Anatabine (BioDeep_00001871985)

Main id: BioDeep_00000002611

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(-)-Anatabine

化学式: C10H12N2 (160.1)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CCC(c2cccnc2)NC1
InChI: InChI=1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h1-4,6,8,10,12H,5,7H2/t10-/m0/s1

描述信息

同义名列表

3 个代谢物同义名

(-)-Anatabine; Anatabine; Anatabine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

150 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AIF1, AZIN2, GFAP, IL18, PTGS2, QPRT, STAT3
Peripheral membrane protein 6 ACHE, AIF1, GBA1, GORASP1, HSD17B6, PTGS2
Endosome membrane 1 BACE1
Endoplasmic reticulum membrane 2 HMOX1, PTGS2
Nucleus 6 ACHE, AIF1, AZIN2, GABPA, HMOX1, STAT3
cytosol 8 AIF1, AZIN2, GFAP, HMOX1, IL18, MB, QPRT, STAT3
dendrite 2 AZIN2, BACE1
trans-Golgi network 3 AZIN2, BACE1, GBA1
nucleoplasm 3 GABPA, HMOX1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ACHE, BACE1, TNF
Cytoplasmic side 3 AIF1, GORASP1, HMOX1
lamellipodium 1 AIF1
ruffle membrane 1 AIF1
Cell projection, axon 1 BACE1
Early endosome membrane 1 HSD17B6
Golgi apparatus membrane 1 GORASP1
Synapse 1 ACHE
cell surface 3 ACHE, BACE1, TNF
Golgi apparatus 4 ACHE, BACE1, GBA1, GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 GBA1
neuromuscular junction 1 ACHE
neuronal cell body 2 BACE1, TNF
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 IL18
Lysosome 2 BACE1, GBA1
endosome 1 BACE1
plasma membrane 5 ACHE, BACE1, IFNLR1, STAT3, TNF
Membrane 5 ACHE, AZIN2, BACE1, HMOX1, IFNLR1
axon 2 AZIN2, BACE1
caveola 1 PTGS2
extracellular exosome 3 GBA1, MB, QPRT
Lysosome membrane 1 GBA1
Lumenal side 2 GBA1, HSD17B6
endoplasmic reticulum 5 BACE1, GBA1, HMOX1, HSD17B6, PTGS2
extracellular space 7 ACHE, CRP, HMOX1, IL10, IL18, TG, TNF
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 4 ACHE, AIF1, AZIN2, HMOX1
mitochondrion 1 AZIN2
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 1 HSD17B6
Microsome membrane 2 HSD17B6, PTGS2
Single-pass type I membrane protein 2 BACE1, IFNLR1
Secreted 5 ACHE, CRP, IL10, IL18, TG
extracellular region 6 ACHE, CRP, IL10, IL18, TG, TNF
mitochondrial outer membrane 1 HMOX1
astrocyte end-foot 1 GFAP
hippocampal mossy fiber to CA3 synapse 1 BACE1
Extracellular side 1 ACHE
transcription regulator complex 1 STAT3
external side of plasma membrane 1 TNF
multivesicular body 1 BACE1
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
sarcoplasm 1 MB
Early endosome 1 BACE1
recycling endosome 2 BACE1, TNF
Single-pass type II membrane protein 1 TNF
Cell projection, ruffle membrane 1 AIF1
Membrane raft 2 BACE1, TNF
Cytoplasm, cytoskeleton 1 AIF1
cis-Golgi network 2 AZIN2, GORASP1
basement membrane 1 ACHE
intermediate filament 1 GFAP
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 BACE1
ruffle 1 AIF1
neuron projection 1 PTGS2
chromatin 2 GABPA, STAT3
Cell projection, phagocytic cup 1 AIF1
cell projection 1 GFAP
phagocytic cup 2 AIF1, TNF
Golgi apparatus, trans-Golgi network 1 BACE1
actin filament 1 AIF1
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 1 BACE1
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
cell body 1 GFAP
side of membrane 1 ACHE
intermediate filament cytoskeleton 1 GFAP
endoplasmic reticulum lumen 2 BACE1, PTGS2
transport vesicle 1 AZIN2
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 AZIN2, GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
synaptic cleft 1 ACHE
Golgi apparatus, cis-Golgi network 1 AZIN2
cytoplasmic side of lysosomal membrane 1 GFAP
glial cell projection 1 AIF1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Cytoplasm, sarcoplasm 1 MB
catalytic complex 1 QPRT
[Isoform H]: Cell membrane 1 ACHE
Golgi-associated vesicle lumen 1 BACE1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
granular vesicle 1 AZIN2


文献列表

  • Kacper Piotr Kaminski, Lucien Bovet, Aurore Hilfiker, Helene Laparra, Joanne Schwaar, Nicolas Sierro, Gerhard Lang, Damien De Palo, Philippe Alexandre Guy, Csaba Laszlo, Simon Goepfert, Nikolai V Ivanov. Suppression of pyrrolidine ring biosynthesis and its effects on gene expression and subsequent accumulation of anatabine in leaves of tobacco (N. tabacum L.). BMC genomics. 2023 Sep; 24(1):516. doi: 10.1186/s12864-023-09588-8. [PMID: 37667170]
  • Andrew B Hawkey, Julia Hoeng, Manuel C Peitsch, Edward D Levin, Kyoko Koshibu. Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish. Pharmacology, biochemistry, and behavior. 2021 08; 207(?):173223. doi: 10.1016/j.pbb.2021.173223. [PMID: 34197843]
  • Wenhao Xia, Aditya Reddy Kolli, Kyoko Koshibu, Florian Martin, Athanasios Kondylis, Arkadiusz Kuczaj, Wei Teck Tan, Ying Shan Yeo, Glenda Tan, Charles Teng, Kaing Woon, Thomas Schneider, Marja Talikka, Blaine W Phillips, Patrick Vanscheeuwijck, Manuel C Peitsch, Julia Hoeng. In Vivo Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy. Journal of natural products. 2021 04; 84(4):1012-1021. doi: 10.1021/acs.jnatprod.0c01044. [PMID: 33706515]
  • Qiuda Zheng, Geoff Eaglesham, Benjamin J Tscharke, Jake W O'Brien, Jiaying Li, Jack Thompson, Katja M Shimko, Tim Reeks, Cobus Gerber, Kevin V Thomas, Phong K Thai. Determination of anabasine, anatabine, and nicotine biomarkers in wastewater by enhanced direct injection LC-MS/MS and evaluation of their in-sewer stability. The Science of the total environment. 2020 Nov; 743(?):140551. doi: 10.1016/j.scitotenv.2020.140551. [PMID: 32653706]
  • Richard Bade, Jason M White, Benjamin J Tscharke, Maulik Ghetia, Ahmed Abdelaziz, Cobus Gerber. Anabasine-based measurement of cigarette consumption using wastewater analysis. Drug testing and analysis. 2020 Sep; 12(9):1393-1398. doi: 10.1002/dta.2874. [PMID: 32506745]
  • Hai Liu, Tatyana I Kotova, Michael P Timko. Increased Leaf Nicotine Content by Targeting Transcription Factor Gene Expression in Commercial Flue-Cured Tobacco (Nicotiana tabacum L.). Genes. 2019 11; 10(11):. doi: 10.3390/genes10110930. [PMID: 31739571]
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  • C De Bleye, E Dumont, A Dispas, C Hubert, P-Y Sacré, L Netchacovitch, B De Muyt, C Kevers, J Dommes, Ph Hubert, E Ziemons. Monitoring of anatabine release by methyl jasmonate elicited BY-2 cells using surface-enhanced Raman scattering. Talanta. 2016 Nov; 160(?):754-760. doi: 10.1016/j.talanta.2016.08.027. [PMID: 27591672]
  • Linda B von Weymarn, Nicole M Thomson, Eric C Donny, Dorothy K Hatsukami, Sharon E Murphy. Quantitation of the Minor Tobacco Alkaloids Nornicotine, Anatabine, and Anabasine in Smokers' Urine by High Throughput Liquid Chromatography-Mass Spectrometry. Chemical research in toxicology. 2016 Mar; 29(3):390-7. doi: 10.1021/acs.chemrestox.5b00521. [PMID: 26825008]
  • Keita Kato, Nobukazu Shitan, Tsubasa Shoji, Takashi Hashimoto. Tobacco NUP1 transports both tobacco alkaloids and vitamin B6. Phytochemistry. 2015 May; 113(?):33-40. doi: 10.1016/j.phytochem.2014.05.011. [PMID: 24947336]
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  • Binnian Wei, June Feng, Imran J Rehmani, Sharyn Miller, James E McGuffey, Benjamin C Blount, Lanqing Wang. A high-throughput robotic sample preparation system and HPLC-MS/MS for measuring urinary anatabine, anabasine, nicotine and major nicotine metabolites. Clinica chimica acta; international journal of clinical chemistry. 2014 Sep; 436(?):290-7. doi: 10.1016/j.cca.2014.06.012. [PMID: 24968308]
  • Nathaniel D M Jenkins, Terry J Housh, Kristen C Cochrane, Haley C Bergstrom, Daniel A Traylor, Robert W Lewis, Samuel L Buckner, Richard J Schmidt, Glen O Johnson, Joel T Cramer. Effects of anatabine and unilateral maximal eccentric isokinetic muscle actions on serum markers of muscle damage and inflammation. European journal of pharmacology. 2014 Apr; 728(?):161-6. doi: 10.1016/j.ejphar.2014.01.054. [PMID: 24509134]
  • Lowell R Schmeltz, Thomas C Blevins, Stephen L Aronoff, Kerem Ozer, Jonathan D Leffert, Marc A Goldberg, Barry S Horowitz, Richard H Bertenshaw, Pedro Troya, Amy E Cohen, Ryan K Lanier, Curtis Wright. Anatabine supplementation decreases thyroglobulin antibodies in patients with chronic lymphocytic autoimmune (Hashimoto's) thyroiditis: a randomized controlled clinical trial. The Journal of clinical endocrinology and metabolism. 2014 Jan; 99(1):E137-42. doi: 10.1210/jc.2013-2951. [PMID: 24178792]
  • Nobukazu Shitan, Shota Minami, Masahiko Morita, Minaho Hayashida, Shingo Ito, Kojiro Takanashi, Hiroshi Omote, Yoshinori Moriyama, Akifumi Sugiyama, Alain Goossens, Masataka Moriyasu, Kazufumi Yazaki. Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum. PloS one. 2014; 9(9):e108789. doi: 10.1371/journal.pone.0108789. [PMID: 25268729]
  • James E McGuffey, Binnian Wei, John T Bernert, John C Morrow, Baoyun Xia, Lanqing Wang, Benjamin C Blount. Validation of a LC-MS/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids--anatabine and anabasine--in smokers' urine. PloS one. 2014; 9(7):e101816. doi: 10.1371/journal.pone.0101816. [PMID: 25013964]
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  • Daniel Paris, David Beaulieu-Abdelahad, Laila Abdullah, Corbin Bachmeier, Ghania Ait-Ghezala, Jon Reed, Megha Verma, Fiona Crawford, Michael Mullan. Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation. European journal of pharmacology. 2013 Jan; 698(1-3):145-53. doi: 10.1016/j.ejphar.2012.11.017. [PMID: 23178521]
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  • Yupynn Chintapakorn, John D Hamill. Antisense-mediated down-regulation of putrescine N-methyltransferase activity in transgenic Nicotiana tabacum L. can lead to elevated levels of anatabine at the expense of nicotine. Plant molecular biology. 2003 Sep; 53(1-2):87-105. doi: 10.1023/b:plan.0000009268.45851.95. [PMID: 14756309]
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