fleroxacin (BioDeep_00000001788)

   

human metabolite blood metabolite


代谢物信息卡片


6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

化学式: C17H18F3N3O3 (369.13)
中文名称: 氟罗沙星
谱图信息: 最多检出来源 Homo sapiens(blood) 41.43%

分子结构信息

SMILES: CN1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(CCF)c3c2F)CC1
InChI: InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

11 个代谢物同义名

6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; ABBR fle; Fleroxacinum; Fleroxacine; Fleroxacino; fleroxacin; Megalocin; Megalone; Quinodis; FLRX; Fleroxacin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 CAT, CNR1, GFAP, HPGDS, PRPF19, SENP1
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 6 FOS, HSP90B1, OMP, PCNA, PRPF19, SENP1
cytosol 9 CAT, FOS, GFAP, GPT, HPGDS, HSP90B1, IL1B, OMP, PRKCQ
nuclear body 1 PCNA
centrosome 1 PCNA
nucleoplasm 5 FOS, HPGDS, PCNA, PRPF19, SENP1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 2 CNR1, TNF
Cell projection, axon 1 CNR1
Multi-pass membrane protein 1 CNR1
Synapse 1 OMP
cell surface 1 TNF
glutamatergic synapse 2 CNR1, SENP1
growth cone 1 CNR1
mitochondrial inner membrane 1 FECH
neuronal cell body 2 OMP, TNF
presynaptic membrane 1 CNR1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
Presynapse 1 CNR1
plasma membrane 4 CNR1, CSF2, PRKCQ, TNF
Membrane 3 CAT, HSP90B1, PRPF19
axon 2 CNR1, OMP
extracellular exosome 4 CAT, GPT, HSP90B1, PCNA
endoplasmic reticulum 2 FOS, HSP90B1
extracellular space 5 CSF2, CXCL8, IL1B, IL3, TNF
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 2 CAT, FECH
protein-containing complex 2 CAT, HSP90B1
intracellular membrane-bounded organelle 3 CAT, CSF2, HPGDS
Secreted 4 CSF2, CXCL8, IL1B, IL3
extracellular region 7 CAT, CSF2, CXCL8, HSP90B1, IL1B, IL3, TNF
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
astrocyte end-foot 1 GFAP
mitochondrial matrix 2 CAT, FECH
centriolar satellite 1 PRKCQ
nuclear membrane 1 SENP1
external side of plasma membrane 1 TNF
actin cytoskeleton 1 CNR1
midbody 1 HSP90B1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 FECH
Membrane raft 2 CNR1, TNF
Cytoplasm, cytoskeleton, spindle 1 PRPF19
focal adhesion 3 CAT, HSP90B1, SENP1
spindle 1 PRPF19
GABA-ergic synapse 1 CNR1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 IL1B
intermediate filament 1 GFAP
nuclear speck 1 PRPF19
chromatin 2 FOS, PCNA
cell projection 1 GFAP
phagocytic cup 1 TNF
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
spliceosomal complex 1 PRPF19
site of double-strand break 1 PRPF19
Lipid droplet 1 PRPF19
Nucleus, nucleoplasm 1 PRPF19
Melanosome 1 HSP90B1
cell body 1 GFAP
replication fork 1 PCNA
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 GFAP
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 HSP90B1
nuclear matrix 1 FOS
male germ cell nucleus 1 PCNA
Secreted, extracellular exosome 1 IL1B
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
nuclear lamina 1 PCNA
Sarcoplasmic reticulum lumen 1 HSP90B1
U2-type catalytic step 1 spliceosome 1 PRPF19
protein-DNA complex 1 FOS
catalytic step 2 spliceosome 1 PRPF19
Prp19 complex 1 PRPF19
U2-type catalytic step 2 spliceosome 1 PRPF19
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
cytoplasmic side of lysosomal membrane 1 GFAP
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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