1H-indol-3-amine (BioDeep_00001869484)

Main id: BioDeep_00000004764

 

natural product


代谢物信息卡片


1H-indol-3-amine

化学式: C8H8N2 (132.0687448)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CN2)N
InChI: InChI=1S/C8H8N2/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,9H2

描述信息

同义名列表

2 个代谢物同义名

1H-indol-3-amine; Indoleamine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Giuseppe Mannino, Carlo Pernici, Graziella Serio, Carla Gentile, Cinzia M Bertea. Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals-An Overview. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189996. [PMID: 34576159]
  • Ahmet Özer Şehirli, Serkan Sayıner. Daylight is critical to preserve 5-methoxytryptophol levels in suspected and confirmed COVID-19 patients. Medical hypotheses. 2021 Feb; 147(?):110504. doi: 10.1016/j.mehy.2021.110504. [PMID: 33485026]
  • R Ramakrishnan. Brain signalling systems: A target for treating type I diabetes mellitus. Brain research bulletin. 2019 10; 152(?):191-201. doi: 10.1016/j.brainresbull.2019.07.017. [PMID: 31325597]
  • Alma Rus, Francisco Molina, María Luisa Del Moral, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos. Catecholamine and Indolamine Pathway: A Case-Control Study in Fibromyalgia. Biological research for nursing. 2018 10; 20(5):577-586. doi: 10.1177/1099800418787672. [PMID: 30009619]
  • Christina E Turi, Susan J Murch. Targeted and untargeted phytochemistry of Ligusticum canbyi: indoleamines, phthalides, antioxidant potential, and use of metabolomics as a hypothesis-generating technique for compound discovery. Planta medica. 2013 Sep; 79(14):1370-9. doi: 10.1055/s-0033-1350618. [PMID: 23877920]
  • C A Browne, F E O'Brien, T J Connor, T G Dinan, J F Cryan. Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: effects of stress. Neuroscience. 2012 Dec; 225(?):237-48. doi: 10.1016/j.neuroscience.2012.08.031. [PMID: 22917616]
  • Masakazu Fukunaga, Yasuko Yamamoto, Misaki Kawasoe, Yuko Arioka, Yuki Murakami, Masato Hoshi, Kuniaki Saito. Studies on tissue and cellular distribution of indoleamine 2,3-dioxygenase 2: the absence of IDO1 upregulates IDO2 expression in the epididymis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2012 Nov; 60(11):854-60. doi: 10.1369/0022155412458926. [PMID: 22895526]
  • Chao Li, Ping Wang, Zhiwei Wei, Dong Liang, Changhai Liu, Lihua Yin, Dongfeng Jia, Mingyang Fu, Fengwang Ma. The mitigation effects of exogenous melatonin on salinity-induced stress in Malus hupehensis. Journal of pineal research. 2012 Oct; 53(3):298-306. doi: 10.1111/j.1600-079x.2012.00999.x. [PMID: 22507106]
  • Dingbo Shi, Xiangsheng Xiao, Jingshu Wang, Liqun Liu, Wangbing Chen, Lingyi Fu, Fangyun Xie, Wenlin Huang, Wuguo Deng. Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling. Journal of pineal research. 2012 Sep; 53(2):154-65. doi: 10.1111/j.1600-079x.2012.00982.x. [PMID: 22348531]
  • Yuko Arioka, Yasuko Yamamoto, Masato Hoshi, Keishi Matsumoto, Manabu Takamatsu, Akira Hara, Mitsuru Seishima, Kuniaki Saito. Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice. Life sciences. 2012 Aug; 91(3-4):100-6. doi: 10.1016/j.lfs.2012.06.018. [PMID: 22749866]
  • Martina M Hughes, Angela Carballedo, Declan M McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl, Thomas J Connor. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, behavior, and immunity. 2012 Aug; 26(6):979-87. doi: 10.1016/j.bbi.2012.05.010. [PMID: 22683764]
  • Hyangin Kim, Lucy Chen, Grewo Lim, Backil Sung, Shuxing Wang, Michael F McCabe, Gabriel Rusanescu, Liling Yang, Yinghong Tian, Jianren Mao. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. The Journal of clinical investigation. 2012 Aug; 122(8):2940-54. doi: 10.1172/jci61884. [PMID: 22751107]
  • Mattìa Panin, Gianfranco Gabai, Cristina Ballarin, Antonella Peruffo, Bruno Cozzi. Evidence of melatonin secretion in cetaceans: plasma concentration and extrapineal HIOMT-like presence in the bottlenose dolphin Tursiops truncatus. General and comparative endocrinology. 2012 Jun; 177(2):238-45. doi: 10.1016/j.ygcen.2012.04.012. [PMID: 22554922]
  • Michael Weed, Robert J Adams, Robert D Hienz, Kelly A Meulendyke, Michael E Linde, Janice E Clements, Joseph L Mankowski, M Christine Zink. SIV/macaque model of HIV infection in cocaine users: minimal effects of cocaine on behavior, virus replication, and CNS inflammation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 Jun; 7(2):401-11. doi: 10.1007/s11481-011-9281-8. [PMID: 21626125]
  • Gui-ping Li, Jie Yang, Jun Hao, Yi-ming Yang, Ya-na Ren, Ru-feng Xie, Hua-hua Fan, Kai-cheng Qian. [The role of third-party tolerogenic dendritic cells in the prevention of acute graft-versus-host-disease following allogeneic bone marrow transplantation in mice]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2012 Jun; 33(6):461-6. doi: NULL. [PMID: 22967381]
  • Margit Lanzinger, Birgit Jürgens, Ursula Hainz, Barbara Dillinger, Julia Raberger, Dietmar Fuchs, Andreas Heitger. Ambivalent effects of dendritic cells displaying prostaglandin E2-induced indoleamine 2,3-dioxygenase. European journal of immunology. 2012 May; 42(5):1117-28. doi: 10.1002/eji.201141765. [PMID: 22539287]
  • Annemarieke de Jonghe, Barbara C van Munster, Durk Fekkes, Hannah E van Oosten, Sophia E de Rooij. The tryptophan depletion theory in delirium: not confirmed in elderly hip fracture patients. Psychosomatics. 2012 May; 53(3):236-43. doi: 10.1016/j.psym.2011.09.009. [PMID: 22458995]
  • Dong Zheng, Qi Cao, Vincent W S Lee, Ya Wang, Guoping Zheng, YuanMin Wang, Thian Kui Tan, Changqi Wang, Stephen I Alexander, David C H Harris, Yiping Wang. Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney international. 2012 May; 81(9):892-902. doi: 10.1038/ki.2011.471. [PMID: 22318423]
  • Juulia Jylhävä, Marja Jylhä, Terho Lehtimäki, Antti Hervonen, Mikko Hurme. Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study. Experimental gerontology. 2012 May; 47(5):372-8. doi: 10.1016/j.exger.2012.02.011. [PMID: 22406558]
  • Michael Maes, Winfried Rief. Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway. Psychiatry research. 2012 Apr; 196(2-3):243-9. doi: 10.1016/j.psychres.2011.09.029. [PMID: 22364930]
  • Huiyong Wang, Erin J Walaszczyk, Ke Li, Yu-Wen Chung-Davidson, Weiming Li. High-performance liquid chromatography with fluorescence detection and ultra-performance liquid chromatography with electrospray tandem mass spectrometry method for the determination of indoleamine neurotransmitters and their metabolites in sea lamprey plasma. Analytica chimica acta. 2012 Apr; 721(?):147-53. doi: 10.1016/j.aca.2012.01.025. [PMID: 22405313]
  • Paula N Brown, Christina E Turi, Paul R Shipley, Susan J Murch. Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. Planta medica. 2012 Apr; 78(6):630-40. doi: 10.1055/s-0031-1298239. [PMID: 22337317]
  • Yuzo Suzuki, Takafumi Suda, Kazuhiro Asada, Seiichi Miwa, Masako Suzuki, Michio Fujie, Kazuki Furuhashi, Yutaro Nakamura, Naoki Inui, Toshihiro Shirai, Hiroshi Hayakawa, Hirotoshi Nakamura, Kingo Chida. Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis. Clinical and vaccine immunology : CVI. 2012 Mar; 19(3):436-42. doi: 10.1128/cvi.05402-11. [PMID: 22219312]
  • Brian Leonard, Michael Maes. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neuroscience and biobehavioral reviews. 2012 Feb; 36(2):764-85. doi: 10.1016/j.neubiorev.2011.12.005. [PMID: 22197082]
  • Theodoros Eleftheriadis, Efi Yiannaki, Georgia Antoniadi, Vassilios Liakopoulos, Georgios Pissas, Grammati Galaktidou, Ioannis Stefanidis. Plasma indoleamine 2,3-dioxygenase and arginase type I may contribute to decreased blood T-cell count in hemodialysis patients. Renal failure. 2012; 34(9):1118-22. doi: 10.3109/0886022x.2012.713297. [PMID: 22897519]
  • Tadakazu Hisamatsu, Susumu Okamoto, Masaki Hashimoto, Takahiko Muramatsu, Ayatoshi Andou, Michihide Uo, Mina T Kitazume, Katsuyoshi Matsuoka, Tomoharu Yajima, Nagamu Inoue, Takanori Kanai, Haruhiko Ogata, Yasushi Iwao, Minoru Yamakado, Ryosei Sakai, Nobukazu Ono, Toshihiko Ando, Manabu Suzuki, Toshifumi Hibi. Novel, objective, multivariate biomarkers composed of plasma amino acid profiles for the diagnosis and assessment of inflammatory bowel disease. PloS one. 2012; 7(1):e31131. doi: 10.1371/journal.pone.0031131. [PMID: 22303484]
  • Nikoletta Dobos, Erik F J de Vries, Ido P Kema, Konstantinos Patas, Marloes Prins, Ingrid M Nijholt, Rudi A Dierckx, Jakob Korf, Johan A den Boer, Paul G M Luiten, Ulrich L M Eisel. The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. Journal of Alzheimer's disease : JAD. 2012; 28(4):905-15. doi: 10.3233/jad-2011-111097. [PMID: 22112548]
  • Anupa Kamat, Vikas Misra, Edana Cassol, Petronela Ancuta, Zhenyu Yan, Cheng Li, Susan Morgello, Dana Gabuzda. A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PloS one. 2012; 7(2):e30881. doi: 10.1371/journal.pone.0030881. [PMID: 22363505]
  • Daniel H Libraty, Satu Mäkelä, Jennifer Vlk, Mikko Hurme, Antti Vaheri, Francis A Ennis, Jukka Mustonen. The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica. PloS one. 2012; 7(4):e35402. doi: 10.1371/journal.pone.0035402. [PMID: 22523590]
  • Peisong Gao. Sensitization to cockroach allergen: immune regulation and genetic determinants. Clinical & developmental immunology. 2012; 2012(?):563760. doi: 10.1155/2012/563760. [PMID: 22272212]
  • Julia García-Lestón, Joana Roma-Torres, Olga Mayan, Sebastian Schroecksnadel, Dietmar Fuchs, Ana O Moreira, Eduardo Pásaro, Josefina Méndez, João Paulo Teixeira, Blanca Laffon. Assessment of immunotoxicity parameters in individuals occupationally exposed to lead. Journal of toxicology and environmental health. Part A. 2012; 75(13-15):807-18. doi: 10.1080/15287394.2012.690327. [PMID: 22788368]
  • J Y Ajay, Pradeep Kumar Gajula, K Kalaimagal, B N Vedha Hari. Chronopharmacognosy. Pharmacognosy reviews. 2012 Jan; 6(11):6-15. doi: 10.4103/0973-7847.95852. [PMID: 22654399]
  • Tuula K Outinen, Taru Kuparinen, Juulia Jylhävä, Sonja Leppänen, Jukka Mustonen, Satu Mäkelä, Ilkka Pörsti, Jaana Syrjänen, Antti Vaheri, Mikko Hurme. Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection. PloS one. 2012; 7(2):e31455. doi: 10.1371/journal.pone.0031455. [PMID: 22347483]
  • Jolanta Zuwała-Jagiello, Monika Pazgan-Simon, Krzysztof Simon, Maria Warwas. Picolinic acid in patients with chronic hepatitis C infection: a preliminary report. Mediators of inflammation. 2012; 2012(?):762863. doi: 10.1155/2012/762863. [PMID: 22701277]
  • January Weiner, Shreemanta K Parida, Jeroen Maertzdorf, Gillian F Black, Dirk Repsilber, Anna Telaar, Robert P Mohney, Cordelia Arndt-Sullivan, Christian A Ganoza, Kellen C Faé, Gerhard Walzl, Stefan H E Kaufmann. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PloS one. 2012; 7(7):e40221. doi: 10.1371/journal.pone.0040221. [PMID: 22844400]
  • Theodoros Eleftheriadis, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis, Grammati Galaktidou. Plasma indoleamine 2,3-dioxygenase concentration is increased in hemodialysis patients and may contribute to the pathogenesis of coronary heart disease. Renal failure. 2012; 34(1):68-72. doi: 10.3109/0886022x.2011.623562. [PMID: 22017594]
  • Mei Zhang, Hongwei Zhang, Tong Zhang, Yunxia Ji, Yanmei Jiao, Hao Wu. Longitudinal changes of peripheral blood DC subsets and regulatory T cells in Chinese chronic HIV-1-infected patients during antiretroviral therapy. PloS one. 2012; 7(5):e37966. doi: 10.1371/journal.pone.0037966. [PMID: 22701538]
  • Thanavadee Prachason, Kanittha Konhan, Piyapat Pongnarin, Somruedee Chatsiricharoenkul, Yupin Suputtamongkol, Chanin Limwongse. Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi. PLoS neglected tropical diseases. 2012; 6(7):e1731. doi: 10.1371/journal.pntd.0001731. [PMID: 22860140]
  • George Anderson, Michael Maes, Michael Berk. Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization. Advances in protein chemistry and structural biology. 2012; 88(?):27-48. doi: 10.1016/b978-0-12-398314-5.00002-7. [PMID: 22814705]
  • Svetlana E Nikoulina, Dietmar Fuchs, Phillip Moheno. Effect of orally administered dipterinyl calcium pentahydrate on oral glucose tolerance in diet-induced obese mice. Diabetes, metabolic syndrome and obesity : targets and therapy. 2012; 5(?):43-7. doi: 10.2147/dmso.s29159. [PMID: 22419880]
  • Marco Antonioli, Joanna Rybka, Livia A Carvalho. Neuroimmune endocrine effects of antidepressants. Neuropsychiatric disease and treatment. 2012; 8(?):65-83. doi: 10.2147/ndt.s16409. [PMID: 22347798]
  • Haïfa Maalmi, Anissa Berraïes, Eya Tangour, Jamel Ammar, Hanadi Abid, Kamel Hamzaoui, Agnes Hamzaoui. The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study. Journal of asthma and allergy. 2012; 5(?):11-9. doi: 10.2147/jaa.s29566. [PMID: 22690128]
  • Sergio Rutella, Franco Locatelli. Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes. Clinical & developmental immunology. 2012; 2012(?):196063. doi: 10.1155/2012/196063. [PMID: 22567028]
  • Gerard Clarke, Declan P McKernan, Gabor Gaszner, Eamonn M Quigley, John F Cryan, Timothy G Dinan. A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome. Frontiers in pharmacology. 2012; 3(?):90. doi: 10.3389/fphar.2012.00090. [PMID: 22661947]
  • Chenjie Yang, Paul D Robbins. Immunosuppressive exosomes: a new approach for treating arthritis. International journal of rheumatology. 2012; 2012(?):573528. doi: 10.1155/2012/573528. [PMID: 22548070]
  • Tao Guo, Xin F Liu, Xiang B Ding, Fei F Yang, Yong W Nie, Yu J An, Hong Guo. Fat-1 transgenic cattle as a model to study the function of ω-3 fatty acids. Lipids in health and disease. 2011 Dec; 10(?):244. doi: 10.1186/1476-511x-10-244. [PMID: 22206437]
  • Karin Landfried, Wentao Zhu, Magdalena C Waldhier, Ute Schulz, Julia Ammer, Barbara Holler, Daniel Wolff, Matthias Edinger, Katrin Peter, Marina Kreutz, Reinhard Andreesen, Peter J Oefner, Ernst Holler. Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase. Blood. 2011 Dec; 118(26):6971-4. doi: 10.1182/blood-2011-06-357814. [PMID: 22039265]
  • Nicholas H Hunt. Redox pioneer: professor Roland Stocker. Antioxidants & redox signaling. 2011 Dec; 15(12):3101-5. doi: 10.1089/ars.2010.3842. [PMID: 21609251]
  • Shalini John, Sundarapandian Thangapandian, Mahreen Arooj, Jong Chan Hong, Kwang Dong Kim, Keun Woo Lee. Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors. BMC bioinformatics. 2011 Dec; 12 Suppl 14(?):S4. doi: 10.1186/1471-2105-12-s14-s4. [PMID: 22372967]
  • Isabelle T M N Daissormont, Anette Christ, Lieve Temmerman, Stefan Sampedro Millares, Tom Seijkens, Marco Manca, Mat Rousch, Marjorie Poggi, Louis Boon, Chris van der Loos, Mat Daemen, Esther Lutgens, Bente Halvorsen, Pal Aukrust, Edith Janssen, Erik A L Biessen. Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity. Circulation research. 2011 Dec; 109(12):1387-95. doi: 10.1161/circresaha.111.256529. [PMID: 22021930]
  • Qing-Feng Sun, Ji-Guang Ding, Ji-Fang Sheng, Man-Hua Zhu, Jun-Jie Li, Zi-Ke Sheng, Xiao-Feng Tang. Novel action of 3,4-DAA ameliorating acute liver allograft injury. Cell biochemistry and function. 2011 Dec; 29(8):673-8. doi: 10.1002/cbf.1805. [PMID: 21932299]
  • M-Z Weng, Y-G Xu, Y Zhang, J-Y Zhang, Z-W Quan, J-M Xu, Z H Peng. Indoleamine 2,3-dioxygenase as a predictor of acute rejection after orthotopic liver transplantation in rat model. Transplantation proceedings. 2011 Dec; 43(10):3969-72. doi: 10.1016/j.transproceed.2011.09.061. [PMID: 22172881]
  • Takeshi Hara, Hisashi Tsurumi. [Indoleamine 2, 3-dioxygenasase (IDO) as a prognostic factor of hematological malignancies]. Rinsho byori. The Japanese journal of clinical pathology. 2011 Dec; 59(12):1133-43. doi: NULL. [PMID: 22338916]
  • Gregory Oxenkrug. Interferon-gamma - Inducible Inflammation: Contribution to Aging and Aging-Associated Psychiatric Disorders. Aging and disease. 2011 Dec; 2(6):474-86. doi: . [PMID: 22396896]
  • Praveen Kumar Munipally, Satish G Agraharm, Vijay Kumar Valavala, Sridhar Gundae, Naga Raju Turlapati. Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients. Archives of physiology and biochemistry. 2011 Dec; 117(5):254-8. doi: 10.3109/13813455.2011.623705. [PMID: 22034910]
  • Iciar Gárate, Borja García-Bueno, José L M Madrigal, Lidia Bravo, Esther Berrocoso, Javier R Caso, Juan A Micó, Juan C Leza. Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression. Journal of neuroinflammation. 2011 Nov; 8(?):151. doi: 10.1186/1742-2094-8-151. [PMID: 22053929]
  • Nady Braidy, Gilles J Guillemin, Hussein Mansour, Tailoi Chan-Ling, Ross Grant. Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS journal. 2011 Nov; 278(22):4425-34. doi: 10.1111/j.1742-4658.2011.08366.x. [PMID: 22032336]
  • Julio J Ochoa, Javier Díaz-Castro, Naroa Kajarabille, Carmen García, Isabel M Guisado, Carlos De Teresa, Rafael Guisado. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. Journal of pineal research. 2011 Nov; 51(4):373-80. doi: 10.1111/j.1600-079x.2011.00899.x. [PMID: 21615492]
  • Kenichi Sakurai, Shigeru Fujisaki, Saki Nagashima, Masahiko Shibata, Tetsuyo Maeda, Yuichi Ueda, Yukiko Hara, Katsuhisa Enomoto, Sadao Amano. [Study of indoleamine 2,3-dioxygenase expression in patients of thyroid cancer]. Gan to kagaku ryoho. Cancer & chemotherapy. 2011 Nov; 38(12):1927-9. doi: NULL. [PMID: 22202241]
  • Saara Marttila, Juulia Jylhävä, Carita Eklund, Antti Hervonen, Marja Jylhä, Mikko Hurme. Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells. Immunity & ageing : I & A. 2011 Oct; 8(?):9. doi: 10.1186/1742-4933-8-9. [PMID: 21989355]
  • Yosuke Osawa, Hiromitsu Kanamori, Ekihiro Seki, Masato Hoshi, Hirofumi Ohtaki, Yoichi Yasuda, Hiroyasu Ito, Atsushi Suetsugu, Masahito Nagaki, Hisataka Moriwaki, Kuniaki Saito, Mitsuru Seishima. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. The Journal of biological chemistry. 2011 Oct; 286(40):34800-8. doi: 10.1074/jbc.m111.235473. [PMID: 21841000]
  • Stephan Winnik, Christine Lohmann, Eva K Richter, Nicola Schäfer, Wen-Liang Song, Florian Leiber, Pavani Mocharla, Janin Hofmann, Roland Klingenberg, Jan Borén, Burkhard Becher, Garret A Fitzgerald, Thomas F Lüscher, Christian M Matter, Jürg H Beer. Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. European heart journal. 2011 Oct; 32(20):2573-84. doi: 10.1093/eurheartj/ehq501. [PMID: 21285075]
  • Renske A de Jong, Hans W Nijman, H Marike Boezen, Marcel Volmer, Klaske A Ten Hoor, Jasper Krijnen, Ate G J van der Zee, Harry Hollema, Ido P Kema. Serum tryptophan and kynurenine concentrations as parameters for indoleamine 2,3-dioxygenase activity in patients with endometrial, ovarian, and vulvar cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2011 Oct; 21(7):1320-7. doi: 10.1097/igc.0b013e31822017fb. [PMID: 21720257]
  • Stephanie W Watts, Samantha Shaw, Robert Burnett, Anne M Dorrance. Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. American journal of physiology. Heart and circulatory physiology. 2011 Oct; 301(4):H1236-47. doi: 10.1152/ajpheart.00384.2011. [PMID: 21841011]
  • Chantal Mengus, Clémentine Le Magnen, Emanuele Trella, Kawa Yousef, Lukas Bubendorf, Maurizio Provenzano, Alexander Bachmann, Michael Heberer, Giulio C Spagnoli, Stephen Wyler. Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer. Journal of translational medicine. 2011 Sep; 9(?):162. doi: 10.1186/1479-5876-9-162. [PMID: 21943235]
  • Kenji Nakajima, Tomoya Yamashita, Tomoyuki Kita, Masafumi Takeda, Naoto Sasaki, Kazuyuki Kasahara, Masakazu Shinohara, Yoshiyuki Rikitake, Tatsuro Ishida, Mitsuhiro Yokoyama, Ken-ichi Hirata. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2011 Sep; 31(9):1963-72. doi: 10.1161/atvbaha.111.229443. [PMID: 21817104]
  • Yuzo Suzuki, Takafumi Suda, Koushi Yokomura, Masako Suzuki, Michio Fujie, Kazuki Furuhashi, Dai Hahimoto, Noriyuki Enomto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Yutaka Nakano, Hirotoshi Nakamura, Kingo Chida. Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia. The Journal of infection. 2011 Sep; 63(3):215-22. doi: 10.1016/j.jinf.2011.07.003. [PMID: 21784100]
  • An Kang, Haiping Hao, Xiao Zheng, Yan Liang, Yuan Xie, Tong Xie, Chen Dai, Qijin Zhao, Xiaolan Wu, Lin Xie, Guangji Wang. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. Journal of neuroinflammation. 2011 Aug; 8(?):100. doi: 10.1186/1742-2094-8-100. [PMID: 21843370]
  • Luiz Gustavo A Chuffa, Fábio R F Seiva, Wagner José Fávaro, Giovana R Teixeira, João P A Amorim, Leonardo O Mendes, Beatriz A Fioruci, Patrícia Fernanda F Pinheiro, Ana Angélica H Fernandes, Janete A A Franci, Flávia K Delella, Marcelo Martinez, Francisco E Martinez. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation. Reproductive biology and endocrinology : RB&E. 2011 Aug; 9(?):108. doi: 10.1186/1477-7827-9-108. [PMID: 21810236]
  • Xin Fu, Marcus A Lawson, Keith W Kelley, Robert Dantzer. HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner. Journal of neuroinflammation. 2011 Aug; 8(?):88. doi: 10.1186/1742-2094-8-88. [PMID: 21810259]
  • Luiz Gustavo A Chuffa, João P A Amorim, Giovana R Teixeira, Leonardo O Mendes, Beatriz A Fioruci, Patrícia F F Pinheiro, Fábio R F Seiva, Ethel L B Novelli, Wilson de Mello Júnior, Marcelo Martinez, Camila C D Almeida-Francia, Francisco E Martinez. Long-term exogenous melatonin treatment modulates overall feed efficiency and protects ovarian tissue against injuries caused by ethanol-induced oxidative stress in adult UChB rats. Alcoholism, clinical and experimental research. 2011 Aug; 35(8):1498-508. doi: 10.1111/j.1530-0277.2011.01486.x. [PMID: 21438888]
  • Shixiu Qiu, Zhengfeng Fang, De Wu, Yan Lin, Lianqiang Che. Tryptophan supplements promote pregnancy success in mice challenged with pseudorabies virus (PRV) by regulating the expression of systemic cytokines, immunoglobulins, PRV-specific protein profiles, and toll-like receptors. Journal of medicinal food. 2011 Jul; 14(7-8):857-65. doi: 10.1089/jmf.2010.1146. [PMID: 21663516]
  • Debra E Lyon, Jeanne M Walter, Angela R Starkweather, Christine M Schubert, Nancy L McCain. Tryptophan degradation in women with breast cancer: a pilot study. BMC research notes. 2011 May; 4(?):156. doi: 10.1186/1756-0500-4-156. [PMID: 21615916]
  • Xiao-Su Zhao, Kai-Yan Liu, Dai-Hong Liu, Lan-Ping Xu, Huan Chen, Xiao-Jun Huang. Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT. Clinical transplantation. 2011 May; 25(3):E304-11. doi: 10.1111/j.1399-0012.2011.01416.x. [PMID: 21355883]
  • Katharina Kurz, Manfred Herold, Christiana Winkler, Werner Klotz, Elisabeth Russe, Dietmar Fuchs. Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis. Autoimmunity. 2011 May; 44(3):235-42. doi: 10.3109/08916934.2010.528476. [PMID: 21434757]
  • Erika Cecon, Regina P Markus. Relevance of the chronobiological and non-chronobiological actions of melatonin for enhancing therapeutic efficacy in neurodegenerative disorders. Recent patents on endocrine, metabolic & immune drug discovery. 2011 May; 5(2):91-9. doi: 10.2174/187221411799015381. [PMID: 22074584]
  • J Jylhävä, A Haarala, M Kähönen, T Lehtimäki, A Jula, L Moilanen, Y A Kesäniemi, M S Nieminen, M Hurme. Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. Clinical and experimental immunology. 2011 May; 164(2):211-7. doi: 10.1111/j.1365-2249.2011.04354.x. [PMID: 21391986]
  • Katherine A Jackman, Vanessa H Brait, Yutang Wang, Ghassan J Maghzal, Helen J Ball, Gavin McKenzie, T Michael De Silva, Roland Stocker, Christopher G Sobey. Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2011 May; 383(5):471-81. doi: 10.1007/s00210-011-0611-4. [PMID: 21359968]
  • Michael Maes. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Progress in neuro-psychopharmacology & biological psychiatry. 2011 Apr; 35(3):664-75. doi: 10.1016/j.pnpbp.2010.06.014. [PMID: 20599581]
  • M Maes, B E Leonard, A M Myint, M Kubera, R Verkerk. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Progress in neuro-psychopharmacology & biological psychiatry. 2011 Apr; 35(3):702-21. doi: 10.1016/j.pnpbp.2010.12.017. [PMID: 21185346]
  • Madeleine Ingelsten, Alex Karlsson-Parra, Anna Björnson Granqvist, Johan Mölne, Michael Olausson, Börje Haraldsson, Jenny Nyström. Postischemic inflammatory response in an auxiliary liver graft predicts renal graft outcome in sensitized patients. Transplantation. 2011 Apr; 91(8):888-94. doi: 10.1097/tp.0b013e3182100f19. [PMID: 21494202]
  • Valentina Durastanti, Alessandra Lugaresi, Placido Bramanti, Mariapia Amato, Paolo Bellantonio, Giovanna De Luca, Orietta Picconi, Roberta Fantozzi, Laura Locatelli, Annalisa Solda', Edoardo Sessa, Rocco Totaro, Silvia Marino, Valentina Zipoli, Marino Zorzon, Enrico Millefiorini. Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients. Journal of translational medicine. 2011 Apr; 9(?):42. doi: 10.1186/1479-5876-9-42. [PMID: 21501517]
  • Marcel Jenny, Angela Wondrak, Elissaveta Zvetkova, Nguyen Thi Ngoc Tram, Phan Thi Phi Phi, Harald Schennach, Zoran Culig, Florian Ueberall, Dietmar Fuchs. Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells. Scientia pharmaceutica. 2011 Apr; 79(2):323-35. doi: 10.3797/scipharm.1011-13. [PMID: 21773069]
  • Tuula K Outinen, Satu M Mäkelä, Ilpo O Ala-Houhala, Heini S A Huhtala, Mikko Hurme, Daniel H Libraty, Simo S Oja, Ilkka H Pörsti, Jaana T Syrjänen, Antti Vaheri, Jukka T Mustonen. High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica. Journal of medical virology. 2011 Apr; 83(4):731-7. doi: 10.1002/jmv.22018. [PMID: 21328391]
  • Xiong B Wang, Zhong Z Fan, Doina Anton, Annika V Vollenhoven, Zhen H Ni, Xiao F Chen, Ann K Lefvert. CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation. BMC immunology. 2011 Mar; 12(?):21. doi: 10.1186/1471-2172-12-21. [PMID: 21414236]
  • Rikke Bæk Sørensen, Tania Køllgaard, Rikke Sick Andersen, Joost Huibert van den Berg, Inge Marie Svane, Per thor Straten, Mads Hald Andersen. Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer research. 2011 Mar; 71(6):2038-44. doi: 10.1158/0008-5472.can-10-3403. [PMID: 21406395]
  • Theodoros Eleftheriadis, Vassilios Liakopoulos, Georgia Antoniadi, Ioannis Stefanidis, Grammati Galaktidou. Indoleamine 2,3-dioxygenase is increased in hemodialysis patients and affects immune response to hepatitis B vaccination. Vaccine. 2011 Mar; 29(12):2242-7. doi: 10.1016/j.vaccine.2011.01.051. [PMID: 21292009]
  • Naveen Kumar Singhal, Garima Srivastava, Devendra Kumar Patel, Swatantra Kumar Jain, Mahendra Pratap Singh. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Journal of pineal research. 2011 Mar; 50(2):97-109. doi: 10.1111/j.1600-079x.2010.00819.x. [PMID: 20964710]
  • L G A Chuffa, J P A Amorim, G R Teixeira, L O Mendes, B A Fioruci, P F F Pinheiro, F R F Seiva, E L B Novelli, W Mello Júnior, M Martinez, F E Martinez. Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2011 Mar; 44(3):217-23. doi: 10.1590/s0100-879x2011007500018. [PMID: 21344135]
  • Kyoung Ja Kwon, Jung Nam Kim, Min Kyeong Kim, Jongmin Lee, Louis J Ignarro, Hee-Jin Kim, Chan Young Shin, Seol-Heui Han. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. Journal of pineal research. 2011 Mar; 50(2):110-23. doi: 10.1111/j.1600-079x.2010.00820.x. [PMID: 21073519]
  • Barbara Sperner-Unterweger, Gabriele Neurauter, Martin Klieber, Katharina Kurz, Verena Meraner, Alain Zeimet, Dietmar Fuchs. Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers. Immunobiology. 2011 Mar; 216(3):296-301. doi: 10.1016/j.imbio.2010.07.010. [PMID: 20822828]
  • J Drobnik, D Slotwinska, S Olczak, D Tosik, A Pieniazek, K Matczak, A Koceva-Chyla, A Szczepanowska. Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2011 Feb; 62(1):29-35. doi: ". [PMID: 21451207]
  • Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology. Lipids in health and disease. 2011 Jan; 10(?):16. doi: 10.1186/1476-511x-10-16. [PMID: 21247506]
  • Jennifer M Babik, Deborah Cohan, Alexander Monto, Dennis J Hartigan-O'Connor, Joseph M McCune. The human fetal immune response to hepatitis C virus exposure in utero. The Journal of infectious diseases. 2011 Jan; 203(2):196-206. doi: 10.1093/infdis/jiq044. [PMID: 21288819]
  • Anne-Laure Dinel, Caroline André, Agnès Aubert, Guillaume Ferreira, Sophie Layé, Nathalie Castanon. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PloS one. 2011; 6(9):e24325. doi: 10.1371/journal.pone.0024325. [PMID: 21949705]
  • Yohei Miyagi, Masahiko Higashiyama, Akira Gochi, Makoto Akaike, Takashi Ishikawa, Takeshi Miura, Nobuhiro Saruki, Etsuro Bando, Hideki Kimura, Fumio Imamura, Masatoshi Moriyama, Ichiro Ikeda, Akihiko Chiba, Fumihiro Oshita, Akira Imaizumi, Hiroshi Yamamoto, Hiroshi Miyano, Katsuhisa Horimoto, Osamu Tochikubo, Toru Mitsushima, Minoru Yamakado, Naoyuki Okamoto. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PloS one. 2011; 6(9):e24143. doi: 10.1371/journal.pone.0024143. [PMID: 21915291]
  • Daniel Louis Albert van den Hove, Daniel Van den Hove, Sissi Brigitte Jakob, Karla-Gerlinde Schraut, Gunter Kenis, Angelika Gertrud Schmitt, Susanne Kneitz, Claus-Jürgen Scholz, Valentina Wiescholleck, Gabriela Ortega, Jos Prickaerts, Harry Steinbusch, Klaus-Peter Lesch. Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions. PloS one. 2011; 6(8):e22715. doi: 10.1371/journal.pone.0022715. [PMID: 21857948]
  • Christabelle J Darcy, Joshua S Davis, Tonia Woodberry, Yvette R McNeil, Dianne P Stephens, Tsin W Yeo, Nicholas M Anstey. An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. PloS one. 2011; 6(6):e21185. doi: 10.1371/journal.pone.0021185. [PMID: 21731667]
  • . [Oxidative stress and possibilities of its correction by melatonin]. Klinicheskaia meditsina. 2011; 89(5):21-5. doi: . [PMID: 22242261]