erumbone (BioDeep_00001867577)

Main id: BioDeep_00000000986

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

化学式: C15H22O (218.1671)
中文名称: 花姜酮, 球姜酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C1=C\CC(C)(C)/C=C/C(=O)/C(C)=C/CC1
InChI: InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+

描述信息

Zerumbone is a sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia. It has a role as an anti-inflammatory agent, a plant metabolite and a glioma-associated oncogene inhibitor. It is a sesquiterpenoid and a cyclic ketone. It derives from a hydride of an alpha-humulene.
Zerumbone is a natural product found in Curcuma amada, Curcuma longa, and other organisms with data available.
A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity[1][2].
Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity[1][2].

同义名列表

8 个代谢物同义名

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one; (E,E,E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one; 2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one; 2E,6E,9E-humulatrien-8-one; Zerumbone, >=98\\% (HPLC); Zerumbone; erumbone; 2,6,10-Cycloundecatrien-1-one, 2,6,9,9-tetramethyl-, (E,E,E)-



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANG, BCL2, CASP3, CASP9, CAT, CDKN1A, MAPK14, MAPK8, NFE2L2, NOS2, PIK3CA, PTGS2, STAT3, TP53, VEGFA
Peripheral membrane protein 2 GORASP1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 13 ANG, BCL2, CASP3, CASP9, CDKN1A, HMOX1, MAPK14, MAPK8, NFE2L2, NOS2, STAT3, TP53, VEGFA
cytosol 14 ANG, BCL2, CASP3, CASP9, CAT, CDKN1A, HMOX1, MAPK14, MAPK8, NFE2L2, NOS2, PIK3CA, STAT3, TP53
nuclear body 1 CDKN1A
centrosome 2 NFE2L2, TP53
nucleoplasm 9 CASP3, CDKN1A, HMOX1, MAPK14, MAPK8, NFE2L2, NOS2, STAT3, TP53
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 1 TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 2 TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 3 GORASP1, NFE2L2, VEGFA
Golgi membrane 1 GORASP1
growth cone 1 ANG
neuronal cell body 3 ANG, CASP3, TNF
Cytoplasm, cytosol 2 NFE2L2, NOS2
plasma membrane 5 NFE2L2, NOS2, PIK3CA, STAT3, TNF
Membrane 5 BCL2, CAT, HMOX1, TP53, VEGFA
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 1 CAT
endoplasmic reticulum 5 BCL2, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 ANG, CCL2, HMOX1, IL6, TNF, VEGFA
perinuclear region of cytoplasm 4 CDKN1A, HMOX1, NOS2, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CAT, MAPK14, TP53
protein-containing complex 6 BCL2, CASP9, CAT, CDKN1A, PTGS2, TP53
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 4 ANG, CCL2, IL6, VEGFA
extracellular region 7 ANG, CAT, CCL2, IL6, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 3 ANG, CDKN1A, TP53
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, NOS2
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 3 NFE2L2, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
site of double-strand break 1 TP53
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Haslinda Mohd Salleh, Abdulwali Ablat, Soon-Lim Chong, Hazrina Hazni, Norsita Tohar, Nurulwahidah Fauzi, Habibah A Wahab, Muhamad Aqmal Othman, Sook Yee Liew, Khalijah Awang. The protective effects of Zingiber zerumbet rhizome against fevers in rats. Die Naturwissenschaften. 2024 Apr; 111(2):20. doi: 10.1007/s00114-024-01907-7. [PMID: 38558027]
  • Dipak Biswas, Bharat Gopalrao Somkuwar, Jagat Chandra Borah, Pritish Kumar Varadwaj, Saurabh Gupta, Zeeshan Ahmad Khan, Gopinath Mondal, Asamanja Chattoraj, Lokesh Deb. Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis. Scientific reports. 2023 08; 13(1):13612. doi: 10.1038/s41598-023-37729-2. [PMID: 37604838]
  • Jutao Li, Lingying Wang, Yuxin Sun, Zhe Wang, Ye Qian, Vidhya Duraisamy, Tawfiq M Al Antary. Zerumbone-induced reactive oxygen species-mediated oxidative stress re-sensitizes breast cancer cells to paclitaxel. Biotechnology and applied biochemistry. 2023 Feb; 70(1):28-37. doi: 10.1002/bab.2326. [PMID: 35240000]
  • Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang, Xingyun Chai. Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system. Journal of ethnopharmacology. 2023 Jan; 301(?):115813. doi: 10.1016/j.jep.2022.115813. [PMID: 36220513]
  • Jin-Guo Wang, Da-Lei Li, Rong Fan, Meng-Jun Yan. Zerumbone combined with gefitinib alleviates lung cancer cell growth through the AKT/STAT3/SLC7A11 axis. Neoplasma. 2023 Jan; ?(?):. doi: 10.4149/neo_2022_220418n423. [PMID: 36637083]
  • Nurul Huda Alwakil, Mohamad Suffian Mohamad Annuar, Mahanom Jalil. Synergistic Effects of Plant Growth Regulators and Elicitors on α-Humulene and Zerumbone Production in Zingiber zerumbet Smith Adventitious Root Cultures. Molecules (Basel, Switzerland). 2022 Jul; 27(15):. doi: 10.3390/molecules27154744. [PMID: 35897918]
  • Junjun Li, Fuxing Ge, Shana Wuken, Shungang Jiao, Panlong Chen, Meiwen Huang, Xiaoli Gao, Juan Liu, Pengfei Tu, Xingyun Chai, Luqi Huang. Zerumbone, a humulane sesquiterpene from Syringa pinnatifolia, attenuates cardiac fibrosis by inhibiting of the TGF-β1/Smad signaling pathway after myocardial infarction in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):154078. doi: 10.1016/j.phymed.2022.154078. [PMID: 35405613]
  • Julia Schnoell, Isabella Stanisz, Bernhard J Jank, Victoria Stanek, Rainer Schmid, Markus Brunner, Gregor Heiduschka, Ulana Kotowski. Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma. Investigational new drugs. 2022 04; 40(2):224-231. doi: 10.1007/s10637-021-01190-7. [PMID: 34613571]
  • Shaymaa Fadhel Abbas Albaayit, Rasedee Abdullah, Mohd Hezmee Mohd Noor. Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats. BioMed research international. 2022; 2022(?):1129297. doi: 10.1155/2022/1129297. [PMID: 36124067]
  • Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185700. [PMID: 34577171]
  • Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Hanis Zakaria, Nurul Izzaty Hassan, Enoch Kumar Perimal. Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models. Molecules (Basel, Switzerland). 2021 Jun; 26(13):. doi: 10.3390/molecules26133849. [PMID: 34202590]
  • Banulata Gopalsamy, Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Enoch Kumar Perimal. Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain. Molecules (Basel, Switzerland). 2020 Aug; 25(17):. doi: 10.3390/molecules25173880. [PMID: 32858809]
  • Yuen Ping Tan, Andrei I Savchenko, Kylie A Agnew-Francis, Glen M Boyle, Paul V Bernhardt, James A Fraser, Craig M Williams. Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian Dysphania Species That Suggests a Putative Biogenetic Link to Zerumbone. Journal of natural products. 2020 05; 83(5):1473-1479. doi: 10.1021/acs.jnatprod.9b01039. [PMID: 32302147]
  • Da-Seul Shin, Yong-Bin Eom. Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus. Microbial pathogenesis. 2019 Dec; 137(?):103768. doi: 10.1016/j.micpath.2019.103768. [PMID: 31585154]
  • Nabilah Mohammad Yaqoob Akhtar, Ibrahim Jantan, Laiba Arshad, Md Areeful Haque. Standardized ethanol extract, essential oil and zerumbone of Zingiber zerumbet rhizome suppress phagocytic activity of human neutrophils. BMC complementary and alternative medicine. 2019 Nov; 19(1):331. doi: 10.1186/s12906-019-2748-5. [PMID: 31752812]
  • Soonjae Hwang, Minjeong Jo, Ju Eun Hong, Chan Oh Park, Chang Gun Lee, Miyong Yun, Ki-Jong Rhee. Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-κΒ. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184560. [PMID: 31540059]
  • Hye-Rim Kim, Ki-Jong Rhee, Yong-Bin Eom. Anti-biofilm and antimicrobial effects of zerumbone against Bacteroides fragilis. Anaerobe. 2019 Jun; 57(?):99-106. doi: 10.1016/j.anaerobe.2019.04.001. [PMID: 30953693]
  • Meilin Wang, Jingling Niu, Lina Ou, Bo Deng, Yingyi Wang, Sanqiang Li. Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-κB/COX-2 Pathway. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101964. [PMID: 31121820]
  • A Rosa, D Caprioglio, R Isola, M Nieddu, G Appendino, A M Falchi. Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity. Food & function. 2019 Mar; 10(3):1629-1642. doi: 10.1039/c8fo02395f. [PMID: 30834410]
  • Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Shazliana Ghazalee. Standardized extract of Zingiber zerumbet suppresses LPS-induced pro-inflammatory responses through NF-κB, MAPK and PI3K-Akt signaling pathways in U937 macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 54(?):195-205. doi: 10.1016/j.phymed.2018.09.183. [PMID: 30668369]
  • You-Cheng Hseu, Chih-Ting Chang, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Hui-Chang Lin, Hung-Rong Yen, Hsin-Ling Yang. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway. Oxidative medicine and cellular longevity. 2019; 2019(?):4098674. doi: 10.1155/2019/4098674. [PMID: 31814875]
  • Min-Ju Kim, Jung-Mi Yun. Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages. Journal of medicinal food. 2019 Jan; 22(1):62-73. doi: 10.1089/jmf.2018.4253. [PMID: 30383973]
  • Taek-In Oh, Hye-Jeong Jung, Yoon-Mi Lee, Sujin Lee, Geon-Hee Kim, Sang-Yeon Kan, Hyeji Kang, Taerim Oh, Hyun Myung Ko, Keun-Chang Kwak, Ji-Hong Lim. Zerumbone, a Tropical Ginger Sesquiterpene of Zingiber officinale Roscoe, Attenuates α-MSH-Induced Melanogenesis in B16F10 Cells. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103149. [PMID: 30322121]
  • Ruifei Zhang, Xiao Feng, Guozhu Su, Zejing Mu, Hexinge Zhang, Yanan Zhao, Shungang Jiao, Lan Cao, Suyile Chen, Pengfei Tu, Xingyun Chai. Bioactive Sesquiterpenoids from the Peeled Stems of Syringa pinnatifolia. Journal of natural products. 2018 08; 81(8):1711-1720. doi: 10.1021/acs.jnatprod.7b01071. [PMID: 30024153]
  • Chien-Ying Lee, Shih-Pin Chen, Chun-Hung Su, Yung-Chyuan Ho, Ming-Ling Yang, Shiuan-Shinn Lee, Rosa Huang-Liu, Ching-Ping Yang, Chun-Jung Chen, Yu-Hsiang Kuan. Zerumbone from Zingiber zerumbet Ameliorates Lipopolysaccharide-Induced ICAM-1 and Cytokines Expression via p38 MAPK/JNK-IκB/NF-κB Pathway in Mouse Model of Acute Lung Injury. The Chinese journal of physiology. 2018 Jun; 61(3):171-180. doi: 10.4077/cjp.2018.bag562. [PMID: 29962177]
  • Le T Huong, Nguyen V Hung, Mai V Chung, Do N Dai, Isiaka A Ogunwande. Essential oils Constituents of the leaves of Amomum gagnepainii and Amomum repoense. Natural product research. 2018 Feb; 32(3):316-321. doi: 10.1080/14786419.2017.1346643. [PMID: 28670920]
  • Nissar Ahmad Wani, Bo Zhang, Kun-Yu Teng, Juan M Barajas, Tasneem Motiwala, Peng Hu, Lianbo Yu, Rafael Brüschweiler, Kalpana Ghoshal, Samson T Jacob. Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis. Molecular cancer research : MCR. 2018 02; 16(2):256-268. doi: 10.1158/1541-7786.mcr-17-0304. [PMID: 29187559]
  • Giovanni Benelli, Marimuthu Govindarajan, Mohan Rajeswary, Baskaralingam Vaseeharan, Sami A Alyahya, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Filippo Maggi. Insecticidal activity of camphene, zerumbone and α-humulene from Cheilocostus speciosus rhizome essential oil against the Old-World bollworm, Helicoverpa armigera. Ecotoxicology and environmental safety. 2018 Feb; 148(?):781-786. doi: 10.1016/j.ecoenv.2017.11.044. [PMID: 29190597]
  • Thomas Sithara, B P Dhanya, K B Arun, Suresh Sini, Mathew Dan, Radhakrishnan Kokkuvayil Vasu, P Nisha. Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. Journal of agricultural and food chemistry. 2018 Jan; 66(3):602-612. doi: 10.1021/acs.jafc.7b04472. [PMID: 29276946]
  • Albaayit Sf, Rukesh Maharjan. Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells. Pakistan journal of biological sciences : PJBS. 2018 Jan; 21(9):475-479. doi: 10.3923/pjbs.2018.475.479. [PMID: 30724050]
  • Krishnadas Nandagopal, Mihir Halder, Biswabhusan Dash, Sanghamitra Nayak, Sumita Jha. Biotechnological Approaches for Production of Anti-Cancerous Compounds Resveratrol, Podophyllotoxin and Zerumbone. Current medicinal chemistry. 2018; 25(36):4693-4717. doi: 10.2174/0929867324666170404145656. [PMID: 28393691]
  • Jia Ning Foong, Gayathri Thevi Selvarajah, Abdullah Rasedee, Heshu Sulaiman Rahman, Chee Wun How, Chaw Yee Beh, Guan Young Teo, Chi Ling Ku. Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells. BioMed research international. 2018; 2018(?):8691569. doi: 10.1155/2018/8691569. [PMID: 30410940]
  • Kyu-Sik Chang, Jin-Hwan Jeon, Gi-Hun Kim, Chang-Won Jang, Se-Jin Jeong, Young-Ran Ju, Young-Joon Ahn. Repellency of zerumbone identified in Cyperus rotundus rhizome and other constituents to Blattella germanica. Scientific reports. 2017 11; 7(1):16643. doi: 10.1038/s41598-017-16099-6. [PMID: 29192195]
  • Chomanahalli B Shrikanth, Nandini D Chilkunda. Zerumbone Ameliorates High Glucose-Induced Reduction in AMP-Activated Protein Kinase Phosphorylation in Tubular Kidney Cells. Journal of agricultural and food chemistry. 2017 Oct; 65(42):9208-9216. doi: 10.1021/acs.jafc.7b02379. [PMID: 28971677]
  • Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Syed Nasir Abbas Bukhari. Exploring the immunomodulatory and anticancer properties of zerumbone. Food & function. 2017 Oct; 8(10):3410-3431. doi: 10.1039/c7fo00595d. [PMID: 28714500]
  • Ritis K Shyanti, Anuradha Sehrawat, Shivendra V Singh, J P N Mishra, Rana P Singh. Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Oct; 44(?):74-84. doi: 10.1016/j.tiv.2017.06.016. [PMID: 28633979]
  • Katayoon Kalantari, Mona Moniri, Amin Boroumand Moghaddam, Raha Abdul Rahim, Arbakariya Bin Ariff, Zahra Izadiyan, Rosfarizan Mohamad. A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extraction from Ginger Rhizomes. Molecules (Basel, Switzerland). 2017 Sep; 22(10):. doi: 10.3390/molecules22101645. [PMID: 28974019]
  • Wayne Young Liu, Thing-Fong Tzeng, I-Min Liu. Healing potential of zerumbone ointment on experimental full-thickness excision cutaneous wounds in rat. Journal of tissue viability. 2017 Aug; 26(3):202-207. doi: 10.1016/j.jtv.2017.04.002. [PMID: 28454680]
  • Jiyun Ahn, Hyunjung Lee, Chang Hwa Jung, Won Hee Choi, Tae Youl Ha. Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis. Oncotarget. 2017 Jun; 8(23):36984-36995. doi: 10.18632/oncotarget.16974. [PMID: 28445161]
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