Carbamoyl phosphate (BioDeep_00001868775)

Main id: BioDeep_00000004389

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


Carbamoyl phosphate

化学式: CH4NO5P (140.9827)
中文名称: 氨基甲酰磷酸 二钠盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=O)(N)OP(=O)(O)O
InChI: InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)

描述信息

同义名列表

2 个代谢物同义名

Carbamoyl phosphate; Carbamoyl phosphate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, ARG1, ASL, ASS1, CAT, ELANE, GLUL, MTOR, OAT, ODC1, PC
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 6 ALB, ARG1, GLUL, MTOR, RFC2, SIRT5
cytosol 14 ALB, ARG1, ASL, ASS1, CAT, DHODH, ELANE, GLS, GLUL, GPT, MTOR, ODC1, PC, SIRT5
dendrite 1 MTOR
phagocytic vesicle 2 ELANE, MTOR
centrosome 1 ALB
nucleoplasm 6 ASS1, ATP2B1, DHODH, MTOR, OAT, RFC2
Cell membrane 2 ATP2B1, GLUL
Lipid-anchor 1 GLUL
Cytoplasmic side 1 MTOR
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 MTOR
Synapse 2 ATP2B1, GLS
cell surface 1 ELANE
glutamatergic synapse 1 ATP2B1
Golgi apparatus 1 ALB
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 2 DHODH, OTC
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 4 ASS1, GLS, GLUL, SIRT5
Lysosome 1 MTOR
plasma membrane 2 ATP2B1, GLUL
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, CAT, DHODH, MTOR
basolateral plasma membrane 1 ATP2B1
extracellular exosome 8 ALB, ASL, ASS1, ATP2B1, CAT, ELANE, GLUL, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, GLUL
extracellular space 5 ALB, ARG1, CPA1, CPA2, ELANE
mitochondrion 8 CAT, DHODH, GLS, GLUL, OAT, OTC, PC, SIRT5
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 2 ATP2B1, CAT
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 ALB, CPA1, CPA2
extracellular region 5 ALB, ARG1, CAT, CPA2, ELANE
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 DHODH
mitochondrial outer membrane 2 ASS1, MTOR
Mitochondrion matrix 3 OAT, OTC, PC
mitochondrial matrix 6 CAT, GLS, OAT, OTC, PC, SIRT5
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
perikaryon 1 ASS1
Mitochondrion inner membrane 1 DHODH
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
mitochondrial intermembrane space 1 SIRT5
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 GLS
[Isoform 2]: Mitochondrion 1 SIRT5
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
cell body fiber 1 ASS1
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
[Isoform 1]: Cytoplasm 1 SIRT5
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 ALB
transcription repressor complex 1 ELANE
platelet alpha granule lumen 1 ALB
specific granule lumen 2 ARG1, ELANE
azurophil granule lumen 2 ARG1, ELANE
immunological synapse 1 ATP2B1
Vacuole 1 CPA2
[Isoform 3]: Mitochondrion 1 GLS
Cytoplasmic vesicle, phagosome 2 ELANE, MTOR
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
glial cell projection 1 GLUL
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
Ctf18 RFC-like complex 1 RFC2
DNA replication factor C complex 1 RFC2
ciliary transition fiber 1 ALB


文献列表

  • Z Hu, S Zhang, H Zhang, L Cao, R Chang, Z Liu, H Zhang, Z Xu, G Liu. Identification and expression pattern analysis of PtCarA and PtCarB genes in Populus trichocarpa under different nitrogen treatments. Plant biology (Stuttgart, Germany). 2023 Jan; 25(1):131-141. doi: 10.1111/plb.13471. [PMID: 36178874]
  • Sisi Zhang, Yue Hu, Zilong Wu, Xiaoshu Zhou, Tong Wu, Pindong Li, Qiuyu Lian, Shuangbing Xu, Jin Gu, Lei Chen, Gang Wu, Tao Zhang, Jing Tang, Jun Xue. Deficiency of Carbamoyl Phosphate Synthetase 1 Engenders Radioresistance in Hepatocellular Carcinoma via Deubiquitinating c-Myc. International journal of radiation oncology, biology, physics. 2022 Nov; ?(?):. doi: 10.1016/j.ijrobp.2022.11.022. [PMID: 36423742]
  • Qin Qi, Rui Zhong, Ya-Nan Liu, Chen Zhao, Yan Huang, Yuan Lu, Zhe Ma, Han-Dan Zheng, Lu-Yi Wu. Mechanism of electroacupuncture and herb-partitioned moxibustion on ulcerative colitis animal model: A study based on proteomics. World journal of gastroenterology. 2022 Jul; 28(28):3644-3665. doi: 10.3748/wjg.v28.i28.3644. [PMID: 36161055]
  • Yunha Choi, Arum Oh, Yena Lee, Gu-Hwan Kim, Jin-Ho Choi, Han-Wook Yoo, Beom Hee Lee. Unfavorable clinical outcomes in patients with carbamoyl phosphate synthetase 1 deficiency. Clinica chimica acta; international journal of clinical chemistry. 2022 Feb; 526(?):55-61. doi: 10.1016/j.cca.2021.11.029. [PMID: 34973183]
  • Qingqun Tan, Xuanzhu Zhao, Haiyong He, Junxiang Zhang, Tuyong Yi. Carbamoyl phosphate synthetase subunit Cpa1 interacting with Dut1, controls development, arginine biosynthesis, and pathogenicity of Colletotrichum gloeosporioides. Fungal biology. 2021 03; 125(3):184-190. doi: 10.1016/j.funbio.2020.10.009. [PMID: 33622534]
  • Suhail Khoja, Matt Nitzahn, Kip Hermann, Brian Truong, Roberta Borzone, Brandon Willis, Mitchell Rudd, Donna J Palmer, Philip Ng, Nicola Brunetti-Pierri, Gerald S Lipshutz. Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy. Molecular genetics and metabolism. 2018 08; 124(4):243-253. doi: 10.1016/j.ymgme.2018.04.001. [PMID: 29801986]
  • Vijay Joshi, Alisdair R Fernie. Citrulline metabolism in plants. Amino acids. 2017 09; 49(9):1543-1559. doi: 10.1007/s00726-017-2468-4. [PMID: 28741223]
  • Alice Matone, Marie-Pier Scott-Boyer, Jerome Carayol, Parastoo Fazelzadeh, Gregory Lefebvre, Armand Valsesia, Celine Charon, Jacques Vervoort, Arne Astrup, Wim H M Saris, Melissa Morine, Jörg Hager. Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance. PloS one. 2016; 11(3):e0150495. doi: 10.1371/journal.pone.0150495. [PMID: 26938218]
  • Maria Sole Chimenti, Paola Triggianese, Marzia Nuccetelli, Chiara Terracciano, Anna Crisanti, Maria Domenica Guarino, Sergio Bernardini, Roberto Perricone. Auto-reactions, autoimmunity and psoriatic arthritis. Autoimmunity reviews. 2015 Dec; 14(12):1142-6. doi: 10.1016/j.autrev.2015.08.003. [PMID: 26254734]
  • Maria M Adeva, Gema Souto, Natalia Blanco, Cristóbal Donapetry. Ammonium metabolism in humans. Metabolism: clinical and experimental. 2012 Nov; 61(11):1495-511. doi: 10.1016/j.metabol.2012.07.007. [PMID: 22921946]
  • Dae Eun Choi, Kang Wook Lee, Young Tai Shin, Ki Ryang Na. Hyperammonemia in a patient with late-onset ornithine carbamoyltransferase deficiency. Journal of Korean medical science. 2012 May; 27(5):556-9. doi: 10.3346/jkms.2012.27.5.556. [PMID: 22563224]
  • Candida Vannini, Milena Marsoni, Carlo Cantara, Maria Concetta De Pinto, Vittoria Locato, Laura De Gara, Marcella Bracale. The soluble proteome of tobacco Bright Yellow-2 cells undergoing H₂O₂-induced programmed cell death. Journal of experimental botany. 2012 May; 63(8):3137-55. doi: 10.1093/jxb/ers031. [PMID: 22355080]
  • Ganwu Li, Subhashinie Kariyawasam, Kelly A Tivendale, Yvonne Wannemuehler, Christa Ewers, Lothar H Wieler, Catherine M Logue, Lisa K Nolan. tkt1, located on a novel pathogenicity island, is prevalent in avian and human extraintestinal pathogenic Escherichia coli. BMC microbiology. 2012 Apr; 12(?):51. doi: 10.1186/1471-2180-12-51. [PMID: 22471764]
  • Wataru Takagi, Makiko Kajimura, Justin D Bell, Tes Toop, John A Donald, Susumu Hyodo. Hepatic and extrahepatic distribution of ornithine urea cycle enzymes in holocephalan elephant fish (Callorhinchus milii). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2012 Apr; 161(4):331-40. doi: 10.1016/j.cbpb.2011.12.006. [PMID: 22227372]
  • Nikolay Ishkitiev, Ken Yaegaki, Toshio Imai, Tomoko Tanaka, Taka Nakahara, Hiroshi Ishikawa, Vanyo Mitev, Markus Haapasalo. High-purity hepatic lineage differentiated from dental pulp stem cells in serum-free medium. Journal of endodontics. 2012 Apr; 38(4):475-80. doi: 10.1016/j.joen.2011.12.011. [PMID: 22414832]
  • Hana Janečková, Karel Hron, Petr Wojtowicz, Eva Hlídková, Anna Barešová, David Friedecký, Lenka Zídková, Petr Hornik, Darina Behúlová, Dagmar Procházková, Hana Vinohradská, Karolína Pešková, Per Bruheim, Vratislav Smolka, Sylvie Sťastná, Tomáš Adam. Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. Journal of chromatography. A. 2012 Feb; 1226(?):11-7. doi: 10.1016/j.chroma.2011.09.074. [PMID: 22018716]
  • Daniela Münch, Terry Roemer, Sang Ho Lee, Marianne Engeser, Hans Georg Sahl, Tanja Schneider. Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus. PLoS pathogens. 2012 Jan; 8(1):e1002509. doi: 10.1371/journal.ppat.1002509. [PMID: 22291598]
  • Fang Peng, Xianquan Zhan, Mao-Yu Li, Fan Fang, Guoqing Li, Cui Li, Peng-Fei Zhang, Zhuchu Chen. Proteomic and bioinformatics analyses of mouse liver microsomes. International journal of proteomics. 2012; 2012(?):832569. doi: 10.1155/2012/832569. [PMID: 22500222]
  • Paul Szpak, Fred J Longstaffe, Jean-François Millaire, Christine D White. Stable isotope biogeochemistry of seabird guano fertilization: results from growth chamber studies with maize (Zea mays). PloS one. 2012; 7(3):e33741. doi: 10.1371/journal.pone.0033741. [PMID: 22479435]
  • Arjun Sengupta, Soumita Ghosh, Angika Basant, Suhas Malusare, Parul Johri, Sulabha Pathak, Shobhona Sharma, Haripalsingh M Sonawat. Global host metabolic response to Plasmodium vivax infection: a 1H NMR based urinary metabonomic study. Malaria journal. 2011 Dec; 10(?):384. doi: 10.1186/1475-2875-10-384. [PMID: 22196439]
  • Timothy R Bates, Barry D Lewis, John R Burnett, Kenji So, Andrew Mitchell, Luc Delriviere, Gary P Jeffrey. Late-onset carbamoyl phosphate synthetase 1 deficiency in an adult cured by liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2011 Dec; 17(12):1481-4. doi: 10.1002/lt.22407. [PMID: 21837743]
  • Gautham Vivek Sridharan, Soha Hassoun, Kyongbum Lee. Identification of biochemical network modules based on shortest retroactive distances. PLoS computational biology. 2011 Nov; 7(11):e1002262. doi: 10.1371/journal.pcbi.1002262. [PMID: 22102800]
  • Hyo Jeong Kim, Se Jin Park, Kook In Park, Jin Sung Lee, Ho Sun Eun, Ji Hong Kim, Jae Il Shin. Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency. Korean journal of pediatrics. 2011 Oct; 54(10):425-8. doi: 10.3345/kjp.2011.54.10.425. [PMID: 22232626]
  • Eva Arrebola, Francisco M Cazorla, Alejandro Perez-García, Antonio de Vicente. Chemical and metabolic aspects of antimetabolite toxins produced by Pseudomonas syringae pathovars. Toxins. 2011 09; 3(9):1089-110. doi: 10.3390/toxins3091089. [PMID: 22069758]
  • Kirstin Mittelstrass, Janina S Ried, Zhonghao Yu, Jan Krumsiek, Christian Gieger, Cornelia Prehn, Werner Roemisch-Margl, Alexey Polonikov, Annette Peters, Fabian J Theis, Thomas Meitinger, Florian Kronenberg, Stephan Weidinger, Heinz Erich Wichmann, Karsten Suhre, Rui Wang-Sattler, Jerzy Adamski, Thomas Illig. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS genetics. 2011 Aug; 7(8):e1002215. doi: 10.1371/journal.pgen.1002215. [PMID: 21852955]
  • Cissi Gardmo, Antonio Tamburro, Salvatore Modica, Antonio Moschetta. Proteomics for the discovery of nuclear bile acid receptor FXR targets. Biochimica et biophysica acta. 2011 Aug; 1812(8):836-41. doi: 10.1016/j.bbadis.2011.03.009. [PMID: 21439373]
  • Roseline Froissart, Monique Piraud, Alix Mollet Boudjemline, Christine Vianey-Saban, François Petit, Aurélie Hubert-Buron, Pascale Trioche Eberschweiler, Vincent Gajdos, Philippe Labrune. Glucose-6-phosphatase deficiency. Orphanet journal of rare diseases. 2011 May; 6(?):27. doi: 10.1186/1750-1172-6-27. [PMID: 21599942]
  • Diana Chernikova, Sam Motamedi, Miklós Csürös, Eugene V Koonin, Igor B Rogozin. A late origin of the extant eukaryotic diversity: divergence time estimates using rare genomic changes. Biology direct. 2011 May; 6(?):26. doi: 10.1186/1745-6150-6-26. [PMID: 21595937]
  • Fábio O Pedrosa, Rose Adele Monteiro, Roseli Wassem, Leonardo M Cruz, Ricardo A Ayub, Nelson B Colauto, Maria Aparecida Fernandez, Maria Helena P Fungaro, Edmundo C Grisard, Mariangela Hungria, Humberto M F Madeira, Rubens O Nodari, Clarice A Osaku, Maria Luiza Petzl-Erler, Hernán Terenzi, Luiz G E Vieira, Maria Berenice R Steffens, Vinicius A Weiss, Luiz F P Pereira, Marina I M Almeida, Lysangela R Alves, Anelis Marin, Luiza Maria Araujo, Eduardo Balsanelli, Valter A Baura, Leda S Chubatsu, Helisson Faoro, Augusto Favetti, Geraldo Friedermann, Chirlei Glienke, Susan Karp, Vanessa Kava-Cordeiro, Roberto T Raittz, Humberto J O Ramos, Enilze Maria S F Ribeiro, Liu Un Rigo, Saul N Rocha, Stefan Schwab, Anilda G Silva, Eliel M Souza, Michelle Z Tadra-Sfeir, Rodrigo A Torres, Audrei N G Dabul, Maria Albertina M Soares, Luciano S Gasques, Ciela C T Gimenes, Juliana S Valle, Ricardo R Ciferri, Luiz C Correa, Norma K Murace, João A Pamphile, Eliana Valéria Patussi, Alberto J Prioli, Sonia Maria A Prioli, Carmem Lúcia M S C Rocha, Olívia Márcia N Arantes, Márcia Cristina Furlaneto, Leandro P Godoy, Carlos E C Oliveira, Daniele Satori, Laurival A Vilas-Boas, Maria Angélica E Watanabe, Bibiana Paula Dambros, Miguel P Guerra, Sandra Marisa Mathioni, Karine Louise Santos, Mario Steindel, Javier Vernal, Fernando G Barcellos, Rubens J Campo, Ligia Maria O Chueire, Marisa Fabiana Nicolás, Lilian Pereira-Ferrari, José L da Conceição Silva, Nereida M R Gioppo, Vladimir P Margarido, Maria Amélia Menck-Soares, Fabiana Gisele S Pinto, Rita de Cássia G Simão, Elizabete K Takahashi, Marshall G Yates, Emanuel M Souza. Genome of Herbaspirillum seropedicae strain SmR1, a specialized diazotrophic endophyte of tropical grasses. PLoS genetics. 2011 May; 7(5):e1002064. doi: 10.1371/journal.pgen.1002064. [PMID: 21589895]
  • Dan Qian, Lin Jiang, Lu Lu, Chunhong Wei, Yi Li. Biochemical and structural properties of cyanases from Arabidopsis thaliana and Oryza sativa. PloS one. 2011 Mar; 6(3):e18300. doi: 10.1371/journal.pone.0018300. [PMID: 21494323]
  • Almudena Mollá-Morales, Raquel Sarmiento-Mañús, Pedro Robles, Víctor Quesada, José M Pérez-Pérez, Rebeca González-Bayón, Matthew A Hannah, Lothar Willmitzer, María R Ponce, José L Micol. Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development. The Plant journal : for cell and molecular biology. 2011 Feb; 65(3):335-45. doi: 10.1111/j.1365-313x.2010.04425.x. [PMID: 21265888]
  • Jan Huege, Jan Goetze, Doreen Schwarz, Hermann Bauwe, Martin Hagemann, Joachim Kopka. Modulation of the major paths of carbon in photorespiratory mutants of synechocystis. PloS one. 2011 Jan; 6(1):e16278. doi: 10.1371/journal.pone.0016278. [PMID: 21283704]
  • Marta Daniotti, Giancarlo la Marca, Patrizio Fiorini, Luca Filippi. New developments in the treatment of hyperammonemia: emerging use of carglumic acid. International journal of general medicine. 2011 Jan; 4(?):21-8. doi: 10.2147/ijgm.s10490. [PMID: 21403788]
  • Johannes Häberle. Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency. Therapeutics and clinical risk management. 2011; 7(?):327-32. doi: 10.2147/tcrm.s12703. [PMID: 21941437]
  • Darryl Hudson, David Guevara, Mahmoud W Yaish, Carol Hannam, Nykoll Long, Joseph D Clarke, Yong-Mei Bi, Steven J Rothstein. GNC and CGA1 modulate chlorophyll biosynthesis and glutamate synthase (GLU1/Fd-GOGAT) expression in Arabidopsis. PloS one. 2011; 6(11):e26765. doi: 10.1371/journal.pone.0026765. [PMID: 22102866]
  • Anna-Maria Nässl, Isabel Rubio-Aliaga, Manuela Sailer, Hannelore Daniel. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet. PloS one. 2011; 6(10):e26407. doi: 10.1371/journal.pone.0026407. [PMID: 22031831]
  • Juliet Oerton, Javaria M Khalid, Guy Besley, R Neil Dalton, Melanie Downing, Anne Green, Mick Henderson, Steve Krywawych, James Leonard, Brage S Andresen, Carol Dezateux. Newborn screening for medium chain acyl-CoA dehydrogenase deficiency in England: prevalence, predictive value and test validity based on 1.5 million screened babies. Journal of medical screening. 2011; 18(4):173-81. doi: 10.1258/jms.2011.011086. [PMID: 22166308]
  • Kazuki Miyaji, Kenji Nagao, Makoto Bannai, Hiroshi Asakawa, Kaoru Kohyama, Dai Ohtsu, Fumio Terasawa, Shu Ito, Hajime Iwao, Nobuyo Ohtani, Mitsuaki Ohta. Characteristic metabolism of free amino acids in cetacean plasma: cluster analysis and comparison with mice. PloS one. 2010 Nov; 5(11):e13808. doi: 10.1371/journal.pone.0013808. [PMID: 21072195]
  • Nicolas L Taylor, Katharine A Howell, Joshua L Heazlewood, Tzu Yien W Tan, Reena Narsai, Shaobai Huang, James Whelan, A Harvey Millar. Analysis of the rice mitochondrial carrier family reveals anaerobic accumulation of a basic amino acid carrier involved in arginine metabolism during seed germination. Plant physiology. 2010 Oct; 154(2):691-704. doi: 10.1104/pp.110.162214. [PMID: 20720170]
  • Philippe Goffin, Bert van de Bunt, Marco Giovane, Johan H J Leveau, Sachie Höppener-Ogawa, Bas Teusink, Jeroen Hugenholtz. Understanding the physiology of Lactobacillus plantarum at zero growth. Molecular systems biology. 2010 Sep; 6(?):413. doi: 10.1038/msb.2010.67. [PMID: 20865006]
  • Prabhakar Sripadi, Bindesh Shrestha, Rebecca L Easley, Lawrence Carpio, Kylene Kehn-Hall, Sebastien Chevalier, Renaud Mahieux, Fatah Kashanchi, Akos Vertes. Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. PloS one. 2010 Sep; 5(9):e12590. doi: 10.1371/journal.pone.0012590. [PMID: 20830293]
  • Yong He, Hao-lan Song, Gui-xing Li, Jin Xu, Bao-xiu Gao, Ting Yu, Shu-qiang Tang. [The relationship of CPS-I, OCT and hepatic encephalopathy]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2010 Sep; 18(9):699-702. doi: 10.3760/cma.j.issn.1007-3418.2010.09.013. [PMID: 20943084]
  • Junfang Wu, Wenxin Xu, Zhenping Ming, Huifen Dong, Huiru Tang, Yulan Wang. Metabolic changes reveal the development of schistosomiasis in mice. PLoS neglected tropical diseases. 2010 Aug; 4(8):. doi: 10.1371/journal.pntd.0000807. [PMID: 20824219]
  • Brian S Brady, Bradley C Hyman, Carol J Lovatt. Regulation of CPSase, ACTase, and OCTase genes in Medicago truncatula: Implications for carbamoylphosphate synthesis and allocation to pyrimidine and arginine de novo biosynthesis. Gene. 2010 Aug; 462(1-2):18-25. doi: 10.1016/j.gene.2010.04.007. [PMID: 20451592]
  • Chunjie Tian, Beth Kasiborski, Raman Koul, Peter J Lammers, Heike Bücking, Yair Shachar-Hill. Regulation of the nitrogen transfer pathway in the arbuscular mycorrhizal symbiosis: gene characterization and the coordination of expression with nitrogen flux. Plant physiology. 2010 Jul; 153(3):1175-87. doi: 10.1104/pp.110.156430. [PMID: 20448102]
  • Rob M J Moonen, Iballa Reyes, Giacomo Cavallaro, Gema González-Luis, Jaap A Bakker, Eduardo Villamor. The T1405N carbamoyl phosphate synthetase polymorphism does not affect plasma arginine concentrations in preterm infants. PloS one. 2010 May; 5(5):e10792. doi: 10.1371/journal.pone.0010792. [PMID: 20520828]
  • Seth B Roberts, Christopher M Gowen, J Paul Brooks, Stephen S Fong. Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production. BMC systems biology. 2010 Mar; 4(?):31. doi: 10.1186/1752-0509-4-31. [PMID: 20307315]
  • Giulia Friso, Wojciech Majeran, Mingshu Huang, Qi Sun, Klaas J van Wijk. Reconstruction of metabolic pathways, protein expression, and homeostasis machineries across maize bundle sheath and mesophyll chloroplasts: large-scale quantitative proteomics using the first maize genome assembly. Plant physiology. 2010 Mar; 152(3):1219-50. doi: 10.1104/pp.109.152694. [PMID: 20089766]
  • Jennifer E Langer, William G Wilson, Prashant Raghavan, Robert S Rust, Howard P Goodkin. Extrapontine myelinolysis resulting in transient cortical blindness. Pediatric neurology. 2010 Feb; 42(2):154-6. doi: 10.1016/j.pediatrneurol.2009.08.012. [PMID: 20117757]
  • Jie Chen, Michael J Bennett. Quantitation of orotic acid in urine using isotope dilution-selected ion gas chromatography-mass spectrometry. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):445-51. doi: 10.1007/978-1-60761-459-3_43. [PMID: 20077096]
  • Alejandro Hernández-Morales, Susana De la Torre-Zavala, Enrique Ibarra-Laclette, José Luis Hernández-Flores, Alba Estela Jofre-Garfias, Agustino Martínez-Antonio, Ariel Alvarez-Morales. Transcriptional profile of Pseudomonas syringae pv. phaseolicola NPS3121 in response to tissue extracts from a susceptible Phaseolus vulgaris L. cultivar. BMC microbiology. 2009 Dec; 9(?):257. doi: 10.1186/1471-2180-9-257. [PMID: 20003402]
  • Y K Ip, A M Loong, B Ching, G H Y Tham, W P Wong, S F Chew. The freshwater Amazonian stingray, Potamotrygon motoro, up-regulates glutamine synthetase activity and protein abundance, and accumulates glutamine when exposed to brackish (15 per thousand) water. The Journal of experimental biology. 2009 Dec; 212(Pt 23):3828-36. doi: 10.1242/jeb.034074. [PMID: 19915125]
  • Stephen I Deutsch, Jessica A Burket, Richard B Rosse. Valproate-induced hyperammonemic encephalopathy and normal liver functions: possible synergism with topiramate. Clinical neuropharmacology. 2009 Nov; 32(6):350-2. doi: 10.1097/wnf.0b013e3181ac3615. [PMID: 19952878]
  • Norman B Barr, Brian M Wiegmann. Phylogenetic relationships of Ceratitis fruit flies inferred from nuclear CAD and tango/ARNT gene fragments: testing monophyly of the subgenera Ceratitis (Ceratitis) and C. (Pterandrus). Molecular phylogenetics and evolution. 2009 Nov; 53(2):412-24. doi: 10.1016/j.ympev.2009.07.008. [PMID: 19607929]
  • G Bobe, J C Velez, D C Beitz, S S Donkin. Glucagon increases hepatic mRNA concentrations of ureagenic and gluconeogenic enzymes in early-lactation dairy cows. Journal of dairy science. 2009 Oct; 92(10):5092-9. doi: 10.3168/jds.2009-2152. [PMID: 19762827]
  • Tammy Laberge, Patrick J Walsh, M Danielle McDonald. Effects of crowding on ornithine-urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta). The Journal of experimental biology. 2009 Aug; 212(Pt 15):2394-402. doi: 10.1242/jeb.030411. [PMID: 19617432]
  • Fabien Potel, Marie-Hélène Valadier, Sylvie Ferrario-Méry, Olivier Grandjean, Halima Morin, Laure Gaufichon, Stéphanie Boutet-Mercey, Jérémy Lothier, Steven J Rothstein, Naoya Hirose, Akira Suzuki. Assimilation of excess ammonium into amino acids and nitrogen translocation in Arabidopsis thaliana--roles of glutamate synthases and carbamoylphosphate synthetase in leaves. The FEBS journal. 2009 Aug; 276(15):4061-76. doi: 10.1111/j.1742-4658.2009.07114.x. [PMID: 19555410]
  • Dezhao Lu, Xingde Wo, Like Wo, Yi Li, Lihua Tang, Zhen Yang. [Effects of warm and tonify kidney-yang herbs on liver mitochondria proteome of kidney-yang deficiency rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 May; 34(10):1251-6. doi: . [PMID: 19673389]
  • Don J Durzan. Arginine, scurvy and Cartier's 'tree of life'. Journal of ethnobiology and ethnomedicine. 2009 Feb; 5(?):5. doi: 10.1186/1746-4269-5-5. [PMID: 19187550]
  • Aurélie Huser, Hiroyuki Takahara, Wolfgang Schmalenbach, Richard O'Connell. Discovery of pathogenicity genes in the crucifer anthracnose fungus Colletotrichum higginsianum, using random insertional mutagenesis. Molecular plant-microbe interactions : MPMI. 2009 Feb; 22(2):143-56. doi: 10.1094/mpmi-22-2-0143. [PMID: 19132867]
  • S Jones, C A B Reed, S Vijay, J H Walter, A A M Morris. N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia. Journal of inherited metabolic disease. 2008 Dec; 31 Suppl 2(?):S219-22. doi: 10.1007/s10545-008-0777-1. [PMID: 18338235]
  • Jun Liang, Cheryl Clark-Dixon, Shaoxiao Wang, Todd R Flower, Tara Williams-Hart, Richard Zweig, Lucy C Robinson, Kelly Tatchell, Stephan N Witt. Novel suppressors of alpha-synuclein toxicity identified using yeast. Human molecular genetics. 2008 Dec; 17(23):3784-95. doi: 10.1093/hmg/ddn276. [PMID: 18772193]
  • Milka Sokolović, Aleksandar Sokolović, Diederik Wehkamp, Emiel Ver Loren van Themaat, Dirk R de Waart, Lisa A Gilhuijs-Pederson, Yuri Nikolsky, Antoine H C van Kampen, Theodorus B M Hakvoort, Wouter H Lamers. The transcriptomic signature of fasting murine liver. BMC genomics. 2008 Nov; 9(?):528. doi: 10.1186/1471-2164-9-528. [PMID: 18990241]
  • Nantaporn Haskins, Maria Panglao, Qiuhao Qu, Himani Majumdar, Juan Cabrera-Luque, Hiroki Morizono, Mendel Tuchman, Ljubica Caldovic. Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods. BMC biochemistry. 2008 Sep; 9(?):24. doi: 10.1186/1471-2091-9-24. [PMID: 18801197]
  • M Takagi, T Yonezawa, S Haga, H Shingu, Y Kobayashi, T Takahashi, Y Ohtani, Y Obara, K Katoh. Changes of activity and mRNA expression of urea cycle enzymes in the liver of developing Holstein calves. Journal of animal science. 2008 Jul; 86(7):1526-32. doi: 10.2527/jas.2007-0799. [PMID: 18344300]
  • Chris M Wood, Makiko Kajimura, Thomas P Mommsen, Patrick J Walsh. Is the alkaline tide a signal to activate metabolic or ionoregulatory enzymes in the dogfish shark (Squalus acanthias)?. Physiological and biochemical zoology : PBZ. 2008 May; 81(3):278-87. doi: 10.1086/587094. [PMID: 18419554]
  • Min Peng, Marni J Falk, Volker H Haase, Rhonda King, Erzsebet Polyak, Mary Selak, Marc Yudkoff, Wayne W Hancock, Ray Meade, Ryoichi Saiki, Adam L Lunceford, Catherine F Clarke, David L Gasser. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS genetics. 2008 Apr; 4(4):e1000061. doi: 10.1371/journal.pgen.1000061. [PMID: 18437205]
  • Frances M Dupont. Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. BMC plant biology. 2008 Apr; 8(?):39. doi: 10.1186/1471-2229-8-39. [PMID: 18419817]
  • R Johnson Pradeep. Valproate monotherapy induced-delirium due to hyperammonemia: A report of three adult cases with different types of presentation. Indian journal of psychiatry. 2008 Apr; 50(2):121-3. doi: 10.4103/0019-5545.42400. [PMID: 19742224]
  • Karyn L Newman, Subhadeep Chatterjee, Kimberly A Ho, Steven E Lindow. Virulence of plant pathogenic bacteria attenuated by degradation of fatty acid cell-to-cell signaling factors. Molecular plant-microbe interactions : MPMI. 2008 Mar; 21(3):326-34. doi: 10.1094/mpmi-21-3-0326. [PMID: 18257682]
  • Virginie Levrat, Isabelle Forest, Alain Fouilhoux, Cécile Acquaviva, Christine Vianey-Saban, Nathalie Guffon. Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?. Orphanet journal of rare diseases. 2008 Jan; 3(?):2. doi: 10.1186/1750-1172-3-2. [PMID: 18234091]
  • A K Azad, Takayuki Ishikawa, Takahiro Ishikawa, Y Sawa, H Shibata. Intracellular energy depletion triggers programmed cell death during petal senescence in tulip. Journal of experimental botany. 2008; 59(8):2085-95. doi: 10.1093/jxb/ern066. [PMID: 18515833]
  • Xiaoyan Gong, Yanping Fu, Daohong Jiang, Guoqing Li, Xianhong Yi, Youliang Peng. L-arginine is essential for conidiation in the filamentous fungus Coniothyrium minitans. Fungal genetics and biology : FG & B. 2007 Dec; 44(12):1368-79. doi: 10.1016/j.fgb.2007.07.007. [PMID: 17897846]
  • Rob M J Moonen, Aimee D C Paulussen, Nicole Y P Souren, Alfons G H Kessels, M Estela Rubio-Gozalbo, Eduardo Villamor. Carbamoyl phosphate synthetase polymorphisms as a risk factor for necrotizing enterocolitis. Pediatric research. 2007 Aug; 62(2):188-90. doi: 10.1203/pdr.0b013e3180a0324e. [PMID: 17597649]
  • Tomiko Kuhara. Noninvasive human metabolome analysis for differential diagnosis of inborn errors of metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Aug; 855(1):42-50. doi: 10.1016/j.jchromb.2007.03.031. [PMID: 17467347]
  • James A Coker, Priya DasSarma, Jeffrey Kumar, Jochen A Müller, Shiladitya DasSarma. Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature. Saline systems. 2007 Jul; 3(?):6. doi: 10.1186/1746-1448-3-6. [PMID: 17651475]
  • Nirmalendu Saha, Shritapa Datta, Zaiba Y Kharbuli, Kuheli Biswas, Arundhati Bhattacharjee. Air-breathing catfish, Clarias batrachus upregulates glutamine synthetase and carbamyl phosphate synthetase III during exposure to high external ammonia. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2007 Jul; 147(3):520-30. doi: 10.1016/j.cbpb.2007.03.007. [PMID: 17451989]
  • F Tulli, C Vachot, E Tibaldi, V Fournier, S J Kaushik. Contribution of dietary arginine to nitrogen utilisation and excretion in juvenile sea bass (Dicentrarchus labrax) fed diets differing in protein source. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2007 May; 147(1):179-88. doi: 10.1016/j.cbpa.2006.12.036. [PMID: 17321177]
  • Susanne Schouw Nielsen, Thorbjørn Grøfte, Henning Grønbaek, Niels Tygstrup, Hendrik Vilstrup. Opposite effects on regulation of urea synthesis by early and late uraemia in rats. Clinical nutrition (Edinburgh, Scotland). 2007 Apr; 26(2):245-51. doi: 10.1016/j.clnu.2006.11.005. [PMID: 17250930]
  • Serene M L Lee, Wai P Wong, Ai M Loong, Kum C Hiong, Shit F Chew, Yuen K Ip. Postprandial increases in nitrogenous excretion and urea synthesis in the Chinese soft-shelled turtle, Pelodiscus sinensis. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2007 Jan; 177(1):19-29. doi: 10.1007/s00360-006-0105-8. [PMID: 16838133]
  • Wan-Chun Li, Kate L Ralphs, Jonathan M W Slack, David Tosh. Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors. The international journal of biochemistry & cell biology. 2007; 39(3):541-54. doi: 10.1016/j.biocel.2006.10.017. [PMID: 17129745]
  • Hyoung Jin Kim, Hong-Jin Kim. Glycosylation variant analysis of recombinant human tissue plasminogen activator produced in urea-cycle-enzyme-expressing Chinese hamster ovary (CHO) cell line. Journal of bioscience and bioengineering. 2006 Nov; 102(5):447-51. doi: 10.1263/jbb.102.447. [PMID: 17189173]
  • J Marco Schnater, Elisabeth Bruder, Sibylle Bertschin, Thomas Woodtli, Chiel de Theije, Torsten Pietsch, Daniel C Aronson, Dietrich von Schweinitz, Wouter H Lamers, Eleonore S Köhler. Subcutaneous and intrahepatic growth of human hepatoblastoma in immunodeficient mice. Journal of hepatology. 2006 Sep; 45(3):377-86. doi: 10.1016/j.jhep.2006.03.018. [PMID: 16780998]
  • Makiko Kajimura, Patrick J Walsh, Thomas P Mommsen, Chris M Wood. The dogfish shark (Squalus acanthias) increases both hepatic and extrahepatic ornithine urea cycle enzyme activities for nitrogen conservation after feeding. Physiological and biochemical zoology : PBZ. 2006 May; 79(3):602-13. doi: 10.1086/501060. [PMID: 16691526]
  • Francine Goulet, Ioana Diana Napa, Luc Solomon, Odette Morin, Nazrul Islam. Modulated expression of a nuclear-associated glycoprotein during normal rat liver development and in various hepatoma cells. Progress in neuro-psychopharmacology & biological psychiatry. 2006 Jan; 30(1):159-65. doi: 10.1016/j.pnpbp.2005.08.022. [PMID: 16233943]
  • Elena Adinolfi, Cinzia Pizzirani, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Francesco Di Virgilio, Davide Ferrari. P2X(7) receptor: Death or life?. Purinergic signalling. 2005 Sep; 1(3):219-27. doi: 10.1007/s11302-005-6322-x. [PMID: 18404507]
  • Hsiang-Po Huang, Yin-Hsiu Chien, Li-Min Huang, Yen-Hsuan Ni, Mei-Hwei Chang, Ming-Chih Ho, Po-Huang Lee, Wuh-Liang Hwu. Viral infections and prolonged fever after liver transplantation in young children with inborn errors of metabolism. Journal of the Formosan Medical Association = Taiwan yi zhi. 2005 Sep; 104(9):623-9. doi: NULL. [PMID: 16276436]
  • Jasna Kojic, Patricia L Robertson, Douglas J Quint, Donna M Martin, Yuxi Pang, Pia C Sundgren. Brain glutamine by MRS in a patient with urea cycle disorder and coma. Pediatric neurology. 2005 Feb; 32(2):143-6. doi: 10.1016/j.pediatrneurol.2004.07.013. [PMID: 15664780]
  • Louise Mallet, Steve Babin, José A Morais. Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman. The Annals of pharmacotherapy. 2004 Oct; 38(10):1643-7. doi: 10.1345/aph.1e063. [PMID: 15316109]
  • Peter Lundberg, Per-Olof Lundquist. Primary metabolism in N2-fixing Alnus incana-Frankia symbiotic root nodules studied with 15N and 31P nuclear magnetic resonance spectroscopy. Planta. 2004 Aug; 219(4):661-72. doi: 10.1007/s00425-004-1271-0. [PMID: 15179512]
  • Béatrice Mouillé, Véronique Robert, François Blachier. Adaptative increase of ornithine production and decrease of ammonia metabolism in rat colonocytes after hyperproteic diet ingestion. American journal of physiology. Gastrointestinal and liver physiology. 2004 Aug; 287(2):G344-51. doi: 10.1152/ajpgi.00445.2003. [PMID: 15064231]
  • Patricia Wright, Paul Anderson, Lei Weng, Natasha Frick, Wei Peng Wong, Yuen Kwong Ip. The crab-eating frog, Rana cancrivora, up-regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity. Journal of experimental zoology. Part A, Comparative experimental biology. 2004 Jul; 301(7):559-68. doi: 10.1002/jez.a.54. [PMID: 15229866]
  • J C Velez, S S Donkin. Bovine somatotropin increases hepatic phosphoenolpyruvate carboxykinase mRNA in lactating dairy cows. Journal of dairy science. 2004 May; 87(5):1325-35. doi: 10.3168/jds.s0022-0302(04)73282-8. [PMID: 15290980]
  • Yuen K Ip, Ramdzan M Zubaidah, Pei C Liew, Ai M Loong, Kum C Hiong, Wai P Wong, Shit F Chew. African sharptooth catfish Clarias gariepinus does not detoxify ammonia to urea or amino acids but actively excretes ammonia during exposure to environmental ammonia. Physiological and biochemical zoology : PBZ. 2004 Mar; 77(2):242-54. doi: 10.1086/383499. [PMID: 15095244]
  • Shit F Chew, Tan F Ong, Lilian Ho, Wai L Tam, Ai M Loong, Kum C Hiong, Wai P Wong, Yuen K Ip. Urea synthesis in the African lungfish Protopterus dolloi--hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure. The Journal of experimental biology. 2003 Oct; 206(Pt 20):3615-24. doi: 10.1242/jeb.00619. [PMID: 12966053]
  • Yuen K Ip, Wai L Tam, Wai P Wong, Ai M Loong, Kum C Hiong, James S Ballantyne, Shit F Chew. A comparison of the effects of environmental ammonia exposure on the Asian freshwater stingray Himantura signifer and the Amazonian freshwater stingray Potamotrygon motoro. The Journal of experimental biology. 2003 Oct; 206(Pt 20):3625-33. doi: 10.1242/jeb.00612. [PMID: 12966054]
  • Wai L Tam, Wai P Wong, Ai M Loong, Kum C Hiong, Shit F Chew, James S Ballantyne, Yuen K Ip. The osmotic response of the Asian freshwater stingray (Himantura signifer) to increased salinity: a comparison with marine (Taeniura lymma) and Amazonian freshwater (Potamotrygon motoro) stingrays. The Journal of experimental biology. 2003 Sep; 206(Pt 17):2931-40. doi: 10.1242/jeb.00510. [PMID: 12878662]
  • Angela M Valverde, Deborah J Burks, Isabel Fabregat, Tracey L Fisher, José Carretero, Morris F White, Manuel Benito. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. 2003 Sep; 52(9):2239-48. doi: 10.2337/diabetes.52.9.2239. [PMID: 12941762]
  • Boris Gebhardt, Stefan Vlaho, Doris Fischer, Adrian Sewell, Hansjosef Böhles. N-carbamylglutamate enhances ammonia detoxification in a patient with decompensated methylmalonic aciduria. Molecular genetics and metabolism. 2003 Aug; 79(4):303-4. doi: 10.1016/s1096-7192(03)00095-7. [PMID: 12948747]