BROMODICHLOROMETHANE (BioDeep_00001873639)
Main id: BioDeep_00000010097
Volatile Flavor Compounds
代谢物信息卡片
BROMODICHLOROMETHANE
化学式: CHBrCl2 (161.8638666)
中文名称: 二氯一溴甲烷, 溴二氯甲烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(Br)(Cl)Cl
InChI: InChI=1S/CHBrCl2/c2-1(3)4/h1H
描述信息
D009676 - Noxae > D002273 - Carcinogens
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:34591
- KEGG: C14708
- PubChem: 6359
- ChEMBL: CHEMBL346231
- CAS: 75-27-4
- PubChem: 17395707
- NIKKAJI: J1.448F
- RefMet: Bromodichloromethane
- KNApSAcK: 34591
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 52969 - Ascophyllum nodosum: 10.1126/SCIENCE.227.4690.1033
- 49266 - Fucus vesiculosus: 10.1126/SCIENCE.227.4690.1033
- 29227 - Mastocarpus stellatus: 10.1126/SCIENCE.227.4690.1033
- 63409 - Ulva linza: 10.1126/SCIENCE.227.4690.1033
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui Li, Yangyang Chu, Yanping Zhu, Xiaomeng Han, Shihu Shu. Trihalomethane prediction model for water supply system based on machine learning and Log-linear regression.
Environmental geochemistry and health.
2024 Jan; 46(2):31. doi:
10.1007/s10653-023-01778-3. [PMID: 38227052] - Naseeba Parveen, Papiya Mondal, Kumar Raja Vanapalli, Abhijit Das, Sudha Goel. Phytotoxicity of trihalomethanes and trichloroacetic acid on Vigna radiata and Allium cepa plant models.
Environmental science and pollution research international.
2024 Jan; 31(4):5100-5115. doi:
10.1007/s11356-023-31419-2. [PMID: 38110686] - Yang Sun, Yi-Xin Wang, Vicente Mustieles, Zhilei Shan, Yu Zhang, Carmen Messerlian. Blood trihalomethane concentrations and allergic sensitization: A nationwide cross-sectional study.
The Science of the total environment.
2023 Feb; ?(?):162100. doi:
10.1016/j.scitotenv.2023.162100. [PMID: 36764558] - Yang Sun, Yi-Xin Wang, Chong Liu, Ying-Jun Chen, Wen-Qing Lu, Carmen Messerlian. Trimester-Specific Blood Trihalomethane and Urinary Haloacetic Acid Concentrations and Adverse Birth Outcomes: Identifying Windows of Vulnerability during Pregnancy.
Environmental health perspectives.
2020 10; 128(10):107001. doi:
10.1289/ehp7195. [PMID: 33026246] - Bin Zhou, Pan Yang, Ya-Jie Gong, Qiang Zeng, Wen-Qing Lu, Xiao-Ping Miao. Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.
Environmental pollution (Barking, Essex : 1987).
2018 Dec; 243(Pt B):1126-1133. doi:
10.1016/j.envpol.2018.09.083. [PMID: 30253304] - Ying Zhang, Ning Zhang, Zhiguang Niu. Health risk assessment of trihalomethanes mixtures from daily water-related activities via multi-pathway exposure based on PBPK model.
Ecotoxicology and environmental safety.
2018 Nov; 163(?):427-435. doi:
10.1016/j.ecoenv.2018.07.073. [PMID: 30075445] - Cong Li, Feng Luo, Feilong Dong, Jingguo Zhao, Tuqiao Zhang, Guilin He, Leslie Cizmas, Virender K Sharma. Chlorine decay and trihalomethane formation following ferrate(VI) preoxidation and chlorination of drinking water.
Chemosphere.
2017 Nov; 187(?):413-420. doi:
10.1016/j.chemosphere.2017.08.084. [PMID: 28863294] - Jelle Vlaanderen, Karin van Veldhoven, Laia Font-Ribera, Cristina M Villanueva, Marc Chadeau-Hyam, Lützen Portengen, Joan O Grimalt, Christian Zwiener, Dick Heederik, Xiangru Zhang, Paolo Vineis, Manolis Kogevinas, Roel Vermeulen. Acute changes in serum immune markers due to swimming in a chlorinated pool.
Environment international.
2017 08; 105(?):1-11. doi:
10.1016/j.envint.2017.04.009. [PMID: 28478232] - Hiroshi Matsumoto, Fumiyo Saito, Masahiro Takeyoshi. Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats.
The Journal of toxicological sciences.
2017; 42(2):175-181. doi:
10.2131/jts.42.175. [PMID: 28321044] - Firas Alhasson, Diptadip Dattaroy, Suvarthi Das, Varun Chandrashekaran, Ratanesh Kumar Seth, Rick G Schnellmann, Saurabh Chatterjee. NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
American journal of physiology. Renal physiology.
2016 Jan; 310(1):F85-F101. doi:
10.1152/ajprenal.00243.2015. [PMID: 26447219] - Minashree Kumari, S K Gupta, B K Mishra. Multi-exposure cancer and non-cancer risk assessment of trihalomethanes in drinking water supplies - A case study of Eastern region of India.
Ecotoxicology and environmental safety.
2015 Mar; 113(?):433-8. doi:
10.1016/j.ecoenv.2014.12.028. [PMID: 25544653] - Ratanesh Kumar Seth, Suvarthi Das, Ashutosh Kumar, Anindya Chanda, Maria B Kadiiska, Gregory Michelotti, Jose Manautou, Anna Mae Diehl, Saurabh Chatterjee. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis.
Toxicology and applied pharmacology.
2014 Jan; 274(1):42-54. doi:
10.1016/j.taap.2013.10.029. [PMID: 24211274] - Jing Liao, Xiao-Feng Li, Shun-Chang Zhou, Yan Luo, Ai-Lin Liu, Wen-Qing Lu. Bromodichloromethane induces cell proliferation in different tissues of male F344 rats by suppression of E-cadherin expression via hypermethylation or transcriptional activation of c-myc and cyclin D1.
Toxicology letters.
2013 Nov; 223(2):162-74. doi:
10.1016/j.toxlet.2013.08.016. [PMID: 24001804] - Ratanesh Kumar Seth, Ashutosh Kumar, Suvarthi Das, Maria B Kadiiska, Gregory Michelotti, Anna Mae Diehl, Saurabh Chatterjee. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Aug; 134(2):291-303. doi:
10.1093/toxsci/kft104. [PMID: 23640861] - Suvarthi Das, Ashutosh Kumar, Ratanesh Kumar Seth, Erik J Tokar, Maria B Kadiiska, Michael P Waalkes, Ronald P Mason, Saurabh Chatterjee. Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity.
Toxicology and applied pharmacology.
2013 Jun; 269(3):297-306. doi:
10.1016/j.taap.2013.02.003. [PMID: 23438451] - Marianne E McMaster. Heated indoor swimming pools, infants, and the pathogenesis of adolescent idiopathic scoliosis: a neurogenic hypothesis.
Environmental health : a global access science source.
2011 Oct; 10(?):86. doi:
10.1186/1476-069x-10-86. [PMID: 21975145] - Mrittika Basu, Sunil Kumar Gupta, Gurdeep Singh, Ujjal Mukhopadhyay. Multi-route risk assessment from trihalomethanes in drinking water supplies.
Environmental monitoring and assessment.
2011 Jul; 178(1-4):121-34. doi:
10.1007/s10661-010-1677-z. [PMID: 20824332] - Laia Font-Ribera, Manolis Kogevinas, Jan-Paul Zock, Federico P Gómez, Esther Barreiro, Mark J Nieuwenhuijsen, Pilar Fernandez, Carolina Lourencetti, Maitane Pérez-Olabarría, Mariona Bustamante, Ricard Marcos, Joan O Grimalt, Cristina M Villanueva. Short-term changes in respiratory biomarkers after swimming in a chlorinated pool.
Environmental health perspectives.
2010 Nov; 118(11):1538-44. doi:
10.1289/ehp.1001961. [PMID: 20833607] - Manolis Kogevinas, Cristina M Villanueva, Laia Font-Ribera, Danae Liviac, Mariona Bustamante, Felicidad Espinoza, Mark J Nieuwenhuijsen, Aina Espinosa, Pilar Fernandez, David M DeMarini, Joan O Grimalt, Tamara Grummt, Ricard Marcos. Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools.
Environmental health perspectives.
2010 Nov; 118(11):1531-7. doi:
10.1289/ehp.1001959. [PMID: 20833606] - Susan D Richardson, David M DeMarini, Manolis Kogevinas, Pilar Fernandez, Esther Marco, Carolina Lourencetti, Clara Ballesté, Dick Heederik, Kees Meliefste, A Bruce McKague, Ricard Marcos, Laia Font-Ribera, Joan O Grimalt, Cristina M Villanueva. What's in the pool? A comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming pool water.
Environmental health perspectives.
2010 Nov; 118(11):1523-30. doi:
10.1289/ehp.1001965. [PMID: 20833605] - Damien Mouly, Eric Joulin, Christophe Rosin, Pascal Beaudeau, Abdelkrim Zeghnoun, Agnès Olszewski-Ortar, Jean François Munoz, Bénédicte Welté, Michel Joyeux, René Seux, Antoine Montiel, M J Rodriguez. Variations in trihalomethane levels in three French water distribution systems and the development of a predictive model.
Water research.
2010 Oct; 44(18):5168-79. doi:
10.1016/j.watres.2010.06.028. [PMID: 20663536] - Gilda Carrasco, Miguel Urrestarazu. Green chemistry in protected horticulture: the use of peroxyacetic acid as a sustainable strategy.
International journal of molecular sciences.
2010 May; 11(5):1999-2009. doi:
10.3390/ijms11051999. [PMID: 20559497] - Natalia Jakubowska, Bernhard Henkelmann, Karl-Werner Schramm, Jacek Namiesnik. Optimization of a novel procedure for determination of VOCs in water and human urine samples based on SBSE coupled with TD-GC-HRMS.
Journal of chromatographic science.
2009 Sep; 47(8):689-93. doi:
10.1093/chromsci/47.8.689. [PMID: 19772746] - Wen-Hsi Cheng. Using a biological aerated filter to treat mixed water-borne volatile organic compounds and assessing its emissions.
Journal of environmental sciences (China).
2009; 21(11):1497-502. doi:
10.1016/s1001-0742(08)62446-8. [PMID: 20108681] - J Caro, M Gallego. Alveolar air and urine analyses as biomarkers of exposure to trihalomethanes in an indoor swimming pool.
Environmental science & technology.
2008 Jul; 42(13):5002-7. doi:
10.1021/es800415p. [PMID: 18678040] - Orapin Thapsingkaew, Werawan Ruangyuttikarn, Vilailuck Kijjanapanich. Reduction of trihalomethane formation and detoxification of microcystins in tap water by ozonation.
Journal of water and health.
2008 Jun; 6(2):281-8. doi:
10.2166/wh.2008.031. [PMID: 18209290] - Marisa Mazari-Hiriart, Sergio Ponce-de-León, Yolanda López-Vidal, Pilar Islas-Macías, Rosa Isabel Amieva-Fernández, Francisco Quiñones-Falconi. Microbiological implications of periurban agriculture and water reuse in Mexico City.
PloS one.
2008 May; 3(5):e2305. doi:
10.1371/journal.pone.0002305. [PMID: 18509453] - C Andrew James, Gang Xin, Sharon L Doty, Stuart E Strand. Degradation of low molecular weight volatile organic compounds by plants genetically modified with mammalian cytochrome P450 2E1.
Environmental science & technology.
2008 Jan; 42(1):289-93. doi:
10.1021/es071197z. [PMID: 18350910] - Yu-Mei Tan, Kai H Liao, Harvey J Clewell. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling.
Journal of exposure science & environmental epidemiology.
2007 Nov; 17(7):591-603. doi:
10.1038/sj.jes.7500540. [PMID: 17108893] - Teresa L Leavens, Benjamin C Blount, David M DeMarini, Michael C Madden, John L Valentine, Martin W Case, Lalith K Silva, Sarah H Warren, Nancy M Hanley, Rex A Pegram. Disposition of bromodichloromethane in humans following oral and dermal exposure.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Oct; 99(2):432-45. doi:
10.1093/toxsci/kfm190. [PMID: 17656487] - S R Bielmeier, A S Murr, D S Best, R A Harrison, R A Pegram, J M Goldman, M G Narotsky. Effects of bromodichloromethane on ex vivo and in vitro luteal function and bromodichloromethane tissue dosimetry in the pregnant F344 rat.
Toxicology in vitro : an international journal published in association with BIBRA.
2007 Aug; 21(5):919-28. doi:
10.1016/j.tiv.2007.01.017. [PMID: 17344021] - J Caro, M Gallego. Assessment of exposure of workers and swimmers to trihalomethanes in an indoor swimming pool.
Environmental science & technology.
2007 Jul; 41(13):4793-8. doi:
10.1021/es070084c. [PMID: 17695931] - . Toxicology studies of bromodichloromethane (CAS No. 75-27-4) in genetically modified (FVB Tg.AC Hemizygous) mice (dermal, drinking water, and gavage studies) and carcinogenicity studies of bromodichloromethane in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water and gavage studies).
National Toxicology Program genetically modified model report.
2007 May; ?(5):1-227. doi:
. [PMID: 18784761] - J Caro, A Serrano, M Gallego. Sensitive headspace gas chromatography-mass spectrometry determination of trihalomethanes in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):277-82. doi:
10.1016/j.jchromb.2006.10.034. [PMID: 17092785] - . NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in male F344/N rats and female B6C3F1 mice (Drinking Water Studies).
National Toxicology Program technical report series.
2006 Feb; ?(532):1-248. doi:
. [PMID: 16741555] - Uffe Ravnskov. Experimental glomerulonephritis induced by hydrocarbon exposure: a systematic review.
BMC nephrology.
2005 Dec; 6(?):15. doi:
10.1186/1471-2369-6-15. [PMID: 16354301] - Kevin S McDorman, Brian F Pachkowski, Jun Nakamura, Douglas C Wolf, James A Swenberg. Oxidative DNA damage from potassium bromate exposure in Long-Evans rats is not enhanced by a mixture of drinking water disinfection by-products.
Chemico-biological interactions.
2005 Apr; 152(2-3):107-17. doi:
10.1016/j.cbi.2005.02.003. [PMID: 15840384] - Bunyarit Panyapinyopol, Taha F Marhaba, Vorapot Kanokkantapong, Prasert Pavasant. Characterization of precursors to trihalomethanes formation in Bangkok source water.
Journal of hazardous materials.
2005 Apr; 120(1-3):229-36. doi:
10.1016/j.jhazmat.2005.01.009. [PMID: 15811685] - Luigi Robbiano, Debora Baroni, Roberto Carrozzino, Eugenio Mereto, Giovanni Brambilla. DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney.
Toxicology.
2004 Nov; 204(2-3):187-95. doi:
10.1016/j.tox.2004.06.057. [PMID: 15388244] - Jeffrey Charrois, David Graham, Steve Hrudey, Kenneth Froese. Disinfection by-products in small Alberta community drinking-water supplies.
Journal of toxicology and environmental health. Part A.
2004 Oct; 67(20-22):1797-803. doi:
10.1080/15287390490492494. [PMID: 15371217] - Ted Lock, Lisa Cottrell, Tony Soames, Matt Jacobsen, Rebecca Williams. Formic acid excretion in rats and mice exposed to bromodichloromethane: a possible link to renal tubule cell proliferation in long-term studies.
Archives of toxicology.
2004 Jul; 78(7):410-7. doi:
10.1007/s00204-004-0548-1. [PMID: 15141287] - N Campillo, P Viñas, I López-García, N Aguinaga, M Hernández-Córdoba. Purge-and-trap capillary gas chromatography with atomic emission detection for volatile halogenated organic compounds determination in waters and beverages.
Journal of chromatography. A.
2004 Apr; 1035(1):1-8. doi:
10.1016/j.chroma.2004.02.029. [PMID: 15117067] - Matthew K Ross, Rex A Pegram. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
Toxicology and applied pharmacology.
2004 Mar; 195(2):166-81. doi:
10.1016/j.taap.2003.11.019. [PMID: 14998683] - Susan R Bielmeier, Deborah S Best, Michael G Narotsky. Serum hormone characterization and exogeneous hormone rescue of bromodichloromethane-induced pregnancy loss in the F344 rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2004 Jan; 77(1):101-8. doi:
10.1093/toxsci/kfh017. [PMID: 14657523] - Kevin S McDorman, Michelle J Hooth, Thomas B Starr, Douglas C Wolf. Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products.
Toxicology.
2003 May; 187(1):1-12. doi:
10.1016/s0300-483x(03)00004-0. [PMID: 12679048] - A Sarmiento, M Rojas, E Medina, C Olivet, J Casanova. [Trihalomethanes in the drinking water of Carabobo State, Venezuela].
Gaceta sanitaria.
2003 Mar; 17(2):137-43. doi:
10.1016/s0213-9111(03)71711-7. [PMID: 12729541] - Michelle J Hooth, Kevin S McDorman, Susan D Hester, Michael H George, Lance R Brooks, Adam E Swank, Douglas C Wolf. The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Oct; 69(2):322-31. doi:
10.1093/toxsci/69.2.322. [PMID: 12377981] - John W Allis, Brian P Anderson, Guangyu Zhao, Tracey M Ross, Rex A Pegram. Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane in rat liver.
Toxicology.
2002 Jul; 176(1-2):25-37. doi:
10.1016/s0300-483x(02)00088-4. [PMID: 12062927] - T K Nissinen, I T Miettinen, P J Martikainen, T Vartiainen. Disinfection by-products in Finnish drinking waters.
Chemosphere.
2002 Jul; 48(1):9-20. doi:
10.1016/s0045-6535(02)00034-6. [PMID: 12137063] - Guangyu Zhao, John W Allis. Kinetics of bromodichloromethane metabolism by cytochrome P450 isoenzymes in human liver microsomes.
Chemico-biological interactions.
2002 May; 140(2):155-68. doi:
10.1016/s0009-2797(02)00021-2. [PMID: 12076522] - Michael H George, Greg R Olson, Donald Doerfler, Tanya Moore, Steve Kilburn, Anthony B DeAngelo. Carcinogenicity of bromodichloromethane administered in drinking water to Male F344/N Rats and B6C3F1 mice.
International journal of toxicology.
2002 May; 21(3):219-30. doi:
10.1080/10915810290096351. [PMID: 12055023] - Stuart Batterman, Lian Zhang, Shugin Wang, Alfred Franzblau. Partition coefficients for the trihalomethanes among blood, urine, water, milk and air.
The Science of the total environment.
2002 Feb; 284(1-3):237-47. doi:
10.1016/s0048-9697(01)00890-7. [PMID: 11846168] - Hekap Kim, Jaeho Shim, Soohyung Lee. Formation of disinfection by-products in chlorinated swimming pool water.
Chemosphere.
2002 Jan; 46(1):123-30. doi:
10.1016/s0045-6535(00)00581-6. [PMID: 11806524] - V R Torti, A J Cobb, J I Everitt, M W Marshall, G A Boorman, B E Butterworth. Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 Dec; 64(2):269-80. doi:
10.1093/toxsci/64.2.269. [PMID: 11719710] - M S Christian, R G York, A M Hoberman, R M Diener, L C Fisher, G A Gates. Biodisposition of dibromoacetic acid (DBA) and bromodichloromethane (BDCM) administered to rats and rabbits in drinking water during range-finding reproduction and developmental toxicity studies.
International journal of toxicology.
2001 Jul; 20(4):239-53. doi:
10.1080/109158101750408064. [PMID: 11563419] - S R Bielmeier, D S Best, D L Guidici, M G Narotsky. Pregnancy loss in the rat caused by bromodichloromethane.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 Feb; 59(2):309-15. doi:
10.1093/toxsci/59.2.309. [PMID: 11158724] - T E Keegan, J E Simmons, R A Pegram. NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F344 rats.
Journal of toxicology and environmental health. Part A.
1998 Sep; 55(1):65-75. doi:
10.1080/009841098158629. [PMID: 9747604] - P D Lilly, M E Andersen, T M Ross, R A Pegram. A physiologically based pharmacokinetic description of the oral uptake, tissue dosimetry, and rates of metabolism of bromodichloromethane in the male rat.
Toxicology and applied pharmacology.
1998 Jun; 150(2):205-17. doi:
10.1006/taap.1998.8405. [PMID: 9653052] - R L Melnick, M C Kohn, J K Dunnick, J R Leininger. Regenerative hyperplasia is not required for liver tumor induction in female B6C3F1 mice exposed to trihalomethanes.
Toxicology and applied pharmacology.
1998 Jan; 148(1):137-47. doi:
10.1006/taap.1997.8302. [PMID: 9465273] - P D Lilly, M E Andersen, T M Ross, R A Pegram. Physiologically based estimation of in vivo rates of bromodichloromethane metabolism.
Toxicology.
1997 Dec; 124(2):141-52. doi:
10.1016/s0300-483x(97)00146-7. [PMID: 9458004] - M G Narotsky, R A Pegram, R J Kavlock. Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride in rats.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1997 Nov; 40(1):30-6. doi:
10.1006/faat.1997.2376. [PMID: 9398485] - P D Lilly, T M Ross, R A Pegram. Trihalomethane comparative toxicity: acute renal and hepatic toxicity of chloroform and bromodichloromethane following aqueous gavage.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1997 Nov; 40(1):101-10. doi:
10.1006/faat.1997.2372. [PMID: 9398492] - P Gao, J R Thornton-Manning, R A Pegram. Protective effects of glutathione on bromodichloromethane in vivo toxicity and in vitro macromolecular binding in Fischer 344 rats.
Journal of toxicology and environmental health.
1996 Oct; 49(2):145-59. doi:
10.1080/009841096160899. [PMID: 8874533] - P D Lilly, J E Simmons, R A Pegram. Effect of subchronic corn oil gavage on the acute toxicity of orally administered bromodichloromethane.
Toxicology letters.
1996 Oct; 87(2-3):93-102. doi:
10.1016/0378-4274(96)03765-4. [PMID: 8914616] - J R Thornton-Manning, J C Seely, R A Pegram. Toxicity of bromodichloromethane in female rats and mice after repeated oral dosing.
Toxicology.
1994 Nov; 94(1-3):3-18. doi:
10.1016/0300-483x(94)90024-8. [PMID: 7801327] - P D Lilly, J E Simmons, R A Pegram. Dose-dependent vehicle differences in the acute toxicity of bromodichloromethane.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1994 Jul; 23(1):132-40. doi:
10.1006/faat.1994.1089. [PMID: 7958557] - M M Lipsky, M Skinner, C O'Connell. Effects of chloroform and bromodichloromethane on DNA synthesis in male F344 rat kidney.
Environmental health perspectives.
1993 Dec; 101 Suppl 5(?):249-52. doi:
10.1289/ehp.93101s5249. [PMID: 8013415] - Y Aida, K Takada, O Uchida, K Yasuhara, Y Kurokawa, M Tobe. Toxicities of microencapsulated tribromomethane, dibromochloromethane and bromodichloromethane administered in the diet to Wistar rats for one month.
The Journal of toxicological sciences.
1992 Aug; 17(3):119-33. doi:
10.2131/jts.17.119. [PMID: 1453497] - Y Aida, K Yasuhara, K Takada, Y Kurokawa, M Tobe. Chronic toxicity of microencapsulated bromodichloromethane administered in the diet to Wistar rats.
The Journal of toxicological sciences.
1992 May; 17(2):51-68. doi:
10.2131/jts.17.51. [PMID: 1507274] - J M Mathews, P S Troxler, A R Jeffcoat. Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses.
Journal of toxicology and environmental health.
1990 May; 30(1):15-22. doi:
10.1080/15287399009531406. [PMID: 2112202] - J K Dunnick, S L Eustis, H S Lilja. Bromodichloromethane, a trihalomethane that produces neoplasms in rodents.
Cancer research.
1987 Oct; 47(19):5189-93. doi:
. [PMID: 3621204] - Y Koyama, Y Nakazawa. Comparison of the effect of trihalomethanes on lipid metabolism in rat liver slice.
Toxicology letters.
1986 Apr; 31(1):37-44. doi:
10.1016/0378-4274(86)90192-x. [PMID: 3715915] - Y Koyama, Y Nakazawa. Acute effect of bromodichloromethane on lipid metabolism in rat liver microsomes.
Toxicology letters.
1985 Dec; 29(2-3):123-30. doi:
10.1016/0378-4274(85)90032-3. [PMID: 4089880] - W R Hewitt, E M Brown, G L Plaa. Acetone-induced potentiation of trihalomethane toxicity in male rats.
Toxicology letters.
1983 May; 16(3-4):285-96. doi:
10.1016/0378-4274(83)90189-3. [PMID: 6857724] - J A Ruddick, D C Villeneuve, I Chu, V E Valli. A teratological assessment of four trihalomethanes in the rat.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
1983; 18(3):333-49. doi:
10.1080/03601238309372373. [PMID: 6875216] - L W Condie, C L Smallwood, R D Laurie. Comparative renal and hepatotoxicity of halomethanes: bromodichloromethane, bromoform, chloroform, dibromochloromethane and methylene chloride.
Drug and chemical toxicology.
1983; 6(6):563-78. doi:
10.3109/01480548309017810. [PMID: 6653442] - I Chu, D C Villeneuve, V E Secours, G C Becking, V E Valli. Toxicity of trihalomethanes: I. The acute and subacute toxicity of chloroform, bromodichloromethane, chlorodibromomethane and bromoform in rats.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
1982; 17(3):205-24. doi:
10.1080/03601238209372314. [PMID: 7096898]