DL-Methamphetamine (BioDeep_00000178467)

   

human metabolite blood metabolite


代谢物信息卡片


methyl(1-phenylpropan-2-yl)amine

化学式: C10H15N (149.1204)
中文名称: (+/-)-甲基苯丙胺, DL-甲基苯丙胺
谱图信息: 最多检出来源 Homo sapiens(blood) 25.51%

分子结构信息

SMILES: CC(CC1=CC=CC=C1)NC
InChI: InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

15 个代谢物同义名

methyl(1-phenylpropan-2-yl)amine; (+)-N,α-dimethylphenethylamine; Hydrochloride, methamphetamine; Methamphetamine hydrochloride; (+/-)-methamphetamine; N-Methylamphetamine; N Methylamphetamine; DL-Methamphetamine; Methylamphetamine; Methamphetamine; Desoxyephedrine; Deoxyephedrine; Metamfetamine; Desoxyn; Madrine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 BPI, DCP2, PARG, POP7, PRKN, TLR2, TLR4
Peripheral membrane protein 2 CYP1B1, DRP2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 7 ACD, DCP2, MYB, NSL1, PARG, POP7, PRKN
cytosol 7 BAK1, DCP2, MYB, NSL1, PARG, PRKN, SHC2
dendrite 2 DRP2, NECTIN1
nuclear body 2 ACD, PARG
nucleoplasm 6 ACD, DCP2, MYB, NSL1, PARG, POP7
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 5 ADRB3, DRP2, NECTIN1, TLR4, TLR5
Cytoplasmic granule 1 POP7
Multi-pass membrane protein 1 ADRB3
cell junction 1 DCP2
cell surface 3 TLR2, TLR4, TNR
glutamatergic synapse 2 DRP2, TNR
Golgi apparatus 2 PRKN, TLR2
Cytoplasm, cytosol 1 PRKN
Presynapse 1 PRKN
plasma membrane 9 ADRB3, CXCR5, DRP2, NECTIN1, NPR1, SHC2, TLR2, TLR4, TLR5
Membrane 10 BAK1, BPI, CXCR5, CYP1B1, MYB, NECTIN1, NPR1, TLR2, TLR4, TLR5
extracellular exosome 1 BPI
endoplasmic reticulum 2 BAK1, PRKN
extracellular space 2 BPI, TNR
perinuclear region of cytoplasm 2 PRKN, TLR4
Schaffer collateral - CA1 synapse 1 TNR
adherens junction 1 NECTIN1
mitochondrion 5 BAK1, CYP1B1, NSL1, PARG, PRKN
intracellular membrane-bounded organelle 2 CYP1B1, POP7
Microsome membrane 1 CYP1B1
postsynaptic density 2 DRP2, PRKN
Single-pass type I membrane protein 4 NECTIN1, TLR2, TLR4, TLR5
Secreted 1 BPI
extracellular region 3 BPI, NECTIN1, TNR
Mitochondrion outer membrane 2 BAK1, PRKN
Single-pass membrane protein 1 BAK1
mitochondrial outer membrane 2 BAK1, PRKN
hippocampal mossy fiber to CA3 synapse 1 NECTIN1
mitochondrial matrix 1 PARG
BAK complex 1 BAK1
Bcl-2 family protein complex 1 BAK1
external side of plasma membrane 2 CXCR5, TLR4
Secreted, extracellular space, extracellular matrix 1 TNR
perikaryon 1 DRP2
nucleolus 1 POP7
Cytoplasm, P-body 1 DCP2
P-body 1 DCP2
Early endosome 1 TLR4
presynaptic active zone membrane 1 NECTIN1
Membrane raft 2 TLR2, TNR
pore complex 1 BAK1
Cell junction, adherens junction 1 NECTIN1
collagen-containing extracellular matrix 1 TNR
nuclear speck 2 NSL1, PRKN
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 4 ADRB3, NPR1, TLR2, TLR4
Cell projection, neuron projection 1 PRKN
neuron projection 1 PRKN
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 TLR2
cytoplasmic ribonucleoprotein granule 1 DCP2
Nucleus, nucleolus 1 POP7
spindle pole 1 NSL1
Chromosome, telomere 1 ACD
chromosome, telomeric region 1 ACD
Chromosome, centromere, kinetochore 1 NSL1
NSL complex 1 NSL1
Cell projection, dendrite 1 DRP2
Presynaptic cell membrane 1 NECTIN1
cell body 1 TLR2
ubiquitin ligase complex 1 PRKN
[Isoform 3]: Cytoplasm 1 PARG
[Isoform 4]: Cytoplasm 1 PARG
lipopolysaccharide receptor complex 1 TLR4
secretory granule membrane 1 TLR2
MLL1 complex 1 NSL1
nuclear matrix 1 MYB
specific granule lumen 1 BPI
kinetochore 1 NSL1
azurophil granule lumen 1 BPI
perineuronal net 1 TNR
aggresome 1 PRKN
nuclear telomere cap complex 1 ACD
telomerase holoenzyme complex 1 ACD
outer kinetochore 1 NSL1
[Isoform 2]: Cytoplasm 1 PARG
[Isoform 1]: Nucleus 1 PARG
histone acetyltransferase complex 1 NSL1
apical junction complex 1 NECTIN1
dopaminergic synapse 1 PRKN
Lewy body 1 PRKN
Parkin-FBXW7-Cul1 ubiquitin ligase complex 1 PRKN
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
RISC complex 1 DCP2
multimeric ribonuclease P complex 1 POP7
nucleolar ribonuclease P complex 1 POP7
ribonuclease MRP complex 1 POP7
cell-cell contact zone 1 NECTIN1
ANPR-A receptor complex 1 NPR1
Cytoplasmic granule membrane 1 BPI
growth cone membrane 1 NECTIN1
tenascin complex 1 TNR
shelterin complex 1 ACD
[Isoform Alpha]: Cell membrane 1 NECTIN1
[Isoform Delta]: Cell membrane 1 NECTIN1
[Isoform Gamma]: Secreted 1 NECTIN1
MIS12/MIND type complex 1 NSL1
[Isoform 5]: Mitochondrion matrix 1 PARG


文献列表

  • Ying Wang, Ke Li, Weijian Shen, Xingxu Huang, Lina Wu. Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors. Analytical biochemistry. 2024 Aug; 691(?):115526. doi: 10.1016/j.ab.2024.115526. [PMID: 38621604]
  • Bryce Pardo, Alexandre Nobajas Ganau, Irmgard Zeiler. Modelling the amount of inputs needed for methamphetamine manufacture in Afghanistan. Addiction (Abingdon, England). 2024 Jun; 119(6):1013-1020. doi: 10.1111/add.16474. [PMID: 38509858]
  • Chongke Zheng, Shulin Niu, Ying Yan, Guanhua Zhou, Yongbin Peng, Yanan He, Jinjun Zhou, Yaping Li, Xianzhi Xie. Moderate Salinity Stress Affects Rice Quality by Influencing Expression of Amylose- and Protein-Content-Associated Genes. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074042. [PMID: 38612852]
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  • Marina Bellot, Fernando Soria, Raul López-Arnau, Cristian Gómez-Canela, Carlos Barata. Daphnia magna an emerging environmental model of neuro and cardiotoxicity of illicit drugs. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 344(?):123355. doi: 10.1016/j.envpol.2024.123355. [PMID: 38228265]
  • Mariana Angoa-Perez, Donald M Kuhn. The pharmacology and neurotoxicology of synthetic cathinones. Advances in pharmacology (San Diego, Calif.). 2024; 99(?):61-82. doi: 10.1016/bs.apha.2023.12.001. [PMID: 38467489]
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  • Liang Wang, Qingfan Wei, Rui Xu, Yaxing Chen, Shu Li, Qian Bu, Ying Zhao, Hongchun Li, Yue Zhao, Linhong Jiang, Yuanyuan Chen, Yanping Dai, Yinglan Zhao, Xiaobo Cen. Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice. ACS chemical neuroscience. 2023 05; 14(9):1585-1601. doi: 10.1021/acschemneuro.2c00709. [PMID: 37043723]
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  • Ann-Kathrin Harsch, Alexander Kunert, Daniel Koska, Christian Maiwald. Quantifying workload using nonlinear dynamical measures of biomechanical parameters during cycling on a roller trainer. PloS one. 2023; 18(5):e0285408. doi: 10.1371/journal.pone.0285408. [PMID: 37159473]
  • Ilaria Ottonelli, Aruna Sharma, Barbara Ruozi, Giovanni Tosi, Jason Thomas Duskey, Maria Angela Vandelli, José Vicente Lafuente, Ala Nozari, Dafin Fior Muresanu, Anca Dana Buzoianu, Z Ryan Tian, Zhiqiang Zhang, Cong Li, Lianyuan Feng, Lars Wiklund, Hari Shanker Sharma. Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor. Advances in neurobiology. 2023; 32(?):385-416. doi: 10.1007/978-3-031-32997-5_10. [PMID: 37480467]
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  • Andrea Estévez-Danta, Lubertus Bijlsma, Ricardo Capela, Rafael Cela, Alberto Celma, Félix Hernández, Unax Lertxundi, João Matias, Rosa Montes, Gorka Orive, Ailette Prieto, Miguel M Santos, Rosario Rodil, José Benito Quintana. Use of illicit drugs, alcohol and tobacco in Spain and Portugal during the COVID-19 crisis in 2020 as measured by wastewater-based epidemiology. The Science of the total environment. 2022 Aug; 836(?):155697. doi: 10.1016/j.scitotenv.2022.155697. [PMID: 35523346]
  • Kai-Kai Zhang, Jia-Li Liu, Li-Jian Chen, Jia-Hao Li, Jian-Zheng Yang, Ling-Ling Xu, Yu-Kui Chen, Qin-Yao Zhang, Xiu-Wen Li, Yi Liu, Dong Zhao, Xiao-Li Xie, Qi Wang. Gut microbiota mediates methamphetamine-induced hepatic inflammation via the impairment of bile acid homeostasis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Aug; 166(?):113208. doi: 10.1016/j.fct.2022.113208. [PMID: 35688268]
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  • Peng-Ju Yan, Zhao-Xiang Ren, Zhi-Feng Shi, Chun-Lei Wan, Chao-Jun Han, Liu-Shuai Zhu, Ning-Ning Li, John L Waddington, Xue-Chu Zhen. Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice. Acta pharmacologica Sinica. 2022 Jul; 43(7):1686-1698. doi: 10.1038/s41401-021-00806-1. [PMID: 34811513]
  • Shiling Xiong, Huanhuan Hong, Luhong Wen, Shundi Hu, Anqi Chen, Wei Xiong, La Chen. [Detection of drugs in urine by ambient direct ionization mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Jul; 40(7):677-683. doi: 10.3724/sp.j.1123.2022.01013. [PMID: 35791607]
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  • Li-Bin Wang, Li-Jian Chen, Qi Wang, Xiao-Li Xie. Silencing the Tlr4 Gene Alleviates Methamphetamine-Induced Hepatotoxicity by Inhibiting Lipopolysaccharide-Mediated Inflammation in Mice. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126810. [PMID: 35743253]
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  • Karolina E Kolaczynska, Paula Ducret, Daniel Trachsel, Marius C Hoener, Matthias E Liechti, Dino Luethi. Pharmacological characterization of 3,4-methylenedioxyamphetamine (MDA) analogs and two amphetamine-based compounds: N,α-DEPEA and DPIA. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2022 06; 59(?):9-22. doi: 10.1016/j.euroneuro.2022.03.006. [PMID: 35378384]
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  • Isabel Gomila Muñiz, Elena Lendoiro, Ana de-Castro-Ríos, Miguel Ángel Elorza Guerrero, Jordi Puiguriguer Ferrando, Laura Sahuquillo Frias, Pilar Sanchís Cortés, Bernardino Barceló Martín. Detection of unsuspected cathinone and piperazine-type drugs in urine samples positive for methamphetamine and amphetamine collected in emergency departments. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2022 06; 34(3):174-180. doi: . [PMID: 35736521]
  • Tsung-Yu Tsai, Tzu-Yun Wang, Huai-Hsuan Tseng, Kao Chin Chen, Ching-Ju Chiu, Po See Chen, Yen Kuang Yang. Correlation between loneliness, personality traits, and treatment outcomes in patients with methamphetamine use disorder. Scientific reports. 2022 05; 12(1):8629. doi: 10.1038/s41598-022-11901-6. [PMID: 35606379]
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  • Cheng-Fang Yen, Chih-Hung Ko, Chih-Yao Hsu, Hung-Chi Wu, Yu-Yi Yang, Peng-Wei Wang. A Pilot Randomized Control Study on Effect Brief Heart Rate Variability Biofeedback as a Complementary Treatment in Men with Methamphetamine Use Disorder. International journal of environmental research and public health. 2022 04; 19(9):. doi: 10.3390/ijerph19095230. [PMID: 35564623]
  • Le Minh Giang, Nguyen Thu Trang, Nguyen Bich Diep, Dao Thi Dieu Thuy, Dinh Thanh Thuy, Han Dinh Hoe, Hoang Thi Hai Van, Thai Thanh Truc, Hoa H Nguyen, Nguyen Ly Lai, Pham Thi Dan Linh, Vu Thi Tuong Vi, Cathy J Reback, Arleen Leibowitz, Li Li, Chunqing Lin, Michael Li, Do Van Dung, Steve Shoptaw. An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial. Trials. 2022 Apr; 23(1):342. doi: 10.1186/s13063-022-06278-w. [PMID: 35461300]
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