3beta-hydroxy-5-cholestenoic acid (BioDeep_00001869641)

Main id: BioDeep_00000011647

 


代谢物信息卡片


3beta-hydroxy-5-cholestenoic acid

化学式: C27H44O3 (416.329)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1

描述信息

同义名列表

2 个代谢物同义名

3beta-hydroxy-5-cholestenoic acid; 3beta-Hydroxy-5-cholestenoate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, APOE, EGFR, ESR1, NR1H2
Peripheral membrane protein 2 CYP27A1, ESR1
Endosome membrane 2 EGFR, LDLR
Endoplasmic reticulum membrane 5 CYP7A1, CYP7B1, EGFR, HSD3B7, STAR
Mitochondrion membrane 1 CYP27A1
Nucleus 6 ALB, APOE, EGFR, ESR1, NR1H2, NR1H4
cytosol 5 ALB, APOA1, ESR1, GPT, NR1H2
dendrite 1 APOE
centrosome 1 ALB
nucleoplasm 3 ESR1, NR1H2, NR1H4
RNA polymerase II transcription regulator complex 2 NR1H2, NR1H4
Cell membrane 4 EGFR, ESR1, LDLR, STAR
Cytoplasmic side 1 ESR1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 CYP7B1, SPG7
cell junction 1 EGFR
cell surface 2 EGFR, LDLR
glutamatergic synapse 2 APOE, EGFR
Golgi apparatus 4 ALB, APOE, ESR1, LDLR
Golgi membrane 1 EGFR
mitochondrial inner membrane 2 CYP27A1, SPG7
neuronal cell body 1 APOE
Lysosome 1 LDLR
endosome 1 EGFR
plasma membrane 6 APOA1, APOE, EGFR, ESR1, LDLR, STAR
Membrane 6 APOE, CYP7B1, EGFR, ESR1, LDLR, SPG7
apical plasma membrane 1 EGFR
basolateral plasma membrane 2 EGFR, LDLR
extracellular exosome 4 ALB, APOA1, APOE, GPT
endoplasmic reticulum 2 ALB, APOE
extracellular space 4 ALB, APOA1, APOE, EGFR
perinuclear region of cytoplasm 1 EGFR
mitochondrion 4 CYP27A1, FDX1, SPG7, STAR
protein-containing complex 3 ALB, EGFR, ESR1
intracellular membrane-bounded organelle 1 CYP7A1
Microsome membrane 2 CYP7A1, CYP7B1
Single-pass type I membrane protein 3 EGFR, LDLR, STAR
Secreted 3 ALB, APOA1, APOE
extracellular region 3 ALB, APOA1, APOE
Single-pass membrane protein 2 CYP7A1, LDLR
Mitochondrion matrix 1 FDX1
mitochondrial matrix 3 CYP27A1, FDX1, STAR
anchoring junction 1 ALB
transcription regulator complex 1 ESR1
nuclear membrane 1 EGFR
external side of plasma membrane 1 LDLR
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOA1, APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 2 APOA1, APOE
high-density lipoprotein particle 2 APOA1, APOE
low-density lipoprotein particle 3 APOA1, APOE, LDLR
multivesicular body 1 APOE
very-low-density lipoprotein particle 2 APOA1, APOE
cytoplasmic vesicle 1 APOA1
axon cytoplasm 1 SPG7
Early endosome 3 APOA1, APOE, LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
Mitochondrion inner membrane 2 CYP27A1, SPG7
Membrane raft 1 EGFR
focal adhesion 1 EGFR
extracellular matrix 1 APOE
intracellular vesicle 1 EGFR
mitochondrial intermembrane space 1 STAR
collagen-containing extracellular matrix 2 APOA1, APOE
Late endosome 1 LDLR
receptor complex 3 EGFR, LDLR, NR1H4
ciliary basal body 1 ALB
chromatin 3 ESR1, NR1H2, NR1H4
[Isoform 3]: Nucleus 1 NR1H4
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 3 ALB, APOA1, APOE
Endomembrane system 1 LDLR
sorting endosome 1 LDLR
Lipid droplet 1 HSD3B7
Melanosome 1 APOE
euchromatin 2 ESR1, NR1H4
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 APOA1
endoplasmic reticulum lumen 3 ALB, APOA1, APOE
platelet alpha granule lumen 1 ALB
endocytic vesicle 1 APOA1
clathrin-coated endocytic vesicle membrane 3 APOE, EGFR, LDLR
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 2 ESR1, NR1H4
synaptic cleft 1 APOE
endolysosome membrane 1 LDLR
somatodendritic compartment 1 LDLR
[Isoform 4]: Nucleus 1 NR1H4
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 1 APOA1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 2 APOA1, APOE
PCSK9-LDLR complex 1 LDLR
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mitochondrial permeability transition pore complex 1 SPG7
ciliary transition fiber 1 ALB
m-AAA complex 1 SPG7


文献列表

  • Yunlu He, Yanbo Luo, Huan Chen, Jian Chen, Yaning Fu, Hongwei Hou, Qingyuan Hu. Profiling of carboxyl-containing metabolites in smokers and non-smokers by stable isotope labeling combined with LC-MS/MS. Analytical biochemistry. 2019 03; 569(?):1-9. doi: 10.1016/j.ab.2018.12.006. [PMID: 30543805]
  • Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H Koo, Gideon Shapiro, Kevin M Felsenstein, Todd E Golde. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Molecular neurodegeneration. 2015 Jul; 10(?):29. doi: 10.1186/s13024-015-0021-z. [PMID: 26169917]
  • William J Griffiths, Martin Hornshaw, Gary Woffendin, Sharon F Baker, Andrew Lockhart, Sibylle Heidelberger, Magnus Gustafsson, Jan Sjövall, Yuqin Wang. Discovering oxysterols in plasma: a window on the metabolome. Journal of proteome research. 2008 Aug; 7(8):3602-12. doi: 10.1021/pr8001639. [PMID: 18605750]
  • Akira Honda, Tadashi Yoshida, Guorong Xu, Yasushi Matsuzaki, Sugano Fukushima, Naomi Tanaka, Mikio Doy, Sarah Shefer, Gerald Salen. Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. Metabolism: clinical and experimental. 2004 Jan; 53(1):42-8. doi: 10.1016/j.metabol.2003.07.018. [PMID: 14681840]
  • Steve Meaney, Amir Babiker, Dieter Lütjohann, Ulf Diczfalusy, Magnus Axelson, Ingemar Björkhem. On the origin of the cholestenoic acids in human circulation. Steroids. 2003 Sep; 68(7-8):595-601. doi: 10.1016/s0039-128x(03)00081-3. [PMID: 12957664]
  • Magnus Hansson, Ewa Ellis, Mary C Hunt, Gerd Schmitz, Amir Babiker. Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. Biochimica et biophysica acta. 2003 Feb; 1593(2-3):283-9. doi: 10.1016/s0167-4889(02)00398-1. [PMID: 12581873]
  • C Song, S Liao. Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha. Endocrinology. 2000 Nov; 141(11):4180-4. doi: 10.1210/endo.141.11.7772. [PMID: 11089551]
  • A Babiker, U Diczfalusy. Transport of side-chain oxidized oxysterols in the human circulation. Biochimica et biophysica acta. 1998 Jun; 1392(2-3):333-9. doi: 10.1016/s0005-2760(98)00047-2. [PMID: 9630709]
  • A B Reiss, K O Martin, D E Rojer, S Iyer, E A Grossi, A C Galloway, N B Javitt. Sterol 27-hydroxylase: expression in human arterial endothelium. Journal of lipid research. 1997 Jun; 38(6):1254-60. doi: ". [PMID: 9215552]
  • M Axelson, B Mörk, A Aly, O Wisén, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with liver disease. Journal of lipid research. 1989 Dec; 30(12):1877-82. doi: . [PMID: 2621414]
  • M Axelson, B Mörk, A Aly, G Walldius, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with reduced intestinal reabsorption of bile acids. Journal of lipid research. 1989 Dec; 30(12):1883-7. doi: . [PMID: 2621415]
  • M Axelson, B Mörk, J Sjövall. Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. Journal of lipid research. 1988 May; 29(5):629-41. doi: 10.1016/s0022-2275(20)38509-6. [PMID: 3411238]
  • G Janssen, G Parmentier. A further study of the bile acids in infants with coprostanic acidemia. Steroids. 1981 Jan; 37(1):81-9. doi: 10.1016/0039-128x(81)90010-6. [PMID: 6784283]
  • . . . . doi: . [PMID: 8078928]