Valnemulin (BioDeep_00000184900)
Secondary id: BioDeep_00000002530, BioDeep_00001869704
human metabolite blood metabolite
代谢物信息卡片
化学式: C31H52N2O5S (564.3597)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 60%
分子结构信息
SMILES: C=CC1(C)CC(OC(=O)CSC(C)(C)CNC(=O)C(N)C(C)C)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O
InChI: InChI=1S/C31H52N2O5S/c1-10-29(8)15-22(38-23(35)16-39-28(6,7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31/h10,18-20,22,24-26,36H,1,11-17,32H2,2-9H3,(H,33,37)/t19?,20-,22+,24?,25-,26-,29+,30-,31-/m0/s1
描述信息
同义名列表
10 个代谢物同义名
2-Amino-N-(2-{[2-({4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0,]tetradecan-6-yl}oxy)-2-oxoethyl]sulphanyl}-2-methylpropyl)-3-methylbutanimidic acid; 2-Amino-N-(2-{[2-({4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0,]tetradecan-6-yl}oxy)-2-oxoethyl]sulphanyl}-2-methylpropyl)-3-methylbutanimidate; 2-Amino-N-(2-{[2-({4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0,]tetradecan-6-yl}oxy)-2-oxoethyl]sulfanyl}-2-methylpropyl)-3-methylbutanimidate; 4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[1-(2-amino-3-methylbutanamido)-2-methylpropan-2-yl]sulfanyl}acetate; 4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl {[1-(2-amino-3-methylbutanamido)-2-methylpropan-2-yl]sulfanyl}acetate; CID 21706784; CID 443605; Valnemulin; Econor; Valnemulin
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:29705
- KEGG: C12066
- PubChem: 21706784
- PubChem: 443605
- HMDB: HMDB0259752
- chemspider: 11331486
- PMhub: MS000003413
- PubChem: 14219
- CAS: 101312-92-9
- NIKKAJI: J1.823.748B
- RefMet: Valnemulin
- KNApSAcK: 29705
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- F Sun, R Fan, J Wang, L Xiong, J Shen, S Zhang, X Cao. Pharmacokinetics of valnemulin after intravenous, intramuscular, and oral administration in layer chickens.
Journal of veterinary pharmacology and therapeutics.
2017 Aug; 40(4):415-418. doi:
10.1111/jvp.12389. [PMID: 28205246] - Nan Zhang, Xiaomei Ye, Yuzhi Wu, Zilong Huang, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding. Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin.
PloS one.
2017; 12(1):e0169134. doi:
10.1371/journal.pone.0169134. [PMID: 28052123] - Yu-Feng Zhou, Yang Yu, Jian Sun, Meng-Ting Tao, Wen-Jie Zhou, Xiao Li, Xiao-Ping Liao, Ya-Hong Liu. Ex vivo pharmacokinetic/pharmacodynamic relationship of valnemulin against Clostridium perfringens in plasma, the small intestinal and caecal contents of rabbits.
Anaerobe.
2016 Jun; 39(?):150-7. doi:
10.1016/j.anaerobe.2016.04.005. [PMID: 27060276] - Hui Li, Yingyu Wang, Xiaowei Li, Qin Fu, Yawen Shan, Tianhe Liu, Xi Xia. Determination of valnemulin in swine and bovine tissues by ultra-high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Mar; 1014(?):102-6. doi:
10.1016/j.jchromb.2016.02.013. [PMID: 26894685] - Huiyan Zhang, Tiejun Mi, Oleg Yu Khan, Yajie Sheng, Sergei A Eremin, Ross C Beier, Suxia Zhang, Jianzhong Shen, Zhanhui Wang. Fluorescence polarization immunoassay using IgY antibodies for detection of valnemulin in swine tissue.
Analytical and bioanalytical chemistry.
2015 Oct; 407(25):7843-8. doi:
10.1007/s00216-015-8948-z. [PMID: 26277187] - L G Yuan, Y Z Tang, Y X Zhang, J Sun, X Y Luo, L X Zhu, Z Zhang, R Wang, Y H Liu. Dosage assessment of valnemulin in pigs based on population pharmacokinetic and Monte Carlo simulation.
Journal of veterinary pharmacology and therapeutics.
2015 Aug; 38(4):400-9. doi:
10.1111/jvp.12199. [PMID: 25604162] - Xia Xiao, Jian Sun, Yi Chen, Mengting Zou, Dong-Hao Zhao, Ya-Hong Liu. Ex vivo pharmacokinetic and pharmacodynamic analysis of valnemulin against Mycoplasma gallisepticum S6 in Mycoplasma gallisepticum and Escherichia coli co-infected chickens.
Veterinary journal (London, England : 1997).
2015 Apr; 204(1):54-9. doi:
10.1016/j.tvjl.2015.01.020. [PMID: 25744809] - Dong-Hao Zhao, Yu-Feng Zhou, Yang Yu, Wei Shi, Xue Yang, Xia Xiao, Hui Deng, Guilin Gary Qiao, Bing-Hu Fang, Ya-Hong Liu. Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration.
Veterinary journal (London, England : 1997).
2014 Jul; 201(1):109-15. doi:
10.1016/j.tvjl.2014.05.010. [PMID: 24906499] - X Xiao, D H Zhao, X Yang, W Shi, H Deng, J Ma, S Zhang, Y H Liu. Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):99-102. doi:
10.1111/jvp.12065. [PMID: 23782411] - D H Zhao, Z Zhang, C Y Zhang, Z C Liu, H Deng, J J Yu, J P Guo, Y H Liu. Population pharmacokinetics of valnemulin in swine.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):59-65. doi:
10.1111/jvp.12054. [PMID: 23617793] - J Sun, L Yuan, L Zhu, L He, X Luo, R Wang, Y Liu. Pharmacokinetics and bioavailability of valnemulin in Muscovy ducks (Cairina moschata).
British poultry science.
2012; 53(3):374-8. doi:
10.1080/00071668.2012.703776. [PMID: 22978594] - L G Yuan, X Y Luo, L X Zhu, R Wang, Y H Liu. A physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs.
Journal of veterinary pharmacology and therapeutics.
2011 Jun; 34(3):224-31. doi:
10.1111/j.1365-2885.2010.01230.x. [PMID: 20950354] - R Wang, L G Yuan, L M He, L X Zhu, X Y Luo, C Y Zhang, J J Yu, B H Fang, Y H Liu. Pharmacokinetics and bioavailability of valnemulin in broiler chickens.
Journal of veterinary pharmacology and therapeutics.
2011 Jun; 34(3):247-51. doi:
10.1111/j.1365-2885.2010.01215.x. [PMID: 21492189] - Qiushi Huang, Jiancheng Li, Lijun Xia, Xi Xia, Peng Duan, Jianzhong Shen, Shuangyang Ding. Residue depletion of valnemulin in swine tissues after oral administration.
Analytica chimica acta.
2010 Apr; 664(1):62-7. doi:
10.1016/j.aca.2010.01.058. [PMID: 20226933]
