Carbamoyl phosphate (BioDeep_00001868775)
Main id: BioDeep_00000004389
PANOMIX_OTCML-2023
代谢物信息卡片
Carbamoyl phosphate
化学式: CH4NO5P (140.9827104)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=O)(N)OP(=O)(O)O
InChI: InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:17672
- KEGG: C00169
- PubChem: 278
- ChEMBL: CHEMBL369105
- MeSH: Carbamyl Phosphate
- CAS: 590-55-6
- MetaboLights: MTBLC17672
- PubChem: 3469
- KNApSAcK: C00007513
- PDB-CCD: CP
- 3DMET: B00050
- NIKKAJI: J39.574I
分类词条
相关代谢途径
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Z Hu, S Zhang, H Zhang, L Cao, R Chang, Z Liu, H Zhang, Z Xu, G Liu. Identification and expression pattern analysis of PtCarA and PtCarB genes in Populus trichocarpa under different nitrogen treatments.
Plant biology (Stuttgart, Germany).
2023 Jan; 25(1):131-141. doi:
10.1111/plb.13471. [PMID: 36178874] - Sisi Zhang, Yue Hu, Zilong Wu, Xiaoshu Zhou, Tong Wu, Pindong Li, Qiuyu Lian, Shuangbing Xu, Jin Gu, Lei Chen, Gang Wu, Tao Zhang, Jing Tang, Jun Xue. Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc.
International journal of radiation oncology, biology, physics.
2022 Nov; ?(?):. doi:
10.1016/j.ijrobp.2022.11.022. [PMID: 36423742] - Qin Qi, Rui Zhong, Ya-Nan Liu, Chen Zhao, Yan Huang, Yuan Lu, Zhe Ma, Han-Dan Zheng, Lu-Yi Wu. Mechanism of electroacupuncture and herb-partitioned moxibustion on ulcerative colitis animal model: A study based on proteomics.
World journal of gastroenterology.
2022 Jul; 28(28):3644-3665. doi:
10.3748/wjg.v28.i28.3644. [PMID: 36161055] - Yunha Choi, Arum Oh, Yena Lee, Gu-Hwan Kim, Jin-Ho Choi, Han-Wook Yoo, Beom Hee Lee. Unfavorable clinical outcomes in patients with carbamoyl phosphate synthetase 1 deficiency.
Clinica chimica acta; international journal of clinical chemistry.
2022 Feb; 526(?):55-61. doi:
10.1016/j.cca.2021.11.029. [PMID: 34973183] - Qingqun Tan, Xuanzhu Zhao, Haiyong He, Junxiang Zhang, Tuyong Yi. Carbamoyl phosphate synthetase subunit Cpa1 interacting with Dut1, controls development, arginine biosynthesis, and pathogenicity of Colletotrichum gloeosporioides.
Fungal biology.
2021 03; 125(3):184-190. doi:
10.1016/j.funbio.2020.10.009. [PMID: 33622534] - Suhail Khoja, Matt Nitzahn, Kip Hermann, Brian Truong, Roberta Borzone, Brandon Willis, Mitchell Rudd, Donna J Palmer, Philip Ng, Nicola Brunetti-Pierri, Gerald S Lipshutz. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy.
Molecular genetics and metabolism.
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Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S219-22. doi:
10.1007/s10545-008-0777-1. [PMID: 18338235] - Jun Liang, Cheryl Clark-Dixon, Shaoxiao Wang, Todd R Flower, Tara Williams-Hart, Richard Zweig, Lucy C Robinson, Kelly Tatchell, Stephan N Witt. Novel suppressors of alpha-synuclein toxicity identified using yeast.
Human molecular genetics.
2008 Dec; 17(23):3784-95. doi:
10.1093/hmg/ddn276. [PMID: 18772193] - Milka Sokolović, Aleksandar Sokolović, Diederik Wehkamp, Emiel Ver Loren van Themaat, Dirk R de Waart, Lisa A Gilhuijs-Pederson, Yuri Nikolsky, Antoine H C van Kampen, Theodorus B M Hakvoort, Wouter H Lamers. The transcriptomic signature of fasting murine liver.
BMC genomics.
2008 Nov; 9(?):528. doi:
10.1186/1471-2164-9-528. [PMID: 18990241] - Nantaporn Haskins, Maria Panglao, Qiuhao Qu, Himani Majumdar, Juan Cabrera-Luque, Hiroki Morizono, Mendel Tuchman, Ljubica Caldovic. Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods.
BMC biochemistry.
2008 Sep; 9(?):24. doi:
10.1186/1471-2091-9-24. [PMID: 18801197] - M Takagi, T Yonezawa, S Haga, H Shingu, Y Kobayashi, T Takahashi, Y Ohtani, Y Obara, K Katoh. Changes of activity and mRNA expression of urea cycle enzymes in the liver of developing Holstein calves.
Journal of animal science.
2008 Jul; 86(7):1526-32. doi:
10.2527/jas.2007-0799. [PMID: 18344300] - Chris M Wood, Makiko Kajimura, Thomas P Mommsen, Patrick J Walsh. Is the alkaline tide a signal to activate metabolic or ionoregulatory enzymes in the dogfish shark (Squalus acanthias)?.
Physiological and biochemical zoology : PBZ.
2008 May; 81(3):278-87. doi:
10.1086/587094. [PMID: 18419554] - Min Peng, Marni J Falk, Volker H Haase, Rhonda King, Erzsebet Polyak, Mary Selak, Marc Yudkoff, Wayne W Hancock, Ray Meade, Ryoichi Saiki, Adam L Lunceford, Catherine F Clarke, David L Gasser. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease.
PLoS genetics.
2008 Apr; 4(4):e1000061. doi:
10.1371/journal.pgen.1000061. [PMID: 18437205] - Frances M Dupont. Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics.
BMC plant biology.
2008 Apr; 8(?):39. doi:
10.1186/1471-2229-8-39. [PMID: 18419817] - R Johnson Pradeep. Valproate monotherapy induced-delirium due to hyperammonemia: A report of three adult cases with different types of presentation.
Indian journal of psychiatry.
2008 Apr; 50(2):121-3. doi:
10.4103/0019-5545.42400. [PMID: 19742224] - Karyn L Newman, Subhadeep Chatterjee, Kimberly A Ho, Steven E Lindow. Virulence of plant pathogenic bacteria attenuated by degradation of fatty acid cell-to-cell signaling factors.
Molecular plant-microbe interactions : MPMI.
2008 Mar; 21(3):326-34. doi:
10.1094/mpmi-21-3-0326. [PMID: 18257682] - Virginie Levrat, Isabelle Forest, Alain Fouilhoux, Cécile Acquaviva, Christine Vianey-Saban, Nathalie Guffon. Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?.
Orphanet journal of rare diseases.
2008 Jan; 3(?):2. doi:
10.1186/1750-1172-3-2. [PMID: 18234091] - A K Azad, Takayuki Ishikawa, Takahiro Ishikawa, Y Sawa, H Shibata. Intracellular energy depletion triggers programmed cell death during petal senescence in tulip.
Journal of experimental botany.
2008; 59(8):2085-95. doi:
10.1093/jxb/ern066. [PMID: 18515833] - Xiaoyan Gong, Yanping Fu, Daohong Jiang, Guoqing Li, Xianhong Yi, Youliang Peng. L-arginine is essential for conidiation in the filamentous fungus Coniothyrium minitans.
Fungal genetics and biology : FG & B.
2007 Dec; 44(12):1368-79. doi:
10.1016/j.fgb.2007.07.007. [PMID: 17897846] - Rob M J Moonen, Aimee D C Paulussen, Nicole Y P Souren, Alfons G H Kessels, M Estela Rubio-Gozalbo, Eduardo Villamor. Carbamoyl phosphate synthetase polymorphisms as a risk factor for necrotizing enterocolitis.
Pediatric research.
2007 Aug; 62(2):188-90. doi:
10.1203/pdr.0b013e3180a0324e. [PMID: 17597649] - Tomiko Kuhara. Noninvasive human metabolome analysis for differential diagnosis of inborn errors of metabolism.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Aug; 855(1):42-50. doi:
10.1016/j.jchromb.2007.03.031. [PMID: 17467347] - James A Coker, Priya DasSarma, Jeffrey Kumar, Jochen A Müller, Shiladitya DasSarma. Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature.
Saline systems.
2007 Jul; 3(?):6. doi:
10.1186/1746-1448-3-6. [PMID: 17651475] - Nirmalendu Saha, Shritapa Datta, Zaiba Y Kharbuli, Kuheli Biswas, Arundhati Bhattacharjee. Air-breathing catfish, Clarias batrachus upregulates glutamine synthetase and carbamyl phosphate synthetase III during exposure to high external ammonia.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2007 Jul; 147(3):520-30. doi:
10.1016/j.cbpb.2007.03.007. [PMID: 17451989] - F Tulli, C Vachot, E Tibaldi, V Fournier, S J Kaushik. Contribution of dietary arginine to nitrogen utilisation and excretion in juvenile sea bass (Dicentrarchus labrax) fed diets differing in protein source.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2007 May; 147(1):179-88. doi:
10.1016/j.cbpa.2006.12.036. [PMID: 17321177] - Susanne Schouw Nielsen, Thorbjørn Grøfte, Henning Grønbaek, Niels Tygstrup, Hendrik Vilstrup. Opposite effects on regulation of urea synthesis by early and late uraemia in rats.
Clinical nutrition (Edinburgh, Scotland).
2007 Apr; 26(2):245-51. doi:
10.1016/j.clnu.2006.11.005. [PMID: 17250930] - Serene M L Lee, Wai P Wong, Ai M Loong, Kum C Hiong, Shit F Chew, Yuen K Ip. Postprandial increases in nitrogenous excretion and urea synthesis in the Chinese soft-shelled turtle, Pelodiscus sinensis.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2007 Jan; 177(1):19-29. doi:
10.1007/s00360-006-0105-8. [PMID: 16838133] - Wan-Chun Li, Kate L Ralphs, Jonathan M W Slack, David Tosh. Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors.
The international journal of biochemistry & cell biology.
2007; 39(3):541-54. doi:
10.1016/j.biocel.2006.10.017. [PMID: 17129745] - Hyoung Jin Kim, Hong-Jin Kim. Glycosylation variant analysis of recombinant human tissue plasminogen activator produced in urea-cycle-enzyme-expressing Chinese hamster ovary (CHO) cell line.
Journal of bioscience and bioengineering.
2006 Nov; 102(5):447-51. doi:
10.1263/jbb.102.447. [PMID: 17189173] - J Marco Schnater, Elisabeth Bruder, Sibylle Bertschin, Thomas Woodtli, Chiel de Theije, Torsten Pietsch, Daniel C Aronson, Dietrich von Schweinitz, Wouter H Lamers, Eleonore S Köhler. Subcutaneous and intrahepatic growth of human hepatoblastoma in immunodeficient mice.
Journal of hepatology.
2006 Sep; 45(3):377-86. doi:
10.1016/j.jhep.2006.03.018. [PMID: 16780998] - Makiko Kajimura, Patrick J Walsh, Thomas P Mommsen, Chris M Wood. The dogfish shark (Squalus acanthias) increases both hepatic and extrahepatic ornithine urea cycle enzyme activities for nitrogen conservation after feeding.
Physiological and biochemical zoology : PBZ.
2006 May; 79(3):602-13. doi:
10.1086/501060. [PMID: 16691526] - Francine Goulet, Ioana Diana Napa, Luc Solomon, Odette Morin, Nazrul Islam. Modulated expression of a nuclear-associated glycoprotein during normal rat liver development and in various hepatoma cells.
Progress in neuro-psychopharmacology & biological psychiatry.
2006 Jan; 30(1):159-65. doi:
10.1016/j.pnpbp.2005.08.022. [PMID: 16233943] - Elena Adinolfi, Cinzia Pizzirani, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Francesco Di Virgilio, Davide Ferrari. P2X(7) receptor: Death or life?.
Purinergic signalling.
2005 Sep; 1(3):219-27. doi:
10.1007/s11302-005-6322-x. [PMID: 18404507] - Hsiang-Po Huang, Yin-Hsiu Chien, Li-Min Huang, Yen-Hsuan Ni, Mei-Hwei Chang, Ming-Chih Ho, Po-Huang Lee, Wuh-Liang Hwu. Viral infections and prolonged fever after liver transplantation in young children with inborn errors of metabolism.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2005 Sep; 104(9):623-9. doi:
NULL. [PMID: 16276436] - Jasna Kojic, Patricia L Robertson, Douglas J Quint, Donna M Martin, Yuxi Pang, Pia C Sundgren. Brain glutamine by MRS in a patient with urea cycle disorder and coma.
Pediatric neurology.
2005 Feb; 32(2):143-6. doi:
10.1016/j.pediatrneurol.2004.07.013. [PMID: 15664780] - Louise Mallet, Steve Babin, José A Morais. Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman.
The Annals of pharmacotherapy.
2004 Oct; 38(10):1643-7. doi:
10.1345/aph.1e063. [PMID: 15316109] - Peter Lundberg, Per-Olof Lundquist. Primary metabolism in N2-fixing Alnus incana-Frankia symbiotic root nodules studied with 15N and 31P nuclear magnetic resonance spectroscopy.
Planta.
2004 Aug; 219(4):661-72. doi:
10.1007/s00425-004-1271-0. [PMID: 15179512] - Béatrice Mouillé, Véronique Robert, François Blachier. Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Aug; 287(2):G344-51. doi:
10.1152/ajpgi.00445.2003. [PMID: 15064231] - Patricia Wright, Paul Anderson, Lei Weng, Natasha Frick, Wei Peng Wong, Yuen Kwong Ip. The crab-eating frog, Rana cancrivora, up-regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity.
Journal of experimental zoology. Part A, Comparative experimental biology.
2004 Jul; 301(7):559-68. doi:
10.1002/jez.a.54. [PMID: 15229866] - J C Velez, S S Donkin. Bovine somatotropin increases hepatic phosphoenolpyruvate carboxykinase mRNA in lactating dairy cows.
Journal of dairy science.
2004 May; 87(5):1325-35. doi:
10.3168/jds.s0022-0302(04)73282-8. [PMID: 15290980] - Yuen K Ip, Ramdzan M Zubaidah, Pei C Liew, Ai M Loong, Kum C Hiong, Wai P Wong, Shit F Chew. African sharptooth catfish Clarias gariepinus does not detoxify ammonia to urea or amino acids but actively excretes ammonia during exposure to environmental ammonia.
Physiological and biochemical zoology : PBZ.
2004 Mar; 77(2):242-54. doi:
10.1086/383499. [PMID: 15095244] - Shit F Chew, Tan F Ong, Lilian Ho, Wai L Tam, Ai M Loong, Kum C Hiong, Wai P Wong, Yuen K Ip. Urea synthesis in the African lungfish Protopterus dolloi--hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure.
The Journal of experimental biology.
2003 Oct; 206(Pt 20):3615-24. doi:
10.1242/jeb.00619. [PMID: 12966053] - Yuen K Ip, Wai L Tam, Wai P Wong, Ai M Loong, Kum C Hiong, James S Ballantyne, Shit F Chew. A comparison of the effects of environmental ammonia exposure on the Asian freshwater stingray Himantura signifer and the Amazonian freshwater stingray Potamotrygon motoro.
The Journal of experimental biology.
2003 Oct; 206(Pt 20):3625-33. doi:
10.1242/jeb.00612. [PMID: 12966054] - Wai L Tam, Wai P Wong, Ai M Loong, Kum C Hiong, Shit F Chew, James S Ballantyne, Yuen K Ip. The osmotic response of the Asian freshwater stingray (Himantura signifer) to increased salinity: a comparison with marine (Taeniura lymma) and Amazonian freshwater (Potamotrygon motoro) stingrays.
The Journal of experimental biology.
2003 Sep; 206(Pt 17):2931-40. doi:
10.1242/jeb.00510. [PMID: 12878662] - Angela M Valverde, Deborah J Burks, Isabel Fabregat, Tracey L Fisher, José Carretero, Morris F White, Manuel Benito. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.
Diabetes.
2003 Sep; 52(9):2239-48. doi:
10.2337/diabetes.52.9.2239. [PMID: 12941762] - Boris Gebhardt, Stefan Vlaho, Doris Fischer, Adrian Sewell, Hansjosef Böhles. N-carbamylglutamate enhances ammonia detoxification in a patient with decompensated methylmalonic aciduria.
Molecular genetics and metabolism.
2003 Aug; 79(4):303-4. doi:
10.1016/s1096-7192(03)00095-7. [PMID: 12948747]