Dexamethasone Acetate (BioDeep_00000001907)
代谢物信息卡片
Dexamethasone-17-acetate
化学式: C24H31FO6 (434.2105)
中文名称: 乙酸地塞米松
谱图信息:
最多检出来源 Viridiplantae(plant) 12.46%
分子结构信息
SMILES: CC(=O)OCC(=O)C1(O)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
InChI: InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3264
CONFIDENCE standard compound; INTERNAL_ID 2835
同义名列表
数据库引用编号
37 个数据库交叉引用编号
- ChEBI: CHEBI:4463
- KEGG: C08174
- KEGGdrug: D07796
- PubChem: 236702
- PubChem: 3680
- Metlin: METLIN44164
- DrugBank: DB14649
- ChEMBL: CHEMBL1530428
- CAS: 1177-87-3
- MoNA: EQ326459
- MoNA: EQ326458
- MoNA: EQ326457
- MoNA: EQ326456
- MoNA: EQ326455
- MoNA: EQ326454
- MoNA: EQ326453
- MoNA: EQ326452
- MoNA: EQ326451
- MoNA: EQ326409
- MoNA: EQ326408
- MoNA: EQ326407
- MoNA: EQ326406
- MoNA: EQ326405
- MoNA: EQ326404
- MoNA: EQ326403
- MoNA: EQ326402
- MoNA: EQ326401
- MoNA: AU283503
- MoNA: AU283505
- MoNA: AU283501
- MoNA: AU283506
- MoNA: AU283502
- MoNA: AU283504
- PMhub: MS000001425
- PubChem: 10374
- NIKKAJI: J21.193A
- KNApSAcK: 4463
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liang V Tang, Yu Hu. Hemophagocytic lymphohistiocytosis after COVID-19 vaccination.
Journal of hematology & oncology.
2021 06; 14(1):87. doi:
10.1186/s13045-021-01100-7. [PMID: 34088334] - Xianghong Luo, Hao Fu, Chaoqun Xu, Yang Dong, Zhihua Wu, Dongxiao Li, Ying Sun, Ming Shen, Liting Wang, Zhaojun Li, Yourong Duan. Efficient Treatment of Atherosclerosis by Dexamethasone Acetate and Rapamycin Co-Loaded mPEG-DSPE Calcium Phosphate Nanoparticles.
Journal of biomedical nanotechnology.
2020 Jun; 16(6):810-826. doi:
10.1166/jbn.2020.2936. [PMID: 33187578] - Sha Li, Ying-Chun Zeng, Ke Peng, Chang Liu, Zhi-Rong Zhang, Ling Zhang. Design and evaluation of glomerulus mesangium-targeted PEG-PLGA nanoparticles loaded with dexamethasone acetate.
Acta pharmacologica Sinica.
2019 Jan; 40(1):143-150. doi:
10.1038/s41401-018-0052-4. [PMID: 29950614] - Wanping Zhu, Xia Liu, Yuji Wang, Yeling Tong, Yongzhou Hu. Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation.
European journal of medicinal chemistry.
2018 Jan; 143(?):419-425. doi:
10.1016/j.ejmech.2017.07.068. [PMID: 29202404] - X Li, R H Müller, C M Keck, N A Bou-Chacra. Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept.
Die Pharmazie.
2016 Jun; 71(6):327-33. doi:
. [PMID: 27455551] - Fen Mei, Wei-dong Zeng, Tao Wan, Jie-wei Huang, Shuang-hui Luo, Chuan-bin Wu, Yue-hong Xu. [Dexamethasone acetate microemulsions: formulation and effect on skin permeability].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 06; 51(6):979-84. doi:
. [PMID: 29883076] - Nguyen-Thach Tung, Vu-Thu Huyen, Sang-Cheol Chi. Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug.
Archives of pharmacal research.
2015 Nov; 38(11):1999-2007. doi:
10.1007/s12272-015-0608-5. [PMID: 25940221] - Peter J Mark, Caitlin S Wyrwoll, Intan S Zulkafli, Trevor A Mori, Brendan J Waddell. Rescue of glucocorticoid-programmed adipocyte inflammation by omega-3 fatty acid supplementation in the rat.
Reproductive biology and endocrinology : RB&E.
2014 May; 12(?):39. doi:
10.1186/1477-7827-12-39. [PMID: 24886466] - Xuefan Xu, Chunyan Zhao, Hongyun Yang, Yanlin Jian, Zhirong Zhang, Yuan Huang. Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers.
Drug delivery.
2011 Sep; 18(7):485-92. doi:
10.3109/10717544.2011.589087. [PMID: 21692681] - Min-ting Wang, Yun Jin, Yun-xia Yang, Chun-yan Zhao, Hong-yun Yang, Xue-fan Xu, Xuan Qin, Zhao-dan Wang, Zhi-rong Zhang, Yan-lin Jian, Yuan Huang. In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system.
International journal of nanomedicine.
2010 Aug; 5(?):487-97. doi:
10.2147/ijn.s10393. [PMID: 20957171] - Gang Chen, Shi-xiang Hou, Ping Hu, Miao-zhen Jin, Jun Liu. [Preliminary study on brain-targeted drug delivery via inner ear].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Oct; 42(10):1102-6. doi:
. [PMID: 18229622] - Qing-yu Xiang, Min-ting Wang, Fu Chen, Tao Gong, Yan-lin Jian, Zhi-rong Zhang, Yuan Huang. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles.
Archives of pharmacal research.
2007 Apr; 30(4):519-25. doi:
10.1007/bf02980228. [PMID: 17489370] - J T Smith, B J Waddell. Increased fetal glucocorticoid exposure delays puberty onset in postnatal life.
Endocrinology.
2000 Jul; 141(7):2422-8. doi:
10.1210/endo.141.7.7541. [PMID: 10875242] - D M Gries, D R Moffitt, E Pulos, E R Carter. A single dose of intramuscularly administered dexamethasone acetate is as effective as oral prednisone to treat asthma exacerbations in young children.
The Journal of pediatrics.
2000 Mar; 136(3):298-303. doi:
10.1067/mpd.2000.103353. [PMID: 10700684] - Z Szondy, P Molnar, Z Nemes, M Boyiadzis, N Kedei, R Tóth, L Fésüs. Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways.
FEBS letters.
1997 Mar; 404(2-3):307-13. doi:
10.1016/s0014-5793(97)00140-3. [PMID: 9119085] - J F Maillefert, S Aho, C Piroth-Chatard, C Tavernier. Cortisol levels after single local steroid injection.
The American journal of medicine.
1996 May; 100(5):586-7. doi:
10.1016/s0002-9343(96)80111-2. [PMID: 8644775] - H Raff, M M Skelton, A W Cowley. Feedback control of vasopressin and corticotrophin secretion in conscious dogs: effect of hypertonic saline.
The Journal of endocrinology.
1989 Jul; 122(1):41-8. doi:
10.1677/joe.0.1220041. [PMID: 2549155] - T Ogiso, Y Ito, M Iwaki, H Atago, C Tanaka, N Maniwa, S Ishida. Percutaneous absorption of dexamethasone acetate and palmitate, and the plasma concentration.
Chemical & pharmaceutical bulletin.
1987 Oct; 35(10):4263-70. doi:
10.1248/cpb.35.4263. [PMID: 3435951] - J M Hughes, M Hichens, G W Booze, M O Thorner. Cushing's syndrome from the therapeutic use of intramuscular dexamethasone acetate.
Archives of internal medicine.
1986 Sep; 146(9):1848-9. doi:
. [PMID: 3753129] - H Nishigori, J W Lee, Y Iwamoto, R Hayashi, K Maruyama, M Iwatsuru. Alteration of hepatic lipidperoxide levels during cataract formation caused by glucocorticoids in developing chick embryos.
Life sciences.
1984 Aug; 35(9):981-5. doi:
10.1016/0024-3205(84)90664-7. [PMID: 6472060] - S Chilmonczyk. Rainbow trout lymphoid organs: cellular effects of corticosteroids and anti-thymocyte serum.
Developmental and comparative immunology.
1982; 6(2):271-80. doi:
10.1016/s0145-305x(82)80010-4. [PMID: 6980146] - M De Almeida, P Jouannet. Dexamethasone therapy of infertile men with sperm autoantibodies: immunological and sperm follow-up.
Clinical and experimental immunology.
1981 Jun; 44(3):567-75. doi:
NULL. [PMID: 7326866] - A L Sheffer, D T Fearon, K F Austen. Methyltestosterone therapy in hereditary angioedema.
Annals of internal medicine.
1977 Mar; 86(3):306-8. doi:
10.7326/0003-4819-86-3-306. [PMID: 320930]
