Tubulosine (BioDeep_00001869841)

Main id: BioDeep_00000007259

 

natural product


代谢物信息卡片


Tubulosine

化学式: C29H37N3O3 (475.2835)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=C(CCN4)C6=C(N5)C=CC(=C6)O)OC)OC
InChI: InChI=1S/C29H37N3O3/c1-4-17-16-32-10-8-18-13-27(34-2)28(35-3)15-22(18)26(32)12-19(17)11-25-29-21(7-9-30-25)23-14-20(33)5-6-24(23)31-29/h5-6,13-15,17,19,25-26,30-31,33H,4,7-12,16H2,1-3H3/t17-,19-,25+,26-/m0/s1

描述信息

A member of the class of beta-carbolines that is tubulosan bearing methoxy groups at positions 10 and 11 and a hydroxy group at the 8 position.

同义名列表

2 个代谢物同义名

Tubulosine; Tubulosine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ACE, CCND1, CRY1, ERBB2, HIF1A, JAK1, JAK2, JAK3, STAT1, STAT3, TGFB1, TYK2
Peripheral membrane protein 2 JAK2, JAK3
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 1 SLC33A1
Nucleus 11 CCND1, CRY1, ELOF1, ERBB2, HIF1A, JAK1, JAK2, STAT1, STAT3, TGFB1, TYK2
cytosol 9 CCND1, ERBB2, HIF1A, JAK1, JAK2, JAK3, STAT1, STAT3, TYK2
dendrite 1 STAT1
nuclear body 1 HIF1A
centrosome 1 CCND1
nucleoplasm 6 CCND1, ERBB2, HIF1A, JAK2, STAT1, STAT3
RNA polymerase II transcription regulator complex 3 HIF1A, STAT1, STAT3
Cell membrane 4 ACE, AGTR2, ERBB2, IL6R
ruffle membrane 1 ERBB2
Multi-pass membrane protein 2 AGTR2, SLC33A1
cell surface 1 TGFB1
glutamatergic synapse 1 JAK2
Golgi membrane 1 SLC33A1
neuromuscular junction 1 ERBB2
neuronal cell body 1 TGFB1
postsynapse 1 JAK2
presynaptic membrane 1 ERBB2
Lysosome 1 ACE
endosome 3 ACE, JAK1, JAK3
plasma membrane 12 ACE, AGTR2, ERBB2, IL6R, JAK1, JAK2, JAK3, REN, SLC33A1, STAT3, TGFB1, TYK2
Membrane 9 ACE, ERBB2, IL6R, JAK1, JAK2, JAK3, REN, SLC33A1, TYK2
apical plasma membrane 2 ERBB2, IL6R
axon 2 STAT1, TGFB1
basolateral plasma membrane 1 ERBB2
caveola 1 JAK2
extracellular exosome 2 ACE, TYK2
extracellular space 5 ACE, IL2, IL6R, REN, TGFB1
perinuclear region of cytoplasm 2 ERBB2, STAT1
bicellular tight junction 1 CCND1
mitochondrion 1 CRY1
protein-containing complex 2 HIF1A, STAT1
Single-pass type I membrane protein 3 ACE, ERBB2, IL6R
Secreted 4 ACE, IL2, REN, TGFB1
extracellular region 6 ACE, ERBB2, IL2, IL6R, REN, TGFB1
cytoplasmic side of plasma membrane 4 JAK1, JAK2, JAK3, TYK2
[Isoform 2]: Secreted 1 IL6R
transcription regulator complex 1 STAT3
motile cilium 1 HIF1A
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 2 ACE, IL6R
Secreted, extracellular space, extracellular matrix 1 TGFB1
cytoplasmic vesicle 1 ERBB2
nucleolus 1 STAT1
axon cytoplasm 1 HIF1A
Early endosome 1 ERBB2
apical part of cell 1 REN
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 JAK2
focal adhesion 2 JAK1, JAK2
extracellular matrix 1 TGFB1
collagen-containing extracellular matrix 1 TGFB1
secretory granule 1 TGFB1
nuclear speck 1 HIF1A
receptor complex 2 ERBB2, IL6R
chromatin 3 HIF1A, STAT1, STAT3
cytoskeleton 4 JAK1, JAK2, JAK3, TYK2
brush border membrane 1 ACE
blood microparticle 1 TGFB1
sperm midpiece 1 ACE
Endomembrane system 3 JAK1, JAK2, JAK3
endosome lumen 1 JAK2
Nucleus speckle 1 HIF1A
euchromatin 2 HIF1A, JAK2
myelin sheath 1 ERBB2
basal plasma membrane 2 ACE, ERBB2
Golgi lumen 1 TGFB1
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 TGFB1
transcription elongation factor complex 1 ELOF1
semaphorin receptor complex 1 ERBB2
extrinsic component of cytoplasmic side of plasma membrane 4 JAK1, JAK2, JAK3, TYK2
[Isoform 1]: Cell membrane 2 ERBB2, IL6R
extrinsic component of plasma membrane 3 JAK2, JAK3, TYK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 2 JAK2, TYK2
interleukin-23 receptor complex 2 JAK2, TYK2
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
ERBB3:ERBB2 complex 1 ERBB2
interleukin-6 receptor complex 1 IL6R
[Soluble interleukin-6 receptor subunit alpha]: Secreted 1 IL6R
ciliary neurotrophic factor receptor complex 1 IL6R
cyclin D1-CDK4 complex 1 CCND1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
cyclin D1-CDK6 complex 1 CCND1
ISGF3 complex 1 STAT1


文献列表

  • You-Sheng Cai, Cong Wang, Congkui Tian, Wen-Ting Sun, Ling Chen, Di Xiao, Si-Yuan Zhou, Guofu Qiu, Jianqing Yu, Kongkai Zhu, Sheng-Ping Yang. Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of Alangium salviifolium and Their Cytotoxicity. Journal of natural products. 2019 09; 82(9):2645-2652. doi: 10.1021/acs.jnatprod.9b00670. [PMID: 31513408]
  • Paul Klausmeyer, Thomas G McCloud, Badarch Uranchimeg, Giovanni Melillo, Dominic A Scudiero, John H Cardellina, Robert H Shoemaker. Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum. Planta medica. 2008 Feb; 74(3):258-63. doi: 10.1055/s-2008-1034315. [PMID: 18302092]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]
  • C Pareyre, G Deysson. Activity of tubulosine on the kinetics of root meristem cell population. Cell and tissue kinetics. 1975 Jan; 8(1):67-79. doi: 10.1111/j.1365-2184.1975.tb01208.x. [PMID: 1116172]