Dihydrofolic acid (BioDeep_00001868416)

Main id: BioDeep_00000001333

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


Dihydrofolic acid

化学式: C19H21N7O6 (443.1553)
中文名称: 二氢叶酸, 二氢叶酸二水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

描述信息

A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
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SARS
Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid.

同义名列表

2 个代谢物同义名

Dihydrofolic acid; Dihydrofolate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 DHFR, DHPS, GCH1, HDGFL2, ODC1, PMP2, SP1, TUBB4B, TYMS
Peripheral membrane protein 1 HSD17B6
Nucleus 7 GCH1, GGH, HDGFL2, PMP2, SP1, TUBB4B, TYMS
cytosol 12 DHFR, DHFR2, DHPS, GART, GCH1, KRT83, MTHFR, ODC1, PMP2, PPAT, TUBB4B, TYMS
nucleoplasm 2 GCH1, SP1
Cell membrane 1 TNF
Early endosome membrane 1 HSD17B6
cell surface 1 TNF
mitochondrial inner membrane 2 DHFR2, TYMS
neuronal cell body 1 TNF
Lysosome 1 GGH
plasma membrane 2 F2, TNF
extracellular exosome 6 EPX, F2, GART, GGH, PMP2, TUBB4B
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 6 EPX, F2, GGH, KRT83, SP1, TNF
mitochondrion 4 DHFR, DHFR2, GCH1, TYMS
protein-containing complex 1 GCH1
intracellular membrane-bounded organelle 1 HSD17B6
Microsome membrane 1 HSD17B6
Secreted 2 F2, SP1
extracellular region 6 EPX, F2, GGH, SP1, TNF, TUBB4B
Mitochondrion matrix 2 DHFR2, TYMS
mitochondrial matrix 2 DHFR2, TYMS
nuclear membrane 1 GCH1
external side of plasma membrane 1 TNF
Extracellular vesicle 1 TUBB4B
cytoplasmic vesicle 1 GCH1
microtubule cytoskeleton 1 TUBB4B
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 DHFR2, TYMS
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
collagen-containing extracellular matrix 1 F2
chromatin 1 SP1
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
Secreted, extracellular space 1 GGH
blood microparticle 1 F2
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
Melanosome 1 GGH
euchromatin 1 SP1
myelin sheath 1 PMP2
secretory granule lumen 1 EPX
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
transcription repressor complex 1 SP1
specific granule lumen 1 GGH
tertiary granule lumen 1 GGH
azurophil granule lumen 2 GGH, TUBB4B
Vacuole 1 GGH
protein-DNA complex 1 SP1
keratin filament 1 KRT83
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
neuron projection terminus 1 GCH1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Bharadwaja Vadloori, A K Sharath, N Prakash Prabhu, Radheshyam Maurya. Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A. BMC research notes. 2018 Apr; 11(1):246. doi: 10.1186/s13104-018-3354-1. [PMID: 29661206]
  • Mohamed Badr, Christian Kopp, Sandra Theison, Jennifer Meyer, Wolfgang E Trommer. Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor. Biological chemistry. 2014 Dec; 395(12):1461-6. doi: 10.1515/hsz-2013-0270. [PMID: 25205711]
  • Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment. 2010 May; 6(?):159-95. doi: 10.2147/ndt.s6564. [PMID: 20505848]
  • Sindhu Issac, K Girish Kumar. Voltammetric determination of sulfamethoxazole at a multiwalled carbon nanotube modified glassy carbon sensor and its application studies. Drug testing and analysis. 2009 Jul; 1(7):350-4. doi: 10.1002/dta.69. [PMID: 20355213]
  • Tobias Sahr, Stéphane Ravanel, Gilles Basset, Brian P Nichols, Andrew D Hanson, Fabrice Rébeillé. Folate synthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase. The Biochemical journal. 2006 May; 396(1):157-62. doi: 10.1042/bj20051851. [PMID: 16466344]
  • Enma Navarro-Perán, Juan Cabezas-Herrera, Francisco García-Cánovas, Marcus C Durrant, Roger N F Thorneley, José Neptuno Rodríguez-López. The antifolate activity of tea catechins. Cancer research. 2005 Mar; 65(6):2059-64. doi: 10.1158/0008-5472.can-04-3469. [PMID: 15781612]
  • Carsten Kneuer, Kerstin U Honscha, Walther Honscha. Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization. American journal of physiology. Renal physiology. 2004 Mar; 286(3):F564-71. doi: 10.1152/ajprenal.00257.2003. [PMID: 14612385]
  • Maria Eugenia Maciel, Gerardo Daniel Castro, José Alberto Castro. Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. Nutrition and cancer. 2004; 49(1):94-9. doi: 10.1207/s15327914nc4901_13. [PMID: 15456641]
  • B C Nelson, J J Dalluge, S A Margolis. Preliminary application of liquid chromatography-electrospray-ionization mass spectrometry to the detection of 5-methyltetrahydrofolic acid monoglutamate in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 2001 Dec; 765(2):141-50. doi: 10.1016/s0378-4347(01)00412-1. [PMID: 11767307]
  • R G Schoner, J W Littlefield. The organization of the dihydrofolate reductase gene of baby hamster kidney fibroblasts. Nucleic acids research. 1981 Dec; 9(23):6601-14. doi: 10.1093/nar/9.23.6601. [PMID: 6275368]