Murrayanine (BioDeep_00001868933)

Main id: BioDeep_00000007246

 

natural product


代谢物信息卡片


Murrayanine

化学式: C14H11NO2 (225.079)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC2=C1NC3=CC=CC=C32)C=O
InChI: InChI=1S/C14H11NO2/c1-17-13-7-9(8-16)6-11-10-4-2-3-5-12(10)15-14(11)13/h2-8,15H,1H3

描述信息

A natural product found in Clausena harmandiana.

同义名列表

2 个代谢物同义名

Murrayanine; Murrayanine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

44 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACE2, AIMP2, BCL2, CASP3, CASP9, CDK2, CDK4, CDK6, MTOR, PTGS2
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 8 AIMP2, BCL2, CASP3, CASP9, CDK2, CDK4, CDK6, MTOR
cytosol 8 AIMP2, BCL2, CASP3, CASP9, CDK2, CDK4, CDK6, MTOR
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CDK2, CDK6
nucleoplasm 5 CASP3, CDK2, CDK4, CDK6, MTOR
Cell membrane 2 ACE2, TNF
Cytoplasmic side 1 MTOR
Golgi apparatus membrane 1 MTOR
cell surface 2 ACE2, TNF
glutamatergic synapse 1 CASP3
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 1 AIMP2
Lysosome 1 MTOR
endosome 1 CDK2
plasma membrane 2 ACE2, TNF
Membrane 4 ACE2, AIMP2, BCL2, MTOR
apical plasma membrane 1 ACE2
caveola 1 PTGS2
extracellular exosome 1 ACE2
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 2 ACE2, TNF
bicellular tight junction 1 CDK4
mitochondrion 2 BCL2, CASP9
protein-containing complex 3 BCL2, CASP9, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 ACE2
Secreted 1 ACE2
extracellular region 2 ACE2, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 2 CDK2, CDK4
Cell projection, cilium 1 ACE2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK2, CDK6
Nucleus membrane 2 BCL2, CDK4
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDK4
external side of plasma membrane 1 TNF
nucleolus 1 CDK4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ACE2
Membrane raft 2 ACE2, TNF
pore complex 1 BCL2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
ruffle 1 CDK6
neuron projection 1 PTGS2
cilium 1 ACE2
chromatin 1 CDK4
phagocytic cup 1 TNF
brush border membrane 1 ACE2
chromosome, telomeric region 1 CDK2
nuclear envelope 2 CDK2, MTOR
Endomembrane system 1 MTOR
myelin sheath 1 BCL2
endoplasmic reticulum lumen 2 ACE2, PTGS2
male germ cell nucleus 1 CDK2
endocytic vesicle membrane 1 ACE2
apoptosome 1 CASP9
Cajal body 1 CDK2
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
condensed chromosome 1 CDK2
Cytoplasmic vesicle, phagosome 1 MTOR
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 3 CDK2, CDK4, CDK6
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CDK6
cyclin A1-CDK2 complex 1 CDK2
cyclin D3-CDK6 complex 1 CDK6
caspase complex 1 CASP9
cyclin D2-CDK6 complex 1 CDK6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Shilpa Gupta, Vidushi Khajuria, Abubakar Wani, Yedukondalu Nalli, Asha Bhagat, Asif Ali, Zabeer Ahmed. Murrayanine Attenuates Lipopolysaccharide-induced Inflammation and Protects Mice from Sepsis-associated Organ Failure. Basic & clinical pharmacology & toxicology. 2019 Apr; 124(4):351-359. doi: 10.1111/bcpt.13032. [PMID: 29719125]
  • Jingbao Zhang, Yanfei Gao, Changbo Ma, Yi Wang. Murrayanine Induces Cell Cycle Arrest, Oxidative Stress, and Inhibition of Phosphorylated p38 Expression in A549 Lung Adenocarcinoma Cells. Medical science monitor : international medical journal of experimental and clinical research. 2019 03; 25(?):2002-2008. doi: 10.12659/msm.913873. [PMID: 30879017]
  • Hang Liu, Ji-zhong Shen, Hai-xia Zhang. [Chemical constituents from stems of Clausena excavata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Nov; 37(11):2012-5. doi: . [PMID: 26027123]
  • De-Yang Shen, Yu-Yi Chan, Tsong-Long Hwang, Shin-Hun Juang, Shiow-Chyn Huang, Ping-Chung Kuo, Tran Dinh Thang, E-Jian Lee, Amooru G Damu, Tian-Shung Wu. Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. Journal of natural products. 2014 May; 77(5):1215-23. doi: 10.1021/np500088u. [PMID: 24798144]
  • Hang Liu, Chuang-Jun Li, Jing-Zhi Yang, Na Ning, Yi-Kang Si, Li Li, Nai-Hong Chen, Qing Zhao, Dong-Ming Zhang. Carbazole alkaloids from the stems of Clausena lansium. Journal of natural products. 2012 Apr; 75(4):677-82. doi: 10.1021/np200919a. [PMID: 22372931]
  • Uraiwan Songsiang, Tula Thongthoom, Chantana Boonyarat, Chavi Yenjai. Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. Journal of natural products. 2011 Feb; 74(2):208-12. doi: 10.1021/np100654m. [PMID: 21302964]
  • Nguyen Manh Cuong, Tran Quang Hung, Tran Van Sung, Walter Chacles Taylor. A new dimeric carbazole alkaloid from Glycosmis stenocarpa roots. Chemical & pharmaceutical bulletin. 2004 Oct; 52(10):1175-8. doi: 10.1248/cpb.52.1175. [PMID: 15467229]
  • Yun-Song Wang, Hong-Ping He, Yue-Mao Shen, Xin Hong, Xiao-Jiang Hao. Two new carbazole alkaloids from Murraya koenigii. Journal of natural products. 2003 Mar; 66(3):416-8. doi: 10.1021/np020468a. [PMID: 12662104]
  • Arunrat Sunthitikawinsakul, Ngampong Kongkathip, Boonsong Kongkathip, Sida Phonnakhu, John W Daly, Thomas F Spande, Yuth Nimit, Sasarose Rochanaruangrai. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Planta medica. 2003 Feb; 69(2):155-7. doi: 10.1055/s-2003-37716. [PMID: 12624822]