Metiamide (BioDeep_00000006499)
Secondary id: BioDeep_00001868389
human metabolite
代谢物信息卡片
3-methyl-1-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)thiourea
化学式: C9H16N4S2 (244.0816)
中文名称: 甲硫米特
谱图信息:
最多检出来源 Rattus norvegicus(not specific) 2.18%
分子结构信息
SMILES: CC1=C(N=CN1)CSCCNC(=S)NC
InChI: InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
描述信息
Metiamide belongs to the class of organic compounds known as imidazoles. These are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms.
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:6896
- KEGG: C07449
- KEGGdrug: D05004
- PubChem: 1548992
- HMDB: HMDB0061722
- Metlin: METLIN66646
- DrugBank: DB08805
- ChEMBL: CHEMBL275446
- Wikipedia: Metiamide
- MeSH: Metiamide
- CAS: 34839-70-8
- PMhub: MS000019548
- PubChem: 9652
- NIKKAJI: J19.552I
- RefMet: Metiamide
- medchemexpress: HY-15540
- KNApSAcK: 6896
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Metiamide Action Pathway:
Adenosine triphosphate + Hydrogen Ion + Potassium + Water ⟶ Adenosine diphosphate + Hydrogen Ion + Phosphate + Potassium
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Itsuro Matsumoto, Yasuhisa Inoue, Katsuhiko Tsuchiya, Toshio Shimada, Tadaomi Aikawa. Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs.
American journal of physiology. Regulatory, integrative and comparative physiology.
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Life sciences.
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British journal of pharmacology.
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British journal of pharmacology.
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Gastroenterology.
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Southern medical journal.
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1978 Nov; 33(11):484-8. doi:
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1978 Sep; 70(3):286-91. doi:
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1978 Feb; 74(2 Pt 2):366-70. doi:
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1978 Jan; 204(1):183-8. doi:
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The Journal of cell biology.
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Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1977 Dec; 171(3):205-10. doi:
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