Dicloxacillin (BioDeep_00000001779)

 

Secondary id: BioDeep_00000397890

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C19H17Cl2N3O5S (469.0266)
中文名称: 双氯西林
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1

描述信息

Dicloxacillin is only found in individuals that have used or taken this drug. It is one of the penicillins which is resistant to penicillinase. [PubChem]Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that dicloxacillin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

40 个代谢物同义名

(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Bristol-myers squibb brand OF dicloxacillin sodium; Bristol myers squibb brand OF dicloxacillin sodium; SmithKline beecham brand OF dicloxacillin sodium; Dicloxacillin, monosodium salt, mono-hydrate; Infectopharm brand OF dicloxacillin sodium; Antibioticos brand OF dicloxacillin sodium; Dicloxacillin, monosodium salt, anhydrous; Alphapharm brand OF dicloxacillin sodium; Fustery brand OF dicloxacillin sodium; Geneva brand OF dicloxacillin sodium; Sanfer brand OF dicloxacillin sodium; Sigma brand OF dicloxacillin sodium; Wyeth brand OF dicloxacillin sodium; Sodium, dicloxacillin; Dicloxacillin Sodium; Dichloroxacillin; Dicloxacillinum; Diclossacillina; Dicloxacilline; Dicloxacycline; Dicloxaciclin; Dicloxacillin; Dicloxacilina; Dicloxacilin; InfectoStaph; Ditterolina; Dicloxsig; Pathocil; BRL 1702; Diclocil; Distaph; Posipen; Dynapen; Cilpen; Dycill; Dicloxacillin; Dicloxacillin sodium



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ALB, CYP2B6, CYP2C19, CYP2C9, CYP3A4, IGHMBP2
Peripheral membrane protein 2 CYP1B1, CYP2B6
Endoplasmic reticulum membrane 6 CYP1A2, CYP1B1, CYP2B6, CYP2C19, CYP2C9, CYP3A4
Nucleus 3 ALB, IGHMBP2, NR1I2
cytosol 2 ALB, B2M
nuclear body 2 IGHMBP2, NR1I2
centrosome 1 ALB
nucleoplasm 2 IGHMBP2, NR1I2
Cell membrane 4 ABCB1, B2M, NPR3, SELE
Cell projection, axon 1 IGHMBP2
Early endosome membrane 1 B2M
Multi-pass membrane protein 2 ABCB1, ABCC3
cell surface 4 ABCB1, B2M, F3, ICAM1
Golgi apparatus 2 ALB, B2M
Golgi membrane 1 B2M
growth cone 1 IGHMBP2
lysosomal membrane 2 B2M, EGF
plasma membrane 10 ABCB1, ABCC3, B2M, CYP2C19, CYP2C9, EGF, F3, ICAM1, NPR3, SELE
Membrane 10 ABCB1, ABCC3, B2M, CYP1B1, CYP3A4, EGF, F3, ICAM1, IGHMBP2, NPR3
apical plasma membrane 1 ABCB1
axon 1 IGHMBP2
basolateral plasma membrane 1 ABCC3
caveola 1 SELE
extracellular exosome 7 ABCB1, ALB, B2M, EGF, ICAM1, LYZ, NPR3
endoplasmic reticulum 2 ALB, B2M
extracellular space 9 ALB, B2M, CRP, EGF, F3, ICAM1, IL4, LYZ, SELE
perinuclear region of cytoplasm 1 SELE
mitochondrion 1 CYP1B1
protein-containing complex 2 ALB, NPR3
intracellular membrane-bounded organelle 6 CYP1A2, CYP1B1, CYP2B6, CYP2C19, CYP2C9, CYP3A4
Microsome membrane 5 CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP3A4
Single-pass type I membrane protein 4 F3, ICAM1, NPR3, SELE
Secreted 4 ALB, B2M, CRP, IL4
extracellular region 6 ALB, B2M, CRP, EGF, IL4, LYZ
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 1 F3
anchoring junction 1 ALB
transcription regulator complex 1 NR1I2
external side of plasma membrane 4 B2M, F3, ICAM1, SELE
clathrin-coated pit 1 SELE
Apical cell membrane 1 ABCB1
Membrane raft 2 ICAM1, SELE
focal adhesion 2 B2M, ICAM1
collagen-containing extracellular matrix 2 F3, ICAM1
ciliary basal body 1 ALB
chromatin 1 NR1I2
Late endosome membrane 1 B2M
phagocytic vesicle membrane 1 B2M
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ABCC3
Recycling endosome membrane 1 B2M
intermediate filament cytoskeleton 1 NR1I2
basal plasma membrane 1 ABCC3
HFE-transferrin receptor complex 1 B2M
endoplasmic reticulum lumen 2 ALB, B2M
platelet alpha granule lumen 2 ALB, EGF
specific granule lumen 2 B2M, LYZ
tertiary granule lumen 2 B2M, LYZ
azurophil granule lumen 1 LYZ
immunological synapse 1 ICAM1
ER to Golgi transport vesicle membrane 1 B2M
clathrin-coated endocytic vesicle membrane 1 EGF
ribonucleoprotein complex 1 IGHMBP2
Basal cell membrane 1 ABCC3
external side of apical plasma membrane 1 ABCB1
MHC class I peptide loading complex 1 B2M
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
cortical cytoskeleton 1 SELE
serine-type peptidase complex 1 F3
ciliary transition fiber 1 ALB
early endosome lumen 1 B2M


文献列表

  • Marcella Muysson, Palika Datta, Kathleen Rewers-Felkins, Teresa Baker, Thomas W Hale. Transfer of Dicloxacillin into Human Milk. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2020 11; 15(11):715-717. doi: 10.1089/bfm.2020.0156. [PMID: 32678981]
  • Anis Zand Irani, Ahmed Almuwais, Holly Gibbons. Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use. BMJ case reports. 2020 Apr; 13(4):. doi: 10.1136/bcr-2019-233306. [PMID: 32273269]
  • Aws Alshamsan, Fadilah Sfouq Aleanizy, Mohamed Badran, Fulwah Yahya Alqahtani, Haya Alfassam, Abdulaziz Almalik, Sara Alosaimy. Exploring anti-MRSA activity of chitosan-coated liposomal dicloxacillin. Journal of microbiological methods. 2019 01; 156(?):23-28. doi: 10.1016/j.mimet.2018.11.015. [PMID: 30465793]
  • Tore Bjerregaard Stage, Magnus Graff, Susan Wong, Louise Ladebo Rasmussen, Flemming Nielsen, Anton Pottegård, Kim Brøsen, Deanna L Kroetz, S Cyrus Khojasteh, Per Damkier. Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. British journal of clinical pharmacology. 2018 03; 84(3):510-519. doi: 10.1111/bcp.13467. [PMID: 29105855]
  • Kristian Kraft Hansen, Flemming Nielsen, Tore Bjerregaard Stage, Uffe Jørgensen, Ole Skov, Lasse E Rasmussen. Microdialysis as a tool to determine the local tissue concentration of dicloxacillin in man. British journal of clinical pharmacology. 2018 03; 84(3):533-541. doi: 10.1111/bcp.13468. [PMID: 29105799]
  • Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen, Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard. Molecular mechanisms of thioridazine resistance in Staphylococcus aureus. PloS one. 2018; 13(8):e0201767. doi: 10.1371/journal.pone.0201767. [PMID: 30089175]
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  • Guolan Wu, Yunliang Zheng, Huili Zhou, Xingjiang Hu, Jian Liu, You Zhai, Meixiang Zhu, Lihua Wu, Jianzhong Shentu. Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses. Drug design, development and therapy. 2015; 9(?):5687-95. doi: 10.2147/dddt.s92117. [PMID: 26527863]
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