METIAMIDE (BioDeep_00001868389)
Main id: BioDeep_00000006499
代谢物信息卡片
METIAMIDE
化学式: C9H16N4S2 (244.0816)
中文名称: 甲硫米特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N=CN1)CSCCNC(=S)NC
InChI: InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
同义名列表
3 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:6896
- KEGG: C07449
- KEGGdrug: D05004
- PubChem: 1548992
- DrugBank: DB08805
- ChEMBL: CHEMBL275446
- MeSH: Metiamide
- CAS: 34839-70-8
- PubChem: 9652
- NIKKAJI: J19.552I
- RefMet: Metiamide
- medchemexpress: HY-15540
- KNApSAcK: 6896
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Itsuro Matsumoto, Yasuhisa Inoue, Katsuhiko Tsuchiya, Toshio Shimada, Tadaomi Aikawa. Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Oct; 287(4):R969-80. doi:
10.1152/ajpregu.00734.2003. [PMID: 15231494] - S Scaccianoce, K Lombardo, R Nicolai, D Affricano, L Angelucci. Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor.
Life sciences.
2000 Nov; 67(26):3143-52. doi:
10.1016/s0024-3205(00)00899-7. [PMID: 11191621] - M W Beukers, C H Klaassen, W J De Grip, D Verzijl, H Timmerman, R Leurs. Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells.
British journal of pharmacology.
1997 Nov; 122(5):867-74. doi:
10.1038/sj.bjp.0701466. [PMID: 9384502] - M T Zavy, R D Hedde. Effect of histamine-H2 receptor antagonists on serum gastrin levels in swine.
Laboratory animal science.
1991 Oct; 41(5):456-61. doi:
. [PMID: 1686922] - N M Horno, E O Alvarez. The participation of histaminergic receptors of the rostral hypothalamus on the tonic release of luteinizing hormone (LH) in adult spayed rats under estrogen and progesterone treatment.
Journal of neural transmission. General section.
1991; 83(1-2):97-105. doi:
10.1007/bf01244456. [PMID: 2018632] - M C Fyfe, L A Chahl. Mediators of the plasma extravasation response to silver nitrate in the rat skin, subplantar region and ankle joint.
The Journal of pharmacy and pharmacology.
1989 Jan; 41(1):46-9. doi:
10.1111/j.2042-7158.1989.tb06327.x. [PMID: 2565964] - G F Rush, D Alberts, S Lupo, L A Yodis, T H Brown, G J Durant. Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships.
The Journal of pharmacology and experimental therapeutics.
1988 Jan; 244(1):113-7. doi:
. [PMID: 2891842] - T Urushidani, J G Forte. Stimulation-associated redistribution of H+-K+-ATPase activity in isolated gastric glands.
The American journal of physiology.
1987 Apr; 252(4 Pt 1):G458-65. doi:
10.1152/ajpgi.1987.252.4.g458. [PMID: 3031993] - C Bordi, M Amherdt, A Perrelet. Orthogonal arrays of particles in the gastric parietal cell of the rat: differences between superficial and basal cells in the gland and after pentagastrin or metiamide treatment.
The Anatomical record.
1986 May; 215(1):28-34. doi:
10.1002/ar.1092150105. [PMID: 3085548] - M O'Donnell, R Garippa, A F Welton. Relaxant activity of atriopeptins in isolated guinea pig airway and vascular smooth muscle.
Peptides.
1985 Jul; 6(4):597-601. doi:
10.1016/0196-9781(85)90159-7. [PMID: 2933640] - S V Shah. Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated rat glomeruli.
The Journal of clinical investigation.
1984 Aug; 74(2):393-401. doi:
10.1172/jci111434. [PMID: 6086713] - R C Bone, S Lerner, D Stetschulte, E Murphy, J Wolfe, R Sobonya. Histamine and slow reacting substance in acid-induced pneumonitis.
Microcirculation, endothelium, and lymphatics.
1984 Jun; 1(3):365-77. doi:
NULL. [PMID: 6085933] - E O Alvarez. Effects of histamine antagonists injected in the preoptic-anterior hypothalamic area on the prolactin surge induced by estrogen in ovariectomized rats.
Brain research bulletin.
1984 Jan; 12(1):11-5. doi:
10.1016/0361-9230(84)90208-9. [PMID: 6424868] - A J Januszkiewicz, M D Faiman. The effect of in vivo hyperoxic exposure on the release of endogenous histamine from the rat isolated perfused lung.
Toxicology and applied pharmacology.
1984 Jan; 72(1):134-41. doi:
10.1016/0041-008x(84)90257-6. [PMID: 6200952] - A O Donoso, M B Zárate, A Seltzer. Histamine-induced prolactin release: pharmacological characterization of receptors in male rats.
Neuroendocrinology.
1983 Jun; 36(6):436-42. doi:
10.1159/000123495. [PMID: 6308490] - S Vallgren, H A El Munshid, J Hedenbro, J F Rehfeld, R Håkanson. Mechanism of gastric acid response to pylorus ligation: effects of nephrectomy.
Scandinavian journal of gastroenterology.
1983 May; 18(4):491-6. doi:
10.3109/00365528309181628. [PMID: 6669925] - M Kozma, L Vereczkey. Rapid method for determination of cimetidine in biological fluids by high-performance liquid chromatography using Extrelut extraction.
Journal of chromatography.
1983 Mar; 273(1):223-7. doi:
10.1016/s0378-4347(00)80943-3. [PMID: 6853654] - B E Stabile, A F Ippoliti, J H Walsh, E Passaro. Failure of histamine H2-receptor antagonist therapy in Zollinger-Ellison syndrome.
American journal of surgery.
1983 Jan; 145(1):17-23. doi:
10.1016/0002-9610(83)90160-5. [PMID: 6129812] - A O Donoso, M B Zárate. Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized, steroid-treated rats under ether anesthesia.
Experimental brain research.
1983; 52(2):277-80. doi:
10.1007/bf00236637. [PMID: 6139293] - E Dux, F Joó. Effects of histamine on brain capillaries. Fine structural and immunohistochemical studies after intracarotid infusion.
Experimental brain research.
1982; 47(2):252-8. doi:
10.1007/bf00239384. [PMID: 7117450] - A P Baker, L W Chakrin, D A Holden, W J Smith, C P Sung. Effect of histamine agonists and antagonists on the production of murine reaginic antibodies.
International journal of immunopharmacology.
1981; 3(4):349-56. doi:
10.1016/0192-0561(81)90030-8. [PMID: 6460705] - Z Huszti, K Pik, R Frenkl. Induction of gastric histamine synthesis by H2-receptor antagonists: potentiation of their antisecretory activity by histidine decarboxylase inhibitors.
Agents and actions.
1980 Sep; 10(4):302-8. doi:
10.1007/bf01971429. [PMID: 6108701] - A O Donoso, A M Banzan. H1- and H2-histamine receptor antagonists and induced release of prolactin in male rats.
Neuroendocrinology.
1980; 30(1):11-4. doi:
10.1159/000122967. [PMID: 7354886] - H M Vandenberghe, S M MacLeod, W A Mahon, P A Lebert, S J Soldin. Analysis of ranitidine in serum by high performance liquid chromatography.
Therapeutic drug monitoring.
1980; 2(4):379-84. doi:
NULL. [PMID: 6111854] - S B Flynn, D A Owen. Histamine H1- and H2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle.
Agents and actions.
1979 Dec; 9(5-6):450-4. doi:
10.1007/bf01968109. [PMID: 44659] - H E Aksulu, Z S Ercan, R K Türker. A comparative study with impromidine (SKF 92676), a potent agonist for histamine H2-receptors.
Agents and actions.
1979 Dec; 9(5-6):461-6. doi:
10.1007/bf01968111. [PMID: 161854] - D C Taylor, P R Cresswell, E S Pepper. The excretion and metabolism of metiamide in the rat, dog, and man.
Drug metabolism and disposition: the biological fate of chemicals.
1979 Nov; 7(6):393-8. doi:
NULL. [PMID: 43226] - N Chand, L Deroth, P Eyre. Pharmacology of Schultz-Dale reaction in canine lung strip in vitro: possible model for allergic asthma.
British journal of pharmacology.
1979 Aug; 66(4):511-6. doi:
10.1111/j.1476-5381.1979.tb13687.x. [PMID: 37961] - J L Beets, M M Dale. Inhibition of guinea-pig lymphocyte activation by histamine and histamine analogues.
British journal of pharmacology.
1979 Jul; 66(3):365-72. doi:
10.1111/j.1476-5381.1979.tb10839.x. [PMID: 526705] - L Witzel, P U Heitz, F Halter, A J Olah, L Varga, O Werner, W H Häcki. Effects of prolonged administration of metiamide on serum gastrin, gastrin content of the antrum and gastric corpus, and G-cell population in the rat.
Gastroenterology.
1979 May; 76(5 Pt 1):945-9. doi:
. [PMID: 437421] - N E Larsen, P Hesselfeldt, S J Rune, E F Hvidberg. Cimetidine assay in human plasma by liquid chromatography.
Journal of chromatography.
1979 May; 163(1):57-63. doi:
10.1016/s0378-4347(00)81168-8. [PMID: 528627] - S Ahmad. Side effects of cimetidine.
Southern medical journal.
1979 May; 72(5):509-13. doi:
NULL. [PMID: 375397] - C Rudolph, G E Richards, S Kaplan, W F Ganong. Effect of intraventricular histamine on hormone secretion in dogs.
Neuroendocrinology.
1979; 29(3):169-77. doi:
10.1159/000122919. [PMID: 226902] - S J Konturek, J Tasler, M Cieszkowski, J Jaworek. Comparison of intravenous amino acids in the stimulation of gastric secretion.
Gastroenterology.
1978 Nov; 75(5):817-24. doi:
10.1016/0016-5085(78)90463-8. [PMID: 700324] - E Gaetani, C F Laureri, F Ronchini. [High pressure liquid-liquid chromatography. Quantitative determination of histamine H2 antagonists].
Il Farmaco; edizione pratica.
1978 Nov; 33(11):484-8. doi:
NULL. [PMID: 35364] - C B Lamers, H P Festen, J H van Tongeren. Long-term treatment with histamine H2-receptor antagonists in Zollinger-Ellison syndrome.
The American journal of gastroenterology.
1978 Sep; 70(3):286-91. doi:
NULL. [PMID: 717379] - C T Richardson. Effect of H2-receptor antagonists on gastric acid secretion and serum gastrin concentration: a review.
Gastroenterology.
1978 Feb; 74(2 Pt 2):366-70. doi:
10.1016/0016-5085(78)90763-1. [PMID: 23338] - M C Holroyde, P Eyre. Histamine enhances anaphylactic histamine release from bovine lung and leukocytes via histamine H2-receptor.
The Journal of pharmacology and experimental therapeutics.
1978 Jan; 204(1):183-8. doi:
NULL. [PMID: 73583] - K S Carlisle, C S Chew, S J Hersey. Ultrastructural changes and cyclic AMP in frog oxyntic cells.
The Journal of cell biology.
1978 Jan; 76(1):31-42. doi:
10.1083/jcb.76.1.31. [PMID: 201646] - P O Schwille, G Lang, P Hofmann. Rat gastric secretion and mucosal blood flow during restraint stress--effect of a low dose metiamide.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1977 Dec; 171(3):205-10. doi:
10.1007/bf01851504. [PMID: 339307] - D M McCarthy, E J Olinger, R J May, B W Long, J D Gardner. H2-Histamine receptor blocking agents in the Zollinger-Ellison syndrome. Experience in seven cases and implications for long-term therapy.
Annals of internal medicine.
1977 Dec; 87(6):668-75. doi:
10.7326/0003-4819-87-6-668. [PMID: 22304] - T U Hausamen, W P Fritsch, T Scholten, R Jungblut, G Strohmeyer. [Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists (author's transl)].
Deutsche medizinische Wochenschrift (1946).
1977 Nov; 102(47):1709-12. doi:
10.1055/s-0028-1105561. [PMID: 21785] - D M Kruss, S Ilangovan. Metiamide therapy of bleeding peptic ulcer during chronic hemodialysis.
The American journal of digestive diseases.
1977 Jul; 22(7):662-3. doi:
10.1007/bf01073091. [PMID: 879135] - M C Arakelian, C Libertun. H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats.
Endocrinology.
1977 Mar; 100(3):890-5. doi:
10.1210/endo-100-3-890. [PMID: 401035] - R E Pounder, R H Hunt, S H Vincent, G J Milton-Thompson, J J Misiewicz. 24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.
Gut.
1977 Feb; 18(2):85-90. doi:
10.1136/gut.18.2.85. [PMID: 323118] - D H Osborne, J Lennon, M Henderson, G Lidgard, R Creel, D C Carter. Effect of cimetidine on the human lower oesophageal sphincter.
Gut.
1977 Feb; 18(2):99-104. doi:
10.1136/gut.18.2.99. [PMID: 852750] - R A Clark, J A Sandler, J I Gallin, A P Kaplan. Histamine modulation of eosinophil migration.
Journal of immunology (Baltimore, Md. : 1950).
1977 Jan; 118(1):137-45. doi:
. [PMID: 187697] - W W Busse, J Sosman. Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response.
Science (New York, N.Y.).
1976 Nov; 194(4266):737-8. doi:
10.1126/science.185696. [PMID: 185696] - R W Spence, L R Celestin, R F Harvey. Effect of metiamide on basal and stimulated serum cholecystokinin levels in duodenal ulcer patients.
Gut.
1976 Nov; 17(11):920-3. doi:
10.1136/gut.17.11.920. [PMID: 12069] - M H Thompson, D J Sanders, E R Grund. The relationship of the serum gastrin and calcium concentrations in patients with multiple endocrine neoplasia type I.
The British journal of surgery.
1976 Oct; 63(10):779-83. doi:
10.1002/bjs.1800631012. [PMID: 11029] - W B Campbell, H D Itskovitz. Effect of histamine and antihistamines on renal hemodynamics and functions in the isolated perfused canine kidney.
The Journal of pharmacology and experimental therapeutics.
1976 Sep; 198(3):661-7. doi:
NULL. [PMID: 10420] - K Hashizume, T Onaya, A Kojima. [The histaminergic mechanisms in the regulation of prolactin secretion in urethan-anesthetized rats (author's transl)].
Nihon Naibunpi Gakkai zasshi.
1976 Aug; 52(8):784-94. doi:
10.1507/endocrine1927.52.8_784. [PMID: 14035] - M R Thompson. Studies on the acid secretion that occurs during injury to the gastric mucosa.
Gastroenterology.
1976 Aug; 71(2):286-90. doi:
10.1016/s0016-5085(76)80203-x. [PMID: 939391] - K L Brigham, R E Bowers, P J Owen. Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability.
The Journal of clinical investigation.
1976 Aug; 58(2):391-8. doi:
10.1172/jci108483. [PMID: 956373] - E L Blair, E R Grund, J D Reed, D J Sanders, M H Thompson, C W Venables. The effect of metramide on the prolonged serum gastrin response to feeding observed in patients with duodenal ulcer.
The British journal of surgery.
1976 Aug; 63(8):599-602. doi:
10.1002/bjs.1800630810. [PMID: 953462] - S J Haggie, C G Clark, J W Black, J H Wyllie. Clinical experience with metiamide.
Federation proceedings.
1976 Jun; 35(8):1948-52. doi:
NULL. [PMID: 1269779] - V R Grund, E W Pollack, D B Hunninghake. Histamine-induced lipid mobilization in humans and dogs.
The Journal of pharmacology and experimental therapeutics.
1976 Jun; 197(3):662-8. doi:
NULL. [PMID: 932997] - A I Kobrine, T F Doyle, H V Rizzoli. The effect of antihistamines on experimental posttraumatic edema of the spinal cord.
Surgical neurology.
1976 May; 5(5):307-9. doi:
NULL. [PMID: 4901] - J A Forrest, R C Heading, J Park, D C Carter, J Lennon, G Lidgard, D J Shearman. Effect of histamine H2-receptor blockade on gastric emptying and serum gastrin in man.
Scottish medical journal.
1976 Jan; 21(1):23-7. doi:
10.1177/003693307602100107. [PMID: 769156] - M H Thompson, J D Reed, G Dale, C W Venables. Early clinical experience with metiamide, a histamine H2-receptor antagonist, in patients with duodenal ulcer.
The American journal of digestive diseases.
1975 Dec; 20(12):1135-41. doi:
10.1007/bf01070757. [PMID: 1106188] - E L Blair, E R Grund, I T Miller, J D Redd, D J Sanders, M H Thompson, C W Venables. Metiamide in the Zollinger-Ellison syndrome.
The American journal of digestive diseases.
1975 Dec; 20(12):1123-30. doi:
10.1007/bf01070755. [PMID: 1106187] - S Bonfils, J J Bernier, M Mignon, P Hautefeuille, M Corbic, J Marteau. [Zollinger-Ellison syndrome treated medically by an inhibitor of H2 histamine receptors].
La Nouvelle presse medicale.
1975 Oct; 4(33):2377-81. doi:
NULL. [PMID: 653] - S J Konturek, W Obtulowicz, J Tasler. Characteristics of gastric inhibition by acidification of oxyntic gland area.
The Journal of physiology.
1975 Oct; 251(3):699-709. doi:
10.1113/jphysiol.1975.sp011117. [PMID: 491] - L W Way, D W Cairns, C W Deveney. The intestinal phase of gastric secretion: a pharmacological profile of entero-oxyntin.
Surgery.
1975 Jun; 77(6):841-50. doi:
. [PMID: 238296] - G O Barbezat, B Grant, S Bank, A Vinik. The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.
Gut.
1975 Mar; 16(3):186-7. doi:
10.1136/gut.16.3.186. [PMID: 1123173] - L Lundell. Elicidation by a H-2-receptor antagonist of the significance of mucosal histamine mobilization in exciting acid secretion.
The Journal of physiology.
1975 Jan; 244(2):365-83. doi:
10.1113/jphysiol.1975.sp010804. [PMID: 49418]
