Lincomycin (BioDeep_00000001802)

 

Secondary id: BioDeep_00000397484

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide

化学式: C18H34N2O6S (406.21374640000005)
中文名称:
谱图信息: 最多检出来源 Anoectochilus roxburghii(viridiplantae) 20%

分子结构信息

SMILES: CCCC1CC(C(=O)NC(C(C)O)C2OC(SC)C(O)C(O)C2O)N(C)C1
InChI: InChI=1S/C27H30O16/c28-7-14-17(32)20(35)22(37)26(41-14)39-11-5-12(31)16-13(6-11)40-24(9-1-3-10(30)4-2-9)25(19(16)34)43-27-23(38)21(36)18(33)15(8-29)42-27/h1-6,14-15,17-18,20-23,26-33,35-38H,7-8H2/t14-,15-,17-,18-,20+,21+,22-,23-,26-,27+/m1/s1

描述信息

Lincomycin is only found in individuals that have used or taken this drug. It is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections. [PubChem]Lincomycin inhibits protein synthesis in susceptible bacteria by binding to the 50 S subunits of bacterial ribosomes and preventing peptide bond formation upon transcription. It is usually considered bacteriostatic, but may be bactericidal in high concentrations or when used against highly susceptible organisms.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FF - Lincosamides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D055231 - Lincosamides
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C784 - Protein Synthesis Inhibitor > C82922 - Lincosamide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

18 个代谢物同义名

(4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; Lincomycin monohydrochloride, (L-threo)-isomer; Lincomycin monohydrochloride, (2S-cis)-isomer; Lincomycin monohydrochloride, hemihydrate; Hemihydrate lincomycin monohydrochloride; Lincomycin, (L-threo)-isomer; Lincomycin monohydrochloride; Lincomycin, (2S-cis)-isomer; Lincomycin hydrochloride; Epilincomycin; Lincomycin a; Lincolnensin; Lincomyocin; Lincomycine; Lincolcina; Lincomycin; Lincocin; LCM



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shunfen Zhang, Shanlong Tang, Zhengqun Liu, Huiyuan Lv, Xueying Cai, Ruqing Zhong, Liang Chen, Hongfu Zhang. Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway. Pharmacological research. 2024 Jun; 204(?):107194. doi: 10.1016/j.phrs.2024.107194. [PMID: 38663526]
  • Chun-Yan Lin, Yixian Ru, Yanchao Jin, Qi Lin, Guang-Rong Zhao. PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis. Microbial cell factories. 2023 Dec; 22(1):257. doi: 10.1186/s12934-023-02263-3. [PMID: 38093313]
  • Yuru Shen, Xingyu Zeng, Mingjian Chen, Yun Du, Jun Cheng, Qingji Xie. Photoelectrochemical aptasensing of lincomycin based on a AgI-carboxylated multiwalled carbon nanotubes-BiOI Z-scheme heterojunction. Analytica chimica acta. 2023 Oct; 1278(?):341753. doi: 10.1016/j.aca.2023.341753. [PMID: 37709479]
  • Yanhui Che, Dayong Fan, Zhiyuan Teng, Tongtong Yao, Zihan Wang, Hongbo Zhang, Guangyu Sun, Huihui Zhang, Wah Soon Chow. Potassium alleviates over-reduction of the photosynthetic electron transport chain and helps to maintain photosynthetic function under salt-stress. Physiologia plantarum. 2023 Jul; 175(4):e13981. doi: 10.1111/ppl.13981. [PMID: 37616008]
  • Jiamin Chen, Jiawei Liang, Chenjing Li, Jihua Dai, Wenning Mai, Yongjun Wei. An enriched ammonia-oxidizing microbiota enables high removal efficiency of ammonia in antibiotic production wastewater. Chemosphere. 2023 Jan; 310(?):136854. doi: 10.1016/j.chemosphere.2022.136854. [PMID: 36243093]
  • V Matamoros, M Escolà Casas, E Pastor, Đ Tadić, N Cañameras, N Carazo, J M Bayona. Effects of tetracycline, sulfonamide, fluoroquinolone, and lincosamide load in pig slurry on lettuce: Agricultural and human health implications. Environmental research. 2022 12; 215(Pt 1):114237. doi: 10.1016/j.envres.2022.114237. [PMID: 36084673]
  • B-G Liu, M Xie, Y-T Gong, Y Dong, G-M Zheng, H Wu, G-Z Hu, M Bai, E-P Xu. Prevalence, resistance phenotypes, and fluoroquinolone resistance genes of Salmonella isolates from raw milk of healthy dairy cows in Henan province, China. European review for medical and pharmacological sciences. 2022 09; 26(18):6837-6844. doi: 10.26355/eurrev_202209_29786. [PMID: 36196732]
  • Stefania Fortunato, Cecilia Lasorella, Luca Tadini, Nicolaj Jeran, Federico Vita, Paolo Pesaresi, Maria Concetta de Pinto. GUN1 involvement in the redox changes occurring during biogenic retrograde signaling. Plant science : an international journal of experimental plant biology. 2022 Jul; 320(?):111265. doi: 10.1016/j.plantsci.2022.111265. [PMID: 35643615]
  • Shunfen Zhang, Ruqing Zhong, Shanlong Tang, Hui Han, Liang Chen, Hongfu Zhang. Baicalin Alleviates Short-Term Lincomycin-Induced Intestinal and Liver Injury and Inflammation in Infant Mice. International journal of molecular sciences. 2022 May; 23(11):. doi: 10.3390/ijms23116072. [PMID: 35682750]
  • Xingyu Luo, Qian Yang, Yueting Lin, Zhijun Tang, Jeffery K Tomberlin, Wen Liu, Yongping Huang. Black soldier fly larvae effectively degrade lincomycin from pharmaceutical industry wastes. Journal of environmental management. 2022 Apr; 307(?):114539. doi: 10.1016/j.jenvman.2022.114539. [PMID: 35085969]
  • Jingxian Li, Mengyu Luo, Can Jin, Penghui Zhang, Hongfen Yang, Ren Cai, Weihong Tan. Plasmon-Enhanced Electrochemiluminescence of PTP-Decorated Eu MOF-Based Pt-Tipped Au Bimetallic Nanorods for the Lincomycin Assay. ACS applied materials & interfaces. 2022 Jan; 14(1):383-389. doi: 10.1021/acsami.1c21528. [PMID: 34978181]
  • Shanlong Tang, Shunfen Zhang, Ruqing Zhong, Dan Su, Bing Xia, Lei Liu, Liang Chen, Hongfu Zhang. Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine. Applied microbiology and biotechnology. 2021 Nov; 105(21-22):8441-8456. doi: 10.1007/s00253-021-11627-x. [PMID: 34651253]
  • Isaac Osei-Bonsu, Alan M McClain, Berkley J Walker, Thomas D Sharkey, David M Kramer. The roles of photorespiration and alternative electron acceptors in the responses of photosynthesis to elevated temperatures in cowpea. Plant, cell & environment. 2021 07; 44(7):2290-2307. doi: 10.1111/pce.14026. [PMID: 33555066]
  • Yonghong Li, Luping Fu, Xuan Li, Yun Wang, Yongjun Wei, Jinfeng Tang, Hongmin Liu. Novel strains with superior degrading efficiency for lincomycin manufacturing biowaste. Ecotoxicology and environmental safety. 2021 Feb; 209(?):111802. doi: 10.1016/j.ecoenv.2020.111802. [PMID: 33360784]
  • Sandeesha Kodru, Ateeq Ur Rehman, Imre Vass. Chloramphenicol enhances Photosystem II photodamage in intact cells of the cyanobacterium Synechocystis PCC 6803. Photosynthesis research. 2020 Sep; 145(3):227-235. doi: 10.1007/s11120-020-00784-1. [PMID: 32979144]
  • Liu Duan, M Águila Ruiz-Sola, Ana Couso, Nil Veciana, Elena Monte. Red and blue light differentially impact retrograde signalling and photoprotection in rice. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2020 06; 375(1801):20190402. doi: 10.1098/rstb.2019.0402. [PMID: 32362254]
  • Oguz Guvenmez, Hüseyin Keskin, Burak Ay, Suayip Birinci, Muhammed Furkan Kanca. The comparison of the effectiveness of lincocin® and azitro® in the treatment of covid-19-associated pneumonia: A prospective study. Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique. 2020 06; 27(S Pt 1):e5-e10. doi: 10.15586/jptcp.v27isp1.684. [PMID: 32543164]
  • Saurabh Pandey, Jayesh Dhanani, Jeffrey Lipman, Jason A Roberts, Steve C Wallis, Suzanne L Parker. Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study. Clinical chemistry and laboratory medicine. 2020 01; 58(2):274-284. doi: 10.1515/cclm-2019-0780. [PMID: 31714883]
  • Duorong Xu, Ravi Dhiman, Adriana Garibay, Hans-Peter Mock, Dario Leister, Tatjana Kleine. Cellulose defects in the Arabidopsis secondary cell wall promote early chloroplast development. The Plant journal : for cell and molecular biology. 2020 01; 101(1):156-170. doi: 10.1111/tpj.14527. [PMID: 31498930]
  • Allan J Cessna, Sandra L Kuchta, Marley Waiser, Robert B Brua, Jonathan Bailey. Persistence of the antimicrobials lincomycin, chlortetracycline, and sulfamethazine in prairie wetlands. Journal of environmental quality. 2020 Jan; 49(1):236-245. doi: 10.1002/jeq2.20034. [PMID: 33016366]
  • Keri L Colabroy, Alyssa D Horwitz, Victoria R Basciano, Yizhi Fu, Kelly M Travitz, Miranda K Robinson, Brittany A Shimanski, Thomas W Hoffmann. A New Way of Belonging: Active-Site Investigation of L-DOPA Dioxygenase, a VOC Family Enzyme from Lincomycin Biosynthesis. Biochemistry. 2019 12; 58(48):4794-4798. doi: 10.1021/acs.biochem.9b00456. [PMID: 31710815]
  • Cheng-Hua Liu, Ya-Hui Chuang, Hui Li, Stephen A Boyd, Brian J Teppen, Javier M Gonzalez, Cliff T Johnston, Johannes Lehmann, Wei Zhang. Long-term sorption of lincomycin to biochars: The intertwined roles of pore diffusion and dissolved organic carbon. Water research. 2019 Sep; 161(?):108-118. doi: 10.1016/j.watres.2019.06.006. [PMID: 31181446]
  • Wenpeng Zhang, Yue Ren, Ziqing Lin, Zheng Ouyang. High-Precision Quantitation of Biofluid Samples Using Direct Mass Spectrometry Analysis. Analytical chemistry. 2019 06; 91(11):6986-6990. doi: 10.1021/acs.analchem.9b01694. [PMID: 31074609]
  • Chang Sun, Deming Dong, Sinan He, Liwen Zhang, Xun Zhang, Chaoqian Wang, Xiuyi Hua, Zhiyong Guo. Multimedia fate modeling of antibiotic sulfamethoxazole, lincomycin, and florfenicol in a seasonally ice-covered river receiving WWTP effluents. Environmental science and pollution research international. 2019 Jun; 26(17):17351-17361. doi: 10.1007/s11356-019-05121-1. [PMID: 31016586]
  • Shanshan Li, Yuli Qi, Lixue Chen, Di Qu, Zhiman Li, Kun Gao, Jianbo Chen, Yinshi Sun. Effects of Panax ginseng polysaccharides on the gut microbiota in mice with antibiotic-associated diarrhea. International journal of biological macromolecules. 2019 Mar; 124(?):931-937. doi: 10.1016/j.ijbiomac.2018.11.271. [PMID: 30503788]
  • Sylwia M Kacprzak, Nobuyoshi Mochizuki, Belén Naranjo, Duorong Xu, Dario Leister, Tatjana Kleine, Haruko Okamoto, Matthew J Terry. Plastid-to-Nucleus Retrograde Signalling during Chloroplast Biogenesis Does Not Require ABI4. Plant physiology. 2019 01; 179(1):18-23. doi: 10.1104/pp.18.01047. [PMID: 30377235]
  • Xiaobo Zhao, Jianyan Huang, Joanne Chory. genome uncoupled1 Mutants Are Hypersensitive to Norflurazon and Lincomycin. Plant physiology. 2018 11; 178(3):960-964. doi: 10.1104/pp.18.00772. [PMID: 30154176]
  • Min Zhang, You-Sheng Liu, Jian-Liang Zhao, Wang-Rong Liu, Liang-Ying He, Jin-Na Zhang, Jun Chen, Lun-Kai He, Qian-Qian Zhang, Guang-Guo Ying. Occurrence, fate and mass loadings of antibiotics in two swine wastewater treatment systems. The Science of the total environment. 2018 Oct; 639(?):1421-1431. doi: 10.1016/j.scitotenv.2018.05.230. [PMID: 29929305]
  • Prakitchai Chotewutmontri, Alice Barkan. Multilevel effects of light on ribosome dynamics in chloroplasts program genome-wide and psbA-specific changes in translation. PLoS genetics. 2018 08; 14(8):e1007555. doi: 10.1371/journal.pgen.1007555. [PMID: 30080854]
  • Barbara Karpinska, Sarah Owdah Alomrani, Christine H Foyer. Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2017 Sep; 372(1730):. doi: 10.1098/rstb.2016.0392. [PMID: 28808105]
  • Ernesto Llamas, Pablo Pulido, Manuel Rodriguez-Concepcion. Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. PLoS genetics. 2017 Sep; 13(9):e1007022. doi: 10.1371/journal.pgen.1007022. [PMID: 28937985]
  • Yonglan Tian, Petra Ungerer, Huayong Zhang, Alexander V Ruban. Direct impact of the sustained decline in the photosystem II efficiency upon plant productivity at different developmental stages. Journal of plant physiology. 2017 May; 212(?):45-53. doi: 10.1016/j.jplph.2016.10.017. [PMID: 28260626]
  • Da-Yong Fan, Zi-Piao Ye, Shi-Chang Wang, Wah Soon Chow. Multiple roles of oxygen in the photoinactivation and dynamic repair of Photosystem II in spinach leaves. Photosynthesis research. 2016 Mar; 127(3):307-19. doi: 10.1007/s11120-015-0185-y. [PMID: 26297354]
  • Jo-Chien Liao, Wei-Yu Hsieh, Ching-Chih Tseng, Ming-Hsiun Hsieh. Dysfunctional chloroplasts up-regulate the expression of mitochondrial genes in Arabidopsis seedlings. Photosynthesis research. 2016 Feb; 127(2):151-9. doi: 10.1007/s11120-015-0161-6. [PMID: 26008795]
  • Jie Zhou, Kui Zhu, Fei Xu, Wenjun Wang, Haiyang Jiang, Zhanhui Wang, Shuangyang Ding. Development of a microsphere-based fluorescence immunochromatographic assay for monitoring lincomycin in milk, honey, beef, and swine urine. Journal of agricultural and food chemistry. 2014 Dec; 62(49):12061-6. doi: 10.1021/jf5029416. [PMID: 25290082]
  • Renjie Xu, Ying Peng, Mengyue Wang, Lirong Fan, Xiaobo Li. Effects of broad-spectrum antibiotics on the metabolism and pharmacokinetics of ginsenoside Rb1: a study on rats׳ gut microflora influenced by lincomycin. Journal of ethnopharmacology. 2014 Dec; 158 Pt A(?):338-44. doi: 10.1016/j.jep.2014.10.054. [PMID: 25446586]
  • Milena Marsoni, Fabrizio De Mattia, Massimo Labra, Antonia Bruno, Marcella Bracale, Candida Vannini. Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants. Ecotoxicology and environmental safety. 2014 10; 108(?):52-7. doi: 10.1016/j.ecoenv.2014.05.029. [PMID: 25042244]
  • H Szajewska, M Urbańska, A Chmielewska, Z Weizman, R Shamir. Meta-analysis: Lactobacillus reuteri strain DSM 17938 (and the original strain ATCC 55730) for treating acute gastroenteritis in children. Beneficial microbes. 2014 Sep; 5(3):285-93. doi: 10.3920/bm2013.0056. [PMID: 24463209]
  • Sreedharan Sreeshitha Gouri, Dinakaran Venkatachalam, Vinod Kumar Dumka. Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves. Tropical animal health and production. 2014 Aug; 46(6):1099-102. doi: 10.1007/s11250-014-0595-4. [PMID: 24792222]
  • Yuan-Yuan Hu, Da-Yong Fan, Pasquale Losciale, Wah Soon Chow, Wang-Feng Zhang. Whole-tissue determination of the rate coefficients of photoinactivation and repair of photosystem II in cotton leaf discs based on flash-induced P700 redox kinetics. Photosynthesis research. 2013 Nov; 117(1-3):517-28. doi: 10.1007/s11120-013-9822-5. [PMID: 23589088]
  • Kamelia M Osman, Sherif H Marouf, Nayerah Alatfeehy. Antimicrobial resistance and virulence-associated genes of Salmonella enterica subsp. enterica serotypes Muenster, Florian, Omuna, and Noya strains isolated from clinically diarrheic humans in Egypt. Microbial drug resistance (Larchmont, N.Y.). 2013 Oct; 19(5):370-7. doi: 10.1089/mdr.2012.0151. [PMID: 23621859]
  • Esra Bayram Dilek, Ömer İrfan Küfrevioğlu, Şükrü Beydemir. Impacts of some antibiotics on human serum paraoxonase 1 activity. Journal of enzyme inhibition and medicinal chemistry. 2013 Aug; 28(4):758-64. doi: 10.3109/14756366.2012.681653. [PMID: 22591317]
  • Ching-Chih Tseng, Chih-Jen Lee, Yi-Ting Chung, Tzu-Ying Sung, Ming-Hsiun Hsieh. Differential regulation of Arabidopsis plastid gene expression and RNA editing in non-photosynthetic tissues. Plant molecular biology. 2013 Jul; 82(4-5):375-92. doi: 10.1007/s11103-013-0069-5. [PMID: 23645360]
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  • Yong-Yi Chen, Ying Wang, Lung-Jiun Shin, Jing-Fen Wu, Varanavasiappan Shanmugam, Munkhtsetseg Tsednee, Jing-Chi Lo, Chyi-Chuann Chen, Shu-Hsing Wu, Kuo-Chen Yeh. Iron is involved in the maintenance of circadian period length in Arabidopsis. Plant physiology. 2013 Mar; 161(3):1409-20. doi: 10.1104/pp.112.212068. [PMID: 23307650]
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