Chloroprocaine (BioDeep_00000002709)
Secondary id: BioDeep_00001867926
human metabolite blood metabolite
代谢物信息卡片
4-Amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
化学式: C13H19ClN2O2 (270.1135)
中文名称: 氯普鲁卡因
谱图信息:
最多检出来源 Homo sapiens(blood) 85.71%
分子结构信息
SMILES: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
InChI: InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
描述信息
Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BA - Esters of aminobenzoic acid
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
15 个代谢物同义名
4-Amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester; 4-Amino-2-chlorobenzoate 2-(diethylamino)ethyl ester; 2-(diethylamino)ethyl 4-amino-2-chlorobenzoate; Chloroprocaine Hydrochloride; 2-Chloroprocaine; Chloroprocainum; CHLOROPROCAINE; Chlor-procaine; Chloroprocain; Chlorprocaine; Cloroprocaina; Nesacaine MPF; Nesacaine; Chloroprocaine; Chloroprocaine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3636
- KEGG: C07877
- KEGGdrug: D07678
- PubChem: 8612
- HMDB: HMDB0015292
- Metlin: METLIN3958
- DrugBank: DB01161
- ChEMBL: CHEMBL1179047
- Wikipedia: Chloroprocaine
- chemspider: 8293
- CAS: 133-16-4
- PMhub: MS000004577
- PubChem: 10079
- NIKKAJI: J5.584K
- RefMet: Chloroprocaine
- KNApSAcK: 3636
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elsbeth J Wesselink, Seppe J Koopman, Rien van der Vegt, Peter M van de Ven, Jan P van der Aa, Carlijne Stapper, Friso Wesdorp, Laura de Kok, Yiyi Zhang, Eric J Franssen, Eleonora L Swart, Christa Boer, Marcel A de Leeuw. ED90 of spinal 2-chloroprocaine 1\% in ambulatory knee arthroscopy up to 45 min: a randomized biased-coin- up-and-down sequential allocation trial.
Regional anesthesia and pain medicine.
2022 04; 47(4):212-216. doi:
10.1136/rapm-2021-103089. [PMID: 35027477] - Allison Lee, Ben Shatil, Ruth Landau, Prahlad Menon, Richard Smiley. Intrathecal 2-Chloroprocaine 3\% Versus Hyperbaric Bupivacaine 0.75\% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Anesthesia and analgesia.
2022 03; 134(3):624-632. doi:
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BMC anesthesiology.
2021 02; 21(1):58. doi:
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Paediatric anaesthesia.
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1996 Jan; 675(2):336-41. doi:
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Anesthesiology.
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1993 Sep; 81(3):309-22. doi:
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1993 Mar; 5(2):129-33. doi:
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Anesthesia and analgesia.
1992 Dec; 75(6):906-21. doi:
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American journal of perinatology.
1992 May; 9(3):214-8. doi:
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Regional anesthesia.
1991 Jul; 16(4):199-203. doi:
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1991 Jun; 74(6):1029-34. doi:
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Acta anaesthesiologica Scandinavica.
1989 Jul; 33(5):409-12. doi:
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The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):406-13. doi:
". [PMID: 2746508] - H C Powell, M W Kalichman, R S Garrett, R R Myers. Selective vulnerability of unmyelinated fiber Schwann cells in nerves exposed to local anesthetics.
Laboratory investigation; a journal of technical methods and pathology.
1988 Aug; 59(2):271-80. doi:
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American journal of obstetrics and gynecology.
1987 Nov; 157(5):1275-8. doi:
10.1016/s0002-9378(87)80313-7. [PMID: 3688090] - A R Smith, D Hur, F Resano. Grand mal seizures after 2-chloroprocaine epidural anesthesia in a patient with plasma cholinesterase deficiency.
Anesthesia and analgesia.
1987 Jul; 66(7):677-8. doi:
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1986 Mar; 65(3):273-8. doi:
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1985 Feb; 151(3):322-4. doi:
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1983 Dec; 62(12):1089-94. doi:
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The Journal of urology.
1983 Nov; 130(5):861-2. doi:
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1982 Jun; 56(6):477-8. doi:
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1982 May; 319(2):95-100. doi:
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1981 Feb; 54(2):173. doi:
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Acta anaesthesiologica Scandinavica.
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1979 Jan; 68(1):75-8. doi:
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