chartreusin (BioDeep_00001868704)

Main id: BioDeep_00000003753

 

natural product


代谢物信息卡片


chartreusin

化学式: C32H32O14 (640.1792)
中文名称: 沙特菌素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2=CC=CC3=C2C4=C5C6=C(C=CC(=C6C(=O)O4)C)OC(=O)C5=C3O)OC7C(C(C(C(O7)C)O)OC)O)O)O
InChI: InChI=1S/C32H32O14/c1-10-8-9-15-18-16(10)29(38)45-26-17-13(23(35)20(19(18)26)30(39)43-15)6-5-7-14(17)44-32-28(24(36)21(33)11(2)42-32)46-31-25(37)27(40-4)22(34)12(3)41-31/h5-9,11-12,21-22,24-25,27-28,31-37H,1-4H3/t11-,12-,21+,22+,24+,25-,27+,28-,31-,32+/m1/s1

描述信息

D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

chartreusin; Chartreusin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CEP104, EGFR, MYC, PDGFRB, S100G, SP1
Peripheral membrane protein 1 HK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 CALR3, EGFR
Nucleus 9 ANKRD42, CALB1, CETN2, EGFR, KDR, MYC, PDGFRB, SP1, TOP1
cytosol 5 CALB1, CETN2, HK1, PRKCQ, SLC26A6
dendrite 2 C4A, CALB1
centrosome 2 CEP104, CETN2
nucleoplasm 4 CETN2, MYC, SP1, TOP1
Cell membrane 4 EGFR, EPHA2, KDR, SLC26A6
lamellipodium 1 EPHA2
ruffle membrane 2 EGFR, EPHA2
Cell projection, axon 1 C4A
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 CACNA1I, SLC26A6
Synapse 2 C4A, CALB1
cell junction 2 EGFR, KDR
cell surface 2 EGFR, EPHA2
glutamatergic synapse 2 CALB1, EGFR
Golgi apparatus 2 KDR, PDGFRB
Golgi membrane 1 EGFR
neuronal cell body 2 C4A, CALB1
Cytoplasm, cytosol 1 HK1
endosome 2 EGFR, KDR
plasma membrane 8 C4A, CACNA1I, EGFR, EPHA2, KDR, PDGFRB, PRKCQ, SLC26A6
terminal bouton 1 CALB1
Membrane 6 CACNA1I, EGFR, EPHA2, MYC, PDGFRB, SLC26A6
apical plasma membrane 4 EGFR, PDGFRB, S100G, SLC26A6
axon 2 C4A, CALB1
basolateral plasma membrane 3 EGFR, S100G, SLC26A6
extracellular exosome 3 C4A, CALB1, SPINK1
endoplasmic reticulum 3 CALR3, KDR, SLC26A6
extracellular space 4 C4A, EGFR, S100G, SP1
lysosomal lumen 1 PDGFRB
perinuclear region of cytoplasm 1 EGFR
mitochondrion 1 HK1
protein-containing complex 2 EGFR, MYC
intracellular membrane-bounded organelle 1 PDGFRB
Single-pass type I membrane protein 2 EGFR, EPHA2
Secreted 3 C4A, SP1, SPINK1
extracellular region 3 C4A, KDR, SP1
Mitochondrion outer membrane 1 HK1
Single-pass membrane protein 1 EPHA2
mitochondrial outer membrane 1 HK1
hippocampal mossy fiber to CA3 synapse 1 CALB1
[Isoform 2]: Secreted 1 KDR
anchoring junction 1 KDR
Cell projection, cilium 1 CEP104
centriolar satellite 1 PRKCQ
photoreceptor connecting cilium 1 CETN2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CEP104, CETN2
nuclear membrane 1 EGFR
external side of plasma membrane 1 KDR
dendritic spine 1 CALB1
perikaryon 1 TOP1
cytoplasmic vesicle 1 PDGFRB
nucleolus 2 MYC, TOP1
P-body 1 TOP1
Early endosome 1 KDR
apical part of cell 1 CETN2
vesicle 1 SLC26A6
Apical cell membrane 1 SLC26A6
Cell projection, ruffle membrane 1 EPHA2
Membrane raft 3 EGFR, HK1, KDR
Cell junction, focal adhesion 1 EPHA2
focal adhesion 3 EGFR, EPHA2, PDGFRB
GABA-ergic synapse 1 CALB1
intracellular vesicle 1 EGFR
receptor complex 4 EGFR, EPHA2, KDR, PDGFRB
ciliary basal body 1 CETN2
cilium 1 CEP104
chromatin 2 MYC, SP1
Chromosome 1 TOP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 2 CEP104, CETN2
centriole 2 CEP104, CETN2
brush border membrane 1 SLC26A6
Nucleus, nucleolus 2 MYC, TOP1
spindle pole 1 CEP104
blood microparticle 1 C4A
sperm midpiece 1 SLC26A6
Basolateral cell membrane 1 SLC26A6
fibrillar center 1 TOP1
Nucleus, nuclear pore complex 1 CETN2
nuclear envelope 2 CALR3, MYC
Nucleus envelope 1 CETN2
sorting endosome 1 KDR
chloride channel complex 1 SLC26A6
stereocilium 1 CALB1
leading edge membrane 1 EPHA2
Cytoplasmic vesicle membrane 1 SLC26A6
Nucleus, nucleoplasm 2 MYC, TOP1
Cell projection, dendrite 1 C4A
euchromatin 1 SP1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
Microsome 1 SLC26A6
endoplasmic reticulum lumen 2 C4A, CALR3
transcription repressor complex 1 SP1
male germ cell nucleus 1 TOP1
voltage-gated calcium channel complex 1 CACNA1I
RNA polymerase II transcription repressor complex 1 MYC
tight junction 1 EPHA2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
9+2 motile cilium 1 CETN2
calyx of Held 1 CALB1
vesicle membrane 1 SLC26A6
clathrin-coated endocytic vesicle membrane 1 EGFR
nuclear pore nuclear basket 1 CETN2
transcription export complex 2 1 CETN2
protein-DNA complex 2 SP1, TOP1
Rough endoplasmic reticulum 1 MYC
postsynaptic cytosol 1 CALB1
cuticular plate 1 CALB1
presynaptic cytosol 1 CALB1
lamellipodium membrane 1 EPHA2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
Cell projection, lamellipodium membrane 1 EPHA2
[Isoform 6]: Cell membrane 1 SLC26A6
[Isoform 4]: Cell membrane 1 SLC26A6
[Isoform 5]: Cell membrane 1 SLC26A6
XPC complex 1 CETN2
nucleoplasmic reticulum 1 MYC


文献列表

  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Gyo Asai, Nobuyuki Yamamoto, Masakazu Toi, Eisei Shin, Kiyoshi Nishiyama, Tomohisa Sekine, Yasuo Nomura, Shigemitsu Takashima, Morihiko Kimura, Takeshi Tominaga. Pharmacokinetic and pharmacodynamic study of IST-622, a novel synthetic derivative of chartreusin, by oral administration in a phase II study of patients with breast cancer. Cancer chemotherapy and pharmacology. 2002 Jun; 49(6):468-72. doi: 10.1007/s00280-002-0455-1. [PMID: 12107551]
  • I Klein, J Welink, W J van der Vijgh. Determination of Elsamitrucin (BMY-28090) in plasma and urine by high-performance liquid chromatography with fluorescence detection. Journal of chromatography. 1993 Dec; 622(2):249-53. doi: 10.1016/0378-4347(93)80273-7. [PMID: 8150873]
  • J P McGovren, G L Neil, S L Crampton, M I Robinson, J D Douros. Antitumor activity and preliminary drug disposition studies on chartreusin (NSC 5159). Cancer research. 1977 Jun; 37(6):1666-72. doi: . [PMID: 870180]