4-Toluenesulfonamide (BioDeep_00001873626)

   


代谢物信息卡片


4-Toluenesulfonamide

化学式: C7H9NO2S (171.0354)
中文名称: 对甲苯磺酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)S(=O)(=O)N
InChI: InChI=1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

描述信息

C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

4 个代谢物同义名

4-Toluenesulfonamide; P-TOLUENESULFONAMIDE; 4-Toluenesulfonamide; P-Toluenesulfonamide



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 BCL2, CCND1, CUL1, EIF4EBP1, MAPK14, MSMP, MTOR, MYLK, VEGFA
Peripheral membrane protein 2 CYP1B1, MTOR
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, HSP90B1, MTOR
Nucleus 9 BCL2, CA9, CCND1, CUL1, EIF4EBP1, HSP90B1, MAPK14, MTOR, VEGFA
cytosol 9 BCL2, CCND1, CUL1, EIF4EBP1, HCCS, HSP90B1, MAPK14, MTOR, MYLK
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 CCND1
nucleoplasm 5 ATP2B1, CCND1, CUL1, MAPK14, MTOR
Cell membrane 3 ATP2B1, CA9, PDCD1
Lipid-anchor 1 HCCS
Cytoplasmic side 1 MTOR
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 MTOR
Synapse 2 ATP2B1, MYLK
cell surface 1 VEGFA
glutamatergic synapse 2 ATP2B1, MAPK14
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 HCCS
presynaptic membrane 1 ATP2B1
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 1 MTOR
plasma membrane 6 ATP2B1, BCHE, CA9, CUL1, MYLK, PDCD1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 ATP2B1, BCL2, CA9, CYP1B1, HCCS, HSP90B1, MTOR, PDCD1, VEGFA
axon 1 CCK
basolateral plasma membrane 2 ATP2B1, CA9
extracellular exosome 2 ATP2B1, HSP90B1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HSP90B1, VEGFA
extracellular space 4 BCHE, CCK, MSMP, VEGFA
perinuclear region of cytoplasm 1 HSP90B1
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 4 BCL2, CYP1B1, HCCS, MAPK14
protein-containing complex 2 BCL2, HSP90B1
intracellular membrane-bounded organelle 2 ATP2B1, CYP1B1
Microsome membrane 2 CYP1B1, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CA9
Secreted 4 BCHE, CCK, MSMP, VEGFA
extracellular region 5 BCHE, CCK, HSP90B1, MAPK14, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 PDCD1
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 MYLK
nucleolus 1 CA9
midbody 1 HSP90B1
Cell projection, lamellipodium 1 MYLK
Mitochondrion inner membrane 1 HCCS
pore complex 1 BCL2
focal adhesion 1 HSP90B1
extracellular matrix 1 VEGFA
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
lateral plasma membrane 1 ATP2B1
nuclear speck 1 MAPK14
cell projection 1 ATP2B1
Nucleus, nucleolus 1 CA9
spindle pole 1 MAPK14
blood microparticle 1 BCHE
Basolateral cell membrane 1 ATP2B1
Cell projection, microvillus membrane 1 CA9
microvillus membrane 1 CA9
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Melanosome 1 HSP90B1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
stress fiber 1 MYLK
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 BCHE, HSP90B1
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
immunological synapse 1 ATP2B1
nuclear envelope lumen 1 BCHE
Sarcoplasmic reticulum lumen 1 HSP90B1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 CUL1
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
SCF ubiquitin ligase complex 1 CUL1
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
cullin-RING ubiquitin ligase complex 1 CUL1


文献列表

  • Jui-Ling Hsu, Wohn-Jenn Leu, Nan-Shan Zhong, Jih-Hwa Guh. Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26195967. [PMID: 34641511]
  • Ramazan Demirdağ, Veysel Çomaklı, Murat Şentürk, Deniz Ekinci, Ö İrfan Küfrevioğlu, Claudiu T Supuran. Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity. Bioorganic & medicinal chemistry. 2013 Mar; 21(6):1522-5. doi: 10.1016/j.bmc.2012.08.018. [PMID: 22974493]
  • Raffaella Meffe, Claus Kohfahl, Ekkehard Holzbecher, Gudrun Massmann, Doreen Richter, Uwe Dünnbier, Asaf Pekdeger. Modelling the removal of p-TSA (para-toluenesulfonamide) during rapid sand filtration used for drinking water treatment. Water research. 2010 Jan; 44(1):205-13. doi: 10.1016/j.watres.2009.08.046. [PMID: 19766287]
  • Doreen Richter, Gudrun Massmann, Thomas Taute, Uwe Duennbier. Investigation of the fate of sulfonamides downgradient of a decommissioned sewage farm near Berlin, Germany. Journal of contaminant hydrology. 2009 May; 106(3-4):183-94. doi: 10.1016/j.jconhyd.2009.03.001. [PMID: 19371963]
  • Mika Hilvo, Anna Maria Salzano, Alessio Innocenti, Markku S Kulomaa, Andrea Scozzafava, Andrea Scaloni, Seppo Parkkila, Claudiu T Supuran. Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Journal of medicinal chemistry. 2009 Feb; 52(3):646-54. doi: 10.1021/jm801267c. [PMID: 19193158]
  • Doreen Richter, Gudrun Massmann, Uwe Dünnbier. Behaviour and biodegradation of sulfonamides (p-TSA, o-TSA, BSA) during drinking water treatment. Chemosphere. 2008 Apr; 71(8):1574-81. doi: 10.1016/j.chemosphere.2007.11.026. [PMID: 18179813]
  • Mary A Soliman, Joel A Pedersen, Heesu Park, Angelica Castaneda-Jimenez, Michael K Stenstrom, I H Mel Suffet. Human pharmaceuticals, antioxidants, and plasticizers in wastewater treatment plant and water reclamation plant effluents. Water environment research : a research publication of the Water Environment Federation. 2007 Feb; 79(2):156-67. doi: 10.2175/106143006x111961. [PMID: 17370841]
  • S B Levy. Allergenic ingredients in nail polishes. Contact dermatitis. 1998 May; 38(5):303. doi: 10.1111/j.1600-0536.1998.tb05761.x. [PMID: 9667464]
  • B M Hausen, M Milbrodt, W A Koenig. The allergens of nail polish. (I). Allergenic constituents of common nail polish and toluenesulfonamide-formaldehyde resin (TS-F-R). Contact dermatitis. 1995 Sep; 33(3):157-64. doi: 10.1111/j.1600-0536.1995.tb00537.x. [PMID: 8565455]
  • P Eggena, J D Barrett, C E Wiedman, M P Sambhi. Studies on renin activation in normal human plasma. Hypertension (Dallas, Tex. : 1979). 1979 Sep; 1(5):523-8. doi: 10.1161/01.hyp.1.5.523. [PMID: 94312]