2-chloroethanol (BioDeep_00001867840)
Main id: BioDeep_00000006317
代谢物信息卡片
2-chloroethanol
化学式: C2H5ClO (80.002891)
中文名称: 2-氯乙醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCl)O
InChI: InChI=1S/C2H5ClO/c3-1-2-4/h4H,1-2H2
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:28200
- KEGG: C06753
- PubChem: 34
- ChEMBL: CHEMBL191244
- MeSH: Ethylene Chlorohydrin
- CAS: 59826-67-4
- CAS: 107-07-3
- MetaboLights: MTBLC28200
- PubChem: 8974
- 3DMET: B01042
- NIKKAJI: J4.050I
- RefMet: 2-Chloroethanol
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Thomas Bessaire, Thomas Stroheker, Bjorn Eriksen, Claudia Mujahid, Yves-Alexis Hammel, Jesus Varela, Thierry Delatour, Alexandre Panchaud, Pascal Mottier, Richard H Stadler. Analysis of ethylene oxide in ice creams manufactured with contaminated carob bean gum (E410).
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2021 Dec; 38(12):2116-2127. doi:
10.1080/19440049.2021.1970242. [PMID: 34477495] - Hirotaka Sato, Yuki Ito, Miho Inoue, Yuki Nakahira, Satoru Hashimoto, Tamie Nakajima, Michihiro Kamijima. Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry.
Scientific reports.
2019 06; 9(1):9294. doi:
10.1038/s41598-019-45790-z. [PMID: 31243319] - Lisanne C Anders, Anna L Lang, Anwar Anwar-Mohamed, Amanda N Douglas, Adrienne M Bushau, Keith Cameron Falkner, Bradford G Hill, Nikole L Warner, Gavin E Arteel, Matt Cave, Craig J McClain, Juliane I Beier. Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 06; 151(2):312-23. doi:
10.1093/toxsci/kfw045. [PMID: 26962056] - Jie Gao, Caixia Yang, Hui Ding, Yanli Zhang, Jinhua Xue, Yanning Cai. 2,2,2-Trichloroethanol lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells.
Biochemical and biophysical research communications.
2015 Jul; 462(3):239-44. doi:
10.1016/j.bbrc.2015.04.123. [PMID: 25956065] - Rui Yang, Qiao-Cong Lao, Hang-Ping Yu, Yong Zhang, Hong-Cui Liu, Lin Luan, Hui-Min Sun, Chun-Qi Li. Tween-80 and impurity induce anaphylactoid reaction in zebrafish.
Journal of applied toxicology : JAT.
2015 Mar; 35(3):295-301. doi:
10.1002/jat.3069. [PMID: 25345596] - Hong Sik Yoo, Blair U Bradford, Oksana Kosyk, Takeki Uehara, Svitlana Shymonyak, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Journal of toxicology and environmental health. Part A.
2015; 78(1):32-49. doi:
10.1080/15287394.2015.958418. [PMID: 25424545] - Hong Sik Yoo, Blair U Bradford, Oksana Kosyk, Svitlana Shymonyak, Takeki Uehara, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Journal of toxicology and environmental health. Part A.
2015; 78(1):15-31. doi:
10.1080/15287394.2015.958417. [PMID: 25424544] - Mouna Cheikh Rouhou, Ginette Charest-Tardif, Sami Haddad. In vivo effects of naproxen, salicylic acid, and valproic acid on the pharmacokinetics of trichloroethylene and metabolites in rats.
Journal of toxicology and environmental health. Part A.
2015; 78(11):671-84. doi:
10.1080/15287394.2015.1020977. [PMID: 26039745] - Noreen Yaqoob, Andrew Evans, John R Foster, Edward A Lock. Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure.
Toxicology.
2014 Sep; 323(?):70-7. doi:
10.1016/j.tox.2014.06.004. [PMID: 24923549] - O M Zhurba, A N Alekseenko. [To the question of the optimization of methods for detection of vinyl chloride and 1,2-dichloroethane, and their metabolites in biological fluids in workers involved in production of polyvinyl chloride].
Gigiena i sanitariia.
2014 Sep; ?(5):116-20. doi:
. [PMID: 25831943] - Noreen Yaqoob, Andrew R Evans, Edward A Lock. Trichloroethylene-induced formic aciduria: effect of dose, sex and strain of rat.
Toxicology.
2013 Feb; 304(?):49-56. doi:
10.1016/j.tox.2012.11.014. [PMID: 23211455] - Yui Hibino, Hailan Wang, Hisao Naito, Na Zhao, Dong Wang, Xiaofang Jia, Hongling Li, Xiangrong Song, Lili Liu, Yongshun Huang, Yuki Ito, Hanlin Huang, Michihiro Kamijima, Tamie Nakajima. Sex differences in metabolism of trichloroethylene and trichloroethanol in guinea pigs.
Journal of occupational health.
2013; 55(6):443-9. doi:
10.1539/joh.13-0091-oa. [PMID: 24025858] - Ronan Garlantézec, Luc Multigner, Laurence Labat, Nathalie Bonvallot, Juha Pulkkinen, Brigitte Dananché, Christine Monfort, Florence Rouget, Sylvaine Cordier. Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment.
Occupational and environmental medicine.
2012 Jan; 69(1):62-70. doi:
10.1136/oem.2010.062315. [PMID: 21705463] - Qing-Dong Huang, Guo-Xing Zhong, Yang Zhang, Jiang Ren, Yun Fu, Ji Zhang, Wen Zhu, Xiao-Qi Yu. Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells.
PloS one.
2011; 6(8):e23134. doi:
10.1371/journal.pone.0023134. [PMID: 21887233] - Yng-Tay Chen, Jiunn-Wang Liao, Dong-Zong Hung. Protective effects of fomepizole on 2-chloroethanol toxicity.
Human & experimental toxicology.
2010 Jun; 29(6):507-12. doi:
10.1177/0960327109358612. [PMID: 20056735] - Sultan Dogan-Duyar, Johan L Willemse, Paul Van Hee, Elisabeth L Duval, Hugo Neels. Chloral hydrate intoxication in a 3-month-old child: avoidance of hemodialysis by an immediate determination of trichloroethanol.
Clinical biochemistry.
2010 Feb; 43(3):328-30. doi:
10.1016/j.clinbiochem.2009.08.025. [PMID: 19747907] - A K Salous, H Ren, K A Lamb, X-Q Hu, R H Lipsky, R W Peoples. Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit.
British journal of pharmacology.
2009 Nov; 158(5):1395-404. doi:
10.1111/j.1476-5381.2009.00397.x. [PMID: 19788495] - Torsten Arndt, Birgit Gierten, Brunhilde Güssregen, Annika Werle, Joachim Grüner. False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication.
Forensic science international.
2009 Jan; 184(1-3):e27-9. doi:
10.1016/j.forsciint.2008.10.022. [PMID: 19084359] - Xin Huang, Mingfu Li, Xiangmei Lin, Hongjun Chen, Shuifang Zhu. 4-(2-Chloro-ethoxy)phthalonitrile.
Acta crystallographica. Section E, Structure reports online.
2008 Nov; 64(Pt 12):o2337. doi:
10.1107/s1600536808027141. [PMID: 21581312] - Gilda L Mena-Benitez, Fernando Gandia-Herrero, Stuart Graham, Tony R Larson, Simon J McQueen-Mason, Christopher E French, Elizabeth L Rylott, Neil C Bruce. Engineering a catabolic pathway in plants for the degradation of 1,2-dichloroethane.
Plant physiology.
2008 Jul; 147(3):1192-8. doi:
10.1104/pp.108.119008. [PMID: 18467461] - J L Merdink, L M Robison, D K Stevens, M Hu, J C Parker, R J Bull. Kinetics of chloral hydrate and its metabolites in male human volunteers.
Toxicology.
2008 Mar; 245(1-2):130-40. doi:
10.1016/j.tox.2007.12.018. [PMID: 18243465] - Mariella Carrieri, Doriano Magosso, Pierpaolo Piccoli, Edoardo Zanetti, Andrea Trevisan, Giovanni Battista Bartolucci. Acute, nonfatal intoxication with trichloroethylene.
Archives of toxicology.
2007 Jul; 81(7):529-32. doi:
10.1007/s00204-007-0180-y. [PMID: 17285313] - Edward A Lock, Celia J Reed, Joellyn M McMillan, John E Oatis, Rick G Schnellmann. Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid.
Toxicology.
2007 Feb; 230(2-3):234-43. doi:
10.1016/j.tox.2006.11.055. [PMID: 17161896] - E I Ile, P Q Craufurd, N H Battey, R Asiedu. Phases of dormancy in Yam tubers (Dioscorea rotundata).
Annals of botany.
2006 Apr; 97(4):497-504. doi:
10.1093/aob/mcl002. [PMID: 16446288] - Osamu Inoue, Hirohiko Ukai, Masayuki Ikeda. Green chemistry in urinalysis for trichloroethanol and trichloroacetic acid as markers of exposure to chlorinated hydrocarbon solvents.
Industrial health.
2006 Jan; 44(1):207-14. doi:
10.2486/indhealth.44.207. [PMID: 16610561] - S S Anand, M M Mumtaz, H M Mehendale. Dose-dependent liver regeneration in chloroform, trichloroethylene and allyl alcohol ternary mixture hepatotoxicity in rats.
Archives of toxicology.
2005 Nov; 79(11):671-82. doi:
10.1007/s00204-005-0675-3. [PMID: 15940471] - Yogesh Kumar, Salman Muzammil, Saad Tayyab. Influence of fluoro, chloro and alkyl alcohols on the folding pathway of human serum albumin.
Journal of biochemistry.
2005 Oct; 138(4):335-41. doi:
10.1093/jb/mvi131. [PMID: 16272127] - Douglas O Johns, Russell L Dills, Michael S Morgan. Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, trichloroethanol, and trichloroacetic acid in biological samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Mar; 817(2):255-61. doi:
10.1016/j.jchromb.2004.12.013. [PMID: 15686993] - Hideki Igisu, Hayato Narimatsu. [Trichloroacetic acid and trichloroethanol in urine].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Dec; 62 Suppl 12(?):479-81. doi:
NULL. [PMID: 15658368] - Yogesh Kumar, Saad Tayyab, Salman Muzammil. Molten-globule like partially folded states of human serum albumin induced by fluoro and alkyl alcohols at low pH.
Archives of biochemistry and biophysics.
2004 Jun; 426(1):3-10. doi:
10.1016/j.abb.2004.03.025. [PMID: 15130777] - Trevor Green, Jacky Dow, John Foster. Increased formic acid excretion and the development of kidney toxicity in rats following chronic dosing with trichloroethanol, a major metabolite of trichloroethylene.
Toxicology.
2003 Sep; 191(2-3):109-19. doi:
10.1016/s0300-483x(03)00206-3. [PMID: 12965114] - Wolfgang Fischer, Kerstin Wirkner, Marco Weber, Christoph Eberts, Laszlo Köles, Robert Reinhardt, Heike Franke, Clemens Allgaier, Clemens Gillen, Peter Illes. Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol.
Journal of neurochemistry.
2003 May; 85(3):779-90. doi:
10.1046/j.1471-4159.2003.01716.x. [PMID: 12694404] - Kazuo Harada, Keiko Yasui. Decomposition of ethylene, a flower-senescence hormone, with electrolyzed anode water.
Bioscience, biotechnology, and biochemistry.
2003 Apr; 67(4):790-6. doi:
10.1271/bbb.67.790. [PMID: 12784619] - Linda S Von Tungeln, Ping Yi, Thomas J Bucci, Victor M Samokyszyn, Ming W Chou, Fred F Kadlubar, Peter P Fu. Tumorigenicity of chloral hydrate, trichloroacetic acid, trichloroethanol, malondialdehyde, 4-hydroxy-2-nonenal, crotonaldehyde, and acrolein in the B6C3F(1) neonatal mouse.
Cancer letters.
2002 Nov; 185(1):13-9. doi:
10.1016/s0304-3835(02)00231-8. [PMID: 12142074] - Xiaoyan Chen, Hongyan Wang, Yue Du, Dafang Zhong. Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Aug; 775(2):169-78. doi:
10.1016/s1570-0232(02)00288-x. [PMID: 12113983] - Poh-Gek Forkert, Lawrence H Lash, Veronique Nadeau, Robert Tardif, Andrea Simmonds. Metabolism and toxicity of trichloroethylene in epididymis and testis.
Toxicology and applied pharmacology.
2002 Aug; 182(3):244-54. doi:
10.1006/taap.2002.9421. [PMID: 12183104] - Thomas Mensing, Peter Welge, Bruno Voss, Lüder M Fels, Hajo Hennig Fricke, Thomas Brüning, Michael Wilhelm. Renal toxicity after chronic inhalation exposure of rats to trichloroethylene.
Toxicology letters.
2002 Mar; 128(1-3):243-7. doi:
10.1016/s0378-4274(01)00545-8. [PMID: 11869834] - Ken Solt, Jonas S Johansson. Binding of the active metabolite of chloral hydrate, 2,2,2-trichloroethanol, to serum albumin demonstrated using tryptophan fluorescence quenching.
Pharmacology.
2002; 64(3):152-9. doi:
10.1159/000056165. [PMID: 11834892] - T Q Shang, S L Doty, A M Wilson, W N Howald, M P Gordon. Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway.
Phytochemistry.
2001 Dec; 58(7):1055-65. doi:
10.1016/s0031-9422(01)00369-7. [PMID: 11730869] - J M Gaulier, G Merle, E Lacassie, B Courtiade, P Haglund, P Marquet, G Lachâtre. Fatal intoxications with chloral hydrate.
Journal of forensic sciences.
2001 Nov; 46(6):1507-9. doi:
. [PMID: 11714169] - L J Bloemen, A C Monster, S Kezic, J N Commandeur, H Veulemans, N P Vermeulen, J W Wilmer. Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans.
International archives of occupational and environmental health.
2001 Mar; 74(2):102-8. doi:
10.1007/s004200000198. [PMID: 11317702] - L Köles, K Wirkner, S Fürst, S Wnendt, P Illes. Trichloroethanol inhibits ATP-induced membrane currents in cultured HEK 293-hP2X3 cells.
European journal of pharmacology.
2000 Dec; 409(3):R3-5. doi:
10.1016/s0014-2999(00)00833-5. [PMID: 11108830] - B Dehon, L Humbert, L Devisme, M Stievenart, D Mathieu, N Houdret, M Lhermitte. Tetrachloroethylene and trichloroethylene fatality: case report and simple headspace SPME-capillary gas chromatographic determination in tissues.
Journal of analytical toxicology.
2000 Jan; 24(1):22-6. doi:
10.1093/jat/24.1.22. [PMID: 10654565] - Z Yan, G N Henderson, M O James, P W Stacpoole. Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
1999 Mar; 19(3-4):309-18. doi:
10.1016/s0731-7085(98)00123-x. [PMID: 10704096] - M S Greenberg, G A Burton, J W Fisher. Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.
Toxicology and applied pharmacology.
1999 Feb; 154(3):264-78. doi:
10.1006/taap.1998.8594. [PMID: 9931286] - J W Fisher, D Mahle, R Abbas. A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.
Toxicology and applied pharmacology.
1998 Oct; 152(2):339-59. doi:
10.1006/taap.1998.8486. [PMID: 9853003] - A A Elfarra, R J Krause, A R Last, L H Lash, J C Parker. Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
1998 Aug; 26(8):779-85. doi:
. [PMID: 9698293] - D A Engelhart, E S Lavins, C B Hazenstab, C A Sutheimer. Unusual death attributed to the combined effects of chloral hydrate, lidocaine, and nitrous oxide.
Journal of analytical toxicology.
1998 May; 22(3):246-7. doi:
10.1093/jat/22.3.246. [PMID: 9602943] - M D Krasowski, S E Finn, Q Ye, N L Harrison. Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors.
The Journal of pharmacology and experimental therapeutics.
1998 Mar; 284(3):934-42. doi:
NULL. [PMID: 9495852] - R Abbas, J W Fisher. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice.
Toxicology and applied pharmacology.
1997 Nov; 147(1):15-30. doi:
10.1006/taap.1997.8190. [PMID: 9356303] - G N Henderson, Z Yan, M O James, N Davydova, P W Stacpoole. Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite.
Biochemical and biophysical research communications.
1997 Jun; 235(3):695-8. doi:
10.1006/bbrc.1997.6868. [PMID: 9207222] - R D Stenner, J L Merdink, D K Stevens, D L Springer, R J Bull. Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene.
Drug metabolism and disposition: the biological fate of chemicals.
1997 May; 25(5):529-35. doi:
. [PMID: 9152590] - S G Benane, C F Blackman, D E House. Effect of perchloroethylene and its metabolites on intercellular communication in clone 9 rat liver cells.
Journal of toxicology and environmental health.
1996 Aug; 48(5):427-37. doi:
10.1080/009841096161168. [PMID: 8751833] - N V Medvedeva, A Iu Misharin. [Effect of denaturing agents, ionic strength and 2-chloroethanol on the structure of spin-labelled apolipoprotein A-1 in solution].
Bioorganicheskaia khimiia.
1996 Jun; 22(6):415-9. doi:
NULL. [PMID: 8975669] - M Yoshida, S Fukabori, K Hara, H Yuasa, K Nakaaki, Y Yamamura, K Yoshida. Concentrations of trichloroethylene and its metabolites in blood and urine after acute poisoning by ingestion.
Human & experimental toxicology.
1996 Mar; 15(3):254-8. doi:
10.1177/096032719601500312. [PMID: 8839215] - G Birner, A Rutkowska, W Dekant. N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jan; 24(1):41-8. doi:
. [PMID: 8825189] - Y C Ni, T Y Wong, R V Lloyd, T M Heinze, S Shelton, D Casciano, F F Kadlubar, P P Fu. Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jan; 24(1):81-90. doi:
. [PMID: 8825194] - P Kintz, C Jamey, P Mangin. Trichloroethanol is not a metabolite of alpha chloralose.
International journal of legal medicine.
1996; 108(4):191-3. doi:
10.1007/bf01369790. [PMID: 8652423] - R Garnier, J Bédouin, G Pépin, Y Gaillard. Coin-operated dry cleaning machines may be responsible for acute tetrachloroethylene poisoning: report of 26 cases including one death.
Journal of toxicology. Clinical toxicology.
1996; 34(2):191-7. doi:
10.3109/15563659609013769. [PMID: 8618253] - Y C Ni, F F Kadlubar, P P Fu. Formation of malondialdehyde-modified 2'-deoxyguanosinyl adduct from metabolism of chloral hydrate by mouse liver microsomes.
Biochemical and biophysical research communications.
1995 Nov; 216(3):1110-7. doi:
10.1006/bbrc.1995.2735. [PMID: 7488187] - T J Amiss, I W Smoak. Determination of chlorobutanol in mouse serum, urine and embryos by capillary gas chromatography with electron capture detection.
Journal of chromatography. B, Biomedical applications.
1995 Nov; 673(1):59-66. doi:
10.1016/0378-4347(95)00240-j. [PMID: 8925075] - M V Templin, D K Stevens, R D Stenner, P L Bonate, D Tuman, R J Bull. Factors affecting species differences in the kinetics of metabolites of trichloroethylene.
Journal of toxicology and environmental health.
1995 Apr; 44(4):435-47. doi:
10.1080/15287399509531972. [PMID: 7723076] - K Mizunuma, T Kawai, S Horiguchi, M Ikeda. Urinary methylchloroform rather than urinary metabolites as an indicator of occupational exposure to methylchloroform.
International archives of occupational and environmental health.
1995; 67(1):19-25. doi:
10.1007/bf00383128. [PMID: 7622275] - S Laparé, R Tardif, J Brodeur. Effect of various exposure scenarios on the biological monitoring of organic solvents in alveolar air. II. 1,1,1-Trichloroethane and trichloroethylene.
International archives of occupational and environmental health.
1995; 67(6):375-94. doi:
10.1007/bf00381051. [PMID: 8567088] - L Humbert, M C Jacquemont, E Leroy, F Leclerc, N Houdret, M Lhermitte. Determination of chloral hydrate and its metabolites (trichloroethanol and trichloracetic acid) in human plasma and urine using electron capture gas chromatography.
Biomedical chromatography : BMC.
1994 Nov; 8(6):273-7. doi:
10.1002/bmc.1130080604. [PMID: 7888728] - H Itoh, S Ikeda, N Ichinose. Determination of 2,2,2-trichloroethanol in plasma and urine by ion-exclusion chromatography.
The Analyst.
1994 Mar; 119(3):409-13. doi:
10.1039/an9941900409. [PMID: 8192227] - G D Loizou, M W Anders. Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).
Drug metabolism and disposition: the biological fate of chemicals.
1993 Jul; 21(4):634-9. doi:
NULL. [PMID: 8104122] - B Tranchand, C Lucas, P Biron, B Giroux, B Gordon, R Richards, P Solere, N Roux, E Evene, F Mornex. Phase I pharmacokinetics study of high-dose fotemustine and its metabolite 2-chloroethanol in patients with high-grade gliomas.
Cancer chemotherapy and pharmacology.
1993; 32(1):46-52. doi:
10.1007/bf00685875. [PMID: 8462123] - A Ulander, A Seldén, G Ahlborg. Assessment of intermittent trichloroethylene exposure in vapor degreasing.
American Industrial Hygiene Association journal.
1992 Nov; 53(11):742-3. doi:
10.1080/15298669291360454. [PMID: 1442565] - D L Onks, A F Robertson, R Brodersen. The effect of chloral hydrate and its metabolites, trichloroethanol and trichloroacetic acid, on bilirubin-albumin binding.
Pharmacology & toxicology.
1992 Sep; 71(3 Pt 1):196-7. doi:
10.1111/j.1600-0773.1992.tb00544.x. [PMID: 1438041] - P F Heller, B A Goldberger, Y H Caplan. Chloral hydrate overdose: trichloroethanol detection by gas chromatography/mass spectrometry.
Forensic science international.
1992 Jan; 52(2):231-4. doi:
10.1016/0379-0738(92)90112-a. [PMID: 1601354] - D J Mayers, K W Hindmarsh, D K Gorecki, K Sankaran. Sedative/hypnotic effects of chloral hydrate in the neonate: trichloroethanol or parent drug?.
Developmental pharmacology and therapeutics.
1992; 19(2-3):141-6. doi:
10.1159/000457475. [PMID: 1340434] - A Ohara, H Michitsuji, Y Jyoyama, K Yamaguchi, Y Fujiki. [Determination of trichloroacetic acid and trichloroethanol by head-space gas chromatography (HS.GC)].
Sangyo igaku. Japanese journal of industrial health.
1991 Mar; 33(2):94-103. doi:
10.1539/joh1959.33.94. [PMID: 2067138] - S Tomiyasu, N Sakanishi, J Amano, Y Tsunoda, T Yoshida, T Maruyama, A Suzuki. [Investigation of limulus test during and after cardiopulmonary bypass. Part II. Effect of washing of the bypass circuit].
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai.
1991 Mar; 39(3):311-4. doi:
NULL. [PMID: 2051088] - Y Motohashi, T Kawakami, Y Miyazaki, T Takano, W Ekataksin. Circadian variations in trichloroethylene toxicity under a 12:12 hr light-dark cycle and their alterations under constant darkness in rats.
Toxicology and applied pharmacology.
1990 Jun; 104(1):139-48. doi:
10.1016/0041-008x(90)90289-7. [PMID: 2360203] - R N Gupta. Determination of trichloroethanol, the active metabolite of chloral hydrate, in plasma by liquid chromatography.
Journal of chromatography.
1990 Feb; 500(?):655-9. doi:
10.1016/s0021-9673(00)96100-4. [PMID: 2329156] - R M Ings, A J Gray, A R Taylor, B H Gordon, M Breen, M Hiley, R Brownsill, N Marchant, R Richards, D Wallace. Disposition, pharmacokinetics, and metabolism of 14C-fotemustine in cancer patients.
European journal of cancer (Oxford, England : 1990).
1990; 26(7):838-42. doi:
10.1016/0277-5379(90)90166-q. [PMID: 2145908] - J L Larson, R J Bull. Effect of ethanol on the metabolism of trichloroethylene.
Journal of toxicology and environmental health.
1989; 28(4):395-406. doi:
10.1080/15287398909531359. [PMID: 2593173] - L D Reimche, K Sankaran, K W Hindmarsh, G F Kasian, D K Gorecki, L Tan. Chloral hydrate sedation in neonates and infants--clinical and pharmacologic considerations.
Developmental pharmacology and therapeutics.
1989; 12(2):57-64. doi:
10.1159/000480965. [PMID: 2714158] - A Iu Misharin, N V Medvedeva, N G Bushmakina, I V Antonov, T L Bushueva. [Formation of micellar complexes of apolipoprotein A-I with dimyristoylphosphatidylcholine].
Bioorganicheskaia khimiia.
1988 Nov; 14(11):1551-6. doi:
. [PMID: 2853635] - J M Fraser, L S Kaminsky. 2,2,2-Trifluoroethanol intestinal and bone marrow toxicity: the role of its metabolism to 2,2,2-trifluoroacetaldehyde and trifluoroacetic acid.
Toxicology and applied pharmacology.
1988 Jun; 94(1):84-92. doi:
10.1016/0041-008x(88)90339-0. [PMID: 3376117] - T Hobara, H Kobayashi, T Kawamoto, S Iwamoto, T Sakai. Intestinal absorption of chloral hydrate, free trichloroethanol and trichloroacetic acid in dogs.
Pharmacology & toxicology.
1988 May; 62(5):250-8. doi:
10.1111/j.1600-0773.1988.tb01883.x. [PMID: 3413026] - T Hobara, H Kobayashi, T Kawamoto, S Iwamoto, T Sakai. The absorption of trichloroethylene and its metabolites from the urinary bladder of anesthetized dogs.
Toxicology.
1988 Feb; 48(2):141-53. doi:
10.1016/0300-483x(88)90096-0. [PMID: 3341043] - L K Lowry. The biological exposure index: its use in assessing chemical exposures in the workplace.
Toxicology.
1987 Dec; 47(1-2):55-69. doi:
10.1016/0300-483x(87)90160-0. [PMID: 3686532] - T Hobara, H Kobayashi, T Kawamoto, S Iwamoto, T Sakai. Extrahepatic metabolism of chloral hydrate, trichloroethanol and trichloroacetic acid in dogs.
Pharmacology & toxicology.
1987 Jul; 61(1):58-62. doi:
10.1111/j.1600-0773.1987.tb01773.x. [PMID: 3628182] - W K Surewicz, M A Moscarello, H H Mantsch. Secondary structure of the hydrophobic myelin protein in a lipid environment as determined by Fourier-transform infrared spectrometry.
The Journal of biological chemistry.
1987 Jun; 262(18):8598-602. doi:
. [PMID: 3597388] - J O Dickinson, R C Braun. Effect of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and 2-chloroethanol against pyrrole production and chronic toxicity of monocrotaline in chickens.
Veterinary and human toxicology.
1987 Feb; 29(1):11-5. doi:
. [PMID: 3103314] - D Godenèche, J C Madelmont, P Labarre, R Plagne, G Meyniel. Disposition of new sulphur-containing 2-(chloroethyl)nitrosoureas in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1987 Jan; 17(1):59-70. doi:
10.3109/00498258709047175. [PMID: 3825177] - T Hobara, H Kobayashi, T Kawamoto, S Iwamoto, S Hirota, W Shimazu, T Sakai. Extrahepatic organs metabolism of inhaled trichloroethylene.
Toxicology.
1986 Nov; 41(3):289-303. doi:
10.1016/0300-483x(86)90183-6. [PMID: 3775778] - I V Antonov, N V Medvedeva, Misharin AJu, A D Morozkin, E K Ruuge. Recombinant models of lipoproteins. Apolipoprotein A-I/phosphatidylcholine/cholesterol complexes formed in a 2-chloroethanol-water mixture.
Biochimica et biophysica acta.
1985 Jun; 835(1):50-7. doi:
10.1016/0005-2760(85)90029-3. [PMID: 2988634] - J A Buben, E J O'Flaherty. Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study.
Toxicology and applied pharmacology.
1985 Mar; 78(1):105-22. doi:
10.1016/0041-008x(85)90310-2. [PMID: 2994252] - R D Storer, R B Conolly. An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane.
Toxicology and applied pharmacology.
1985 Jan; 77(1):36-46. doi:
10.1016/0041-008x(85)90265-0. [PMID: 3966241] - K Pekari, A Aitio. Determination of 2,2,2-trichloroethanol in urine.
IARC scientific publications.
1985; ?(68):473-8. doi:
NULL. [PMID: 4065986] - A Koizumi, H Fujita, T Sadamoto, M Yamamoto, M Kumai, M Ikeda. Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene.
Toxicology.
1984 Mar; 30(2):93-102. doi:
10.1016/0300-483x(84)90120-3. [PMID: 6710543] - M T Rinaudo, M Curto, R Bruno. [Levels of glutathione and anaerobic glycolysis in the kidney and liver of rats treated with chloroethanol].
Bollettino della Societa italiana di biologia sperimentale.
1983 Nov; 59(11):1583-9. doi:
. [PMID: 6230087] - T Hobara, H Kobayashi, E Higashihara, T Kawamoto, T Sakai. [Experimental studies of trichloroethylene toxicity. II. Changes in trichloroethylene metabolites in blood serum and in urine during and after exposure to trichloroethylene].
Nihon eiseigaku zasshi. Japanese journal of hygiene.
1983 Oct; 38(4):772-9. doi:
NULL. [PMID: 6668718] - J E Andrews, K D Courtney, W E Donaldson. The effects of ethylene chlorohydrin on fatty acid synthesis.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
1983; 18(3):351-67. doi:
10.1080/03601238309372374. [PMID: 6308094] - L Martis, R Kroes, T D Darby, E F Woods. Disposition kinetics of ethylene oxide, ethylene glycol, and 2-chlorethanol in the dog.
Journal of toxicology and environmental health.
1982 Oct; 10(4-5):847-56. doi:
10.1080/15287398209530299. [PMID: 7161831] - W Grunow, H J Altmann. Toxicokinetics of chloroethanol in the rat after single oral administration.
Archives of toxicology.
1982 Mar; 49(3-4):275-84. doi:
10.1007/bf00347875. [PMID: 7092566]