cephamycin C (BioDeep_00000177156)

   

human metabolite blood metabolite


代谢物信息卡片


7-[(5-Amino-5-carboxy-1-hydroxypentylidene)amino]-3-[(C-hydroxycarbonimidoyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

化学式: C16H22N4O9S (446.1107)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: COC1(C2N(C1=O)C(=C(CS2)COC(=O)N)C(=O)O)NC(=O)CCCC(C(=O)O)N
InChI: InChI=1S/C16H22N4O9S/c1-28-16(19-9(21)4-2-3-8(17)11(22)23)13(26)20-10(12(24)25)7(5-29-15(18)27)6-30-14(16)20/h8,14H,2-6,17H2,1H3,(H2,18,27)(H,19,21)(H,22,23)(H,24,25)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002513 - Cephamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

同义名列表

4 个代谢物同义名

7-[(5-Amino-5-carboxy-1-hydroxypentylidene)amino]-3-[(C-hydroxycarbonimidoyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-(5-amino-5-carboxypentanamido)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; cephamycin C; Cephamycin C



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, CTH, DAO, GLI3, GPER1, HSPA9, PRKX, RELA, RPL11
Peripheral membrane protein 2 CYP1B1, DAO
Endoplasmic reticulum membrane 3 AMFR, CYP1B1, GPER1
Mitochondrion membrane 1 GPER1
Nucleus 6 ANKRD42, GLI3, GPER1, HSPA9, PRKX, RELA
cytosol 9 AMFR, COMT, CTH, DAO, GLI3, GPER1, RELA, RPL11, SLC22A7
dendrite 3 AMFR, COMT, GPER1
mitochondrial membrane 1 GPER1
trans-Golgi network 1 GPER1
nucleoplasm 6 GLI3, GPER1, NEO1, PRKX, RELA, RPL11
Cell membrane 4 ACE, COMT, DAO, SLC22A7
Cell projection, axon 1 GPER1
Multi-pass membrane protein 4 AMFR, GPER1, SLC22A7, TPRA1
Golgi apparatus membrane 1 GPER1
Synapse 1 COMT
cell surface 1 NEO1
dendritic shaft 1 GPER1
glutamatergic synapse 2 NEO1, RELA
Golgi apparatus 3 AMFR, GPER1, NEO1
Golgi membrane 1 GPER1
growth cone 1 AMFR
mitochondrial inner membrane 1 HSPA9
neuronal cell body 1 AMFR
presynaptic membrane 1 GPER1
Cytoplasm, cytosol 1 DAO
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 9 ACE, COMT, CTH, DAO, GPER1, NEO1, REN, SLC22A7, TPRA1
presynaptic active zone 2 DAO, GPER1
Membrane 11 ACE, AMFR, COMT, CTH, CYP1B1, GPER1, NEO1, REN, RPL11, SLC22A7, TPRA1
apical plasma membrane 1 SLC22A7
axon 2 COMT, GPER1
basolateral plasma membrane 1 SLC22A7
extracellular exosome 6 ACE, COMT, CTH, DAO, HSPA9, RPL11
endoplasmic reticulum 2 AMFR, GPER1
extracellular space 4 ACE, DAO, PNLIP, REN
perinuclear region of cytoplasm 2 AMFR, GPER1
bicellular tight junction 1 DAO
mitochondrion 2 CYP1B1, HSPA9
protein-containing complex 2 AMFR, RPL11
intracellular membrane-bounded organelle 4 COMT, CYP1B1, GLI3, GPER1
Microsome membrane 1 CYP1B1
postsynaptic density 1 GPER1
Single-pass type I membrane protein 3 ACE, CTH, NEO1
Secreted 4 ACE, DAO, PNLIP, REN
extracellular region 4 ACE, DAO, PNLIP, REN
hippocampal mossy fiber to CA3 synapse 1 GPER1
Mitochondrion matrix 1 HSPA9
mitochondrial matrix 1 HSPA9
Extracellular side 2 COMT, DAO
transcription regulator complex 1 RELA
external side of plasma membrane 1 ACE
nucleolus 4 GLI3, GPER1, HSPA9, RPL11
Early endosome 1 GPER1
apical part of cell 1 REN
recycling endosome 1 GPER1
Single-pass type II membrane protein 1 COMT
Apical cell membrane 1 SLC22A7
focal adhesion 1 HSPA9
mitochondrial nucleoid 1 HSPA9
Peroxisome 1 DAO
intracellular vesicle 1 NEO1
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 1 RELA
axonal growth cone 1 NEO1
cell projection 1 DAO
Secreted, extracellular space 1 DAO
plasma membrane protein complex 1 NEO1
brush border membrane 1 ACE
Nucleus, nucleolus 2 HSPA9, RPL11
sperm midpiece 1 ACE
Basolateral cell membrane 1 SLC22A7
nuclear envelope 1 GPER1
Cytoplasmic vesicle membrane 1 GPER1
Cell projection, dendrite 1 GPER1
ubiquitin ligase complex 1 AMFR
basal plasma membrane 2 ACE, SLC22A7
endoplasmic reticulum quality control compartment 1 AMFR
transcription repressor complex 1 GLI3
axon terminus 1 GPER1
specific granule lumen 1 DAO
postsynaptic density membrane 1 NEO1
TIM23 mitochondrial import inner membrane translocase complex 1 HSPA9
ribonucleoprotein complex 1 RPL11
[Isoform 1]: Cytoplasm, cytosol 1 SLC22A7
keratin filament 1 GPER1
cytosolic ribosome 1 RPL11
dendritic spine head 1 GPER1
MIB complex 1 HSPA9
SAM complex 1 HSPA9
Cell projection, dendritic spine membrane 1 GPER1
dendritic spine membrane 1 GPER1
ribosome 1 RPL11
cytosolic large ribosomal subunit 1 RPL11
GLI-SUFU complex 1 GLI3
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
NF-kappaB p50/p65 complex 1 RELA
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
NF-kappaB complex 1 RELA
Derlin-1 retrotranslocation complex 1 AMFR
[Isoform 2]: Basolateral cell membrane 1 SLC22A7


文献列表

  • Mamoru Komatsu, Takuma Uchiyama, Satoshi Omura, David E Cane, Haruo Ikeda. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2010 Feb; 107(6):2646-51. doi: 10.1073/pnas.0914833107. [PMID: 20133795]
  • Y S Park, I Momose, K Tsunoda, M Okabe. Enhancement of cephamycin C production using soybean oil as the sole carbon source. Applied microbiology and biotechnology. 1994 Feb; 40(6):773-9. doi: 10.1007/bf00173973. [PMID: 7764568]
  • T M Jacks, C J Welter, G R Fitzgerald, B M Miller. Cephamycin C treatment of induced swine salmonellosis. Antimicrobial agents and chemotherapy. 1981 Apr; 19(4):562-6. doi: 10.1128/aac.19.4.562. [PMID: 7247378]
  • T M Jacks, K D Schleim, F R Judith, B M Miller. Cephamycin C treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. Antimicrobial agents and chemotherapy. 1980 Sep; 18(3):397-402. doi: 10.1128/aac.18.3.397. [PMID: 6999985]