CHLOROPROCAINE (BioDeep_00001867926)
Main id: BioDeep_00000002709
代谢物信息卡片
CHLOROPROCAINE
化学式: C13H19ClN2O2 (270.1135)
中文名称: 氯普鲁卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
InChI: InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BA - Esters of aminobenzoic acid
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:3636
- KEGG: C07877
- KEGGdrug: D07678
- PubChem: 8612
- DrugBank: DB01161
- ChEMBL: CHEMBL1179047
- PubChem: 10079
- CAS: 133-16-4
- NIKKAJI: J5.584K
- RefMet: Chloroprocaine
- KNApSAcK: 3636
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elsbeth J Wesselink, Seppe J Koopman, Rien van der Vegt, Peter M van de Ven, Jan P van der Aa, Carlijne Stapper, Friso Wesdorp, Laura de Kok, Yiyi Zhang, Eric J Franssen, Eleonora L Swart, Christa Boer, Marcel A de Leeuw. ED90 of spinal 2-chloroprocaine 1\% in ambulatory knee arthroscopy up to 45 min: a randomized biased-coin- up-and-down sequential allocation trial.
Regional anesthesia and pain medicine.
2022 04; 47(4):212-216. doi:
10.1136/rapm-2021-103089. [PMID: 35027477] - Allison Lee, Ben Shatil, Ruth Landau, Prahlad Menon, Richard Smiley. Intrathecal 2-Chloroprocaine 3\% Versus Hyperbaric Bupivacaine 0.75\% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Anesthesia and analgesia.
2022 03; 134(3):624-632. doi:
10.1213/ane.0000000000005653. [PMID: 34153006] - Daniela Ghisi, Giorgia Boschetto, Alessandra Maria Spinelli, Sandra Giannone, Jacopo Frugiuele, Marcello Ciccarello, Stefano Bonarelli. Spinal anaesthesia with Chloroprocaine HCl 1\% for elective lower limb procedures of short duration: a prospective, randomised, observer-blind study in adult patients.
BMC anesthesiology.
2021 02; 21(1):58. doi:
10.1186/s12871-021-01279-9. [PMID: 33610175] - Giorgio Veneziano, Joseph D Tobias. Chloroprocaine for epidural anesthesia in infants and children.
Paediatric anaesthesia.
2017 Jun; 27(6):581-590. doi:
10.1111/pan.13134. [PMID: 28321983] - Giorgio Veneziano, Peter Iliev, Jennifer Tripi, David Martin, Jennifer Aldrink, Tarun Bhalla, Joseph Tobias. Continuous chloroprocaine infusion for thoracic and caudal epidurals as a postoperative analgesia modality in neonates, infants, and children.
Paediatric anaesthesia.
2016 Jan; 26(1):84-91. doi:
10.1111/pan.12807. [PMID: 26530835] - Philipp Lirk, Susanne Picardi, Markus W Hollmann. Local anaesthetics: 10 essentials.
European journal of anaesthesiology.
2014 Nov; 31(11):575-85. doi:
10.1097/eja.0000000000000137. [PMID: 25192265] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Joel S Goldberg. Low Molecular Weight Opioid Peptide Esters Could be Developed as a New Class of Analgesics.
Perspectives in medicinal chemistry.
2011; 5(?):19-26. doi:
10.4137/pmc.s6803. [PMID: 21863129] - Beyazit Zencirci. Sertraline-induced pseudocholinesterase enzyme deficiency.
International journal of general medicine.
2010 Nov; 3(?):375-8. doi:
10.2147/ijgm.s14365. [PMID: 21189834] - Cynthia A Wong. Advances in labor analgesia.
International journal of women's health.
2010 Aug; 1(?):139-54. doi:
10.2147/ijwh.s4553. [PMID: 21072284] - Joel S Goldberg. Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions.
Perspectives in medicinal chemistry.
2010 Aug; 4(?):23-31. doi:
10.4137/pmc.s5490. [PMID: 20703328] - Michael F Mulroy, Francis V Salinas, Kathleen L Larkin, Nayak L Polissar. Ambulatory surgery patients may be discharged before voiding after short-acting spinal and epidural anesthesia.
Anesthesiology.
2002 Aug; 97(2):315-9. doi:
10.1097/00000542-200208000-00005. [PMID: 12151918] - Joel B Gunter. Benefit and risks of local anesthetics in infants and children.
Paediatric drugs.
2002; 4(10):649-72. doi:
10.2165/00128072-200204100-00003. [PMID: 12269841] - K M Wilcox, I A Paul, G A Ordway, W L Woolverton. Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in rats.
Psychopharmacology.
2001 Sep; 157(3):260-8. doi:
10.1007/s002130100796. [PMID: 11605081] - H Kutchai, L M Geddis. Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Pharmacological research.
2001 Apr; 43(4):399-403. doi:
10.1006/phrs.2001.0803. [PMID: 11352545] - M Durrani, J A Barwise, R F Johnson, J R Kambam, P K Janicki. Intravenous chloroprocaine attenuates hemodynamic changes associated with direct laryngoscopy and tracheal intubation.
Anesthesia and analgesia.
2000 May; 90(5):1208-12. doi:
10.1097/00000539-200005000-00039. [PMID: 10781481] - Q C Meng, T H Kramer, G R Arthur, P S Kim, F M Ferrante. High-performance liquid chromatographic analysis of the 2-chloroprocaine metabolite, diethylaminoethanol, in blood and serum.
Regional anesthesia and pain medicine.
1999 May; 24(3):242-5. doi:
10.1016/s1098-7339(99)90135-9. [PMID: 10338175] - P K Janicki, R Johnson, J R Kambam. Rapid determination of chloroprocaine and its major metabolite, 2-chloroaminobenzoic acid, in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1996 Jan; 675(2):336-41. doi:
10.1016/0378-4347(95)00376-2. [PMID: 8852724] - R A Stevens, D Beardsley, J L White, T C Kao, P J Teague, L Spitzer. Does the choice of local anesthetic affect the catecholamine response to stress during epidural anesthesia?.
Anesthesiology.
1993 Dec; 79(6):1219-26. doi:
10.1097/00000542-199312000-00012. [PMID: 8267197] - C Y Quon, H F Stampfli. Biochemical characterization of flestolol esterase.
Research communications in chemical pathology and pharmacology.
1993 Sep; 81(3):309-22. doi:
. [PMID: 8235065] - K Henderson, N F Sethna, C B Berde. Continuous caudal anesthesia for inguinal hernia repair in former preterm infants.
Journal of clinical anesthesia.
1993 Mar; 5(2):129-33. doi:
10.1016/0952-8180(93)90140-a. [PMID: 8476619] - S A Raymond. Subblocking concentrations of local anesthetics: effects on impulse generation and conduction in single myelinated sciatic nerve axons in frog.
Anesthesia and analgesia.
1992 Dec; 75(6):906-21. doi:
10.1213/00000539-199212000-00008. [PMID: 1443710] - D M Spencer, K A Miller, M O'Quin, J P Tomsovic, B Anderson, D Wong, W E Williams. Dorsal penile nerve block in neonatal circumcision: chloroprocaine versus lidocaine.
American journal of perinatology.
1992 May; 9(3):214-8. doi:
10.1055/s-2007-999324. [PMID: 1575846] - R A Stevens, W L Chester, J D Artuso, J G Bray, J A Nellestein. Back pain after epidural anesthesia with chloroprocaine in volunteers: preliminary report.
Regional anesthesia.
1991 Jul; 16(4):199-203. doi:
. [PMID: 1832945] - R A Stevens, J D Artuso, T C Kao, J G Bray, L Spitzer, D L Louwsma. Changes in human plasma catecholamine concentrations during epidural anesthesia depend on the level of block.
Anesthesiology.
1991 Jun; 74(6):1029-34. doi:
10.1097/00000542-199106000-00010. [PMID: 2042758] - G J Grant, S Ramanathan, N Patel, H Turndorf. The effects of local anesthetics on maternal and neonatal platelet function.
Acta anaesthesiologica Scandinavica.
1989 Jul; 33(5):409-12. doi:
10.1111/j.1399-6576.1989.tb02934.x. [PMID: 2529733] - M W Kalichman, H C Powell, R R Myers. Quantitative histologic analysis of local anesthetic-induced injury to rat sciatic nerve.
The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):406-13. doi:
". [PMID: 2746508] - H C Powell, M W Kalichman, R S Garrett, R R Myers. Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics.
Laboratory investigation; a journal of technical methods and pathology.
1988 Aug; 59(2):271-80. doi:
. [PMID: 3404978] - E H Philipson, B R Kuhnert, C D Syracuse. 2-Chloroprocaine for local perineal infiltration.
American journal of obstetrics and gynecology.
1987 Nov; 157(5):1275-8. doi:
10.1016/s0002-9378(87)80313-7. [PMID: 3688090] - A R Smith, D Hur, F Resano. Grand mal seizures after 2-chloroprocaine epidural anesthesia in a patient with plasma cholinesterase deficiency.
Anesthesia and analgesia.
1987 Jul; 66(7):677-8. doi:
. [PMID: 3111302] - B R Kuhnert, P M Kuhnert, E H Philipson, C D Syracuse, C J Kaine, C H Yun. The half-life of 2-chloroprocaine.
Anesthesia and analgesia.
1986 Mar; 65(3):273-8. doi:
NULL. [PMID: 3954093] - E H Philipson, B R Kuhnert, C D Syracuse. Fetal acidosis, 2-chloroprocaine, and epidural anesthesia for cesarean section.
American journal of obstetrics and gynecology.
1985 Feb; 151(3):322-4. doi:
10.1016/0002-9378(85)90295-9. [PMID: 3970100] - B R Kuhnert, P M Kuhnert, A L Reese, E H Philipson, M G Rosen. Maternal and neonatal elimination of CABA after epidural anesthesia with 2-chloroprocaine during parturition.
Anesthesia and analgesia.
1983 Dec; 62(12):1089-94. doi:
NULL. [PMID: 6650892] - G H Jordan, N C Babcock, J J Mocnik, D F Lynch. Pain control following renal infarction/ablation using continuous epidural combined anesthesia/analgesia.
The Journal of urology.
1983 Nov; 130(5):861-2. doi:
10.1016/s0022-5347(17)51536-0. [PMID: 6632091] - E H Philipson, B R Kuhnert, C B Syracuse, A L Reese, M G Rosen. Intrapartum paracervical block anesthesia with 2-chloroprocaine.
American journal of obstetrics and gynecology.
1983 May; 146(1):16-22. doi:
10.1016/0002-9378(83)90920-1. [PMID: 6846422] - B R Kuhnert, E H Philipson, R Pimental, P M Kuhnert. A prolonged chloroprocaine epidural block in a postpartum patient with abnormal pseudocholinesterase.
Anesthesiology.
1982 Jun; 56(6):477-8. doi:
10.1097/00000542-198206000-00017. [PMID: 7081736] - B R Kuhnert, P M Kuhnert, A L Reese. Urinary metabolites of chloroprocaine.
Anesthesiology.
1982 Jun; 56(6):483-4. doi:
10.1097/00000542-198206000-00020. [PMID: 7081739] - P H Rosenberg, A Alila. Hydrophobic membrane interaction of etidocaine, bupivacaine and 2-chloroprocaine. A spin and fluorescent probe study.
Naunyn-Schmiedeberg's archives of pharmacology.
1982 May; 319(2):95-100. doi:
10.1007/bf00503919. [PMID: 7110378] - K Krohg, E Jellum. Urinary metabolites of chloroprocaine studied by combined gas chromatography--mass spectrometry.
Anesthesiology.
1981 Apr; 54(4):329-32. doi:
10.1097/00000542-198104000-00014. [PMID: 7212334] - T L Gross, P M Kuhnert, B R Kuhnert, R Pimental. Plasma levels of 2-chloroprocaine and lack of sequelae following an apparent inadvertent intravenous injection.
Anesthesiology.
1981 Feb; 54(2):173. doi:
10.1097/00000542-198102000-00017. [PMID: 7469097] - C Carlsson, N Dahlgren, J Magnusson, A Hanson. Epidural block with chloroprocaine during labour.
Acta anaesthesiologica Scandinavica.
1980 Dec; 24(6):469-71. doi:
10.1111/j.1399-6576.1980.tb01585.x. [PMID: 7246029] - P P Raj, D Ohlweiler, B A Hitt, D D Denson. Kinetics of local anesthetic esters and the effects of adjuvant drugs on 2-chloroprocaine hydrolysis.
Anesthesiology.
1980 Oct; 53(4):307-14. doi:
10.1097/00000542-198010000-00007. [PMID: 7425357] - B R Kuhnert, P M Kuhnert, A L Prochaska, T L Gross. Plasma levels of 2-chloroprocaine in obstetric patients and their neonates after epidural anesthesia.
Anesthesiology.
1980 Jul; 53(1):21-5. doi:
10.1097/00000542-198007000-00005. [PMID: 7386904] - J E O'Brien, V Abbey, O Hinsvark, J Perel, M Finster. Metabolism and measurement of chloroprocaine, an ester-type local anesthetic.
Journal of pharmaceutical sciences.
1979 Jan; 68(1):75-8. doi:
10.1002/jps.2600680123. [PMID: 758470] - R H Smith, M A Brewster, J A MacDonald, D S Thompson. Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography.
Clinical chemistry.
1978 Sep; 24(9):1599-602. doi:
. [PMID: 688624] - D Lalka, N Vicuna, S R Burrow, D J Jones, T M Ludden, K D Haegele, J L McNay. Bupivacaine and other amide local anesthetics inhibit the hydrolysis of chloroprocaine by human serum.
Anesthesia and analgesia.
1978 Sep; 57(5):534-9. doi:
10.1213/00000539-197809000-00004. [PMID: 568420] - F F FOLDES, M H AVEN. The inhibition of the hydrolysis of procaine and 2-chloroprocaine in plasma by neostigmine and dimethylcarbamate of (2-hydroxy-5-phenylbenzyl) trimethylammonium bromide (Ro-2-683).
The Journal of pharmacology and experimental therapeutics.
1952 Jul; 105(3):253-8. doi:
NULL. [PMID: 14946666]
