Psilocybine (BioDeep_00001867947)
Main id: BioDeep_00000002567
Volatile Flavor Compounds
代谢物信息卡片
Psilocybine
化学式: C12H17N2O4P (284.0925892)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O
InChI: InChI=1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17)
描述信息
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:8614
- KEGG: C07576
- PubChem: 10624
- DrugBank: DB11664
- ChEMBL: CHEMBL194378
- MeSH: Psilocybin
- CAS: 520-52-5
- PubChem: 9779
- PDB-CCD: X8Q
- NIKKAJI: J6.604D
- KNApSAcK: 8614
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Esmaeel Ghasemi Gojani, Bo Wang, Dong-Ping Li, Olga Kovalchuk, Igor Kovalchuk. The Impact of Psilocybin on High Glucose/Lipid-Induced Changes in INS-1 Cell Viability and Dedifferentiation.
Genes.
2024 Jan; 15(2):. doi:
10.3390/genes15020183. [PMID: 38397173] - Alistair R McTaggart, Stephen McLaughlin, Jason C Slot, Kevin McKernan, Chris Appleyard, Tia L Bartlett, Matthew Weinert, Caine Barlow, Leon N Warne, Louise S Shuey, André Drenth, Timothy Y James. Domestication through clandestine cultivation constrained genetic diversity in magic mushrooms relative to naturalized populations.
Current biology : CB.
2023 12; 33(23):5147-5159.e7. doi:
10.1016/j.cub.2023.10.059. [PMID: 38052161] - Marco Pepe, Mohsen Hesami, Karla A de la Cerda, Melissa L Perreault, Tom Hsiang, Andrew Maxwell Phineas Jones. A journey with psychedelic mushrooms: From historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond.
Biotechnology advances.
2023 12; 69(?):108247. doi:
10.1016/j.biotechadv.2023.108247. [PMID: 37659744] - Lei-Qi Liu, Jing-Ze Chen, Wu-Sheng Fu, Cui-Ying Tang. [Determination of amanita peptide and tryptamine toxins in wild mushrooms by high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2023 Nov; 41(11):976-985. doi:
10.3724/sp.j.1123.2023.07013. [PMID: 37968816] - Tao Chen, Ling Cheng, Jingwen Ma, Jiyuan Yuan, Chao Pi, Linjin Xiong, Jinglin Chen, Huiyang Liu, Jia Tang, Yueting Zhong, Xiaomei Zhang, Zerong Liu, Ying Zuo, Hongping Shen, Yumeng Wei, Ling Zhao. Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants.
Pharmacological research.
2023 Jun; 194(?):106837. doi:
10.1016/j.phrs.2023.106837. [PMID: 37379962] - Matthew Meyer, Jason Slot. The evolution and ecology of psilocybin in nature.
Fungal genetics and biology : FG & B.
2023 06; 167(?):103812. doi:
10.1016/j.fgb.2023.103812. [PMID: 37210028] - Alistair R McTaggart, Timothy Y James, Jason C Slot, Caine Barlow, Nigel Fechner, Louise S Shuey, André Drenth. Genome sequencing progenies of magic mushrooms (Psilocybe subaeruginosa) identifies tetrapolar mating and gene duplications in the psilocybin pathway.
Fungal genetics and biology : FG & B.
2022 Dec; 165(?):103769. doi:
10.1016/j.fgb.2022.103769. [PMID: 36587787] - Ahmed Al-Imam, Marek A Motyka, Zuzanna Witulska, Manal Younus, Michał Michalak. Spatiotemporal Mapping of Online Interest in Cannabis and Popular Psychedelics before and during the COVID-19 Pandemic in Poland.
International journal of environmental research and public health.
2022 05; 19(11):. doi:
10.3390/ijerph19116619. [PMID: 35682204] - Friederike Holze, Laura Ley, Felix Müller, Anna M Becker, Isabelle Straumann, Patrick Vizeli, Sebastian Silva Kuehne, Marc A Roder, Urs Duthaler, Karolina E Kolaczynska, Nimmy Varghese, Anne Eckert, Matthias E Liechti. Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2022 05; 47(6):1180-1187. doi:
10.1038/s41386-022-01297-2. [PMID: 35217796] - R C Van Court, M S Wiseman, K W Meyer, D J Ballhorn, K R Amses, J C Slot, B T M Dentinger, R Garibay-Orijel, J K Uehling. Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development.
Fungal biology.
2022 04; 126(4):308-319. doi:
10.1016/j.funbio.2022.01.003. [PMID: 35314062] - Anna M Becker, Friederike Holze, Tanja Grandinetti, Aaron Klaiber, Vanja E Toedtli, Karolina E Kolaczynska, Urs Duthaler, Nimmy Varghese, Anne Eckert, Edna Grünblatt, Matthias E Liechti. Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects.
Clinical pharmacology and therapeutics.
2022 04; 111(4):886-895. doi:
10.1002/cpt.2487. [PMID: 34743319] - James Rucker, Hassan Jafari, Tim Mantingh, Catherine Bird, Nadav Liam Modlin, Gemma Knight, Frederick Reinholdt, Camilla Day, Ben Carter, Allan Young. Psilocybin-assisted therapy for the treatment of resistant major depressive disorder (PsiDeR): protocol for a randomised, placebo-controlled feasibility trial.
BMJ open.
2021 12; 11(12):e056091. doi:
10.1136/bmjopen-2021-056091. [PMID: 34853114] - Martin K Madsen, Dea S Stenbæk, Albin Arvidsson, Sophia Armand, Maja R Marstrand-Joergensen, Sys S Johansen, Kristian Linnet, Brice Ozenne, Gitte M Knudsen, Patrick M Fisher. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2021 09; 50(?):121-132. doi:
10.1016/j.euroneuro.2021.06.001. [PMID: 34246868] - J R Kelly, M T Crockett, L Alexander, M Haran, A Baker, L Burke, C Brennan, V O'Keane. Psychedelic science in post-COVID-19 psychiatry.
Irish journal of psychological medicine.
2021 06; 38(2):93-98. doi:
10.1017/ipm.2020.94. [PMID: 32811575] - Natalie Hesselgrave, Timothy A Troppoli, Andreas B Wulff, Anthony B Cole, Scott M Thompson. Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice.
Proceedings of the National Academy of Sciences of the United States of America.
2021 04; 118(17):. doi:
10.1073/pnas.2022489118. [PMID: 33850049] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Karolina E Kolaczynska, Matthias E Liechti, Urs Duthaler. Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin's main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Feb; 1164(?):122486. doi:
10.1016/j.jchromb.2020.122486. [PMID: 33485158] - Faez Iqbal Khan, Fakhrul Hassan, Dakun Lai. In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor.
Frontiers in immunology.
2021; 12(?):794780. doi:
10.3389/fimmu.2021.794780. [PMID: 35095870] - Martin K Madsen, Gitte M Knudsen. Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2021 01; 46(1):257-258. doi:
10.1038/s41386-020-00823-4. [PMID: 32843702] - Lene Lundgaard Donovan, Jens Vilstrup Johansen, Nídia Fernandez Ros, Elham Jaberi, Kristian Linnet, Sys Stybe Johansen, Brice Ozenne, Shohreh Issazadeh-Navikas, Hanne Demant Hansen, Gitte Moos Knudsen. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2021 01; 42(?):1-11. doi:
10.1016/j.euroneuro.2020.11.013. [PMID: 33288378] - Júlia Nagy, Tibor Veress. Systematic Error for Extraction of Controlled Substances from Plant/Fungal Materials.
Journal of chromatographic science.
2020 Oct; 58(10):985-991. doi:
10.1093/chromsci/bmaa067. [PMID: 32945334] - Nige Netzband, Simon Ruffell, S Linton, W F Tsang, T Wolff. Modulatory effects of ayahuasca on personality structure in a traditional framework.
Psychopharmacology.
2020 Oct; 237(10):3161-3171. doi:
10.1007/s00213-020-05601-0. [PMID: 32700023] - Janis Fricke, Robert Kargbo, Lars Regestein, Claudius Lenz, Gundela Peschel, Miriam A Rosenbaum, Alexander Sherwood, Dirk Hoffmeister. Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin.
Chemistry (Weinheim an der Bergstrasse, Germany).
2020 Jul; 26(37):8281-8285. doi:
10.1002/chem.202000134. [PMID: 32101345] - Anna Poliwoda, Katarzyna Zielińska, Piotr P Wieczorek. Direct Analysis of Psilocin and Muscimol in Urine Samples Using Single Drop Microextraction Technique In-Line with Capillary Electrophoresis.
Molecules (Basel, Switzerland).
2020 Mar; 25(7):. doi:
10.3390/molecules25071566. [PMID: 32235328] - Christopher B Germann. The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.
Medical hypotheses.
2020 Jan; 134(?):109406. doi:
10.1016/j.mehy.2019.109406. [PMID: 31634774] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Emma Honyiglo, Angélique Franchi, Nathalie Cartiser, Charline Bottinelli, Anne-Sophie Advenier, Fabien Bévalot, Laurent Fanton. Unpredictable Behavior Under the Influence of 'Magic Mushrooms': A Case Report and Review of the Literature.
Journal of forensic sciences.
2019 Jul; 64(4):1266-1270. doi:
10.1111/1556-4029.13982. [PMID: 30548541] - Martin K Madsen, Patrick M Fisher, Daniel Burmester, Agnete Dyssegaard, Dea S Stenbæk, Sara Kristiansen, Sys S Johansen, Sczabolz Lehel, Kristian Linnet, Claus Svarer, David Erritzoe, Brice Ozenne, Gitte M Knudsen. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 06; 44(7):1328-1334. doi:
10.1038/s41386-019-0324-9. [PMID: 30685771] - Paul Webster. Denver votes to decriminalise psilocybin mushrooms.
Lancet (London, England).
2019 05; 393(10185):2023. doi:
10.1016/s0140-6736(19)31082-7. [PMID: 31106737] - William E Rosa, Stephanie Hope, Marianne Matzo. Palliative Nursing and Sacred Medicine: A Holistic Stance on Entheogens, Healing, and Spiritual Care.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association.
2019 Mar; 37(1):100-106. doi:
10.1177/0898010118770302. [PMID: 29669454] - Felix Blei, Janis Fricke, Jonas Wick, Jason C Slot, Dirk Hoffmeister. Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication.
Chembiochem : a European journal of chemical biology.
2018 10; 19(20):2160-2166. doi:
10.1002/cbic.201800336. [PMID: 30098085] - Marc Aixalà, Rafael G Dos Santos, Jaime E C Hallak, José Carlos Bouso. Psychedelics and Personality.
ACS chemical neuroscience.
2018 10; 9(10):2304-2306. doi:
10.1021/acschemneuro.8b00237. [PMID: 29863323] - Christopher R Nicholas, Kelsey M Henriquez, Michele C Gassman, Karen M Cooper, Daniel Muller, Scott Hetzel, Randall T Brown, Nicholas V Cozzi, Chantelle Thomas, Paul R Hutson. High dose psilocybin is associated with positive subjective effects in healthy volunteers.
Journal of psychopharmacology (Oxford, England).
2018 07; 32(7):770-778. doi:
10.1177/0269881118780713. [PMID: 29945469] - Anna Bravermanová, Michaela Viktorinová, Filip Tylš, Tomáš Novák, Renáta Androvičová, Jakub Korčák, Jiří Horáček, Marie Balíková, Inga Griškova-Bulanova, Dominika Danielová, Přemysl Vlček, Pavel Mohr, Martin Brunovský, Vlastimil Koudelka, Tomáš Páleníček. Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing-study on P300 and mismatch negativity in healthy volunteers.
Psychopharmacology.
2018 02; 235(2):491-503. doi:
10.1007/s00213-017-4807-2. [PMID: 29302713] - Randall T Brown, Christopher R Nicholas, Nicholas V Cozzi, Michele C Gassman, Karen M Cooper, Daniel Muller, Chantelle D Thomas, Scott J Hetzel, Kelsey M Henriquez, Alexandra S Ribaudo, Paul R Hutson. Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults.
Clinical pharmacokinetics.
2017 12; 56(12):1543-1554. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2017 Oct; 42(11):2105-2113. doi:
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Postepy higieny i medycyny doswiadczalnej (Online).
2015 Sep; 69(?):986-95. doi:
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Journal of psychopharmacology (Oxford, England).
2014 Nov; 28(11):983-92. doi:
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Journal of psychopharmacology (Oxford, England).
2014 Nov; 28(11):981-2. doi:
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Forensic science international.
2014 Apr; 237(?):1-6. doi:
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Scandinavian journal of clinical and laboratory investigation.
2013 Aug; 73(5):400-6. doi:
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International journal of legal medicine.
2013 May; 127(3):593-601. doi:
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International journal of legal medicine.
2012 Nov; 126(6):845-9. doi:
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Drug testing and analysis.
2011 Sep; 3(9):594-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2669-72. doi:
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Forensic science international.
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The American journal of emergency medicine.
2008 Oct; 26(8):972.e3-4. doi:
10.1016/j.ajem.2008.01.058. [PMID: 18926381] - Sławomir Majdanik, Krzysztof Borowiak, Maria Brzezńska, Anna Machoy-Mokrzyńska. [Concentration of selected microelements in blood serum of rats exposed to the action of psilocin and phenylethylamine].
Annales Academiae Medicae Stetinensis.
2007; 53 Suppl 2(?):153-8. doi:
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Journal of analytical toxicology.
2006 Jun; 30(5):342-5. doi:
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European journal of emergency medicine : official journal of the European Society for Emergency Medicine.
2005 Dec; 12(6):306-8. doi:
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International journal of legal medicine.
2004 Dec; 118(6):326-31. doi:
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Psychopharmacology.
2004 Mar; 172(2):145-56. doi:
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Forensic science international.
2003 Dec; 138(1-3):85-90. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Lab on a chip.
2003 May; 3(2):67-72. doi:
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Journal of pharmaceutical and biomedical analysis.
2002 Sep; 30(2):331-9. doi:
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The Journal of pharmacy and pharmacology.
2002 Sep; 54(9):1265-70. doi:
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Journal of forensic sciences.
2001 May; 46(3):627-30. doi:
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Forensic science international.
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Psychopharmacology.
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Journal of chromatography. B, Biomedical sciences and applications.
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Pharmaceutica acta Helvetiae.
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