Cefradine (BioDeep_00001868023)

Main id: BioDeep_00000006375

 


代谢物信息卡片


Cephradine

化学式: C16H19N3O4S (349.10962140000004)
中文名称: 头孢拉定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=O)O)N2C(=O)[C@H]([C@H]2SC1)NC(=O)[C@@H](C1=CCC=CC1)N
InChI: InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1

描述信息

A cephalosporin with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

2 个代谢物同义名

Cephradine; Cefradine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Atiya Butt, Sehrish Jabeen, Numrah Nisar, Atif Islam, Nafisa Gull, Sadia Sagar Iqbal, Shahzad Maqsood Khan, Basit Yameen. Controlled release of cephradine by biopolymers based target specific crosslinked hydrogels. International journal of biological macromolecules. 2019 Jan; 121(?):104-112. doi: 10.1016/j.ijbiomac.2018.10.018. [PMID: 30291928]
  • C O'Halloran, N Walsh, M C O'Grady, L Barry, C Hooton, G D Corcoran, B Lucey. Assessment of the comparability of CLSI, EUCAST and Stokes antimicrobial susceptibility profiles for Escherichia coli uropathogenic isolates. British journal of biomedical science. 2018 Jan; 75(1):24-29. doi: 10.1080/09674845.2017.1392736. [PMID: 29210602]
  • André Dallmann, Ibrahim Ince, Juri Solodenko, Michaela Meyer, Stefan Willmann, Thomas Eissing, Georg Hempel. Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women. Clinical pharmacokinetics. 2017 12; 56(12):1525-1541. doi: 10.1007/s40262-017-0538-0. [PMID: 28391404]
  • Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
  • Ahmed Hamouda, Jacqueline Findlay, Leena Al Hassan, Sebastian G B Amyes. Epidemiology of Acinetobacter baumannii of animal origin. International journal of antimicrobial agents. 2011 Oct; 38(4):314-8. doi: 10.1016/j.ijantimicag.2011.06.007. [PMID: 21831604]
  • Nafisa Hassan Ali, Shaheen Faizi, Shahana Urooj Kazmi. Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan. Pharmaceutical biology. 2011 Aug; 49(8):833-9. doi: 10.3109/13880209.2010.551136. [PMID: 21501041]
  • H Jamalifar, Hr Rahimi, N Samadi, Ar Shahverdi, Z Sharifian, F Hosseini, H Eslahi, Mr Fazeli. Antimicrobial activity of different Lactobacillus species against multi- drug resistant clinical isolates of Pseudomonas aeruginosa. Iranian journal of microbiology. 2011 Mar; 3(1):21-5. doi: NULL. [PMID: 22347578]
  • Daniele Minardi, Gianluca d'Anzeo, Daniele Cantoro, Alessandro Conti, Giovanni Muzzonigro. Urinary tract infections in women: etiology and treatment options. International journal of general medicine. 2011; 4(?):333-43. doi: 10.2147/ijgm.s11767. [PMID: 21674026]
  • Zhuming Wang, Zhenghua Song, Donghua Chen. Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method. Talanta. 2010 Dec; 83(2):312-9. doi: 10.1016/j.talanta.2010.09.029. [PMID: 21111139]
  • Rose McGready, Vanaporn Wuthiekanun, Elizabeth A Ashley, Saw Oo Tan, Mupawjay Pimanpanarak, Samuel Jacher Viladpai-Nguen, Wilarat Jesadapanpong, Stuart D Blacksell, Stephane Proux, Nicholas P Day, Pratap Singhasivanon, Nicholas J White, François Nosten, Sharon J Peacock. Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings. The American journal of tropical medicine and hygiene. 2010 Dec; 83(6):1322-9. doi: 10.4269/ajtmh.2010.10-0332. [PMID: 21118943]
  • Manik C Shill, Naz H Huda, Fahad B Moain, Utpal K Karmakar. Prevalence of uropathogens in diabetic patients and their corresponding resistance pattern: results of a survey conducted at diagnostic centers in dhaka, bangladesh. Oman medical journal. 2010 Oct; 25(4):282-5. doi: 10.5001/omj.2010.82. [PMID: 22043358]
  • M N Islam, M A Khaleque, M Siddika, M A Hossain. Urinary tract infection in children in a tertiary level hospital in bangladesh. Mymensingh medical journal : MMJ. 2010 Oct; 19(4):482-6. doi: . [PMID: 20956885]
  • Kieran M Kennedy, Liam G Glynn, Brendan Dineen. A survey of the management of urinary tract infection in children in primary care and comparison with the NICE guidelines. BMC family practice. 2010 Jan; 11(?):6. doi: 10.1186/1471-2296-11-6. [PMID: 20102638]
  • Sang-Jun Choi, Ju-Hee Ryu, Heon-Woo Lee, Myung-Jae Lee, Ji-Hyung Seo, Seong-Kun Tak, Kyung-Tae Lee. Rapid and simple method for determination of cephradine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to the bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4059-64. doi: 10.1016/j.jchromb.2009.10.011. [PMID: 19854118]
  • Min Zhou, Xin Li, Yi-qin Cheng, Rong Shen, Ying Zhao, Huai-zhi Zhao, Juan Wang, Dong-mei Shi. [Kneading and dispersing manipulation in treatment of early-stage acute mastitis: a randomized controlled trial]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2009 Dec; 7(12):1130-3. doi: 10.3736/jcim20091207. [PMID: 20015432]
  • Mu Li, Lin-Chuan Liao, You-Yi Yan, Lin Yang, Xiao-Min Liu, Jin Dai, Xiao-Na Ma, Xin Sheng, Hong Huang, Gui Su. [Analysis of multiple cephalosporins in blood and urine by HPLC]. Fa yi xue za zhi. 2009 Dec; 25(6):437-9. doi: NULL. [PMID: 20225621]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Lichuan Niu, Zhenghua Song, Xili He. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug metabolism letters. 2009 Aug; 3(3):144-51. doi: 10.2174/187231209789352157. [PMID: 19702549]
  • David R Foster, Shiyin Yee, Barry E Bleske, Peggy L Carver, Michael J Shea, Sujatha S Menon, Chandrasekharan Ramachandran, Lynda S Welage, Gordon L Amidon. Lack of interaction between the peptidomimetic substrates captopril and cephradine. Journal of clinical pharmacology. 2009 Mar; 49(3):360-7. doi: 10.1177/0091270008329554. [PMID: 19246733]
  • Aude Antignac, Alexander Tomasz. Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. Antimicrobial agents and chemotherapy. 2009 Feb; 53(2):435-41. doi: 10.1128/aac.01099-08. [PMID: 19015345]
  • Muhammad Harris Shoaib, Dilnawaz Shaikh, Rabia Ismail Yousuf, Baqir S Naqvi, Khursheed Hashmi. Pharmacokinetic study of cephradine in Pakistani healthy male volunteers. Pakistan journal of pharmaceutical sciences. 2008 Oct; 21(4):400-6. doi: NULL. [PMID: 18930862]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • X Yang, Q Q Yang, Q Y Guo, C Y Yi, H P Mao, J X Lin, Z P Jiang, X Q Yu. Aeromonas salmonicida peritonitis after eating fish in a patient undergoing CAPD. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2008 May; 28(3):316-7. doi: 10.1177/089686080802800323. [PMID: 18474929]
  • Zhoujun Wu, Bo Feng, Jie Weng, Shuxin Qu, Jianxin Wang, Xiong Lu. Biomimetic apatite coatings on titanium coprecipitated with cephradine and salviae miltlorrhizae. Journal of biomedical materials research. Part B, Applied biomaterials. 2008 Feb; 84(2):486-92. doi: 10.1002/jbm.b.30895. [PMID: 17635037]
  • Jinjin Chen, Wei Cai, Yi Feng. Development of intestinal bifidobacteria and lactobacilli in breast-fed neonates. Clinical nutrition (Edinburgh, Scotland). 2007 Oct; 26(5):559-66. doi: 10.1016/j.clnu.2007.03.003. [PMID: 17507117]
  • Yuko Tanihara, Satohiro Masuda, Tomoko Sato, Toshiya Katsura, Osamu Ogawa, Ken-Ichi Inui. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochemical pharmacology. 2007 Jul; 74(2):359-71. doi: 10.1016/j.bcp.2007.04.010. [PMID: 17509534]
  • Seyed Mehdi Hosseini-Mazinani, Fereshteh Eftekhar, Mahnaz Milani, Soheila Ghandili. Characterization of beta-lactamases from urinary isolates of Escherichia coli in Tehran. Iranian biomedical journal. 2007 Apr; 11(2):95-99. doi: . [PMID: 18051951]
  • Khaled A Al-Moyed, Nabil S Harmal, Abdulilah H Al-Harasy, Hassan A Al-Shamahy. Increasing single and multi-antibiotic resistance in Shigella species isolated from shigellosis patients in Sana'a, Yemen. Saudi medical journal. 2006 Aug; 27(8):1157-60. doi: . [PMID: 16883444]
  • Young-Sook Kang, So-Young Lee, Na Hyung Kim, Hong-Mi Choi, Joug Sei Park, Won Kim, Hwa Jeong Lee. A specific and rapid HPLC assay for the determination of cefroxadine in human plasma and its application to pharmacokinetic study in Korean. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(2):369-74. doi: 10.1016/j.jpba.2005.07.026. [PMID: 16137854]
  • Masaki Kobayashi, Yoshitaka Saito, Shirou Itagaki, Takeshi Hirano, Ken Iseki. Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane. Biochimica et biophysica acta. 2005 Aug; 1715(1):19-24. doi: 10.1016/j.bbamem.2005.05.013. [PMID: 16087153]
  • Petra Luckner, Matthias Brandsch. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2005 Jan; 59(1):17-24. doi: 10.1016/j.ejpb.2004.07.008. [PMID: 15567297]
  • Shirou Itagaki, Yoshitaka Saito, Sayaka Kubo, Yukio Otsuka, Yuta Yamamoto, Masaki Kobayashi, Takeshi Hirano, Ken Iseki. H+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine. The Journal of pharmacology and experimental therapeutics. 2005 Jan; 312(1):77-82. doi: 10.1124/jpet.104.074021. [PMID: 15316092]
  • Stanley G Wu, Edward P C Lai, Paul M Mayer. Molecularly imprinted solid phase extraction-pulsed elution-mass spectrometry for determination of cephalexin and alpha-aminocephalosporin antibiotics in human serum. Journal of pharmaceutical and biomedical analysis. 2004 Nov; 36(3):483-90. doi: 10.1016/j.jpba.2003.05.001. [PMID: 15522521]
  • Masaaki Kai, Hiromi Kinoshita, Kazuko Ohta, Shuuji Hara, Myung Koo Lee, Jianzhong Lu. Sensitive determination of a beta-lactam antibiotic, cefaclor by liquid chromatography with chemiluminescence detection. Journal of pharmaceutical and biomedical analysis. 2003 Jan; 30(6):1765-71. doi: 10.1016/s0731-7085(02)00519-8. [PMID: 12485718]
  • Mitsuru Sugawara, Toru Ogawa, Michiya Kobayashi, Katsumi Miyazaki. Uptake of dipeptide and beta-lactam antibiotics by the basolateral membrane vesicles prepared from rat kidney. Biochimica et biophysica acta. 2003 Jan; 1609(1):39-44. doi: 10.1016/s0005-2736(02)00634-x. [PMID: 12507756]
  • Dorota Haznar, Janusz Pluta. Effect of composition on the physicochemical properties and active substance release from gelatin-alginate sponge. Polimery w medycynie. 2003; 33(4):17-27. doi: ". [PMID: 15058110]
  • Junko Takishima, Hiraku Onishi, Yoshiharu Machida. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biological & pharmaceutical bulletin. 2002 Nov; 25(11):1498-502. doi: 10.1248/bpb.25.1498. [PMID: 12419970]
  • Daniel Baczyński, Stefan Antosiewicz, Bozena Pietrzak, Zofia Wańkowicz. [Empirical therapy of peritonitis in peritoneal dialysis patients--it is reasonable to use a new therapeutic schedule?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2002 Nov; 13(77):396-8. doi: NULL. [PMID: 12621757]
  • Yi-wen Shen, Chao Lu, Zi-qin Zhao. [Tryptase and fatal anaphylaxic reaction]. Fa yi xue za zhi. 2002 Aug; 18(3):132-4, 136. doi: . [PMID: 12608287]
  • A I A Ibrahim, M Rashid. Comparison of local povidone-iodine antisepsis with parenteral antibacterial prophylaxis for prevention of infective complications of TURP: a prospective randomized controlled study. European urology. 2002 Mar; 41(3):250-6. doi: 10.1016/s0302-2838(02)00013-1. [PMID: 12180224]
  • Shahla Mansouri, Sorreia Shareifi. Antimicrobial resistance pattern of Escherichia coli causing urinary tract infections, and that of human fecal flora, in the southeast of Iran. Microbial drug resistance (Larchmont, N.Y.). 2002; 8(2):123-8. doi: 10.1089/107662902760190662. [PMID: 12118516]
  • A J Howard, J T Magee, K A Fitzgerald, F D Dunstan. Factors associated with antibiotic resistance in coliform organisms from community urinary tract infection in Wales. The Journal of antimicrobial chemotherapy. 2001 Mar; 47(3):305-13. doi: 10.1093/jac/47.3.305. [PMID: 11222563]
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  • V M Johnson, J P Allanson, R C Causon. Determination of the cephalosporin antibiotic cephradine in human plasma by high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications. 2000 Mar; 740(1):71-80. doi: 10.1016/s0378-4347(00)00023-2. [PMID: 10798295]
  • M E Ganapathy, W Huang, D P Rajan, A L Carter, M Sugawara, K Iseki, F H Leibach, V Ganapathy. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. The Journal of biological chemistry. 2000 Jan; 275(3):1699-707. doi: 10.1074/jbc.275.3.1699. [PMID: 10636865]
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