Acetazolamide (BioDeep_00000001880)
Secondary id: BioDeep_00000412944
human metabolite blood metabolite
代谢物信息卡片
N-[5-(Aminosulphonyl)-1,3,5-thiadiazol-2-yl]acetamide
化学式: C4H6N4O3S2 (221.9881326)
中文名称: 乙酰唑胺
谱图信息:
最多检出来源 Homo sapiens(blood) 9.09%
分子结构信息
SMILES: CC(=O)NC1=NN=C(S1)S(=O)(=O)N
InChI: InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
描述信息
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EC - Carbonic anhydrase inhibitors
D004791 - Enzyme Inhibitors > D002257 - Carbonic Anhydrase Inhibitors
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C471 - Enzyme Inhibitor > C29577 - Carbonic Anhydrase Inhibitor
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic
D045283 - Natriuretic Agents > D004232 - Diuretics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3011
同义名列表
72 个代谢物同义名
N-[5-(Aminosulphonyl)-1,3,5-thiadiazol-2-yl]acetamide; N-[5-(Aminosulphonyl)-1,3,4-thiadiazol-2-yl]acetamide; N-[5-(Aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide; N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide; 5-Acetylamino-1,3,4-thiadiazole-2-sulphonamide; N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide; 2-Acetylamino-1,3,4-thiadiazole-5-sulphonamide; 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide; 5-Acetylamino-1,3,4-thiadiazole-2-sulfonamide; 5-ACETAMIDO-1,3,4-thiadiazole-2-sulphonamide; Théraplix brand OF acetazolamide preparation; Whelehan brand OF acetazolamide preparation; 5-ACETAMIDO-1,3,4-thiadiazole-2-sulfonamide; Cyanamid brand OF acetazolamide preparation; Lederle brand OF acetazolamide preparation; Storz brand OF acetazolamide preparation; Wyeth brand OF acetazolamide preparation; Ciba vision brand OF acetazolamide; Carbonic anhydrase inhibitor 6063; Wassermann brand OF acetazolamide; Novopharm brand OF acetazolamide; Acetazolamide sodium, (sterile); Acetamidothiadiazolesulfonamide; Medphano brand OF acetazolamide; Dioptic brand OF acetazolamide; Acetazolamide, monosodium salt; Llorens brand OF acetazolamide; Acetazolamide wassermann brand; Acetazolamide novopharm brand; Apotex brand OF acetazolamide; Chiesi brand OF acetazolamide; Monosodium salt acetazolamide; Acetazolamide medphano brand; Jumer brand OF acetazolamide; Orion brand OF acetazolamide; Grin brand OF acetazolamide; Acetazolamide llorens brand; Acetazolamide dioptic brand; Acetazolamide apotex brand; ICN brand OF acetazolamide; Acetazolamide chiesi brand; Acetazolamide orion brand; Acetazolamide jumer brand; Acetazolamide grin brand; Acetazolamide icn brand; Apo-acetazolamide; Apo acetazolamide; ApoAcetazolamide; Acetazolamidum; Acetazoleamide; Huma-zolamide; Acetozalamide; Huma zolamide; Acetazolamine; Acetazolamida; acetazolamide; HumaZolamide; Acetazolamid; Acetadiazol; Acetazolam; Glauconox; Défiltran; Defiltran; Diuramide; Glaupax; Diacarb; Diluran; Edemox; Ak zol; Diamox; Ak-zol; AkZol
数据库引用编号
31 个数据库交叉引用编号
- ChEBI: CHEBI:27690
- KEGG: C06805
- KEGGdrug: D00218
- KEGGdrug: D88526
- PubChem: 1986
- HMDB: HMDB0014957
- Metlin: METLIN782
- DrugBank: DB00819
- ChEMBL: CHEMBL20
- Wikipedia: Acetazolamide
- MeSH: Acetazolamide
- chemspider: 1909
- CAS: 124442-28-0
- CAS: 59-66-5
- MoNA: EQ301154
- MoNA: EQ301102
- MoNA: EQ301151
- MoNA: EQ301105
- MoNA: EQ301156
- MoNA: EQ301101
- MoNA: EQ301106
- MoNA: EQ301153
- MoNA: EQ301103
- MoNA: EQ301152
- MoNA: EQ301104
- MoNA: EQ301155
- PMhub: MS000001377
- PubChem: 9024
- PDB-CCD: AZM
- NIKKAJI: J1.395A
- RefMet: Acetazolamide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dimitrios Tsikas. Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship.
Journal of enzyme inhibition and medicinal chemistry.
2024 Dec; 39(1):2291336. doi:
10.1080/14756366.2023.2291336. [PMID: 38078375] - Andrew Burgess, Gareth Andrews, Katie M E Colby, Samuel J E Lucas, Kate Sprecher, Joseph Donnelly, Philip N Ainslie, Aparna S Basnet, Keith R Burgess. Loop gain response to increased cerebral blood flow at high altitude.
Sleep & breathing = Schlaf & Atmung.
2023 Dec; ?(?):. doi:
10.1007/s11325-023-02956-4. [PMID: 38085496] - Li Li, Lin Lin, Bo Wen, Peng-Cheng Zhao, Da-Sheng Liu, Guo-Ming Pang, Zi-Rong Wang, Yong Tan, Cheng Lu. Promising Natural Medicines for the Treatment of High-Altitude Illness.
High altitude medicine & biology.
2023 09; 24(3):175-185. doi:
10.1089/ham.2022.0139. [PMID: 37504973] - Xiaojing Qian, Huifang Chen, Jiaying Chen. Preventing heme-induced nephropathy in children with glucose 6 phosphate dehydrogenase deficiency: is there a role for acetazolamide?.
Pediatric nephrology (Berlin, Germany).
2022 12; 37(12):3249. doi:
10.1007/s00467-022-05642-x. [PMID: 35678880] - Maria A Caravedo, Karen Mozo, Maria L Morales, Hunter Smiley, Jared Stuart, Drake H Tilley, Miguel M Cabada. Risk factors for acute mountain sickness in travellers to Cusco, Peru: coca leaves, obesity and sex.
Journal of travel medicine.
2022 08; 29(5):. doi:
10.1093/jtm/taab102. [PMID: 34230961] - Francesco P Busardò, Alfredo F Lo Faro, Ascanio Sirignano, Raffaele Giorgetti, Jeremy Carlier. In silico, in vitro, and in vivo human metabolism of acetazolamide, a carbonic anhydrase inhibitor and common 'diuretic and masking agent' in doping.
Archives of toxicology.
2022 07; 96(7):1989-2001. doi:
10.1007/s00204-022-03289-z. [PMID: 35410394] - Tomohiko Inoue, Mikako Hisamichi, Daisuke Ichikawa, Yugo Shibagaki, Masahiko Yazawa. The Effect of Add-on Acetazolamide to Conventional Diuretics for Diuretic-resistant Edema Complicated with Hypercapnia: A Report of Two Cases.
Internal medicine (Tokyo, Japan).
2022 Feb; 61(3):373-378. doi:
10.2169/internalmedicine.7896-21. [PMID: 34373379] - Ali Bahadur, Shahid Iqbal, Saiqa Muneer, Hashem O Alsaab, Nasser S Awwad, Hala A Ibrahium. Synthesis, carbonic anhydrase enzyme inhibition evaluations, and anticancer studies of sulfonamide based thiadiazole derivatives.
Bioorganic & medicinal chemistry letters.
2022 02; 57(?):128520. doi:
10.1016/j.bmcl.2021.128520. [PMID: 34965467] - David Daniel, João C Campos, Paulo C Costa, Bruno Nunes. Toxicity of two drugs towards the marine filter feeder Mytilus spp, using biochemical and shell integrity parameters.
Environmental pollution (Barking, Essex : 1987).
2022 Jan; 293(?):118562. doi:
10.1016/j.envpol.2021.118562. [PMID: 34813888] - Brianna N Brun, Shawn C Aylward. Pediatric Intracranial Hypertension: A Spotlight on Imaging, the Idiopathic Intracranial Hypertension Treatment Trial, and COVID-19 Associated Cases.
Seminars in pediatric neurology.
2021 12; 40(?):100922. doi:
10.1016/j.spen.2021.100922. [PMID: 34749916] - Secil Deniz, Tugba Kevser Uysal, Clemente Capasso, Claudiu T Supuran, Ozen Ozensoy Guler. Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):1230-1235. doi:
10.1080/14756366.2021.1924165. [PMID: 34074197] - Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Kun-Liang Lin, Cheng-Liang Peng, Ying-Hsia Shih, Mao-Feng Weng, Chun-Tang Chen, Chung-Hsin Yeh, Ying-Chieh Wang, Shing-Hwa Liu. A novel 111indium-labeled dual carbonic anhydrase 9-targeted probe as a potential SPECT imaging radiotracer for detection of hypoxic colorectal cancer cells.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2021 Nov; 168(?):38-52. doi:
10.1016/j.ejpb.2021.08.004. [PMID: 34450241] - Katsuhiro Matsuura, Tomohiko Yoshida, Takuya Uehara, Shusaku Yamada, Hideki Yotsuida, Mizuki Hasegawa, Sakie Katayose, Kurumi Yamada, Youta Yaginuma. Metabolic alkalosis following mitral valvuloplasty in a dog with preoperative acute kidney injury.
Journal of the American Veterinary Medical Association.
2021 11; 259(11):1332-1336. doi:
10.2460/javma.20.09.0519. [PMID: 34727063] - Christopher N Schmickl, Shane Landry, Jeremy E Orr, Brandon Nokes, Bradley A Edwards, Atul Malhotra, Robert L Owens. Effects of acetazolamide on control of breathing in sleep apnea patients: Mechanistic insights using meta-analyses and physiological model simulations.
Physiological reports.
2021 10; 9(20):e15071. doi:
10.14814/phy2.15071. [PMID: 34699135] - Alexey S Pospelov, Tommi Ala-Kurikka, Samu Kurki, Juha Voipio, Kai Kaila. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia.
Epilepsia.
2021 08; 62(8):1971-1984. doi:
10.1111/epi.16963. [PMID: 34180051] - A M Beal. The effect of acetazolamide, amiloride, bumetanide and SITS on secretion of fluid and electrolytes by the parotid gland of common wombats, Vombatus ursinus.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2021 07; 191(4):777-791. doi:
10.1007/s00360-021-01367-9. [PMID: 33877412] - Yoshinori Tsuji, George Kusi-Appiah, Noriko Kozai, Yuri Fukuda, Takashi Yamano, Hideya Fukuzawa. Characterization of a CO2-Concentrating Mechanism with Low Sodium Dependency in the Centric Diatom Chaetoceros gracilis.
Marine biotechnology (New York, N.Y.).
2021 Jun; 23(3):456-462. doi:
10.1007/s10126-021-10037-4. [PMID: 34109463] - Jean-Paul Richalet, Fabien Pillard, David LE Moal, Daniel Rivière, Philippe Oriol, Mathias Poussel, Bruno Chenuel, Stéphane Doutreleau, Samuel Vergès, Sophie Demanez, Michel Vergnion, Jean-Michel Boulet, Hervé Douard, Maryse Dupré, Olivier Mesland, Romain Remetter, Evelyne Lonsdorfer-Wolf, Alain Frey, Louis Vilcoq, Anne Nedelec Jaffuel, David Debeaumont, Guy Duperrex, François Lecoq, Christophe Hédon, Maurice Hayot, Guido Giardini, François J Lhuissier. Validation of a Score for the Detection of Subjects with High Risk for Severe High-Altitude Illness.
Medicine and science in sports and exercise.
2021 06; 53(6):1294-1302. doi:
10.1249/mss.0000000000002586. [PMID: 33433150] - Kanako Nagaoka, Hiroshi Kuji, Gen Yamagiwa, Takafumi Akanuma, Takahiro Inoue, Junko Fukuda, Mamiko Ohara, Tomo Suzuki. Successful Treatment of Fluid Overload and Metabolic Alkalosis with Acetazolamide for Peritoneal Dialysis.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2021 May; 32(3):890-891. doi:
10.4103/1319-2442.336792. [PMID: 35102939] - Tien-En Chen, Shao-Ying Liu. Severe Metabolic Acidosis and Hyperammonemia Induced by the Concomitant Use of Acetazolamide and Aspirin in a Patient With Impaired Renal Function.
The Journal of emergency medicine.
2021 May; 60(5):e115-e117. doi:
10.1016/j.jemermed.2020.11.022. [PMID: 33608163] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Rana M Abou-Mrad, Mazin Ibrahim, Nuha Osman, Raman Suresh Babu. Anuric Acute Kidney Injury Requiring Dialysis Following Acetazolamide Use for Cataract Surgery.
The American journal of case reports.
2021 Apr; 22(?):e931319. doi:
10.12659/ajcr.931319. [PMID: 33888675] - Eugenia Awuah Boadi, Samuel Shin, Samuel Yeroushalmi, Bok-Eum Choi, Peijun Li, Bidhan C Bandyopadhyay. Modulation of Tubular pH by Acetazolamide in a Ca2+ Transport Deficient Mice Facilitates Calcium Nephrolithiasis.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22063050. [PMID: 33802660] - Amber B Clemmons, Aaron Chase, Phung Duong, Jennifer L Waller, Katherine Saunders, Locke Bryan. Assessing the impact of adding acetazolamide to oral or intravenous sodium bicarbonate as compared with intravenous bicarbonate monotherapy as urinary alkalinization in adults receiving high-dose methotrexate.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2021 Mar; 29(3):1527-1534. doi:
10.1007/s00520-020-05646-z. [PMID: 32725375] - Shimpei Iikuni, Yuya Okada, Yoichi Shimizu, Hiroyuki Watanabe, Masahiro Ono. Modulation of the Pharmacokinetics of a Radioligand Targeting Carbonic Anhydrase-IX with Albumin-Binding Moieties.
Molecular pharmaceutics.
2021 03; 18(3):966-975. doi:
10.1021/acs.molpharmaceut.0c00953. [PMID: 33472371] - Wai Lun Will Pak, Ka Lok Chan, Zi Chan, Wai Ping Law, Yick Hei Wong, Chi Kwan Lam, Sze Ho Sunny Wong. Acetazolamide toxicity and dosing in dialysis patients.
Nephrology (Carlton, Vic.).
2021 Jan; 26(1):88. doi:
10.1111/nep.13654. [PMID: 31478276] - Yu-Rong Mu, Li Cai, Meng-Yuan Zhou, Ming-Ming Liu, Zeng Li, Rong Li. Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway.
International immunopharmacology.
2021 Jan; 90(?):107214. doi:
10.1016/j.intimp.2020.107214. [PMID: 33278748] - Parham Habibzadeh, Mohammad Mofatteh, Saeid Ghavami, Jamshid Roozbeh. The potential effectiveness of acetazolamide in the prevention of acute kidney injury in COVID-19: A hypothesis.
European journal of pharmacology.
2020 Dec; 888(?):173487. doi:
10.1016/j.ejphar.2020.173487. [PMID: 32805256] - Cheng Peng, Duopeng An, Wen-Xin Ding, Yuan-Xing Zhu, Li Ye, Jiyang Li. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum.
Applied microbiology and biotechnology.
2020 Dec; 104(24):10437-10449. doi:
10.1007/s00253-020-10996-z. [PMID: 33170328] - Aidan J Hampson, Jennifer R Schroeder, Kayla N Ellefsen, Luba Yammine, David H Epstein, Kenzie L Preston, Marilyn A Huestis, Christopher D Verrico. Subtherapeutic Acetazolamide Doses as a Noninvasive Method for Assessing Medication Adherence.
Clinical pharmacology and therapeutics.
2020 12; 108(6):1203-1212. doi:
10.1002/cpt.1929. [PMID: 32496573] - Joseph D Tobias. Metabolic Alkalosis in the Pediatric Patient: Treatment Options in the Pediatric ICU or Pediatric Cardiothoracic ICU Setting.
World journal for pediatric & congenital heart surgery.
2020 Nov; 11(6):776-782. doi:
10.1177/2150135120942488. [PMID: 33164684] - R Latorre, F Purroy. [Hypokalemic periodic paralysis: a systematic review of published case reports].
Revista de neurologia.
2020 Nov; 71(9):317-325. doi:
10.33588/rn.7109.2020377. [PMID: 33085076] - Richard I Horowitz, Phyllis R Freeman. Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.
Medical hypotheses.
2020 Oct; 143(?):109851. doi:
10.1016/j.mehy.2020.109851. [PMID: 32534175] - Perwez Alam, Sihame Amlal, Charuhas V Thakar, Hassane Amlal. Acetazolamide causes renal [Formula: see text] wasting but inhibits ammoniagenesis and prevents the correction of metabolic acidosis by the kidney.
American journal of physiology. Renal physiology.
2020 09; 319(3):F366-F379. doi:
10.1152/ajprenal.00501.2019. [PMID: 32657159] - Y Uwai, R Kondo, T Suzuki, T Kawasaki, T Nabekura. Potent Inhibition of Biphasic Tubular Reabsorption of Lithium by Acetazolamide and Foscarnet in Rats.
Physiological research.
2020 08; 69(4):645-651. doi:
10.33549/physiolres.934285. [PMID: 32584131] - Andrew M Luks, Erik R Swenson. COVID-19 Lung Injury and High-Altitude Pulmonary Edema. A False Equation with Dangerous Implications.
Annals of the American Thoracic Society.
2020 08; 17(8):918-921. doi:
10.1513/annalsats.202004-327cme. [PMID: 32735170] - Mark R Geier, David A Geier. Respiratory conditions in coronavirus disease 2019 (COVID-19): Important considerations regarding novel treatment strategies to reduce mortality.
Medical hypotheses.
2020 Jul; 140(?):109760. doi:
10.1016/j.mehy.2020.109760. [PMID: 32344310] - John Ketz, Vijay Saxena, Samuel Arregui, Ashley Jackson, George J Schwartz, Takafumi Yagisawa, Robert L Fairchild, David S Hains, Andrew L Schwaderer. Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility.
American journal of physiology. Renal physiology.
2020 06; 318(6):F1441-F1453. doi:
10.1152/ajprenal.00583.2019. [PMID: 32390512] - Hui Lu, Huaqun Zhang, Yuanying Jiang. Methazolamide in high-altitude illnesses.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 May; 148(?):105326. doi:
10.1016/j.ejps.2020.105326. [PMID: 32251722] - Geoffrey Ginter, Abdulghani Sankari, Mehdi Eshraghi, Harold Obiakor, Hossein Yarandi, Susmita Chowdhuri, Anan Salloum, M Safwan Badr. Effect of acetazolamide on susceptibility to central sleep apnea in chronic spinal cord injury.
Journal of applied physiology (Bethesda, Md. : 1985).
2020 04; 128(4):960-966. doi:
10.1152/japplphysiol.00532.2019. [PMID: 32078469] - Isaac Solaimanzadeh. Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19).
Cureus.
2020 Mar; 12(3):e7343. doi:
10.7759/cureus.7343. [PMID: 32226695] - Silvia Bua, Laura Lucarini, Laura Micheli, Marta Menicatti, Gianluca Bartolucci, Silvia Selleri, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini, Fabrizio Carta, Paola Gratteri, Alessio Nocentini, Claudiu T Supuran. Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
Journal of medicinal chemistry.
2020 03; 63(5):2325-2342. doi:
10.1021/acs.jmedchem.9b01130. [PMID: 31689108] - Matthew Ku, Ali Bazargan, Constantine Tam. Addition of low dose acetazolamide as an adjunct in patients undergoing high dose methotrexate is safe and beneficial.
Internal medicine journal.
2020 03; 50(3):357-362. doi:
10.1111/imj.14468. [PMID: 31403755] - Mojgan Mazaheri, Farahnak Assadi, Simin Sadeghi-Bojd. Adjunctive acetazolamide therapy for the treatment of Bartter syndrome.
International urology and nephrology.
2020 Jan; 52(1):121-128. doi:
10.1007/s11255-019-02351-7. [PMID: 31820361] - Hajime Kataoka. Comparison of Changes in Plasma Volume and Renal Function between Acetazolamide and Conventional Diuretics: Understanding the Mechanical Differences according to the "Chloride Theory".
Cardiology.
2020 ; 145(4):215-223. doi:
10.1159/000504533. [PMID: 31865322] - A Ibrahim, N Hussain. Brief report: Metabolic acidosis in newborn infants following maternal use of acetazolamide during pregnancy.
Journal of neonatal-perinatal medicine.
2020; 13(3):419-425. doi:
10.3233/npm-190333. [PMID: 31771084] - Alastair Jw Brown, Salvatore L Cutuli, Glenn M Eastwood, Laurent Bitker, Philip Marsh, Rinaldo Bellomo. A pilot randomised controlled trial evaluating the pharmacodynamic effects of furosemide versus acetazolamide in critically ill patients.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.
2019 Dec; 21(4):258-64. doi:
. [PMID: 31778632] - Hannes Gatterer, Günther Bernatzky, Johannes Burtscher, Michael Rainer, Bengt Kayser, Martin Burtscher. Are Pre-Ascent Low-Altitude Saliva Cortisol Levels Related to the Subsequent Acute Mountain Sickness Score? Observations from a Field Study.
High altitude medicine & biology.
2019 12; 20(4):337-343. doi:
10.1089/ham.2019.0034. [PMID: 31411495] - Hajime Kataoka. Acetazolamide as a potent chloride-regaining diuretic: short- and long-term effects, and its pharmacologic role under the 'chloride theory' for heart failure pathophysiology.
Heart and vessels.
2019 Dec; 34(12):1952-1960. doi:
10.1007/s00380-019-01433-x. [PMID: 31114959] - Caberry W Yu, Jason M Kwok, Jonathan A Micieli. Resolution of papilledema associated with cyclosporine use after change to tacrolimus.
BMJ case reports.
2019 Nov; 12(11):. doi:
10.1136/bcr-2019-232725. [PMID: 31748372] - Frederik H Verbrugge, Pieter Martens, Koen Ameloot, Veerle Haemels, Joris Penders, Matthias Dupont, Wai Hong Wilson Tang, Walter Droogné, Wilfried Mullens. Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance.
European journal of heart failure.
2019 11; 21(11):1415-1422. doi:
10.1002/ejhf.1478. [PMID: 31074184] - Sahar Ghiasikhou, Samuele Cazzamalli, Jörg Scheuermann, Dario Neri, Renato Zenobi. Automated and enhanced extraction of a small molecule-drug conjugate using an enzyme-inhibitor interaction based SPME tool followed by direct analysis by ESI-MS.
Analytical and bioanalytical chemistry.
2019 Nov; 411(28):7387-7398. doi:
10.1007/s00216-019-02165-7. [PMID: 31667562] - Malcolm Cochran. Would acetazolamide inhibit progression of atheromatous vascular calcification?.
Medical hypotheses.
2019 Nov; 132(?):109354. doi:
10.1016/j.mehy.2019.109354. [PMID: 31421415] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Y Uwai, M Tsuduki, T Kawasaki, T Nabekura. Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3β phosphorylation in rat kidney.
Die Pharmazie.
2019 10; 74(10):611-613. doi:
10.1691/ph.2019.9060. [PMID: 31685087] - Salma Babiker, Mohamed E Elsayed, Ajay Dhaygude, Indira Madgula. A complex case of haemodialysis induced increased intraocular pressure.
European journal of ophthalmology.
2019 Jul; 29(1_suppl):15-17. doi:
10.1177/1120672119842481. [PMID: 31014077] - Jonathan M Whittamore, Marguerite Hatch. Oxalate transport by the mouse intestine in vitro is not affected by chronic challenges to systemic acid-base homeostasis.
Urolithiasis.
2019 Jun; 47(3):243-254. doi:
10.1007/s00240-018-1067-5. [PMID: 29947993] - Antonio F Martínez-Monseny, Mercè Bolasell, Laura Callejón-Póo, Daniel Cuadras, Verónica Freniche, Débora C Itzep, Susanna Gassiot, Pedro Arango, Didac Casas-Alba, Eugenia de la Morena, Javier Corral, Raquel Montero, Celia Pérez-Cerdá, Belén Pérez, Rafael Artuch, Jaak Jaeken, Mercedes Serrano. AZATAX: Acetazolamide safety and efficacy in cerebellar syndrome in PMM2 congenital disorder of glycosylation (PMM2-CDG).
Annals of neurology.
2019 05; 85(5):740-751. doi:
10.1002/ana.25457. [PMID: 30873657] - Meng-Si Luo, Hui-Zi Li, Guan-Jiang Huang, Lun Wu. Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis.
Critical care (London, England).
2019 04; 23(1):138. doi:
10.1186/s13054-019-2384-y. [PMID: 31018866] - Daniel Molano Franco, Víctor H Nieto Estrada, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez. Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.
The Cochrane database of systematic reviews.
2019 04; 4(?):CD013315. doi:
10.1002/14651858.cd013315. [PMID: 31012483] - Manal El Hamamsy, Noha Kamal, Naglaa Samir Bazan, Mostafa El Haddad. Evaluation of the effect of acetazolamide versus mannitol on cisplatin-induced nephrotoxicity, a pilot study.
International journal of clinical pharmacy.
2018 Dec; 40(6):1539-1547. doi:
10.1007/s11096-018-0677-x. [PMID: 30167970] - Julio Núñez, Raquel Heredia, Ana Payá, Ignacio Sanchis, Susana Del Prado, Gema Miñana, Enrique Santas, Rafael de la Espriella, Eduardo Núñez, Juan Sanchis, Antoni Bayés-Genís. Use of acetazolamide in the treatment of patients with refractory congestive heart failure.
Cardiovascular therapeutics.
2018 Dec; 36(6):e12465. doi:
10.1111/1755-5922.12465. [PMID: 30191652] - Hashem O Alsaab, Samaresh Sau, Rami M Alzhrani, Vino T Cheriyan, Lisa A Polin, Ulka Vaishampayan, Arun K Rishi, Arun K Iyer. Tumor hypoxia directed multimodal nanotherapy for overcoming drug resistance in renal cell carcinoma and reprogramming macrophages.
Biomaterials.
2018 11; 183(?):280-294. doi:
10.1016/j.biomaterials.2018.08.053. [PMID: 30179778] - Wilfried Mullens, Frederik H Verbrugge, Petra Nijst, Pieter Martens, Katrien Tartaglia, Evi Theunissen, Liesbeth Bruckers, Walter Droogne, Pierre Troisfontaines, Kevin Damman, Johan Lassus, Alexandre Mebazaa, Gerasimos Filippatos, Frank Ruschitzka, Matthias Dupont. Rationale and design of the ADVOR (Acetazolamide in Decompensated Heart Failure with Volume Overload) trial.
European journal of heart failure.
2018 11; 20(11):1591-1600. doi:
10.1002/ejhf.1307. [PMID: 30238574] - Travis Branigan, Sulaf Elkhalifa, Matthew E Pamenter. Behavioural responses to environmental hypercapnia in two eusocial species of African mole rats.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.
2018 10; 204(9-10):811-819. doi:
10.1007/s00359-018-1283-z. [PMID: 30173381] - Jeppe B Rosenbaek, Erling B Pedersen, Jesper N Bech. The effect of sodium nitrite infusion on renal function, brachial and central blood pressure during enzyme inhibition by allopurinol, enalapril or acetazolamide in healthy subjects: a randomized, double-blinded, placebo-controlled, crossover study.
BMC nephrology.
2018 09; 19(1):244. doi:
10.1186/s12882-018-1035-x. [PMID: 30241504] - Pruthvi Kothari, Omar M Hassan, Peter Macintosh. Young Man With Severe Bilateral Papilledema.
JAMA ophthalmology.
2018 07; 136(7):831-832. doi:
10.1001/jamaophthalmol.2017.6652. [PMID: 29800986] - Tomasz Imiela, Andrzej Budaj. Response to 'Acetazolamide and Cardiac Failure'.
Clinical drug investigation.
2018 Jul; 38(7):651. doi:
10.1007/s40261-018-0654-0. [PMID: 29736884] - A O Youssef. A highly selective and sensitive Tb3+-acetylacetone photo probe for the assessment of acetazolamide in pharmaceutical and serum samples.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Apr; 195(?):47-52. doi:
10.1016/j.saa.2018.01.047. [PMID: 29367026] - Megan A Van Berkel, Jessica L Elefritz. Evaluating off-label uses of acetazolamide.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2018 Apr; 75(8):524-531. doi:
10.2146/ajhp170279. [PMID: 29626002] - Li Cai, Wei-Na Chen, Rong Li, Cheng-Mu Hu, Chao Lei, Chun-Mei Li. Therapeutic effect of acetazolamide, an aquaporin 1 inhibitor, on adjuvant-induced arthritis in rats by inhibiting NF-κB signal pathway.
Immunopharmacology and immunotoxicology.
2018 Apr; 40(2):117-125. doi:
10.1080/08923973.2017.1417998. [PMID: 29303021] - Alexandr V Shitov, Vasily V Terentyev, Sergey K Zharmukhamedov, Margarita V Rodionova, Mehmet Karacan, Nurcan Karacan, Vyacheslav V Klimov, Suleyman I Allakhverdiev. Is carbonic anhydrase activity of photosystem II required for its maximum electron transport rate?.
Biochimica et biophysica acta. Bioenergetics.
2018 Apr; 1859(4):292-299. doi:
10.1016/j.bbabio.2018.01.009. [PMID: 29410217] - Karl-Heinz Altmann. Tumor Targeting with Small Molecule-Drug Conjugates (SMDCs) - Can They be Better than ADCs?.
Chimia.
2018 Mar; 72(3):154-155. doi:
10.2533/chimia.2018.154. [PMID: 29631670] - Katyayani Tatiparti, Samaresh Sau, Kaustubh A Gawde, Arun K Iyer. Copper-Free 'Click' Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia.
International journal of molecular sciences.
2018 Mar; 19(3):. doi:
10.3390/ijms19030838. [PMID: 29534020] - Kunal N More, Jun Young Lee, Dong-Yeon Kim, Nam-Chul Cho, Ayoung Pyo, Misun Yun, Hyeon Sik Kim, Hangun Kim, Kwangseok Ko, Jeong-Hoon Park, Dong-Jo Chang. Acetazolamide-based [18F]-PET tracer: In vivo validation of carbonic anhydrase IX as a sole target for imaging of CA-IX expressing hypoxic solid tumors.
Bioorganic & medicinal chemistry letters.
2018 03; 28(5):915-921. doi:
10.1016/j.bmcl.2018.01.060. [PMID: 29422388] - Kannan Sridharan, Gowri Sivaramakrishnan. Pharmacological interventions for preventing acute mountain sickness: a network meta-analysis and trial sequential analysis of randomized clinical trials.
Annals of medicine.
2018 03; 50(2):147-155. doi:
10.1080/07853890.2017.1407034. [PMID: 29166795] - Zhiqing Zhang, Zhonghai Xiao, Bingnan Deng, Xiaohua Liu, Wei Liu, Hongjing Nie, Xi Li, Zhaoli Chen, Danfeng Yang, Ruifeng Duan. Therapeutic Efficacy of Methazolamide Against Intermittent Hypoxia-Induced Excessive Erythrocytosis in Rats.
High altitude medicine & biology.
2018 03; 19(1):69-80. doi:
10.1089/ham.2017.0044. [PMID: 29077517] - Mohammad Alsady, Theun de Groot, Marleen L A Kortenoeven, Claudia Carmone, Kim Neijman, Melissa Bekkenkamp-Grovenstein, Udo Engelke, Ron Wevers, Ruben Baumgarten, Ron Korstanje, Peter M T Deen. Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
American journal of physiology. Renal physiology.
2018 02; 314(2):F230-F239. doi:
10.1152/ajprenal.00297.2017. [PMID: 29070571] - Russell T Wise, Brady S Moffett, Ayse Akcan-Arikan, Marianne Galati, Natasha Afonso, Paul A Checchia. Enhancement of diuresis with metolazone in infant paediatric cardiac intensive care patients.
Cardiology in the young.
2018 Jan; 28(1):27-31. doi:
10.1017/s1047951117001330. [PMID: 28889825] - Brady S Moffett, Jennifer Morris, Charissa Kam, Marianne Galati, Ankhi Dutta, Ayse Akcan-Arikan. Vancomycin associated acute kidney injury in pediatric patients.
PloS one.
2018; 13(10):e0202439. doi:
10.1371/journal.pone.0202439. [PMID: 30281600] - Shailendra Sharma, Jane Gralla, Joyce Gonzalez Ordonez, Maria-Elena Hurtado, Erik R Swenson, Robert B Schoene, Jackeline Pando Kelly, David Callacondo, Christopher Rivard, Carlos Roncal-Jimenez, Jeffrey Sirota, Richard Fuquay, Brian P Jackson, Kai E Swenson, Richard J Johnson, Abdias Hurtado, Elizabeth Escudero. Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease).
Respiratory physiology & neurobiology.
2017 12; 246(?):1-8. doi:
10.1016/j.resp.2017.07.005. [PMID: 28720395] - Sergio García-Blas, Clara Bonanad, Pau Llàcer, Silvia Ventura, José María Núñez, Ruth Sánchez, Carlos Chamorro, Lorenzo Fácila, Rafael de la Espriella, Juana María Vaquer, Alberto Cordero, Mercè Roqué, Víctor Ortiz, Paolo Racugno, Vicent Bodí, Ernesto Valero, Enrique Santas, María Del Carmen Moreno, Gema Miñana, Arturo Carratalá, Lourdes Bondanza, Ana Payá, Ingrid Cardells, Raquel Heredia, Mauricio Pellicer, Guillermo Valls, Patricia Palau, María José Bosch, Rafael Raso, Andrés Sánchez, Vicente Bertomeu-González, Vicente Bertomeu-Martínez, Vicente Montagud-Balaguer, Cristina Albiach-Montañana, Jezabel Pendás-Meneau, Goitzane Marcaida, Sonia Cervantes-García, Rodolfo San Antonio, Elisabet de Mingo, Francisco J Chorro, Juan Sanchis, Julio Núñez. Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design.
Revista espanola de cardiologia (English ed.).
2017 Dec; 70(12):1067-1073. doi:
10.1016/j.rec.2017.02.028. [PMID: 28341415] - Xiaoxuan Liu, Freda Sii, John Horsburgh, Peter Shah. Anuric acute kidney injury due to low dose oral acetazolamide with hypercrystalluria.
Clinical & experimental ophthalmology.
2017 12; 45(9):927-929. doi:
10.1111/ceo.12980. [PMID: 28486775] - Gulzar Ahmed, Walter Elger, Frederick Meece, Hareesh B Nair, Birgitt Schneider, Ralf Wyrwa, Klaus Nickisch. A prodrug design for improved oral absorption and reduced hepatic interaction.
Bioorganic & medicinal chemistry.
2017 10; 25(20):5569-5575. doi:
10.1016/j.bmc.2017.08.027. [PMID: 28886996] - Theun de Groot, Joan Doornebal, Birgitte M Christensen, Simone Cockx, Anne P Sinke, Ruben Baumgarten, Jennifer J Bedford, Robert J Walker, Jack F M Wetzels, Peter M T Deen. Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.
American journal of physiology. Renal physiology.
2017 09; 313(3):F669-F676. doi:
10.1152/ajprenal.00147.2017. [PMID: 28615247] - Sin-Hyoung Hong, Yong-Su Song, Dong-Jun Seo, Kil-Yong Kim, Woo-Jin Jung. Antifungal activity and expression patterns of extracellular chitinase and β-1,3-glucanase in Wickerhamomyces anomalus EG2 treated with chitin and glucan.
Microbial pathogenesis.
2017 Sep; 110(?):159-164. doi:
10.1016/j.micpath.2017.06.038. [PMID: 28668604] - Arun John, Muthukumaran Sivashanmugam, Vetrivel Umashankar, Sulochana Konerirajapuram Natarajan. Virtual screening, molecular dynamics, and binding free energy calculations on human carbonic anhydrase IX catalytic domain for deciphering potential leads.
Journal of biomolecular structure & dynamics.
2017 Aug; 35(10):2155-2168. doi:
10.1080/07391102.2016.1207565. [PMID: 27373313] - Rosemary Adamson, Erik R Swenson. Acetazolamide Use in Severe Chronic Obstructive Pulmonary Disease. Pros and Cons.
Annals of the American Thoracic Society.
2017 Jul; 14(7):1086-1093. doi:
10.1513/annalsats.201701-016fr. [PMID: 28622013] - Morteza Hamidi, Seyed Mohammad Kazem Aghamir, Alborz Salavati, Ahmad Masoomi. A pilot randomized study on use of oral acetazolamide in patients with refractory dysuria.
International urology and nephrology.
2017 Jun; 49(6):927-930. doi:
10.1007/s11255-017-1566-2. [PMID: 28289931] - G Rialp Cervera, J M Raurich Puigdevall, I Morán Chorro, M C Martín Delgado, G Heras la Calle, A Mas Serra, I Vallverdú Perapoch. Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial.
Pulmonary pharmacology & therapeutics.
2017 06; 44(?):30-37. doi:
10.1016/j.pupt.2017.03.002. [PMID: 28286047] - Manchun Zhao, Hwei-Ting Tan, Johannes Scharwies, Kara Levin, John R Evans, Stephen D Tyerman. Association between water and carbon dioxide transport in leaf plasma membranes: assessing the role of aquaporins.
Plant, cell & environment.
2017 Jun; 40(6):789-801. doi:
10.1111/pce.12830. [PMID: 27620674] - Mohammad Amin Fallahzadeh, Banafshe Dormanesh, Mohammad Kazem Fallahzadeh, Jamshid Roozbeh, Mohammad Hossein Fallahzadeh, Mohammad Mahdi Sagheb. Acetazolamide and Hydrochlorothiazide Followed by Furosemide Versus Furosemide and Hydrochlorothiazide Followed by Furosemide for the Treatment of Adults With Nephrotic Edema: A Randomized Trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Mar; 69(3):420-427. doi:
10.1053/j.ajkd.2016.10.022. [PMID: 28043731] - Simon J A van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike W van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu T Supuran, Ludwig J Dubois, Jean-Yves Winum, Philippe Lambin. New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.
European journal of medicinal chemistry.
2017 Feb; 127(?):691-702. doi:
10.1016/j.ejmech.2016.10.037. [PMID: 27823879] - Samuele Cazzamalli, Alberto Dal Corso, Dario Neri. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma.
Journal of controlled release : official journal of the Controlled Release Society.
2017 01; 246(?):39-45. doi:
10.1016/j.jconrel.2016.11.023. [PMID: 27890855] - J Libien, M J Kupersmith, W Blaner, M P McDermott, S Gao, Y Liu, J Corbett, M Wall. Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial.
Journal of the neurological sciences.
2017 Jan; 372(?):78-84. doi:
10.1016/j.jns.2016.11.014. [PMID: 28017254] - Mina Momayyezi, Robert D Guy. Substantial role for carbonic anhydrase in latitudinal variation in mesophyll conductance of Populus trichocarpa Torr. & Gray.
Plant, cell & environment.
2017 01; 40(1):138-149. doi:
10.1111/pce.12851. [PMID: 27761902] - Samuele Cazzamalli, Alberto Dal Corso, Dario Neri. Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma.
Molecular cancer therapeutics.
2016 12; 15(12):2926-2935. doi:
10.1158/1535-7163.mct-16-0283. [PMID: 27609641] - Carolina López, Andrés José Alcaraz, Blanca Toledo, Lucía Cortejoso, Maite Augusta Gil-Ruiz. Acetazolamide Therapy for Metabolic Alkalosis in Pediatric Intensive Care Patients.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 12; 17(12):e551-e558. doi:
10.1097/pcc.0000000000000971. [PMID: 27748700] - Craig E Gordon, Swapna Vantzelfde, Jean M Francis. Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus.
The New England journal of medicine.
2016 11; 375(20):2008-2009. doi:
10.1056/nejmc1609483. [PMID: 27959610]