Itopride (BioDeep_00000180215)
human metabolite blood metabolite
代谢物信息卡片
N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4-dimethoxybenzene-1-carboximidate
化学式: C20H26N2O4 (358.1892)
中文名称: 伊托必利
谱图信息:
最多检出来源 Homo sapiens(blood) 19.22%
分子结构信息
SMILES: CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC
InChI: InChI=1S/C20H26N2O4/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4/h5-10,13H,11-12,14H2,1-4H3,(H,21,23)
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:94809
- PubChem: 3792
- HMDB: HMDB0253722
- DrugBank: DB04924
- ChEMBL: CHEMBL2107457
- Wikipedia: Itopride
- CAS: 122898-67-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Makiko Shimizu, Shotaro Uehara, Hiroshi Suemizu, Hiroshi Yamazaki. In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice.
Drug metabolism and pharmacokinetics.
2021 Apr; 37(?):100369. doi:
10.1016/j.dmpk.2020.11.004. [PMID: 33513464] - Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.
Journal of pharmacological sciences.
2021 Jan; 145(1):122-129. doi:
10.1016/j.jphs.2020.10.006. [PMID: 33357770] - C Chojnacki, T Poplawski, J Blasiak, M Fila, P Konrad, J Chojnacki. Altered dopamine signalling in chronic epigastric pain syndrome.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Dec; 71(6):. doi:
10.26402/jpp.2020.6.05. [PMID: 33727428] - Muhammad Iqbal Nasiri, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Fahad Siddiqui, Faaiza Qazi, Kamran Ahmed, Sohail Anwer, Kamran Zaheer. Comparative pharmacokinetic evaluation of extended release itopride HCl pellets with once daily tablet formulation in healthy human subjects: a two treatment, four period crossover study in fasted and fed condition.
Drug development and industrial pharmacy.
2019 Mar; 45(3):415-422. doi:
10.1080/03639045.2018.1546312. [PMID: 30457018] - Wangda Zhou, Helen Humphries, Sibylle Neuhoff, Iain Gardner, Eric Masson, Nidal Al-Huniti, Diansong Zhou. Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure.
Biopharmaceutics & drug disposition.
2017 Sep; 38(6):389-393. doi:
10.1002/bdd.2074. [PMID: 28255999] - F M Abdel-Haleem, Adel Madbouly, R M El Nashar, N T Abdel-Ghani. Molecularly imprinted polymer-based bulk optode for the determination of itopride hydrochloride in physiological fluids.
Biosensors & bioelectronics.
2016 Nov; 85(?):740-742. doi:
10.1016/j.bios.2016.05.081. [PMID: 27266658] - Amjad Khan, Zafar Iqbal, Ibrahim Khadra, Lateef Ahmad, Abad Khan, Muhammad Imran Khan, Zia Ullah, Ismail. Simultaneous determination of domperidone and Itopride in pharmaceuticals and human plasma using RP-HPLC/UV detection: Method development, validation and application of the method in in-vivo evaluation of fast dispersible tablets.
Journal of pharmaceutical and biomedical analysis.
2016 Mar; 121(?):6-12. doi:
10.1016/j.jpba.2015.12.036. [PMID: 26773534] - Li-Ping Zhou, Zhi-Rong Tan, Hao Chen, Dong Guo, Yao Chen, Wei-Hua Huang, Lian-Sheng Wang, Guo-Gang Zhang. Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers.
European journal of clinical pharmacology.
2014 Nov; 70(11):1333-8. doi:
10.1007/s00228-014-1724-8. [PMID: 25224784] - Lei Lan, Fang Zeng, Guan J Liu, Li Ying, Xi Wu, Mailan Liu, Fan-Rong Liang. Acupuncture for functional dyspepsia.
The Cochrane database of systematic reviews.
2014 Oct; ?(10):CD008487. doi:
10.1002/14651858.cd008487.pub2. [PMID: 25306866] - Seonghae Yoon, Howard Lee, Tae-Eun Kim, SeungHwan Lee, Dong-Hyun Chee, Joo-Youn Cho, Kyung-Sang Yu, In-Jin Jang. Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers.
Drug design, development and therapy.
2014; 8(?):123-8. doi:
10.2147/dddt.s53027. [PMID: 24470753] - V I Kas'ianenko, N L Denisov, Iu V Vasil'ev. [Use of itopride in the symptoms of functional dyspepsia in Russia: results of a phase IV prospective open-label multicenter clinical trial].
Terapevticheskii arkhiv.
2014; 86(8):35-41. doi:
NULL. [PMID: 25306742] - T T Ma, S Y Yu, Y Li, F R Liang, X P Tian, H Zheng, J Yan, G J Sun, X R Chang, L Zhao, X Wu, F Zeng. Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia.
Alimentary pharmacology & therapeutics.
2012 Mar; 35(5):552-61. doi:
10.1111/j.1365-2036.2011.04979.x. [PMID: 22243034] - Yoshiyuki Kimura, Maho Sumiyoshi. Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice.
Fitoterapia.
2011 Sep; 82(6):827-33. doi:
10.1016/j.fitote.2011.04.008. [PMID: 21571047] - Zhirong Tan, Dongsheng Ouyang, Yao Chen, Gan Zhou, Shan Cao, Yicheng Wang, Xiujuan Peng, Honghao Zhou. Development and validation of a LC-MS/MS method for the determination of clebopride and its application to a pharmacokinetics study in healthy Chinese volunteers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Aug; 878(23):2072-6. doi:
10.1016/j.jchromb.2010.06.006. [PMID: 20598654] - Kyung-Jin Cho, Wonkyung Cho, Kwang-Ho Cha, Junsung Park, Min-Soo Kim, Jeong-Soo Kim, Sung-Joo Hwang. Pharmacokinetic and bioequivalence study of itopride HCl in healthy volunteers.
Arzneimittel-Forschung.
2010; 60(3):137-40. doi:
10.1055/s-0031-1296262. [PMID: 20422945] - Hui Zheng, Xiao-ping Tian, Ying Li, Fan-rong Liang, Shu-guang Yu, Xu-guang Liu, Yong Tang, Xu-guang Yang, Jie Yan, Guo-jie Sun, Xiao-rong Chang, Hong-xing Zhang, Ting-ting Ma, Shu-yuan Yu. Acupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial.
Trials.
2009 Aug; 10(?):75. doi:
10.1186/1745-6215-10-75. [PMID: 19698147] - Pavel Ptácek, Josef Klíma, Jan Macek. Optimized method for the determination of itopride in human plasma by high-performance liquid chromatography with fluorimetric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Mar; 877(8-9):842-6. doi:
10.1016/j.jchromb.2009.02.023. [PMID: 19246254] - Jing Ma, Li-Hua Yuan, Mei-Juan Ding, Jun Zhang, Qing Zhang, Qun-Wei Xu, Xue-Min Zhou. Determination of itopride hydrochloride in human plasma by RP-HPLC with fluorescence detection and its use in bioequivalence study.
Pharmacological research.
2009 Mar; 59(3):189-93. doi:
10.1016/j.phrs.2008.11.007. [PMID: 19101632] - Bijay Kumar Sahoo, Ayan Das, Sangita Agarwal, Uttam Bhaumik, Anirbandeep Bose, Debotri Ghosh, Bikash Roy, Tapan Kumar Pal. Pharmacokinetics and bioequivalence study of a fixed dose combination of rabeprazole and itopride in healthy Indian volunteers.
Arzneimittel-Forschung.
2009; 59(9):451-4. doi:
10.1055/s-0031-1296424. [PMID: 19856792] - Hyun Chul Lim, Young Gyun Kim, Jung Hyun Lim, Hee Sun Kim, Hyojin Park. Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro.
Yonsei medical journal.
2008 Jun; 49(3):472-8. doi:
10.3349/ymj.2008.49.3.472. [PMID: 18581598] - Heon-Woo Lee, Ji-Hyung Seo, Seung-Ki Choi, Kyung-Tae Lee. Determination of itopride in human plasma by liquid chromatography coupled to tandem mass spectrometric detection: application to a bioequivalence study.
Analytica chimica acta.
2007 Jan; 583(1):118-23. doi:
10.1016/j.aca.2006.09.061. [PMID: 17386535] - Fumihiko Katagiri, Toru Shiga, Shin Inoue, Yuhki Sato, Hiroki Itoh, Masaharu Takeyama. Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects.
Pharmacology.
2006; 77(3):115-21. doi:
10.1159/000093485. [PMID: 16717477] - Yong Sung Kim, Tae Hyeon Kim, Chang Soo Choi, Young Woo Shon, Sang Wook Kim, Geom Seog Seo, Yong Ho Nah, Myung Gyu Choi, Suck Chei Choi. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study.
World journal of gastroenterology.
2005 Jul; 11(27):4210-4. doi:
10.3748/wjg.v11.i27.4210. [PMID: 16015691] - Sonu Sundd Singh, Manish Jain, Kuldeep Sharma, Bhavin Shah, Meghna Vyas, Purav Thakkar, Ruchy Shah, Shriprakash Singh, Brajbhushan Lohray. Quantitation of itopride in human serum by high-performance liquid chromatography with fluorescence detection and its application to a bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Apr; 818(2):213-20. doi:
10.1016/j.jchromb.2004.12.035. [PMID: 15734161] - Prabha Sawant, H S Das, Nutan Desai, S Kalokhe, S Patil. Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non-ulcer dyspepsia.
The Journal of the Association of Physicians of India.
2004 Aug; 52(?):626-8. doi:
. [PMID: 15847356] - K T Shenoy, Veenasree, K B Leena. Efficacy and tolerability of itopride hydrochloride in patients with non-ulcer dyspepsia.
Journal of the Indian Medical Association.
2003 Jun; 101(6):387-8. doi:
NULL. [PMID: 14579989] - T Mushiroda, R Douya, E Takahara, O Nagata. The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate.
Drug metabolism and disposition: the biological fate of chemicals.
2000 Oct; 28(10):1231-7. doi:
. [PMID: 10997945]
