semustine (BioDeep_00000006559)

 

Secondary id: BioDeep_00001868020

human metabolite blood metabolite


代谢物信息卡片


1-(2-Chloroethyl)-1-([(4-methylcyclohexyl)amino]carbonyl)-2-oxohydrazine

化学式: C10H18ClN3O2 (247.1087)
中文名称: 司莫司汀, 塞莫司汀
谱图信息: 最多检出来源 Homo sapiens(blood) 81.25%

分子结构信息

SMILES: CC1CCC(CC1)NC(=O)N(CCCl)N=O
InChI: InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AD - Nitrosoureas
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents

同义名列表

14 个代谢物同义名

1-(2-Chloroethyl)-1-([(4-methylcyclohexyl)amino]carbonyl)-2-oxohydrazine; N-(2-Chloroethyl)-n-(4-methylcyclohexyl)-N-nitrosourea; 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea; 3-(2-chloroethyl)-1-(4-methylcyclohexyl)-3-nitrosourea; Methyl-ccnu; Methyl ccnu; Semustinum; semustine; Semustina; Me-ccnu; Me ccnu; MeCCNU; Semustine; Semustine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AKT2, CCND1, CCNG2, CDH1, CDK2, CDK6, CDKN2C, EP300, ID2, MAP2K2, PRKCA, RAF1, SOCS2, STMN1, TP53
Peripheral membrane protein 2 MAP2K2, PRKCA
Mitochondrion membrane 1 PRKCA
Nucleus 17 AKT2, CCND1, CCNG2, CDH1, CDK2, CDK6, CDKN2C, EP300, FGFR1, ID2, IGFBP3, MAP2K2, MDM4, PRKCA, RAF1, TCF7L1, TP53
cytosol 16 AKT2, CCND1, CDH1, CDK2, CDK6, CDKN2C, EP300, FGFR1, ID2, MAP2K2, PRKCA, RAF1, SOCS2, STMN1, TCF7L1, TP53
mitochondrial membrane 1 PRKCA
trans-Golgi network 1 CDH1
centrosome 4 CCND1, CDK2, CDK6, TP53
nucleoplasm 11 AKT2, CCND1, CDH1, CDK2, CDK6, EP300, ID2, MDM4, PRKCA, TCF7L1, TP53
Cell membrane 4 CDH1, FGFR1, PRKCA, RAF1
lamellipodium 1 CDH1
ruffle membrane 1 AKT2
cell cortex 1 AKT2
cell junction 1 CDH1
glutamatergic synapse 2 CDH1, FGFR1
Golgi apparatus 3 CDH1, MAP2K2, RAF1
Golgi membrane 1 PDGFD
postsynapse 2 CDH1, FGFR1
Cytoplasm, cytosol 1 FGFR1
endosome 2 CDH1, CDK2
plasma membrane 5 AKT2, CDH1, FGFR1, PRKCA, RAF1
Membrane 6 CDH1, FGFR1, MAP2K2, PRKCA, STMN1, TP53
extracellular exosome 3 CDH1, PRKCA, STMN1
endoplasmic reticulum 3 MAP2K2, PRKCA, TP53
extracellular space 2 IGFBP3, PDGFD
perinuclear region of cytoplasm 3 CDH1, MAP2K2, PRKCA
adherens junction 1 CDH1
bicellular tight junction 1 CCND1
mitochondrion 4 MAP2K2, PRKCA, RAF1, TP53
protein-containing complex 2 ID2, TP53
intracellular membrane-bounded organelle 1 AKT2
Single-pass type I membrane protein 2 CDH1, FGFR1
Secreted 2 IGFBP3, PDGFD
extracellular region 5 CDH1, FGFR1, IGFBP3, MAP2K2, PDGFD
cytoplasmic side of plasma membrane 2 CDH1, MAP2K2
mitochondrial outer membrane 1 RAF1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 CDK2, EP300, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 CDK2, CDK6, TP53
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, CDH1
actin cytoskeleton 1 CDH1
cytoplasmic vesicle 1 FGFR1
nucleolus 1 TP53
Early endosome 2 AKT2, MAP2K2
cell-cell junction 1 MAP2K2
Cytoplasm, cytoskeleton 2 STMN1, TP53
focal adhesion 1 MAP2K2
microtubule 2 MAP2K2, STMN1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
peroxisomal membrane 1 MAP2K2
Nucleus, PML body 1 TP53
PML body 1 TP53
lateral plasma membrane 1 CDH1
Late endosome 1 MAP2K2
ruffle 1 CDK6
receptor complex 1 FGFR1
neuron projection 1 STMN1
ciliary basal body 1 PRKCA
chromatin 3 EP300, TCF7L1, TP53
Chromosome 1 EP300
Golgi apparatus, trans-Golgi network 1 CDH1
chromosome, telomeric region 1 CDK2
site of double-strand break 1 TP53
nuclear envelope 1 CDK2
euchromatin 1 ID2
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 RAF1
endoplasmic reticulum lumen 2 IGFBP3, PDGFD
nuclear matrix 1 TP53
transcription repressor complex 3 CCND1, MDM4, TP53
male germ cell nucleus 1 CDK2
phosphatidylinositol 3-kinase complex 1 SOCS2
beta-catenin-TCF complex 1 TCF7L1
anaphase-promoting complex 1 CDH1
Cul5-RING ubiquitin ligase complex 1 SOCS2
Cajal body 1 CDK2
[Isoform 2]: Nucleus 1 CDH1
[Isoform 1]: Nucleus 1 TP53
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
apical junction complex 1 CDH1
condensed chromosome 1 CDK2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 4 CCND1, CCNG2, CDK2, CDK6
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
insulin-like growth factor binding protein complex 1 IGFBP3
insulin-like growth factor ternary complex 1 IGFBP3
alphav-beta3 integrin-PKCalpha complex 1 PRKCA
cyclin D1-CDK4 complex 1 CCND1
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 2 CCND1, CDK6
cyclin A1-CDK2 complex 1 CDK2
cyclin D3-CDK6 complex 1 CDK6
cyclin D2-CDK6 complex 1 CDK6


文献列表

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