chlorоphentermine (BioDeep_00001867967)
Main id: BioDeep_00000006538
代谢物信息卡片
chlorоphentermine
化学式: C10H14ClN (183.0814714)
中文名称: 对氯苯丁胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CC1=CC=C(C=C1)Cl)N
InChI: InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:3646
- KEGG: C07559
- PubChem: 10007
- DrugBank: DB01556
- ChEMBL: CHEMBL1201269
- MeSH: Chlorphentermine
- CAS: 461-78-9
- PubChem: 9762
- NIKKAJI: J5.768A
- KNApSAcK: 3646
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Baumann. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
PloS one.
2011 Mar; 6(3):e17735. doi:
10.1371/journal.pone.0017735. [PMID: 21464983] - Robert A Ettlin, Junji Kuroda, Stephanie Plassmann, Makoto Hayashi, David E Prentice. Successful drug development despite adverse preclinical findings part 2: examples.
Journal of toxicologic pathology.
2010 Dec; 23(4):213-34. doi:
10.1293/tox.23.213. [PMID: 22272032] - Daniel Crona, Julie Harral, Serge Adnot, Saadia Eddahibi, James West. Gene expression in lungs of mice lacking the 5-hydroxytryptamine transporter gene.
BMC pulmonary medicine.
2009 May; 9(?):19. doi:
10.1186/1471-2466-9-19. [PMID: 19426553] - K Deventer, P Van Eenoo, F T Delbeke. Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2006; 20(5):877-82. doi:
10.1002/rcm.2372. [PMID: 16470715] - Saadia Eddahibi, Serge Adnot. Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis.
Respiratory research.
2002; 3(?):9. doi:
10.1186/rr181. [PMID: 11806844] - R B Rothman, M A Ayestas, C M Dersch, M H Baumann. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.
Circulation.
1999 Aug; 100(8):869-75. doi:
10.1161/01.cir.100.8.869. [PMID: 10458725] - T Bredehorn, G I Duncker. [Chloroquine- and chlorphentermin-induced lipidosis in rat retina].
Klinische Monatsblatter fur Augenheilkunde.
1999 Mar; 214(3):178-82. doi:
10.1055/s-2008-1034772. [PMID: 10220731] - P Lee, R G Kirk, M J Reasor. X-ray microanalysis of cultured alveolar macrophages with phospholipidosis.
Experimental and molecular pathology.
1993 Apr; 58(2):96-104. doi:
10.1006/exmp.1993.1008. [PMID: 8388333] - P A Coulombe, M Bendayan. Cytochemical demonstration of increased phospholipid content in cell membranes in chlorphentermine-induced phospholipidosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
1989 Feb; 37(2):139-47. doi:
10.1177/37.2.2911004. [PMID: 2911004] - S M White, D B DeNicola, A H Rebar, G S Born, W V Kessler. Effects of chlorphentermine and nitrogen dioxide on murine alveolar macrophages.
Experimental lung research.
1988; 14(5):619-36. doi:
10.3109/01902148809087833. [PMID: 2852102] - S Kacew. Cationic amphiphilic drug-induced renal cortical lysosomal phospholipidosis: an in vivo comparative study with gentamicin and chlorphentermine.
Toxicology and applied pharmacology.
1987 Dec; 91(3):469-76. doi:
10.1016/0041-008x(87)90068-8. [PMID: 3424375] - J Burmester, R Hanpft, K Kröplin, R Lüllmann-Rauch, M Patten. Amantadine-induced lipidosis. A cytological and physicochemical study.
Toxicology.
1987 Apr; 44(1):45-59. doi:
10.1016/0300-483x(87)90045-x. [PMID: 3031849] - R Lüllmann-Rauch, D Watermann. Fusion of storage lysosomes in experimental lipidosis and glycogenosis.
Experimental and molecular pathology.
1987 Feb; 46(1):136-43. doi:
10.1016/0014-4800(87)90037-2. [PMID: 3467980] - C A Heyneman, M J Reasor. Role of the alveolar macrophage in the induction of pulmonary phospholipidosis by chlorphentermine. I. Drug and phospholipid levels.
The Journal of pharmacology and experimental therapeutics.
1986 Jan; 236(1):55-9. doi:
NULL. [PMID: 3941400] - J Y Ma, J K Ma, K C Weber. Fluorescence studies of the binding of amphiphilic amines with phospholipids.
Journal of lipid research.
1985 Jun; 26(6):735-44. doi:
10.1016/s0022-2275(20)34331-5. [PMID: 4031652] - S Kacew, M J Reasor. Newborn response to cationic amphiphilic drugs.
Federation proceedings.
1985 Apr; 44(7):2323-7. doi:
. [PMID: 2579857] - M J Reasor, M E Davis. Prevention of chlorphentermine-induced pulmonary phospholipidosis in rats by phenobarbital.
Drug metabolism and disposition: the biological fate of chemicals.
1985 Mar; 13(2):192-6. doi:
. [PMID: 2859167] - S Kacew. Gentamicin or chlorphentermine induction of phospholipidosis in the developing organism: role of tissue and species in manifestation of toxicity.
The Journal of pharmacology and experimental therapeutics.
1985 Jan; 232(1):239-43. doi:
. [PMID: 3965695] - R Taugner, A Whalley, S Angermüller, C P Bührle, E Hackenthal. Are the renin-containing granules of juxtaglomerular epithelioid cells modified lysosomes?.
Cell and tissue research.
1985; 239(3):575-87. doi:
10.1007/bf00219236. [PMID: 3886148] - M J Reasor. Phospholipidosis in the alveolar macrophage induced by cationic amphiphilic drugs.
Federation proceedings.
1984 Aug; 43(11):2578-81. doi:
. [PMID: 6745447] - E Bichler, M Anniko. Chlorphentermine-induced changes of the peripheral vestibular sense organ of the rat.
Acta oto-laryngologica.
1983 Nov; 96(5-6):421-8. doi:
10.3109/00016488309132728. [PMID: 6138918] - C Gairola, D H Matulionis, M J Reasor. Chlorphentermine-induced alterations in the lungs of vitamin E-deficient and supplemented rats: 1. Biochemical and morphometric analysis of the pulmonary response.
Experimental and molecular pathology.
1983 Jun; 38(3):368-79. doi:
10.1016/0014-4800(83)90076-x. [PMID: 6852209] - E Bichler, M Wieser. Experimental lipidosis of the inner ear. Morphological and functional results.
Acta oto-laryngologica.
1983 Mar; 95(3-4):307-13. doi:
10.3109/00016488309130947. [PMID: 6837284] - E I Christensen, A B Maunsbach, R Lüllmann-Rauch. Renal lysosomal protein digestion in experimental lipidosis.
Virchows Archiv. B, Cell pathology including molecular pathology.
1983; 43(3):309-16. doi:
10.1007/bf02932963. [PMID: 6137902] - L S Angevine, Y Ohmiya, H M Mehendale. Effect of chlorphentermine pretreatment on chlorphentermine uptake by isolated perfused rat lung.
Drug metabolism and disposition: the biological fate of chemicals.
1982 Jan; 10(1):68-73. doi:
. [PMID: 6124387] - W Meerbach, R Gräbner, W Dietz, W Böttger. [A comparative morphological and chemical study of the ambroxol and chlorphentermine action on the lung phospholipid content (author's transl)].
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie.
1982; 126(1-2):185-95. doi:
NULL. [PMID: 7090596] - R Lüllmann-Rauch, B Stoermer. Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Virchows Archiv. B, Cell pathology including molecular pathology.
1982; 39(1):59-73. doi:
10.1007/bf02892837. [PMID: 6123182] - R F Minchin, K F Ilett, B W Madsen. Effect of desmethylimipramine on tissue distribution and anorectic activity of chlorphentermine in rats.
Life sciences.
1981 Apr; 28(17):1931-8. doi:
10.1016/0024-3205(81)90301-5. [PMID: 7253800] - S C Woodward. Induction and reversal of pulmonary lipid histiocytosis in rats following oral administration of anorectics cloforex and chlorphentermine.
Journal of toxicology and environmental health.
1981 Mar; 7(3-4):569-83. doi:
10.1080/15287398109530002. [PMID: 7197305] - M J Reasor. Drug-induced lipidosis and the alveolar macrophage.
Toxicology.
1981; 20(1):1-33. doi:
10.1016/0300-483x(81)90102-5. [PMID: 7022749] - S Kacew, R Narbaitz. The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats.
Virchows Archiv. B, Cell pathology including molecular pathology.
1981; 36(1):59-63. doi:
10.1007/bf02912055. [PMID: 6116324] - H Lüllmann, R Lüllmann-Rauch, E U Mösinger. Impairment of renal function in rats with generalized lipidosis as induced by chlorphentermine.
Arzneimittel-Forschung.
1981; 31(5):795-9. doi:
NULL. [PMID: 7196738] - R Lüllmann-Rauch. Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology.
1981; 215(4):297-303. doi:
10.1007/bf00407668. [PMID: 7013556] - M J Reasor, R A Koshut. Augmentation in antioxidant defense mechanisms in rat alveolar macrophages following induction of phospholipidosis with chlorphentermine.
Toxicology and applied pharmacology.
1980 Sep; 55(2):334-41. doi:
10.1016/0041-008x(80)90095-2. [PMID: 7423522] - M J Reasor, R A Koshut, M J McNulty, M A Trush. Chemiluminescence from rat alveolar macrophages following induction of phospholipidosis with chlorphentermine.
Toxicology and applied pharmacology.
1980 Mar; 52(3):497-506. doi:
10.1016/0041-008x(80)90344-0. [PMID: 7368220] - H Schmalbruch. The early changes in experimental myopathy induced by chloroquine and chlorphentermine.
Journal of neuropathology and experimental neurology.
1980 Jan; 39(1):65-81. doi:
10.1097/00005072-198001000-00006. [PMID: 7359173] - S Kacew, G A Calderwood. Newborn liver and kidney metabolism as influenced by oxygen toxicity and anorectic drugs.
Journal of toxicology and environmental health.
1980 Jan; 6(1):141-54. doi:
10.1080/15287398009529837. [PMID: 6155472] - M J Reasor. Cumene hydroperoxide-mediated lipid peroxidation in rat alveolar macrophages following induction of phospholipidosis with chlorphentermine.
Toxicology.
1980; 18(2):159-68. doi:
10.1016/0300-483x(80)90078-5. [PMID: 7256780] - W Frisch, R Lüllmann-Rauch. Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus.
Acta neuropathologica.
1979 May; 46(3):203-8. doi:
10.1007/bf00690845. [PMID: 223364] - H Lüllmann, E U Mösinger. Increased lysosomal enzyme activities in tissues of rats suffering from chlorphentermine induced lipidosis.
Biochemical pharmacology.
1979 Apr; 28(7):1015-6. doi:
10.1016/0006-2952(79)90296-x. [PMID: 109091] - R Gräbner, W Meerbach. Morphological and biochemical alterations of the lung after application of chlorphentermine.
Experimentelle Pathologie.
1979; 17(6):303-11. doi:
10.1016/s0014-4908(79)80045-9. [PMID: 527695] - H Schmalbruch. Early changes in chlorphentermine myopathy of rat studied by freeze fracturing.
Muscle & nerve.
1978 Sep; 1(5):421-2. doi:
10.1002/mus.880010516. [PMID: 263983] - D Drenckhahn. Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine.
Virchows Archiv. B, Cell pathology.
1978 May; 27(3):255-66. doi:
10.1007/bf02889000. [PMID: 208230] - S Kacew, T C Dubas, A J Stevenson. Renal and hepatic nucleic acid metabolism in neonates: relation to experimental duration, chlorphentermine dose as well as subsequent withdrawal.
Toxicology.
1978 May; 10(1):77-90. doi:
10.1016/0300-483x(78)90057-4. [PMID: 566970] - S Kacew, R Narbaitz, A J Stevenson. The effects of chlorphentermine and phentermine on certain metabolic parameters associated with development of rat kidney and liver.
Chemico-biological interactions.
1977 Oct; 19(1):61-76. doi:
10.1016/0009-2797(77)90042-4. [PMID: 200375] - D Drenckhahn, R Lüllmann-Rauch. Lens opacities associated with lipidosis-like ultrastructural alterations in rats treated with chloroquine, chlorphentermine, or iprindole.
Experimental eye research.
1977 Jun; 24(6):621-32. doi:
10.1016/0014-4835(77)90120-8. [PMID: 872905] - A H Beckett, P M Bélanger. The metabolism, distribution and elimination of chlorphentermine in man.
British journal of clinical pharmacology.
1977 Apr; 4(2):193-200. doi:
10.1111/j.1365-2125.1977.tb00693.x. [PMID: 16634] - T Katayama, J Shimazaki. [Effects of chlormadinone acetate therapy of prostatic neoplasms on liver functions, total serum cholesterol and triglycerides].
Horumon to rinsho. Clinical endocrinology.
1977 Apr; 25(4):411-4. doi:
NULL. [PMID: 68841] - K U Seiler, H J Thiel, O Wassermann. [Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].
Klinische Monatsblatter fur Augenheilkunde.
1977 Jan; 170(1):64-73. doi:
NULL. [PMID: 15159] - M Michel-Lipowsky, J Caldwell, R L Smith. The reversibility of the N-oxidation of chlorphentermine in vivo [proceedings].
Biochemical Society transactions.
1977; 5(4):1005-6. doi:
10.1042/bst0051005. [PMID: 913762] - L Balabanski, T Tashev, A Meretev, Kh Babulkov. [Desopimon in the treatment of obesity].
Vutreshni bolesti.
1976 Dec; 15(6):42-5. doi:
. [PMID: 1014625] - J Gloster, D Heath, P Hasleton, P Harris. Effect of chlorphentermine on the lipids of rat lungs.
Thorax.
1976 Oct; 31(5):558-64. doi:
10.1136/thx.31.5.558. [PMID: 996817] - D Drenckhahn, L Kleine, R Lüllmann-Rauch. Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.
Laboratory investigation; a journal of technical methods and pathology.
1976 Aug; 35(2):116-23. doi:
. [PMID: 957602] - F Hartmann, F Jentzen. [Corticosterone content in the plasma and adrenal glands of rats after treatment with chlorphentermine].
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin.
1976; 82 Pt 2(?):1890-3. doi:
NULL. [PMID: 1030130] - J Caldwell, U Köster, R L Smith, R T Williams. Species variations in the N-oxidation of chlorphentermine.
Biochemical pharmacology.
1975 Dec; 24(24):2225-32. doi:
10.1016/0006-2952(75)90259-2. [PMID: 814901] - E U Mösinger. Proceedings: Changes of renal function in rats treated with chlorphentermine.
Naunyn-Schmiedeberg's archives of pharmacology.
1975; 287 Suppl(?):R54. doi:
NULL. [PMID: 1143453] - K U Seiler, O Wassermann. Drug-induced phospholipidosis. II. Alterations in the phospholipid pattern of organs from mice, rats and guinea-pigs after chronic treatment with chlorphentermine.
Naunyn-Schmiedeberg's archives of pharmacology.
1975; 288(2-3):261-8. doi:
10.1007/bf00500531. [PMID: 1161047] - B Lüllmann-Rauch. Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
Virchows Archiv. B, Cell pathology.
1975; 18(1):51-60. doi:
10.1007/bf02889233. [PMID: 167510] - R J Bussey, R C Backer. Thin-layer chromatographic differentiation of amphetamine from other primary-amine drugs in urine.
Clinical chemistry.
1974 Feb; 20(2):302-4. doi:
10.1093/clinchem/20.2.302. [PMID: 4813012] - K U Seiler, O Wassermann. Evidence for an unusual distribution of chlorphentermine in vivo. An autoradiographic study in mice.
Naunyn-Schmiedeberg's archives of pharmacology.
1974; 282(2):113-22. doi:
10.1007/bf00499026. [PMID: 4277476] - R Schmien, K U Seiler, O Wassermann. Drug-induced phospholipidosis. I. Lipid composition and chlorphentermine content of rat lung tissue and alveolar macrophages after chronic treatment.
Naunyn-Schmiedeberg's archives of pharmacology.
1974; 283(3):331-4. doi:
10.1007/bf00499192. [PMID: 4276759] - R Lüllmann-Rauch, N Pietschmann. Lipidosis-like cellular alterations in lymphatic tissues of chlorphentermine-treated animals.
Virchows Archiv. B, Cell pathology.
1974; 15(4):295-308. doi:
10.1007/bf02889345. [PMID: 4367544] - E Less. Anti-lipaemic effect of Desopimon in obesity and in diabetes mellitus accompanied by obesity.
Therapia Hungarica (English edition).
1974; 22(1):27-31. doi:
NULL. [PMID: 4844928] - H Lüllmann, E Rossen, K U Seiler. The pharmacokinetics of phentermine and chlorphentermine in chronically treated rats.
The Journal of pharmacy and pharmacology.
1973 Mar; 25(3):239-43. doi:
10.1111/j.2042-7158.1973.tb10631.x. [PMID: 4146324] - A H Beckett, L G Brookes. Administration of two or more related drugs to investigate the effect of molecular modification and formulation on drug absorption, metabolism and excretion.
The Journal of pharmacy and pharmacology.
1971 Nov; 23(11):837-41. doi:
10.1111/j.2042-7158.1971.tb10200.x. [PMID: 4400191] - A H Beckett, L G Brookes. The metabolism and urinary excretion in man of phentermine, and the influence of N-methyl and p-chloro-substitution.
The Journal of pharmacy and pharmacology.
1971 Apr; 23(4):288-94. doi:
10.1111/j.2042-7158.1971.tb08659.x. [PMID: 4396907] - M Bülow, H D Dell, J Fiedler, R Kamp, D Lorenz. [Metabolism and distribution of chlorphentermine and clorofex in animal and man].
Arzneimittel-Forschung.
1971 Jan; 21(1):86-93. doi:
NULL. [PMID: 5108205] - A Ryrfeldt. The distribution, elimination, and biotransformation of 14C-cloforex in the mouse and rat.
Acta pharmacologica et toxicologica.
1970; 28(5):391-405. doi:
10.1111/j.1600-0773.1970.tb00565.x. [PMID: 5536739] - M Eichelbaum, J H Hengstmann, H J Dengler. [Distribution pattern of chlorphentermine in rats, rabbits and swine].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1970; 267(5):446-56. doi:
NULL. [PMID: 4249506] - A H Beckett, E J Triggs. Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes.
The Journal of pharmacy and pharmacology.
1967 Dec; 19(?):Suppl:31S-41S. doi:
". [PMID: 4383854] - M L Weischer, K Opitz. [Determination of chlorphentermine, fenfluramine and related substances in urine].
Arzneimittel-Forschung.
1967 May; 17(5):625-7. doi:
NULL. [PMID: 5631594] - K Opitz, M L Weischer. [The excretion of anorectic phenylalkylamines in the urine].
Arzneimittel-Forschung.
1966 Oct; 16(10):1311-3. doi:
NULL. [PMID: 6014915] - G Fassina. [Effect of anorexic drugs on free fatty acids in the plasma].
Archives internationales de pharmacodynamie et de therapie.
1966 Jun; 161(2):410-22. doi:
NULL. [PMID: 4380871] - L Gozariu, O Florescu, J Madar. [The effect of chlorphentermine (Lucofen) on "free" and "bound" plasma insulin in rats].
Endokrinologie.
1966 Jun; 50(1):36-41. doi:
. [PMID: 5987669] - L Cucurachi, A Strata, U Zuliani, S Castello, P Cucurachi. [Lipid-mobilizing action of some anorexic drugs].
Bollettino della Societa italiana di biologia sperimentale.
1965 Dec; 41(24):1477-8. doi:
". [PMID: 5878157] - R Santi, G Fassina. Anorexigenic drugs and lipid mobilisation.
The Journal of pharmacy and pharmacology.
1965 Sep; 17(9):596-7. doi:
10.1111/j.2042-7158.1965.tb07730.x. [PMID: 4379637] - I M JACKSON, W G WHYTE. CHLORPHENTERMINE S.A. IN THE TREATMENT OF OBESITY AND THE EFFECT OF WEIGHT LOSS ON STEROID EXCRETION.
British medical journal.
1965 Aug; 2(5459):453-5. doi:
10.1136/bmj.2.5459.453. [PMID: 14314911] - H J BOSCH, K H BEYER. [ACCIDENTAL POISONING WITH CHLORPHENTERMINE ('AVICOL') IN A SMALL CHILD].
Archiv fur Toxikologie.
1965 Feb; 20(?):274-8. doi:
NULL. [PMID: 14272413]
