Aescin (BioDeep_00000175765)

   

human metabolite blood metabolite natural product


代谢物信息卡片


6-{[9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(2-methylbut-2-enoyl)oxy]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid

化学式: C55H86O24 (1130.5508756)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC=C(C)C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC6OC(CO)C(O)C(O)C6O)C(C)(CO)C5CCC43C)C2CC1(C)C
InChI: InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)

描述信息

同义名列表

22 个代谢物同义名

6-{[9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(2-methylbut-2-enoyl)oxy]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylic acid; 6-{[9-(acetyloxy)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(2-methylbut-2-enoyl)oxy]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-4-hydroxy-3,5-bis({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})oxane-2-carboxylate; sankyo Brand OF escin; Madaus brand OF escin; biomo Brand OF escin; Flebostasin; opino Biomo; beta-Aescin; opino-Biomo; beta Aescin; beta-ESCIN; Opinobiomo; beta Escin; Fepalitan; Aescusan; Feparil; Reparil; Eskuzan; Aescin; Escina; Escin; Opino



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chandrashekhar Jori, Md Meraj Ansari, Anas Ahmad, Nemat Ali, Syed Shadab Raza, Rehan Khan. Biomaterial-based combinatorial approach of aescin-comprised zein-coated gelatin nanoparticles alleviates synovial inflammation in experimental inflammatory arthritis. Nanoscale. 2024 Apr; 16(16):7965-7975. doi: 10.1039/d3nr06476j. [PMID: 38567436]
  • Freddy Armando Peñaranda Figueredo, Josefina Vicente, Andrea Alejandra Barquero, Carlos Alberto Bueno. Aesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2. Scientific reports. 2024 03; 14(1):6418. doi: 10.1038/s41598-024-56759-y. [PMID: 38494515]
  • Yunyu Wang, Xiuwei Han, Xinhuan Wan, Fengjv Niu, Changzheng Zhou. β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity. The American journal of Chinese medicine. 2023 Oct; ?(?):1-26. doi: 10.1142/s0192415x23500908. [PMID: 37865870]
  • Wei Sun, Qinggang Yin, Huihua Wan, Ranran Gao, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, Caixia Wang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, Peng Sun, Xuehua Xie, Zhigang Hu, David R Nelson, Zhichao Xu, Xinxiao Sun, Shilin Chen. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis. Nature communications. 2023 Oct; 14(1):6470. doi: 10.1038/s41467-023-42253-y. [PMID: 37833361]
  • Yuman Wang, Tianjiao Chu, Xianmei Pan, Yifei Bian, Jing Li. Escin ameliorates inflammation via inhibiting mechanical stretch and chemically induced Piezo1 activation in vascular endothelial cells. European journal of pharmacology. 2023 Aug; 956(?):175951. doi: 10.1016/j.ejphar.2023.175951. [PMID: 37541373]
  • Chenyuan Li, Ziqi He, Feng Yao, Shichong Liao, Kai Sun, Shengrong Sun, Zhiyu Li, Zhong Wang. Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin. Apoptosis : an international journal on programmed cell death. 2023 May; ?(?):. doi: 10.1007/s10495-023-01849-x. [PMID: 37149513]
  • Hao Yu, Siru Yan, Meiyu Jin, Yunfei Wei, Lilei Zhao, Jiaqi Cheng, Lu Ding, Haihua Feng. Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 113(?):154746. doi: 10.1016/j.phymed.2023.154746. [PMID: 36905866]
  • Philippe Savarino, Emmanuel Colson, Julien André, Pascal Gerbaux. Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052087. [PMID: 36903330]
  • Sunnatullo Fazliev, Khurshid Tursunov, Jamoliddin Razzokov, Avez Sharipov. Escin's Multifaceted Therapeutic Profile in Treatment and Post-Treatment of Various Cancers: A Comprehensive Review. Biomolecules. 2023 Feb; 13(2):. doi: 10.3390/biom13020315. [PMID: 36830684]
  • Min Li, Shengguang Wang, Ce Zhang, Chenglin Chi, Rongxia Liu, Tian Wang, Fenghua Fu. Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats. International immunopharmacology. 2023 Feb; 115(?):109659. doi: 10.1016/j.intimp.2022.109659. [PMID: 36608442]
  • Min Li, Fang Wang, Ce Zhang, Min-An Li, Tian Wang, Yu-Chen Li, Feng-Hua Fu. Integrated systematic pharmacology analysis and experimental validation to reveal the mechanism of action of Semen aesculi on inflammatory bowel diseases. Journal of ethnopharmacology. 2022 Nov; 298(?):115627. doi: 10.1016/j.jep.2022.115627. [PMID: 35985613]
  • I M Tucker, A Burley, R E Petkova, S L Hosking, J R P Webster, P X Li, K Ma, J Doutch, J Penfoldoo, R K Thomas. Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles. Journal of colloid and interface science. 2022 Nov; 626(?):305-313. doi: 10.1016/j.jcis.2022.06.122. [PMID: 35792461]
  • Q-H Zhang, X-Y Cui, D Wang, Y Jin, Y-X Guan. Anti-obesity effect of escin: a study on high-fat diet-induced obese mice. European review for medical and pharmacological sciences. 2022 11; 26(21):7797-7812. doi: 10.26355/eurrev_202211_30129. [PMID: 36394728]
  • Mustafa Cengiz, Hatice Mehtap Kutlu, Betül Peker Cengiz, Adnan Ayhancı. Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage. Drug and chemical toxicology. 2022 May; 45(3):1180-1187. doi: 10.1080/01480545.2020.1810262. [PMID: 32838567]
  • Peng Qiao, Baokun Zhang, Xueni Liu, Jie Xu, Xuehan Li. Effects of Escin on Oxidative Stress and Apoptosis of H9c2 Cells Induced by H2O2. Disease markers. 2022; 2022(?):7765353. doi: 10.1155/2022/7765353. [PMID: 35126791]
  • Yuqing Sun, Xin Zhang, Xiaofan Shen, Shuo Wang, Qi Wang, Xiuwei Yang. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins. European journal of pharmacology. 2021 Oct; 908(?):174372. doi: 10.1016/j.ejphar.2021.174372. [PMID: 34324856]
  • Shu Hu, Gianni Belcaro, Maria R Cesarone, Beatrice Feragalli, Roberto Cotellese, Mark Dugall, Claudia Scipione, Valeria Scipione, Claudia Maione, Giada Maramaldi, Stefano Togni, Antonella Riva. A sport cream (Harpago-Boswellia-ginger-escin) for localized neck/shoulder pain. Minerva medica. 2021 Apr; 112(2):255-260. doi: 10.23736/s0026-4806.20.06819-6. [PMID: 32880419]
  • Ramsia Geisler, Martin Cramer Pedersen, Natalie Preisig, Yvonne Hannappel, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg. Aescin - a natural soap for the formation of lipid nanodiscs with tunable size. Soft matter. 2021 Feb; 17(7):1888-1900. doi: 10.1039/d0sm02043e. [PMID: 33410858]
  • Sachin V Suryavanshi, Yogesh A Kulkarni. Attenuation of Cardiac Autonomic Neuropathy by Escin in Diabetic Rats. Pharmacology. 2021; 106(3-4):211-217. doi: 10.1159/000509730. [PMID: 32877906]
  • Qian Zhang, Chen Zhao, Lei Zhang, Kai Sun, Linlin Yu, Xianming Wang, Lei Ren, Nan Zhang, Chengyu Chen, Ju Liu, Haimei Wang, Hu Tian. Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):9921839. doi: 10.1155/2021/9921839. [PMID: 34422214]
  • Sachin V Suryavanshi, Yogesh A Kulkarni. Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. Life sciences. 2020 Aug; 254(?):117777. doi: 10.1016/j.lfs.2020.117777. [PMID: 32407839]
  • Sahar Idris, Anuradha Mishra, Mohd Khushtar. Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine. Journal of basic and clinical physiology and pharmacology. 2020 Jul; 31(5):. doi: 10.1515/jbcpp-2019-0115. [PMID: 32649293]
  • Luca Gallelli, Leiming Zhang, Tian Wang, Fenghua Fu. Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin. Journal of clinical pharmacology. 2020 07; 60(7):815-825. doi: 10.1002/jcph.1644. [PMID: 32441805]
  • Sara Mahmmoud El-Dakhly, Abeer Abdallah Ali Salama, Soha Osama Mahmoud Hassanin, Noha Nazeeh Yassen, Alaaeldin Ahmed Hamza, Amr Amin. Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats. BMC research notes. 2020 May; 13(1):259. doi: 10.1186/s13104-020-05094-2. [PMID: 32460808]
  • Ramsia Geisler, Carina Dargel, Thomas Hellweg. The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010117. [PMID: 31892278]
  • Ramsia Geisler, Martin Cramer Pedersen, Yvonne Hannappel, Ralf Schweins, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg. Aescin-Induced Conversion of Gel-Phase Lipid Membranes into Bicelle-like Lipid Nanoparticles. Langmuir : the ACS journal of surfaces and colloids. 2019 12; 35(49):16244-16255. doi: 10.1021/acs.langmuir.9b02077. [PMID: 31618036]
  • Ramsia Sreij, Carina Dargel, Yvonne Hannappel, Jacques Jestin, Sylvain Prévost, Rajeev Dattani, Oliver Wrede, Thomas Hellweg. Temperature dependent self-organization of DMPC membranes promoted by intermediate amounts of the saponin aescin. Biochimica et biophysica acta. Biomembranes. 2019 05; 1861(5):897-906. doi: 10.1016/j.bbamem.2019.01.015. [PMID: 30735626]
  • Ramsia Sreij, Carina Dargel, Ralf Schweins, Sylvain Prévost, Rajeev Dattani, Thomas Hellweg. Aescin-Cholesterol Complexes in DMPC Model Membranes: A DSC and Temperature-Dependent Scattering Study. Scientific reports. 2019 04; 9(1):5542. doi: 10.1038/s41598-019-41865-z. [PMID: 30944386]
  • Flavia M Michelini, Laura E Alché, Carlos A Bueno. Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract. The Journal of pharmacy and pharmacology. 2018 Nov; 70(11):1561-1571. doi: 10.1111/jphp.13002. [PMID: 30168142]
  • Carolin de Groot, Mathias Müsken, Christel C Müller-Goymann. Novel Colloidal Microstructures of β-Escin and the Liposomal Components Cholesterol and DPPC. Planta medica. 2018 Nov; 84(16):1219-1227. doi: 10.1055/a-0624-2706. [PMID: 29797304]
  • Ramsia Sreij, Sylvain Prévost, Carina Dargel, Rajeev Dattani, Yvonne Hertle, Oliver Wrede, Thomas Hellweg. Interaction of the Saponin Aescin with Ibuprofen in DMPC Model Membranes. Molecular pharmaceutics. 2018 10; 15(10):4446-4461. doi: 10.1021/acs.molpharmaceut.8b00421. [PMID: 30102549]
  • J Penfold, R K Thomas, I Tucker, J T Petkov, S D Stoyanov, N Denkov, K Golemanov, S Tcholakova, J R P Webster. Saponin Adsorption at the Air-Water Interface-Neutron Reflectivity and Surface Tension Study. Langmuir : the ACS journal of surfaces and colloids. 2018 08; 34(32):9540-9547. doi: 10.1021/acs.langmuir.8b02158. [PMID: 30028143]
  • Baojian Wang, Xu Mao, Jianwei Zhu. [β-aescin alleviates acute lung injury induced by lipopolysaccharide by inhibiting lipid peroxidation and inflammation in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2018 Jul; 34(7):600-604. doi: ". [PMID: 30381123]
  • Ramsia Sreij, Carina Dargel, Philippe Geisler, Yvonne Hertle, Aurel Radulescu, Stefano Pasini, Javier Perez, Lara H Moleiro, Thomas Hellweg. DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. Physical chemistry chemical physics : PCCP. 2018 Apr; 20(14):9070-9083. doi: 10.1039/c7cp08027a. [PMID: 29505043]
  • Shu-Qi Zhao, Shi-Qiang Xu, Jing Cheng, Xiao-Lu Cao, Ying Zhang, Wei-Ping Zhou, Yan-Juan Huang, Jun Wang, Xia-Min Hu. Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor. Chinese journal of natural medicines. 2018 Feb; 16(2):105-112. doi: 10.1016/s1875-5364(18)30036-0. [PMID: 29455725]
  • HyeongSeob Kwak, Hongyan An, Md Badrul Alam, Won-Sik Choi, Sang Yong Lee, Sang-Han Lee. Inhibition of Migration and Invasion in Melanoma Cells by β-Escin via the ERK/NF-κB Signaling Pathway. Biological & pharmaceutical bulletin. 2018; 41(10):1606-1610. doi: 10.1248/bpb.b18-00251. [PMID: 30270331]
  • Harsimran Singh, Shabir Sidhu, Kanwaljit Chopra, M U Khan. The novel role of β-aescin in attenuating CCl4-induced hepatotoxicity in rats. Pharmaceutical biology. 2017 Dec; 55(1):749-757. doi: 10.1080/13880209.2016.1275023. [PMID: 28064552]
  • Zhao-Rui Liu, Li-Zhi Sun, Tang-Hong Jia, Dao-Fu Jia. β-Aescin shows potent antiproliferative activity in osteosarcoma cells by inducing autophagy, ROS generation and mitochondrial membrane potential loss. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2017 Nov; 22(6):1582-1586. doi: . [PMID: 29332356]
  • Ramsia Sreij, Carina Dargel, Lara H Moleiro, Francisco Monroy, Thomas Hellweg. Aescin Incorporation and Nanodomain Formation in DMPC Model Membranes. Langmuir : the ACS journal of surfaces and colloids. 2017 10; 33(43):12351-12361. doi: 10.1021/acs.langmuir.7b02933. [PMID: 28985678]
  • Ji Won Kim, Thi-Kim-Quy Ha, Hyomoon Cho, Eunhee Kim, Sang Hee Shim, Jun-Li Yang, Won Keun Oh. Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut). Bioorganic & medicinal chemistry letters. 2017 07; 27(13):3019-3025. doi: 10.1016/j.bmcl.2017.05.022. [PMID: 28527823]
  • Jin-Yu Mei, Ming-Jun Zhang, Yuan-Yuan Wang, Ye-Hai Liu. The positive clinical therapeutically effects of Escin on advanced thyroid cancer. Cancer medicine. 2017 May; 6(5):937-943. doi: 10.1002/cam4.1031. [PMID: 28378396]
  • Sheau-Yun Yuan, Chen-Li Cheng, Shian-Shiang Wang, Hao-Chung Ho, Kun-Yuan Chiu, Chuan-Shu Chen, Cheng-Che Chen, Ming-Yuh Shiau, Yen-Chuan Ou. Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways. Oncology reports. 2017 Feb; 37(2):1002-1010. doi: 10.3892/or.2017.5348. [PMID: 28075477]
  • Kun Zhang, Zhongxin Jiang, Xiaowei Ning, Xuhua Yu, Jiajun Xu, Peter Buzzacott, Weigang Xu. Endothelia-Targeting Protection by Escin in Decompression Sickness Rats. Scientific reports. 2017 01; 7(?):41288. doi: 10.1038/srep41288. [PMID: 28112272]
  • David F Yao, Jesse N Mills. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian journal of andrology. 2016 May; 18(3):410-8. doi: 10.4103/1008-682x.175779. [PMID: 26952957]
  • Dominik Domanski, Oliwia Zegrocka-Stendel, Anna Perzanowska, Malgorzata Dutkiewicz, Magdalena Kowalewska, Iwona Grabowska, Dorota Maciejko, Anna Fogtman, Michal Dadlez, Katarzyna Koziak. Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications. PloS one. 2016; 11(10):e0164365. doi: 10.1371/journal.pone.0164365. [PMID: 27727329]
  • Kaijun Wang, Yiqian Jiang, Wei Wang, Jian Ma, Min Chen. Escin activates AKT-Nrf2 signaling to protect retinal pigment epithelium cells from oxidative stress. Biochemical and biophysical research communications. 2015 Dec; 468(4):541-7. doi: 10.1016/j.bbrc.2015.10.117. [PMID: 26505797]
  • J Vašková, A Fejerčáková, G Mojžišová, L Vaško, P Patlevič. Antioxidant potential of Aesculus hippocastanum extract and escin against reactive oxygen and nitrogen species. European review for medical and pharmacological sciences. 2015; 19(5):879-86. doi: . [PMID: 25807442]
  • Wirginia Kukula-Koch, Bartosz Kędzierski, Kazimierz Głowniak. Influence of extrahent on antioxidant capacity of Aesculus hippocastanum seeds. Natural product research. 2015; 29(4):370-3. doi: 10.1080/14786419.2014.945084. [PMID: 25109836]
  • Tian Wang, Shanshan Zhao, Yucun Wang, Yujiao Yang, Le Yao, Liuxiang Chu, Hanhan Du, Fenghua Fu. Protective effects of escin against indomethacin-induced gastric ulcer in mice. Toxicology mechanisms and methods. 2014 Dec; 24(8):560-6. doi: 10.3109/15376516.2014.951815. [PMID: 25137224]
  • Xiu-Jun Wu, Xiang-Yong Cui, Lian-tian Tian, Feng Gao, Xin Guan, Jing-Kai Gu. Pharmacokinetics of escin Ia in rats after intravenous administration. Journal of ethnopharmacology. 2014 Oct; 156(?):125-9. doi: 10.1016/j.jep.2014.08.032. [PMID: 25193683]
  • Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. 2014 Oct; 1585(?):23-36. doi: 10.1016/j.brainres.2014.03.010. [PMID: 24657313]
  • Xiu-Jun Wu, Meng-Liang Zhang, Xiang-Yong Cui, J Paul Fawcett, Jing-Kai Gu. Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats. Journal of ethnopharmacology. 2014 Feb; 151(2):839-45. doi: 10.1016/j.jep.2013.11.039. [PMID: 24334163]
  • Yi Huang, Shuang-li Zheng, Hai-yan Zhu, Zhi-sheng Xu, Ren-ai Xu. Effects of aescin on cytochrome P450 enzymes in rats. Journal of ethnopharmacology. 2014; 151(1):583-90. doi: 10.1016/j.jep.2013.11.016. [PMID: 24252494]
  • Lidiane S Dutra, Magda N Leite, Marcos A F Brandão, Priscila Aparecida de Almeida, Fernando A S Vaz, Marcone A L de Oliveira. A rapid method for total Β-escin analysis in dry, hydroalcoholic and hydroglycolic extracts of Aesculus hippocastanum L. by capillary zone electrophoresis. Phytochemical analysis : PCA. 2013 Nov; 24(6):513-9. doi: 10.1002/pca.2425. [PMID: 23508832]
  • Jagan M R Patlolla, Li Qian, Laura Biddick, Yuting Zhang, Dhimant Desai, Shantu Amin, Stan Lightfoot, Chinthalapally V Rao. β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. Cancer prevention research (Philadelphia, Pa.). 2013 Oct; 6(10):1140-9. doi: 10.1158/1940-6207.capr-13-0216. [PMID: 23963803]
  • Zhihong Yu, Ping Su. Effect of beta-aescin extract from Chinese buckeye seed on chronic venous insufficiency. Die Pharmazie. 2013 Jun; 68(6):428-30. doi: . [PMID: 23875249]
  • D Certan, V Righini, M Oliva, P Fioravanti, M Bevilacqua. Bioavailability of l-thyroxine and its metabolites after topical treatment with an emulsion containing 0.1\% micronised l-thyroxine. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 2013 Jun; 148(3):287-92. doi: NULL. [PMID: 23670065]
  • Yan-Lei Wang, You-Ling Jing, Qing-Yan Cai, Guo-Jin Cui, Yi-Bing Zhang, Feng-Yu Zhang. [Effects of sodium aescinate on the apoptosis-related genes in lung injury induced by intestinal ischemia reperfusion in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2012 Mar; 43(2):170-3. doi: NULL. [PMID: 22650024]
  • Ellen De Geyter, Guy Smagghe, Yvan Rahbé, Danny Geelen. Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum. Pest management science. 2012 Feb; 68(2):164-9. doi: 10.1002/ps.2235. [PMID: 21717567]
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