Dicloxacillin (BioDeep_00000001779)

 

Secondary id: BioDeep_00000397890

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C19H17Cl2N3O5S (469.0265932000001)
中文名称: 双氯西林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C19H17Cl2N3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1

描述信息

Dicloxacillin is only found in individuals that have used or taken this drug. It is one of the penicillins which is resistant to penicillinase. [PubChem]Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that dicloxacillin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

40 个代谢物同义名

(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Bristol-myers squibb brand OF dicloxacillin sodium; Bristol myers squibb brand OF dicloxacillin sodium; SmithKline beecham brand OF dicloxacillin sodium; Dicloxacillin, monosodium salt, mono-hydrate; Infectopharm brand OF dicloxacillin sodium; Antibioticos brand OF dicloxacillin sodium; Dicloxacillin, monosodium salt, anhydrous; Alphapharm brand OF dicloxacillin sodium; Fustery brand OF dicloxacillin sodium; Geneva brand OF dicloxacillin sodium; Sanfer brand OF dicloxacillin sodium; Sigma brand OF dicloxacillin sodium; Wyeth brand OF dicloxacillin sodium; Sodium, dicloxacillin; Dicloxacillin Sodium; Dichloroxacillin; Dicloxacillinum; Diclossacillina; Dicloxacilline; Dicloxacycline; Dicloxaciclin; Dicloxacillin; Dicloxacilina; Dicloxacilin; InfectoStaph; Ditterolina; Dicloxsig; Pathocil; BRL 1702; Diclocil; Distaph; Posipen; Dynapen; Cilpen; Dycill; Dicloxacillin; Dicloxacillin sodium



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Marcella Muysson, Palika Datta, Kathleen Rewers-Felkins, Teresa Baker, Thomas W Hale. Transfer of Dicloxacillin into Human Milk. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2020 11; 15(11):715-717. doi: 10.1089/bfm.2020.0156. [PMID: 32678981]
  • Anis Zand Irani, Ahmed Almuwais, Holly Gibbons. Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use. BMJ case reports. 2020 Apr; 13(4):. doi: 10.1136/bcr-2019-233306. [PMID: 32273269]
  • Aws Alshamsan, Fadilah Sfouq Aleanizy, Mohamed Badran, Fulwah Yahya Alqahtani, Haya Alfassam, Abdulaziz Almalik, Sara Alosaimy. Exploring anti-MRSA activity of chitosan-coated liposomal dicloxacillin. Journal of microbiological methods. 2019 01; 156(?):23-28. doi: 10.1016/j.mimet.2018.11.015. [PMID: 30465793]
  • Tore Bjerregaard Stage, Magnus Graff, Susan Wong, Louise Ladebo Rasmussen, Flemming Nielsen, Anton Pottegård, Kim Brøsen, Deanna L Kroetz, S Cyrus Khojasteh, Per Damkier. Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. British journal of clinical pharmacology. 2018 03; 84(3):510-519. doi: 10.1111/bcp.13467. [PMID: 29105855]
  • Kristian Kraft Hansen, Flemming Nielsen, Tore Bjerregaard Stage, Uffe Jørgensen, Ole Skov, Lasse E Rasmussen. Microdialysis as a tool to determine the local tissue concentration of dicloxacillin in man. British journal of clinical pharmacology. 2018 03; 84(3):533-541. doi: 10.1111/bcp.13468. [PMID: 29105799]
  • Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen, Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard. Molecular mechanisms of thioridazine resistance in Staphylococcus aureus. PloS one. 2018; 13(8):e0201767. doi: 10.1371/journal.pone.0201767. [PMID: 30089175]
  • Elmas Sari, Pawel Berczynski, Aleksandra Kladna, Irena Kruk, Oya Bozdag Dundar, Monika Szymanska, Hassan Y Aboul-Enein. Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds. Medicinal chemistry (Shariqah (United Arab Emirates)). 2018; 14(4):372-386. doi: 10.2174/1573406414666171204105000. [PMID: 29205120]
  • Sandra Johansson, Ole M Christensen, Anders H Thorsmark. A retrospective study of acute kidney injury in hip arthroplasty patients receiving gentamicin and dicloxacillin. Acta orthopaedica. 2016 Dec; 87(6):589-591. doi: 10.1080/17453674.2016.1231008. [PMID: 27648882]
  • Guolan Wu, Yunliang Zheng, Huili Zhou, Xingjiang Hu, Jian Liu, You Zhai, Meixiang Zhu, Lihua Wu, Jianzhong Shentu. Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses. Drug design, development and therapy. 2015; 9(?):5687-95. doi: 10.2147/dddt.s92117. [PMID: 26527863]
  • Somnath D Bhinge, Sharangouda M Malipatil, Lalit V Sonawane. Bioanalytical method development and validation for simultaneous estimation of cefixime and dicloxacillin by RP-HPLC in human plasma. Acta chimica Slovenica. 2014; 61(3):580-6. doi: NULL. [PMID: 25286213]
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  • Anne Sandberg, Klaus Skovbo Jensen, Pierre Baudoux, Françoise Van Bambeke, Paul M Tulkens, Niels Frimodt-Møller. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrobial agents and chemotherapy. 2010 Jun; 54(6):2391-400. doi: 10.1128/aac.01400-09. [PMID: 20308386]
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  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
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