C10-LNO2 (BioDeep_00001874766)

Main id: BioDeep_00000002822

 


代谢物信息卡片


(9E,12Z)-10-Nitrooctadeca-9,12-dienoic acid

化学式: C18H31NO4 (325.2253)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC=CCC(=CCCCCCCCC(=O)O)[N+](=O)[O-]
InChI: InChI=1S/C18H31NO4/c1-2-3-4-5-8-11-14-17(19(22)23)15-12-9-6-7-10-13-16-18(20)21/h8,11,15H,2-7,9-10,12-14,16H2,1H3,(H,20,21)/b11-8-,17-15+



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ELANE, MAPK8, NFKB1, NOS3, PPARG, XDH
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 1 HMOX1
Nucleus 8 GABPA, HMOX1, JUN, MAPK8, NFKB1, NOS3, PPARA, PPARG
cytosol 8 ELANE, HMOX1, MAPK8, NFKB1, NOS3, PPARG, PRKCQ, XDH
mitochondrial membrane 1 SLC25A4
phagocytic vesicle 1 ELANE
nucleoplasm 8 GABPA, HMOX1, JUN, MAPK8, NFKB1, NOS3, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 JUN, PPARG
Cell membrane 3 CD40LG, ITGAM, VCAM1
Cytoplasmic side 2 GORASP1, HMOX1
Multi-pass membrane protein 2 SLC25A4, UCP1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 5 CD40, CD40LG, ELANE, ITGAM, VCAM1
Golgi apparatus 4 CD40LG, GORASP1, NOS3, VCAM1
Golgi membrane 2 GORASP1, NOS3
mitochondrial inner membrane 2 SLC25A4, UCP1
neuronal cell body 1 CD40
sarcolemma 1 VCAM1
plasma membrane 8 CD40, CD40LG, IFNLR1, ITGAM, NOS3, PRKCQ, SLC25A4, VCAM1
Membrane 7 CD40, CD40LG, HMOX1, IFNLR1, ITGAM, SLC25A4, VCAM1
axon 1 MAPK8
caveola 1 NOS3
extracellular exosome 4 CD40, ELANE, ITGAM, VCAM1
endoplasmic reticulum 2 HMOX1, VCAM1
extracellular space 7 CD40, CD40LG, ELANE, HMOX1, ITGAM, VCAM1, XDH
perinuclear region of cytoplasm 3 HMOX1, NOS3, PPARG
mitochondrion 3 NFKB1, SLC25A4, UCP1
intracellular membrane-bounded organelle 2 CD40, PPARG
filopodium 1 VCAM1
Single-pass type I membrane protein 4 CD40, IFNLR1, ITGAM, VCAM1
Secreted 1 CD40LG
extracellular region 2 ELANE, NFKB1
mitochondrial outer membrane 1 HMOX1
transcription regulator complex 2 JUN, NFKB1
centriolar satellite 1 PRKCQ
CD40 receptor complex 1 CD40
external side of plasma membrane 4 CD40, CD40LG, ITGAM, VCAM1
varicosity 1 CD40
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 VCAM1
apical part of cell 1 VCAM1
Single-pass type II membrane protein 1 CD40LG
Mitochondrion inner membrane 2 SLC25A4, UCP1
Membrane raft 1 ITGAM
cis-Golgi network 1 GORASP1
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
receptor complex 1 PPARG
chromatin 5 GABPA, JUN, NFKB1, PPARA, PPARG
cytoskeleton 1 NOS3
podosome 1 VCAM1
nuclear chromosome 1 JUN
microvillus 1 VCAM1
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 JUN
plasma membrane raft 1 ITGAM
secretory granule lumen 1 NFKB1
transcription repressor complex 1 ELANE
specific granule lumen 2 ELANE, NFKB1
endocytic vesicle membrane 1 NOS3
azurophil granule lumen 1 ELANE
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
basal dendrite 1 MAPK8
Cytoplasmic vesicle, phagosome 1 ELANE
integrin complex 1 ITGAM
transcription factor AP-1 complex 1 JUN
integrin alphaM-beta2 complex 1 ITGAM
mitochondrial permeability transition pore complex 1 SLC25A4
[Vascular cell adhesion protein 1]: Cell membrane 1 VCAM1
[Soluble Vascular Cell Adhesion Molecule-1]: Secreted 1 VCAM1
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex 1 VCAM1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[CD40 ligand, soluble form]: Secreted 1 CD40LG
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Qiongju Qiu, Giancarlo Abis, Florence Mattingly-Peck, Steven Lynham, Franca Fraternali, Maria R Conte. Allosteric Regulation of the Soluble Epoxide Hydrolase by Nitro Fatty Acids: a Combined Experimental and Computational Approach. Journal of molecular biology. 2022 09; 434(17):167600. doi: 10.1016/j.jmb.2022.167600. [PMID: 35460669]
  • Tanja K Rudolph, Thorben Ravekes, Anna Klinke, Kai Friedrichs, Martin Mollenhauer, Michaela Pekarova, Gabriela Ambrozova, Hana Martiskova, Jatinder-Jit Kaur, Bianca Matthes, Alex Schwoerer, Steven R Woodcock, Lukas Kubala, Bruce A Freeman, Stephan Baldus, Volker Rudolph. Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation. Cardiovascular research. 2016 Jan; 109(1):174-84. doi: 10.1093/cvr/cvv254. [PMID: 26598510]
  • Xiaochun Tang, Yanhong Guo, Kae Nakamura, Huarong Huang, Milton Hamblin, Lin Chang, Luis Villacorta, Kejie Yin, Hongsheng Ouyang, Jifeng Zhang. Nitroalkenes induce rat aortic smooth muscle cell apoptosis via activation of caspase-dependent pathways. Biochemical and biophysical research communications. 2010 Jun; 397(2):239-44. doi: 10.1016/j.bbrc.2010.05.091. [PMID: 20493166]
  • Marcienne M Wright, Junghyun Kim, Thomas D Hock, Norbert Leitinger, Bruce A Freeman, Anupam Agarwal. Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cAMP, AP-1 and E-box response element interactions. The Biochemical journal. 2009 Aug; 422(2):353-61. doi: 10.1042/bj20090339. [PMID: 19534727]
  • Paola Manini, Luigia Capelli, Samantha Reale, Marianna Arzillo, Orlando Crescenzi, Alessandra Napolitano, Vincenzo Barone, Marco d'Ischia. Chemistry of nitrated lipids: remarkable instability of 9-nitrolinoleic acid in neutral aqueous medium and a novel nitronitrate ester product by concurrent autoxidation/nitric oxide-release pathways. The Journal of organic chemistry. 2008 Oct; 73(19):7517-25. doi: 10.1021/jo801364v. [PMID: 18767799]
  • Richard L Alexander, Darcy J P Bates, Marcus W Wright, S Bruce King, Charles S Morrow. Modulation of nitrated lipid signaling by multidrug resistance protein 1 (MRP1): glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic acid-induced, PPARgamma-dependent transcription activation. Biochemistry. 2006 Jun; 45(25):7889-96. doi: 10.1021/bi0605639. [PMID: 16784241]
  • Emersom S Lima, Marcelo G Bonini, Ohara Augusto, Hermes V Barbeiro, Heraldo P Souza, Dulcineia S P Abdalla. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free radical biology & medicine. 2005 Aug; 39(4):532-9. doi: 10.1016/j.freeradbiomed.2005.04.005. [PMID: 16043024]
  • Francisco J Schopfer, Paul R S Baker, Gregory Giles, Phil Chumley, Carlos Batthyany, Jack Crawford, Rakesh P Patel, Neil Hogg, Bruce P Branchaud, Jack R Lancaster, Bruce A Freeman. Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. The Journal of biological chemistry. 2005 May; 280(19):19289-97. doi: 10.1074/jbc.m414689200. [PMID: 15764811]