Pargyline (BioDeep_00001867836)
Main id: BioDeep_00000001509
代谢物信息卡片
Pargyline
化学式: C11H13N (159.1047938)
中文名称: N-甲基-N-炔丙基苯甲胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CC#C)CC1=CC=CC=C1
InChI: InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KC - Mao inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
1 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianan Guo, Yujia Zhang, Changjun Zhang, Chuansheng Yao, Jingqi Zhang, Xiaoying Jiang, Zhichao Zhong, Jiamin Ge, Tao Zhou, Renren Bai, Yuanyuan Xie. N-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer's disease.
Bioorganic chemistry.
2021 08; 113(?):105013. doi:
10.1016/j.bioorg.2021.105013. [PMID: 34062405] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Dongyang Ma, Tong Han, Mohammad Karimian, Naser Abbasi, Hori Ghaneialvar, Akram Zangeneh. Immobilized Ag NPs on chitosan-biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer.
International journal of biological macromolecules.
2020 Dec; 165(Pt A):767-775. doi:
10.1016/j.ijbiomac.2020.09.193. [PMID: 32991899] - Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
European journal of medicinal chemistry.
2020 Sep; 202(?):112475. doi:
10.1016/j.ejmech.2020.112475. [PMID: 32652406] - Luiz C Klein-Júnior, Sylvian Cretton, Yvan Vander Heyden, André L Gasper, Samad Nejad-Ebrahimi, Philippe Christen, Amélia T Henriques. Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa.
Journal of natural products.
2020 04; 83(4):852-863. doi:
10.1021/acs.jnatprod.9b00469. [PMID: 32150413] - Prakash Bansode, R Anantacharya, Maruti Dhanavade, Subodh Kamble, Sagar Barale, Kailas Sonawane, Nayak D Satyanarayan, Gajanan Rashinkar. Evaluation of drug candidature: In silico ADMET, binding interactions with CDK7 and normal cell line studies of potentially anti-breast cancer enamidines.
Computational biology and chemistry.
2019 Dec; 83(?):107124. doi:
10.1016/j.compbiolchem.2019.107124. [PMID: 31563021] - Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu. Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.
Bioorganic & medicinal chemistry.
2019 05; 27(10):2027-2040. doi:
10.1016/j.bmc.2019.03.060. [PMID: 30975503] - María Goretti Arvizu-Espinosa, Gilsane Lino von Poser, Amelia Teresinha Henriques, Aniceto Mendoza-Ruiz, Anaberta Cardador-Martínez, Reinier Gesto-Borroto, Pablo Noé Núñez-Aragón, María Luisa Villarreal-Ortega, Ashutosh Sharma, Alexandre Cardoso-Taketa. Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum.
Journal of natural products.
2019 04; 82(4):785-791. doi:
10.1021/acs.jnatprod.8b00677. [PMID: 30920216] - Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso, Giorgio Grosa. New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 May; 48(5):478-487. doi:
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European journal of medicinal chemistry.
2017 Oct; 139(?):48-59. doi:
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Bioorganic & medicinal chemistry letters.
2016 10; 26(19):4714-4719. doi:
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2016 07; 59(14):6791-806. doi:
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2016; 39(1):104-13. doi:
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Biochemical and biophysical research communications.
2015 Nov; 467(2):310-5. doi:
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Carbohydrate polymers.
2015 Nov; 132(?):261-73. doi:
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Journal of medicinal chemistry.
2015 Jul; 58(14):5561-78. doi:
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Organic & biomolecular chemistry.
2015 Feb; 13(6):1778-91. doi:
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Chemical communications (Cambridge, England).
2014 Jul; 50(58):7800-2. doi:
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2014 Jan; 26(3):455-60. doi:
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Bioorganic & medicinal chemistry.
2013 Jan; 21(1):186-95. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
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2011 Dec; 56(4):815-9. doi:
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2011 Jul; 26(11):4326-30. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Feb; 26(2):489-98. doi:
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Stem cells and development.
2010 Oct; 19(10):1571-8. doi:
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2010 Sep; 17(?):78. doi:
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The European journal of neuroscience.
2008 Sep; 28(6):1180-90. doi:
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Journal of cardiovascular pharmacology.
2008 Sep; 52(3):268-77. doi:
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Pest management science.
2006 Feb; 62(2):99-113. doi:
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2005 Nov; 19(13):1899-901. doi:
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European journal of pharmacology.
2005 Oct; 522(1-3):139-46. doi:
10.1016/j.ejphar.2005.08.051. [PMID: 16202994] - Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdim. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.
Annals of the New York Academy of Sciences.
2005 Aug; 1053(?):348-55. doi:
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Pflugers Archiv : European journal of physiology.
2005 Jun; 450(3):185-91. doi:
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Biochemistry.
2004 Aug; 43(34):10965-78. doi:
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Journal of the American Chemical Society.
2004 Jun; 126(25):8038-45. doi:
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2004 Mar; 14(2):93-104. doi:
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Biochemical and biophysical research communications.
2003 May; 304(4):788-94. doi:
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Tissue & cell.
2003 Apr; 35(2):101-12. doi:
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Investigative ophthalmology & visual science.
2003 Feb; 44(2):791-8. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2002 Jul; 16(9):1129-31. doi:
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Brain research.
2002 Jun; 941(1-2):72-81. doi:
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The Journal of pharmacology and experimental therapeutics.
2002 May; 301(2):753-64. doi:
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Annals of the New York Academy of Sciences.
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