2-picoline (BioDeep_00001873612)

Main id: BioDeep_00000001198

 

natural product


代谢物信息卡片


2-METHYLPYRIDINE

化学式: C6H7N (93.0578)
中文名称: 2-甲基吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=CC=N1
InChI: InChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3

描述信息

同义名列表

4 个代谢物同义名

2-METHYLPYRIDINE; 2-picoline; 2-Methylpyridine; 2-Methylpyridine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, BCL2, CASP3, CASP7, CAT, CNP, CUL3, DNAH5, PICK1
Golgi apparatus, trans-Golgi network membrane 1 AP4M1
Peripheral membrane protein 4 ACHE, AP4M1, MBP, PICK1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 7 ACHE, BCL2, CASP3, CASP7, CUL3, CUL5, MBP
cytosol 11 AP4M1, BCL2, CASP3, CASP7, CAT, CUL3, CUL5, GPT, GSR, MBP, PICK1
trans-Golgi network 2 AP4M1, PCSK5
centrosome 1 CUL3
nucleoplasm 3 CASP3, CASP7, CUL3
Cell membrane 4 ACE, ACHE, GPRC5A, ITGAM
Lipid-anchor 2 CNP, PICK1
Cytoplasmic side 1 MBP
Multi-pass membrane protein 1 GPRC5A
Synapse 4 ACHE, CNP, MBP, PICK1
cell surface 3 ACHE, ITGAM, MBP
glutamatergic synapse 2 CASP3, CUL3
Golgi apparatus 5 ACHE, AP4M1, CUL3, PCSK5, PICK1
Golgi membrane 1 PCSK5
mitochondrial inner membrane 1 CNP
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, MBP
postsynapse 1 CUL3
presynaptic membrane 1 PICK1
synaptic vesicle 1 PICK1
Cytoplasm, cytosol 1 CASP7
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 8 ACE, ACHE, BCHE, CUL3, GPRC5A, ITGAM, MBP, PICK1
Membrane 9 ACE, ACHE, BCL2, CAT, CNP, CUL3, ITGAM, PCSK5, PICK1
extracellular exosome 10 ACE, AP4M1, CAT, CNP, CUL3, GPRC5A, GPT, GSR, ITGAM, MBP
endoplasmic reticulum 1 BCL2
extracellular space 7 ACE, ACHE, BCHE, CASP7, CNP, ITGAM, PCSK5
perinuclear region of cytoplasm 3 ACHE, CNP, PICK1
mitochondrion 3 BCL2, CAT, GSR
protein-containing complex 3 BCL2, CAT, MBP
intracellular membrane-bounded organelle 3 CAT, GPRC5A, PICK1
postsynaptic density 2 CASP3, PICK1
Single-pass type I membrane protein 2 ACE, ITGAM
Secreted 3 ACE, ACHE, BCHE
extracellular region 7 ACE, ACHE, BCHE, CAT, DNAH5, MBP, PCSK5
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CNP
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
motile cilium 1 DNAH5
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CUL3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ACE, GSR, ITGAM
cytoplasmic vesicle 1 AP4M1
nucleolus 1 GPRC5A
clathrin adaptor complex 1 AP4M1
Early endosome 1 AP4M1
vesicle 1 GPRC5A
Cytoplasm, perinuclear region 1 PICK1
Membrane raft 1 ITGAM
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 PICK1
Cytoplasm, cytoskeleton, spindle 1 CUL3
focal adhesion 1 CAT
microtubule 2 CNP, DNAH5
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 MBP
axoneme 1 DNAH5
receptor complex 1 GPRC5A
neuron projection 1 PICK1
cell periphery 1 MBP
mitotic spindle 1 CUL3
cytoskeleton 1 PICK1
[Isoform 3]: Nucleus 1 MBP
Secreted, extracellular space 1 CASP7
brush border membrane 1 ACE
Golgi apparatus, trans-Golgi network 1 AP4M1
spindle pole 1 CUL3
blood microparticle 1 BCHE
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH5
Cell projection, cilium, flagellum 1 CUL3
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 ACHE
Cytoplasm, cytoskeleton, spindle pole 1 CUL3
sperm flagellum 1 CUL3
Cul3-RING ubiquitin ligase complex 1 CUL3
Endomembrane system 1 AP4M1
endosome lumen 1 AP4M1
microvillus 1 CNP
Cytoplasmic vesicle membrane 1 GPRC5A
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 1 CNP
side of membrane 1 ACHE
myelin sheath 2 BCL2, MBP
pseudopodium 1 CNP
basal plasma membrane 1 ACE
AP-4 adaptor complex 1 AP4M1
trans-Golgi network membrane 2 AP4M1, PICK1
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 2 CAT, MBP
secretory granule lumen 1 CAT
Golgi lumen 1 PCSK5
endoplasmic reticulum lumen 1 BCHE
endocytic vesicle membrane 1 PICK1
transport vesicle 1 MBP
Cul5-RING ubiquitin ligase complex 1 CUL5
9+2 motile cilium 1 DNAH5
dynein complex 1 DNAH5
nuclear envelope lumen 1 BCHE
Synapse, synaptosome 1 PICK1
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
site of DNA damage 1 CUL5
integrin complex 1 ITGAM
compact myelin 1 MBP
internode region of axon 1 MBP
catalase complex 1 CAT
integrin alphaM-beta2 complex 1 ITGAM
myelin sheath abaxonal region 1 CNP
myelin sheath adaxonal region 1 CNP
SCF ubiquitin ligase complex 1 CUL5
BAD-BCL-2 complex 1 BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Bone marrow proteoglycan]: Secreted 1 MBP
postsynaptic early endosome 1 PICK1
[Isoform H]: Cell membrane 1 ACHE
polar microtubule 1 CUL3
Myelin membrane 1 MBP
cullin-RING ubiquitin ligase complex 2 CUL3, CUL5
outer dynein arm 1 DNAH5
9+0 motile cilium 1 DNAH5


文献列表

  • Hassen Touzi, Yves Chevalier, Marie Martin, Hafedh Ben Ouada, Nicole Jaffrezic-Renault. Detection of Gadolinium with an Impedimetric Platform Based on Gold Electrodes Functionalized by 2-Methylpyridine-Substituted Cyclam. Sensors (Basel, Switzerland). 2021 Feb; 21(5):. doi: 10.3390/s21051658. [PMID: 33670860]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Sarah D Brown, Katherine D Trotter, Oliver B Sutcliffe, Jane A Plumb, Bruce Waddell, Naomi E B Briggs, Nial J Wheate. Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton transactions (Cambridge, England : 2003). 2012 Oct; 41(37):11330-9. doi: 10.1039/c2dt31313h. [PMID: 22886151]
  • Kathryn N Kalscheur, Rebecca R Penskar, Allison D Daley, Shannon M Pechauer, John J Kelly, Christopher G Peterson, Kimberly A Gray. Effects of anthropogenic inputs on the organic quality of urbanized streams. Water research. 2012 May; 46(8):2515-24. doi: 10.1016/j.watres.2012.01.043. [PMID: 22406201]
  • Rahele Ghanbari, Farooq Anwar, Khalid M Alkharfy, Anwarul-Hassan Gilani, Nazamid Saari. Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. International journal of molecular sciences. 2012; 13(3):3291-3340. doi: 10.3390/ijms13033291. [PMID: 22489153]
  • Xiangdong Su, Fabienne Pradaux-Caggiano, Nigel Vicker, Mark P Thomas, Heather Halem, Michael D Culler, Barry V L Potter. Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. ChemMedChem. 2011 Sep; 6(9):1616-29. doi: 10.1002/cmdc.201100182. [PMID: 21714097]
  • Chi-Hui Tang, Christi Parham, Ellyn Shocron, Gerald McMahon, Neela Patel. Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin. Cancer chemotherapy and pharmacology. 2011 Jun; 67(6):1389-400. doi: 10.1007/s00280-010-1435-5. [PMID: 20809122]
  • Shuanglian Li, Ying Chen, Shuzhong Zhang, Swati S More, Xiaozhu Huang, Kathleen M Giacomini. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharmaceutical research. 2011 Mar; 28(3):610-25. doi: 10.1007/s11095-010-0312-6. [PMID: 21104302]
  • Poonam Yadav, Nalini V Purohit. Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins. Indian journal of pharmaceutical sciences. 2011 Mar; 73(2):171-8. doi: 10.4103/0250-474x.91586. [PMID: 22303060]
  • Sabine H van Rijt, Hana Kostrhunova, Viktor Brabec, Peter J Sadler. Functionalization of osmium arene anticancer complexes with (poly)arginine: effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate chemistry. 2011 Feb; 22(2):218-26. doi: 10.1021/bc100369p. [PMID: 21271713]
  • L Renee Ruhaak, René Hennig, Carolin Huhn, Matthias Borowiak, Radboud J E M Dolhain, André M Deelder, Erdmann Rapp, Manfred Wuhrer. Optimized workflow for preparation of APTS-labeled N-glycans allowing high-throughput analysis of human plasma glycomes using 48-channel multiplexed CGE-LIF. Journal of proteome research. 2010 Dec; 9(12):6655-64. doi: 10.1021/pr100802f. [PMID: 20886907]
  • George Sachs, Jai Moo Shin, Richard Hunt. Novel approaches to inhibition of gastric acid secretion. Current gastroenterology reports. 2010 Dec; 12(6):437-47. doi: 10.1007/s11894-010-0149-5. [PMID: 20924727]
  • Olivier Berdeaux, Stéphane Gregoire, Cindie Fournier, William W Christie, Pierre Lambelet, Jean-Louis Sébédio. Detection of lactobacillic acid in low erucic rapeseed oil--A note of caution when quantifying cyclic fatty acid monomers in vegetable oils. Chemistry and physics of lipids. 2010 Sep; 163(7):698-702. doi: 10.1016/j.chemphyslip.2010.07.002. [PMID: 20654602]
  • L Renee Ruhaak, Evelyne Steenvoorden, Carolien A M Koeleman, André M Deelder, Manfred Wuhrer. 2-picoline-borane: a non-toxic reducing agent for oligosaccharide labeling by reductive amination. Proteomics. 2010 Jun; 10(12):2330-6. doi: 10.1002/pmic.200900804. [PMID: 20391534]
  • Abhishek Srivastava, Lu-Yun Lian, James L Maggs, Masautso Chaponda, Munir Pirmohamed, Dominic P Williams, B Kevin Park. Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jan; 38(1):122-32. doi: 10.1124/dmd.109.028688. [PMID: 19797610]
  • Mario Kallenbach, Ian T Baldwin, Gustavo Bonaventure. A rapid and sensitive method for the simultaneous analysis of aliphatic and polar molecules containing free carboxyl groups in plant extracts by LC-MS/MS. Plant methods. 2009 Nov; 5(?):17. doi: 10.1186/1746-4811-5-17. [PMID: 19939243]
  • Dayong Sun, Byron E Froman, Robert G Orth, Susan A MacIsaac, Thomas Larosa, Fenggao Dong, Henry E Valentin. Identification of plant sphingolipid desaturases using chromatography and mass spectrometry. Journal of chromatographic science. 2009 Nov; 47(10):895-901. doi: 10.1093/chromsci/47.10.895. [PMID: 19930802]
  • Kouwa Yamashita, Risa Nakagawa, Mitsunobu Okuyama, Seijiro Honma, Madoka Takahashi, Mitsuteru Numazawa. Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids. 2008 Aug; 73(7):727-37. doi: 10.1016/j.steroids.2008.02.009. [PMID: 18394666]
  • Kouwa Yamashita, Mitsunobu Okuyama, Risa Nakagawa, Seijiro Honma, Fumitoshi Satoh, Ryo Morimoto, Sadayoshi Ito, Madoka Takahashi, Mitsuteru Numazawa. Development of sensitive derivatization method for aldosterone in liquid chromatography-electrospray ionization tandem mass spectrometry of corticosteroids. Journal of chromatography. A. 2008 Jul; 1200(2):114-21. doi: 10.1016/j.chroma.2008.05.034. [PMID: 18561939]
  • Alicia E Reid, Yu-Shin Ding, William C Eckelman, Jean Logan, David Alexoff, Colleen Shea, Youwen Xu, Joanna S Fowler. Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET. Nuclear medicine and biology. 2008 Apr; 35(3):287-98. doi: 10.1016/j.nucmedbio.2008.01.001. [PMID: 18355684]
  • Liping Song, Hui Li, Ulas Sunar, Juan Chen, Ian Corbin, Arjun G Yodh, Gang Zheng. Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer imaging and treatment. International journal of nanomedicine. 2007; 2(4):767-74. doi: ". [PMID: 18203443]
  • John T Randolph, Peggy P Huang, William J Flosi, David DeGoey, Larry L Klein, Clinton M Yeung, Charles Flentge, Mingua Sun, Chen Zhao, Tatyana Dekhtyar, Hongmei Mo, Lynn Colletti, Warren Kati, Kennan C Marsh, Akhteruzzaman Molla, Dale J Kempf. Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors. Bioorganic & medicinal chemistry. 2006 Jun; 14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. [PMID: 16504523]
  • A Ali, A Mustafa, S T Abdullah, H Hammid, M Ali. A new picoline alkaloid from the pseudobulb of Desmotrichum fimbriatum Blume. Die Pharmazie. 2003 Oct; 58(10):762-3. doi: ". [PMID: 14609295]
  • Tomoyuki Oe, Ye Tian, Peter J O'Dwyer, David W Roberts, Christopher J Bailey, Ian A Blair. Determination of the platinum drug cis-amminedichloro(2-methylpyridine)platinum(II) in human urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 792(2):217-27. doi: 10.1016/s1570-0232(03)00272-1. [PMID: 12860029]
  • M Bayés, X Rabasseda, J R Prous. Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology. 2003 Jul; 25(6):483-506. doi: . [PMID: 12949633]
  • Suzanne M Budge, Christopher C Parrish. FA determination in cold water marine samples. Lipids. 2003 Jul; 38(7):781-91. doi: 10.1007/s11745-003-1127-4. [PMID: 14506842]
  • P Beale, I Judson, A O'Donnell, J Trigo, C Rees, F Raynaud, A Turner, L Simmons, L Etterley. A Phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473). British journal of cancer. 2003 Apr; 88(7):1128-34. doi: 10.1038/sj.bjc.6600854. [PMID: 12671715]
  • H Murakami, T Tamura, Y Yamada, N Yamamoto, Y Ueda, T Shimoyama, N Saijo. ZD0473 pharmacokinetics in Japanese patients: a Phase I dose-escalation study. European journal of cancer (Oxford, England : 1990). 2002 Dec; 38 Suppl 8(?):S1-5. doi: 10.1016/s0959-8049(02)80012-0. [PMID: 12645906]
  • Philip A Carpino, Bruce A Lefker, Steven M Toler, Lydia C Pan, John R Hadcock, Marianne C Murray, Ewell R Cook, Joseph N DiBrino, Shari L DeNinno, Kristin L Chidsey-Frink, William A Hada, John Inthavongsay, Sharon K Lewis, F Michael Mangano, Michelle A Mullins, David F Nickerson, Oicheng Ng, Christine M Pirie, John A Ragan, Colin R Rose, David A Tess, Ann S Wright, Li Yu, Michael P Zawistoski, John C Pettersen, Paul A DaSilva-Jardine, Theresa C Wilson, David D Thompson. Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorganic & medicinal chemistry letters. 2002 Nov; 12(22):3279-82. doi: 10.1016/s0960-894x(02)00734-5. [PMID: 12392732]
  • Tomoyuki Oe, Ye Tian, Peter J O'Dwyer, David W Roberts, Michael D Malone, Christopher J Bailey, Ian A Blair. A validated liquid chromatography/tandem mass spectrometry assay for cis-amminedichloro(2-methylpyridine)platinum(II) in human plasma ultrafiltrate. Analytical chemistry. 2002 Feb; 74(3):591-9. doi: 10.1021/ac010792v. [PMID: 11838680]
  • O Leiva, F Lozano, C Ramos, P Paniagua, V Borobia. [Diagnosis of renal angiomyolipoma by means of computerized axial tomography]. Actas urologicas espanolas. 1979 Jan; 3(1):43-6. doi: NULL. [PMID: 452977]
  • G Agrup, P Agrup, T Andersson, B Falck, J A Hansson, S Jacobsson, H Rorsman, E Rosengren, A M Rosengren. 5-S-cysteinyldopa in the urine of melanoma patients. Acta dermato-venereologica. 1977; 57(2):113-6. doi: NULL. [PMID: 71802]