semustine (BioDeep_00001868020)

Main id: BioDeep_00000006559

 

Volatile Flavor Compounds


代谢物信息卡片


semustine

化学式: C10H18ClN3O2 (247.1087478)
中文名称: 司莫司汀, 塞莫司汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC(CC1)NC(=O)N(CCCl)N=O
InChI: InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AD - Nitrosoureas
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents

同义名列表

3 个代谢物同义名

semustine; Semustine; Semustine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Guangrong Lu, Liping Chen, Shengjie Wu, Yuao Feng, Tiesu Lin. Comprehensive Analysis of Tumor-Infiltrating Immune Cells and Relevant Therapeutic Strategy in Esophageal Cancer. Disease markers. 2020; 2020(?):8974793. doi: 10.1155/2020/8974793. [PMID: 32454908]
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  • Eu Jin Lim, Ruth Chin, Ueli Nachbur, John Silke, Zhiyuan Jia, Peter W Angus, Joseph Torresi. Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation. PloS one. 2015; 10(9):e0138522. doi: 10.1371/journal.pone.0138522. [PMID: 26390404]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Evrim Sahin, Anna M Petrunkina, Dagmar Waberski, Robin A P Harrison, Edda Töpfer-Petersen. Control of bull sperm cell volume during epididymal maturation. Reproduction, fertility, and development. 2009; 21(3):469-78. doi: 10.1071/rd08162. [PMID: 19261224]
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  • D W Potter, W Levin, D E Ryan, P E Thomas, D J Reed. Stereoselective monooxygenation of carcinostatic 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea by purified cytochrome P-450 isozymes. Biochemical pharmacology. 1984 Feb; 33(4):609-13. doi: 10.1016/0006-2952(84)90316-2. [PMID: 6704177]
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  • R B Weiss, J G Posada, R A Kramer, M R Boyd. Nephrotoxicity of semustine. Cancer treatment reports. 1983 Dec; 67(12):1105-12. doi: . [PMID: 6360348]
  • R A Kramer, M R Boyd. Nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) in the Fischer 344 rat. The Journal of pharmacology and experimental therapeutics. 1983 Nov; 227(2):409-14. doi: NULL. [PMID: 6631721]
  • H Windschitl, M Scott, A Schutt, G McCormack, L Everson, S Cullinan, J Gerstner, J Krook, J Laurie, R Shreck. Randomized phase II studies in advanced colorectal carcinoma: a North Central Cancer Treatment Group study. Cancer treatment reports. 1983 Nov; 67(11):1001-8. doi: NULL. [PMID: 6640551]
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  • B Caddy, O R Idowu. Gas-chromatographic determination of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU) Part II. Reduction to semicarbazide with sodium tetrahydroborate (III). The Analyst. 1982 May; 107(1274):550-5. doi: 10.1039/an9820700550. [PMID: 7103096]
  • B Caddy, O R Idowu, J F Stuart. A high pressure liquid chromatographic procedure for monitoring 1-(2-chloroethyl)-3-(4-trans-methylcyclohexyl)-1-nitrosourea levels in body fluids. Therapeutic drug monitoring. 1982; 4(4):389-95. doi: 10.1097/00007691-198212000-00010. [PMID: 7157463]
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