Talwin (BioDeep_00001873792)
代谢物信息卡片
Talwin
化学式: C19H27NO (285.2093)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2CC3=C(C1(CCN2CC=C(C)C)C)C=C(C=C3)O
InChI: InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:182080
- PubChem: 4736
- ChEMBL: CHEMBL100116
- MeSH: Pentazocine
- CAS: 55643-30-6
- CAS: 39188-58-4
- CAS: 7488-49-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 3469 - Papaver somniferum: 10.1016/J.JPBA.2008.06.022
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.
Asian journal of psychiatry.
2022 May; 71(?):103080. doi:
10.1016/j.ajp.2022.103080. [PMID: 35305452] - Sergei Kopanchuk, Edijs Vavers, Santa Veiksina, Kadri Ligi, Liga Zvejniece, Maija Dambrova, Ago Rinken. Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy.
PloS one.
2022; 17(5):e0268563. doi:
10.1371/journal.pone.0268563. [PMID: 35584184] - Ashish K Mishra, Timur Mavlyutov, Deo R Singh, Gabriel Biener, Jay Yang, Julie A Oliver, Arnold Ruoho, Valerică Raicu. The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.
The Biochemical journal.
2015 Mar; 466(2):263-271. doi:
10.1042/bj20141321. [PMID: 25510962] - Noriaki Satoh, Yumiko Toyohira, Keita Takahashi, Nobuyuki Yanagihara. Effects of various pharmacological agents on the function of norepinephrine transporter.
Journal of UOEH.
2015 Mar; 37(1):33-42. doi:
10.7888/juoeh.37.33. [PMID: 25787100] - Girish G Meshram, Anil Kumar, Waseem Rizvi, C D Tripathi, R A Khan. Central analgesic activity of the aqueous and ethanolic extracts of the leaves of Albizia lebbeck: role of the GABAergic and serotonergic pathways.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2015; 70(1-2):25-30. doi:
10.1515/znc-2014-4115. [PMID: 25854769] - Mohan Pabba, Adrian Y C Wong, Nina Ahlskog, Elitza Hristova, Dante Biscaro, Wissam Nassrallah, Johnny K Ngsee, Melissa Snyder, Jean-Claude Beique, Richard Bergeron. NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Aug; 34(34):11325-38. doi:
10.1523/jneurosci.0458-14.2014. [PMID: 25143613] - Md Abdul Hannan, Md Mohibbullah, Seon-Yeong Hwang, Kyungyong Lee, Yang-Chun Kim, Yong-Ki Hong, Il Soo Moon. Differential neuritogenic activities of two edible brown macroalgae, Undaria pinnatifida and Saccharina japonica.
The American journal of Chinese medicine.
2014; 42(6):1371-84. doi:
10.1142/s0192415x14500864. [PMID: 25413631] - Aarti Khulbe, Savita Pandey, Sangeeta Pilkhwal Sah. Antidepressant-like action of the hydromethanolic flower extract of Tagetes erecta L. in mice and its possible mechanism of action.
Indian journal of pharmacology.
2013 Jul; 45(4):386-90. doi:
10.4103/0253-7613.115026. [PMID: 24014916] - Go Obara, Yumiko Toyohira, Hirohide Inagaki, Keita Takahashi, Takafumi Horishita, Takashi Kawasaki, Susumu Ueno, Masato Tsutsui, Takeyoshi Sata, Nobuyuki Yanagihara. Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells.
Journal of pharmacological sciences.
2013; 121(2):138-47. doi:
10.1254/jphs.12164fp. [PMID: 23370666] - Katsuhisa Kurogi, Mei Chen, Yoonjung Lee, Bo Shi, Teng Yan, Ming-Yih Liu, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Sulfation of buprenorphine, pentazocine, and naloxone by human cytosolic sulfotransferases.
Drug metabolism letters.
2012 Jun; 6(2):109-15. doi:
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Inflammopharmacology.
2011 Apr; 19(2):111-5. doi:
10.1007/s10787-010-0061-5. [PMID: 20957519] - Mohammad Saraji, Mohammad Taghi Jafari, Hossein Sherafatmand. Hollow fiber-based liquid-liquid-liquid microextraction combined with electrospray ionization-ion mobility spectrometry for the determination of pentazocine in biological samples.
Journal of chromatography. A.
2010 Aug; 1217(32):5173-8. doi:
10.1016/j.chroma.2010.06.035. [PMID: 20605025] - Naseem Saud Ahmad, Akbar Waheed, Muhammad Farman, Aisha Qayyum. Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice.
Journal of ethnopharmacology.
2010 May; 129(2):250-3. doi:
10.1016/j.jep.2010.03.017. [PMID: 20359528] - Felix J Kim, Ivanka Kovalyshyn, Maxim Burgman, Claire Neilan, Chih-Cheng Chien, Gavril W Pasternak. Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.
Molecular pharmacology.
2010 Apr; 77(4):695-703. doi:
10.1124/mol.109.057083. [PMID: 20089882] - Takayuki Furuishi, Toshiro Fukami, Toyofumi Suzuki, Kozo Takayama, Kazuo Tomono. Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine.
Biological & pharmaceutical bulletin.
2010; 33(2):294-300. doi:
10.1248/bpb.33.294. [PMID: 20118556] - Molly Johannessen, Subramaniam Ramachandran, Logan Riemer, Andrea Ramos-Serrano, Arnold E Ruoho, Meyer B Jackson. Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems.
American journal of physiology. Cell physiology.
2009 May; 296(5):C1049-57. doi:
10.1152/ajpcell.00431.2008. [PMID: 19279232] - Subramaniam Ramachandran, Uyen B Chu, Timur A Mavlyutov, Arindam Pal, Susan Pyne, Arnold E Ruoho. The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.
European journal of pharmacology.
2009 May; 609(1-3):19-26. doi:
10.1016/j.ejphar.2009.03.003. [PMID: 19285059] - Sylvia B Smith, Jennifer Duplantier, Ying Dun, Barbara Mysona, Penny Roon, Pamela M Martin, Vadivel Ganapathy. In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.
Investigative ophthalmology & visual science.
2008 Sep; 49(9):4154-61. doi:
10.1167/iovs.08-1824. [PMID: 18469181] - Mitsuhiro Wada, Rie Kurogi, Amal Kaddoumi, Mihoko N Nakashima, Kenichiro Nakashima. Pentazocine monitoring in rat hair and plasma by HPLC-fluorescence detection with DIB-Cl as a labelling reagent.
Luminescence : the journal of biological and chemical luminescence.
2007 May; 22(3):157-62. doi:
10.1002/bio.940. [PMID: 17089348] - Samer J Nuwayhid, Linda L Werling. Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
European journal of pharmacology.
2006 Mar; 535(1-3):98-103. doi:
10.1016/j.ejphar.2005.12.077. [PMID: 16480713] - Johann Meunier, Bénédicte Demeilliers, Aurélie Célérier, Tangui Maurice. Compensatory effect by sigma1 (sigma1) receptor stimulation during alcohol withdrawal in mice performing an object recognition task.
Behavioural brain research.
2006 Jan; 166(1):166-76. doi:
10.1016/j.bbr.2005.07.019. [PMID: 16191445] - F A Brightman, D E Leahy, G E Searle, S Thomas. Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jan; 34(1):84-93. doi:
10.1124/dmd.105.004804. [PMID: 16221757] - H R Y Prasad, Binod K Khaitan, M Ramam, Vinod K Sharma, Ravinder K Pandhi, Saurabh Agarwal, Anju Dhawan, Raka Jain, Manoj K Singh. Diagnostic clinical features of pentazocine-induced ulcers.
International journal of dermatology.
2005 Nov; 44(11):910-5. doi:
10.1111/j.1365-4632.2004.02291.x. [PMID: 16336522] - Subrata K Mandal, R Boominathan, B Parimaladevi, Saikat Dewanjee, Subhash C Mandal. Analgesic activity of methanol extract of Eupatorium adenophorum Spreng. leaves.
Indian journal of experimental biology.
2005 Jul; 43(7):662-3. doi:
". [PMID: 16053275] - Daniel Gebreselassie, Wayne D Bowen. Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes.
European journal of pharmacology.
2004 Jun; 493(1-3):19-28. doi:
10.1016/j.ejphar.2004.04.005. [PMID: 15189760] - Teruo Hayashi, Tsung-Ping Su. Intracellular dynamics of sigma-1 receptors (sigma(1) binding sites) in NG108-15 cells.
The Journal of pharmacology and experimental therapeutics.
2003 Aug; 306(2):726-33. doi:
10.1124/jpet.103.051292. [PMID: 12730356] - S B Raju, V Kumar, D Bhowmik, A K Dinda, A B Dey. Renal amyloidosis in a pentazocine addict.
The Journal of the Association of Physicians of India.
2002 Jul; 50(?):970. doi:
. [PMID: 12126358] - Alicia E Derbez, Rupal M Mody, Linda L Werling. Sigma(2)-receptor regulation of dopamine transporter via activation of protein kinase C.
The Journal of pharmacology and experimental therapeutics.
2002 Apr; 301(1):306-14. doi:
10.1124/jpet.301.1.306. [PMID: 11907188] - V Kumar, P N Singh, S K Bhattacharya. Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
Indian journal of experimental biology.
2001 Apr; 39(4):339-43. doi:
". [PMID: 11491578] - W Hamabe, R Fujita, T Yasusa, F Yoneda, A Yoshida, H Ueda. (-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors.
Cellular and molecular neurobiology.
2000 Dec; 20(6):695-702. doi:
10.1023/a:1007050808754. [PMID: 11100977] - T Hayashi, T Maurice, T P Su. Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.
The Journal of pharmacology and experimental therapeutics.
2000 Jun; 293(3):788-98. doi:
. [PMID: 10869377] - H Seno, T Kumazawa, A Ishii, H Matsushima, K Watanabe-Suzuki, O Suzuki. Determination of pentazocine in human whole blood and urine by gas chromatography/surface ionization organic mass spectrometry.
Journal of mass spectrometry : JMS.
2000 Jan; 35(1):33-8. doi:
10.1002/(sici)1096-9888(200001)35:1<33::aid-jms909>3.0.co;2-t. [PMID: 10633232] - P E Benedict, M B Benedict, T P Su, S F Bolling. Opiate drugs and delta-receptor-mediated myocardial protection.
Circulation.
1999 Nov; 100(19 Suppl):II357-60. doi:
10.1161/01.cir.100.suppl_2.ii-357. [PMID: 10567329] - M P Morin-Surun, T Collin, M Denavit-Saubié, E E Baulieu, F P Monnet. Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
Proceedings of the National Academy of Sciences of the United States of America.
1999 Jul; 96(14):8196-9. doi:
10.1073/pnas.96.14.8196. [PMID: 10393971] - J G Li, R B Raffa, P Cheung, T B Tzeng, L Y Liu-Chen. Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
European journal of pharmacology.
1998 Aug; 354(2-3):227-37. doi:
10.1016/s0014-2999(98)00444-0. [PMID: 9754924] - T Beppu, M Ogawa, T Yamanaka, H Egami, C Ohara, Y Masuda, S Kudo, M Kuramoto, K Doi, T Matsuda. [Clinical evaluation of Azasetron Hydrochloride: a new selective 5-HT3 receptor antagonist--antiemetic profile and plasma concentration in transcatheter arterial chemoembolization using CDDP for unresectable hepatocellular carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1998 Jul; 25(8):1197-202. doi:
NULL. [PMID: 9679583] - Y X Pan, J Mei, J Xu, B L Wan, A Zuckerman, G W Pasternak. Cloning and characterization of a mouse sigma1 receptor.
Journal of neurochemistry.
1998 Jun; 70(6):2279-85. doi:
10.1046/j.1471-4159.1998.70062279.x. [PMID: 9603192] - S Izenwasser, D Thompson-Montgomery, S E Deben, I N Chowdhury, L L Werling. Modulation of amphetamine-stimulated (transporter mediated) dopamine release in vitro by sigma2 receptor agonists and antagonists.
European journal of pharmacology.
1998 Apr; 346(2-3):189-96. doi:
10.1016/s0014-2999(98)00063-6. [PMID: 9652359] - P Seth, Y J Fei, H W Li, W Huang, F H Leibach, V Ganapathy. Cloning and functional characterization of a sigma receptor from rat brain.
Journal of neurochemistry.
1998 Mar; 70(3):922-31. doi:
10.1046/j.1471-4159.1998.70030922.x. [PMID: 9489711] - E Ameyibor, J T Stewart. Resolution and quantitation of pentazocine enantiomers in human serum by reversed-phase high-performance liquid chromatography using sulfated beta-cyclodextrin as chiral mobile phase additive and solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Dec; 703(1-2):273-8. doi:
10.1016/s0378-4347(97)00408-8. [PMID: 9448087] - T Suzuki, T Suganuma, J Nishino, M Hanano. Pharmacokinetics of pentazocine and its occupancy of opioid receptors in rat brain.
Biological & pharmaceutical bulletin.
1997 Nov; 20(11):1193-8. doi:
10.1248/bpb.20.1193. [PMID: 9401731] - D Simpson, R A Braithwaite, D R Jarvie, M J Stewart, S Walker, I W Watson, B Widdop. Screening for drugs of abuse (II): Cannabinoids, lysergic acid diethylamide, buprenorphine, methadone, barbiturates, benzodiazepines and other drugs.
Annals of clinical biochemistry.
1997 Sep; 34 ( Pt 5)(?):460-510. doi:
10.1177/000456329703400502. [PMID: 9293303] - J Lötsch, W Ditterich, T Hummel, G Kobal. Antinociceptive effects of the kappa-opioid receptor agonist RP 60180 compared with pentazocine in an experimental human pain model.
Clinical neuropharmacology.
1997 Jun; 20(3):224-33. doi:
10.1097/00002826-199706000-00006. [PMID: 9197945] - D Matecka, D Lewis, R B Rothman, C M Dersch, F H Wojnicki, J R Glowa, A C DeVries, A Pert, K C Rice. Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.
Journal of medicinal chemistry.
1997 Feb; 40(5):705-16. doi:
10.1021/jm9606599. [PMID: 9057857] - M J Eaton, K J Lookingland, K E Moore. The sigma ligand rimcazole activates noradrenergic neurons projecting to the paraventricular nucleus and increases corticosterone secretion in rats.
Brain research.
1996 Sep; 733(2):162-6. doi:
10.1016/0006-8993(96)00290-9. [PMID: 8891298] - C Torrence-Campbell, W D Bowen. Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions.
European journal of pharmacology.
1996 May; 304(1-3):201-10. doi:
10.1016/0014-2999(96)00109-4. [PMID: 8813603] - J Van Bocxlaer, E Meyer, K Clauwaert, W Lambert, M Piette, A De Leenheer. Analysis of zopiclone (Imovane) in postmortem specimens by GC-MS and HPLC with diode-array detection.
Journal of analytical toxicology.
1996 Jan; 20(1):52-4. doi:
10.1093/jat/20.1.52. [PMID: 8837952] - B J Vilner, C S John, W D Bowen. Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
Cancer research.
1995 Jan; 55(2):408-13. doi:
. [PMID: 7812973] - V K Mohan, Y K Batra, S Vaidyanathan, G D Puri. Analgesic and urodynamic effects of epidural meperidine and pentazocine--a comparative study.
International journal of clinical pharmacology and therapeutics.
1995 Jan; 33(1):34-7. doi:
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Biomedical chromatography : BMC.
1994 Sep; 8(5):255-7. doi:
10.1002/bmc.1130080512. [PMID: 7841772] - J Barg, G E Thomas, W T Bem, M D Parnes, A M Ho, M M Belcheva, R J McHale, J A McLachlan, K C Tolman, F E Johnson. In vitro and in vivo expression of opioid and sigma receptors in rat C6 glioma and mouse N18TG2 neuroblastoma cells.
Journal of neurochemistry.
1994 Aug; 63(2):570-4. doi:
10.1046/j.1471-4159.1994.63020570.x. [PMID: 8035181] - H Imaizumi, K Tsuruoka, Y Ujike, M Kaneko, A Namiki. [Hypoxic brain damage after prolonged cardiac arrest during anesthesia--changes in CT and serum NSE concentration].
Masui. The Japanese journal of anesthesiology.
1994 Aug; 43(8):1256-60. doi:
NULL. [PMID: 7933514] - S B Hellewell, A Bruce, G Feinstein, J Orringer, W Williams, W D Bowen. Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.
European journal of pharmacology.
1994 Jun; 268(1):9-18. doi:
10.1016/0922-4106(94)90115-5. [PMID: 7925616] - M J Ruano, V S Martínez-Zorzano, J A Cabezas, P Hueso. Ganglioside content of rat liver after administration of ethanol and pentazocine or sucrose supplemented diets.
Archives of toxicology.
1994; 68(9):576-81. doi:
10.1007/s002040050117. [PMID: 7998825] - I A Paul, A S Basile, E Rojas, M B Youdim, B De Costa, P Skolnick, H B Pollard, G A Kuijpers. Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1993 Sep; 7(12):1171-8. doi:
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European journal of pharmacology.
1993 May; 245(3):247-56. doi:
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Journal of medicinal chemistry.
1993 Mar; 36(5):566-71. doi:
10.1021/jm00057a006. [PMID: 8496936] - A S Basile, I A Paul, A Mirchevich, G Kuijpers, B De Costa. Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations.
Molecular pharmacology.
1992 Nov; 42(5):882-9. doi:
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Masui. The Japanese journal of anesthesiology.
1992 Nov; 41(11):1772-6. doi:
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Masui. The Japanese journal of anesthesiology.
1992 Jun; 41(6):968-72. doi:
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Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.
1992 Mar; 49(3):207-11. doi:
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Die Pharmazie.
1991 Jun; 46(6):464-5. doi:
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Journal of forensic sciences.
1990 Nov; 35(6):1424-30. doi:
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Journal of chromatography.
1990 Aug; 530(1):200-5. doi:
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Cancer research.
1990 Jul; 50(13):3997-4002. doi:
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Experimental and clinical endocrinology.
1990 Apr; 95(2):217-23. doi:
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Journal of veterinary pharmacology and therapeutics.
1990 Mar; 13(1):93-104. doi:
10.1111/j.1365-2885.1990.tb00753.x. [PMID: 2319641] - G Kobal, C Hummel, B Nuernberg, K Brune. Effects of pentazocine and acetylsalicylic acid on pain-rating, pain-related evoked potentials and vigilance in relationship to pharmacokinetic parameters.
Agents and actions.
1990 Mar; 29(3-4):342-59. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1990 Feb; 39(2):151-7. doi:
10.1016/0952-3278(90)90026-h. [PMID: 2111555] - G Misztal. [Identification of pentazocine, piritramide and methadone in blood using thin layer chromatography].
Acta poloniae pharmaceutica.
1990; 47(5-6):5-8. doi:
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Anesthesia and analgesia.
1989 Sep; 69(3):354-9. doi:
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FEBS letters.
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