Bryo 1 (BioDeep_00000176848)
human metabolite blood metabolite
代谢物信息卡片
25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1³,⁷.1¹¹,¹⁵]nonacos-8-en-12-yl octa-2,4-dienoic acid
化学式: C47H68O17 (904.4456278)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 12.5%
分子结构信息
SMILES: CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(C(C)O)OC(=O)CC(O)CC3CC(OC(C)=O)C(C)(C)C(O)(CC4CC(=CC(=O)OC)CC(C=CC(C)(C)C1(O)O2)O4)O3
InChI: InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3
描述信息
同义名列表
4 个代谢物同义名
25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1³,⁷.1¹¹,¹⁵]nonacos-8-en-12-yl octa-2,4-dienoic acid; 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1³,⁷.1¹¹,¹⁵]nonacos-8-en-12-yl octa-2,4-dienoate; 25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1,.1,]nonacos-8-en-12-yl octa-2,4-dienoic acid; Bryo 1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 10212 - Bugula neritina: 10.1016/0145-2126(95)00037-O
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Youngki You, Joydip Das. Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane.
Journal of biomolecular structure & dynamics.
2022; 40(24):14160-14175. doi:
10.1080/07391102.2021.2001375. [PMID: 34779746] - Francisco A Blanco, Agnes Czikora, Noemi Kedei, Youngki You, Gary A Mitchell, Satyabrata Pany, Anamitra Ghosh, Peter M Blumberg, Joydip Das. Munc13 Is a Molecular Target of Bryostatin 1.
Biochemistry.
2019 07; 58(27):3016-3030. doi:
10.1021/acs.biochem.9b00427. [PMID: 31243993] - Xiang Rong Tian, Hai Feng Tang, Xiao Lin Tian, Jia Jun Hu, Li Li Huang, Kirk R Gustafson. Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery.
Future medicinal chemistry.
2018 06; 10(12):1497-1514. doi:
10.4155/fmc-2018-0012. [PMID: 29788787] - Elsayed I Salim, Samar F Harras, Aisha G Abdalla, Mohmmed H Mona. Syphacia muris infection in rats attenuates colorectal carcinogenesis through oxidative stress and gene expression alterations. Implications for modulatory effects by Bryostatin-1.
Acta parasitologica.
2018 Mar; 63(1):198-209. doi:
10.1515/ap-2018-0023. [PMID: 29351079] - Steven M Ryckbosch, Paul A Wender, Vijay S Pande. Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.
Nature communications.
2017 02; 8(1):6. doi:
10.1038/s41467-016-0015-8. [PMID: 28232750] - Carolina Gutiérrez, Sergio Serrano-Villar, Nadia Madrid-Elena, Maria J Pérez-Elías, Maria Elena Martín, Coral Barbas, Javier Ruipérez, Eduardo Muñoz, Maria Angeles Muñoz-Fernández, Trevor Castor, Santiago Moreno. Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy.
AIDS (London, England).
2016 06; 30(9):1385-92. doi:
10.1097/qad.0000000000001064. [PMID: 26891037] - Sergey Iordanskiy, Rachel Van Duyne, Gavin C Sampey, Caitlin M Woodson, Kelsi Fry, Mohammed Saifuddin, Jia Guo, Yuntao Wu, Fabio Romerio, Fatah Kashanchi. Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.
Virology.
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The Journal of clinical investigation.
2015 May; 125(5):1901-12. doi:
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ACS nano.
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The oncologist.
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Leukemia research.
2011 Jan; 35(1):87-94. doi:
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Molecular pharmacology.
2010 Sep; 78(3):325-32. doi:
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2009 Apr; 9(4):498-509. doi:
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European journal of pharmacology.
2008 Apr; 584(2-3):328-37. doi:
10.1016/j.ejphar.2008.02.014. [PMID: 18313045] - Basil F El-Rayes, Shirish Gadgeel, Anthony F Shields, Stephanie Manza, Patricia Lorusso, Philip A Philip. Phase I study of bryostatin 1 and gemcitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2006 Dec; 12(23):7059-62. doi:
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Molecular cancer therapeutics.
2006 Mar; 5(3):602-10. doi:
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Investigational new drugs.
2006 Mar; 24(2):141-9. doi:
10.1007/s10637-006-5935-4. [PMID: 16514482] - Trever G Bivona, Steven E Quatela, Brian O Bodemann, Ian M Ahearn, Michael J Soskis, Adam Mor, John Miura, Heidi H Wiener, Latasha Wright, Shahryar G Saba, Duke Yim, Adam Fein, Ignacio Pérez de Castro, Chi Li, Craig B Thompson, Adrienne D Cox, Mark R Philips. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
Molecular cell.
2006 Feb; 21(4):481-93. doi:
10.1016/j.molcel.2006.01.012. [PMID: 16483930] - Thomas J Manning, Michael Land, Emily Rhodes, Linda Chamberlin, Jack Rudloe, Dennis Phillips, Tukiet T Lam, Jeremiah Purcell, Helen J Cooper, Mark R Emmett, Alan G Marshall. Identifying bryostatins and potential precursors from the bryozoan Bugula neritina.
Natural product research.
2005 Jul; 19(5):467-91. doi:
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Analytical biochemistry.
2005 Feb; 337(1):143-8. doi:
10.1016/j.ab.2004.10.030. [PMID: 15649387] - Caitlin Hammond, Yonghong Shi, Jenny Mena, Jelena Tomic, David Cervi, Liwei He, Amanda E Millar, Mark Debenedette, Andre C Schuh, Jeremy L Baryza, Paul A Wender, Laszlo Radvanyi, David E Spaner. Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells.
Journal of immunotherapy (Hagerstown, Md. : 1997).
2005 Jan; 28(1):28-39. doi:
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Gynecologic oncology.
2004 Apr; 93(1):144-8. doi:
10.1016/j.ygyno.2003.12.021. [PMID: 15047228] - Olga V Leontieva, Jennifer D Black. Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells.
The Journal of biological chemistry.
2004 Feb; 279(7):5788-801. doi:
10.1074/jbc.m308375200. [PMID: 14638691] - Ralf Schmidmaier, Mark Oellerich, Joachim Baumgart, Bertold Emmerich, Gerold Meinhardt. Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1.
Experimental hematology.
2004 Jan; 32(1):76-86. doi:
10.1016/j.exphem.2003.09.023. [PMID: 14725904] - Afshin Dowlati, Hillard M Lazarus, Paul Hartman, James W Jacobberger, Cecilia Whitacre, Stanton L Gerson, Pamela Ksenich, Brenda W Cooper, Phyllis S Frisa, Megan Gottlieb, Anthony J Murgo, Scot C Remick. Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Dec; 9(16 Pt 1):5929-35. doi:
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Molecular pharmacology.
2003 Dec; 64(6):1342-8. doi:
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British journal of cancer.
2003 Oct; 89(8):1418-22. doi:
10.1038/sj.bjc.6601321. [PMID: 14562010] - Traci E Battle, David A Frank. STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1.
Blood.
2003 Oct; 102(8):3016-24. doi:
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British journal of haematology.
2003 Apr; 121(2):251-8. doi:
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Lung cancer (Amsterdam, Netherlands).
2003 Feb; 39(2):191-6. doi:
10.1016/s0169-5002(02)00447-6. [PMID: 12581572] - Tushar Varma, Si Qi Liu, Matthew West, Visith Thongboonkerd, Peter P Ruvolo, W Stratford May, Aruni Bhatnagar. Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase.
FEBS letters.
2003 Jan; 534(1-3):175-9. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Jan; 9(1):109-14. doi:
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Molecular pharmacology.
2002 Oct; 62(4):901-10. doi:
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Biochemical and biophysical research communications.
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The Journal of biological chemistry.
2001 Nov; 276(48):44944-52. doi:
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Cancer.
2000 Aug; 89(3):615-8. doi:
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The Journal of biological chemistry.
1999 Dec; 274(52):37233-9. doi:
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Melanoma research.
1999 Dec; 9(6):599-606. doi:
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Leukemia.
1999 Aug; 13(8):1273-80. doi:
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The Journal of biological chemistry.
1998 Sep; 273(36):23160-8. doi:
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The American journal of physiology.
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