coated vesicle 1 HEATR5B
endocytic vesicle 2 DRD2, HEATR5B
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 UBR4
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
guanylate cyclase complex, soluble 1 GUCY1A1
CBM complex 1 MALT1
polkadots 1 MALT1
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 REL
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB


文献列表

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