Racemetirosine (BioDeep_00000175027)
human metabolite blood metabolite
代谢物信息卡片
2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
化学式: C10H13NO3 (195.0895388)
中文名称: α-甲基-D,L-酪氨酸, α-甲基-DL-酪氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=C(C=C1)O)(C(=O)O)N
InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
22 个代谢物同义名
2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; Hydrochloride, alpha-methyltyrosine; alpha Methyltyrosine hydrochloride; alpha-Methyltyrosine, (D,L)-isomer; alpha-Methyltyrosine, (+,-)-isomer; alpha-Methyltyrosine hydrochloride; alpha-Methyltyrosine, (L)-isomer; alpha Methyl para tyrosine; alpha-Methyl-para-tyrosine; alpha-Methyl- DL-tyrosine; alpha-Methyl-p-tyrosine; alpha Methyl p tyrosine; alpha-Methyltyrosine; alpha Methyltyrosine; a-methyl-D-tyrosine; Racemetirosine; Metyrosine; Metirosine; alpha-MPT; alpha MPT; Demser; AMPT
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 3125
- HMDB: HMDB0247174
- ChEMBL: CHEMBL1330596
- Wikipedia: Metirosine
- MeSH: alpha-Methyltyrosine
- chemspider: 3013
- CAS: 620-30-4
- CAS: 658-48-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lucinda M Gruber, Sina Jasim, Allison Ducharme-Smith, Toby Weingarten, William F Young, Irina Bancos. The Role for Metyrosine in the Treatment of Patients With Pheochromocytoma and Paraganglioma.
The Journal of clinical endocrinology and metabolism.
2021 05; 106(6):e2393-e2401. doi:
10.1210/clinem/dgab130. [PMID: 33693908] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - D-M Zhang, S-L Chen. Cytokine storms caused by novel coronavirus 2019 and treatment for cardiac injury.
European review for medical and pharmacological sciences.
2020 12; 24(23):12527-12535. doi:
10.26355/eurrev_202012_24050. [PMID: 33336773] - Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mendez. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra.
Neuropharmacology.
2020 04; 166(?):107920. doi:
10.1016/j.neuropharm.2019.107920. [PMID: 31870855] - Xuemin Huang, Huanan Zhao, Wen Qiu, Jian Wang, Longhua Guo, Zhenyu Lin, Wei Pan, Yong Wu, Bin Qiu. A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters.
Mikrochimica acta.
2020 03; 187(4):240. doi:
10.1007/s00604-020-4186-y. [PMID: 32198661] - Fang Fang, Li Ding, Qing He, Ming Liu. Preoperative Management of Pheochromocytoma and Paraganglioma.
Frontiers in endocrinology.
2020; 11(?):586795. doi:
10.3389/fendo.2020.586795. [PMID: 33117294] - Kazuhiro Takekoshi, Fumitoshi Satoh, Akiyo Tanabe, Takahiro Okamoto, Atsuhiro Ichihara, Mika Tsuiki, Takuyuki Katabami, Masatoshi Nomura, Tomoaki Tanaka, Tadashi Matsuda, Tsuneo Imai, Masanobu Yamada, Suguru Asada, Nobuyuki Kawata, Mitsuhide Naruse. Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study.
Endocrine journal.
2019 Dec; 66(12):1063-1072. doi:
10.1507/endocrj.ej19-0125. [PMID: 31511435] - Molly A Kwiatkowski, Gerhard Hellemann, Catherine A Sugar, Zackary A Cope, Arpi Minassian, William Perry, Mark A Geyer, Jared W Young. Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.
Pharmacology, biochemistry, and behavior.
2019 03; 178(?):42-50. doi:
10.1016/j.pbb.2017.12.007. [PMID: 29289701] - James J Butz, Toby N Weingarten, Alexandre N Cavalcante, Irina Bancos, William F Young, Travis J McKenzie, Darrell R Schroeder, David P Martin, Juraj Sprung. Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma.
International journal of surgery (London, England).
2017 Oct; 46(?):1-6. doi:
10.1016/j.ijsu.2017.08.026. [PMID: 28803996] - Kabilan Thanapaalasingham, André S Pollmann, Benjamin Schelew. Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2015 Dec; 62(12):1303-7. doi:
10.1007/s12630-015-0480-2. [PMID: 26362800] - Franciane Bobinski, Tamara A A Ferreira, Marina M Córdova, Patrícia A Dombrowski, Cláudio da Cunha, Caroline C do Espírito Santo, Anicleto Poli, Rita G W Pires, Cristina Martins-Silva, Kathleen A Sluka, Adair R S Santos. Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice.
Pain.
2015 Dec; 156(12):2595-2606. doi:
10.1097/j.pain.0000000000000372. [PMID: 26447701] - Katarzyna Młyniec, Magdalena Gaweł, Tadeusz Librowski, Witold Reczyński, Beata Bystrowska, Birgitte Holst. Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission.
Brain research bulletin.
2015 Jun; 115(?):23-9. doi:
10.1016/j.brainresbull.2015.04.005. [PMID: 25917396] - Fernando Caravaggio, Carol Borlido, Margaret Hahn, Zhe Feng, Gagan Fervaha, Philip Gerretsen, Shinichiro Nakajima, Eric Plitman, Jun Ku Chung, Yusuke Iwata, Alan Wilson, Gary Remington, Ariel Graff-Guerrero. Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans.
The international journal of neuropsychopharmacology.
2015 Feb; 18(7):pyv014. doi:
10.1093/ijnp/pyv014. [PMID: 25716779] - Philipp Homan, Simona Grob, Gabriella Milos, Ulrich Schnyder, Anne Eckert, Undine Lang, Gregor Hasler. The role of BDNF, leptin, and catecholamines in reward learning in bulimia nervosa.
The international journal of neuropsychopharmacology.
2014 Dec; 18(5):. doi:
10.1093/ijnp/pyu092. [PMID: 25522424] - James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Joelma Abadia Marciano De Paula, Fagundes Fabio Rocha, Moses A Akanmu, Frederico Argollo Vanderlinde, Jordan K Zjawiony, Elson Alves Costa. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.
Food & function.
2014 Aug; 5(8):1819-28. doi:
10.1039/c4fo00109e. [PMID: 24920211] - Jordy van Enkhuizen, Mark A Geyer, Adam L Halberstadt, Xiaoxi Zhuang, Jared W Young. Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder.
Journal of affective disorders.
2014 Feb; 155(?):247-54. doi:
10.1016/j.jad.2013.08.041. [PMID: 24287168] - Philipp Homan, Wayne C Drevets, Gregor Hasler. Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls.
Psychopharmacology.
2014 Jan; 231(2):409-17. doi:
10.1007/s00213-013-3250-2. [PMID: 23954912] - Rahul Kumar Singh, Radha Chaube, Keerikkattil P Joy. Differential and reproductive stage-dependent regulation of vasotocin secretion by catecholamines in the catfish Heteropneustes fossilis.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2013 Dec; 166(4):619-26. doi:
10.1016/j.cbpa.2013.09.005. [PMID: 24036478] - Fabiana da Silva Alves, Geor Bakker, Nicole Schmitz, Nico Abeling, Gregor Hasler, Johan van der Meer, Aart Nederveen, Lieuwe de Haan, Don Linszen, Therese van Amelsvoort. Dopaminergic modulation of the reward system in schizophrenia: a placebo-controlled dopamine depletion fMRI study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2013 Nov; 23(11):1577-86. doi:
10.1016/j.euroneuro.2013.06.008. [PMID: 23978392] - Philipp Homan, Wayne C Drevets, Gregor Hasler. Growth hormone response to catecholamine depletion in unmedicated, remitted subjects with major depressive disorder and healthy controls.
Journal of clinical psychopharmacology.
2013 Oct; 33(5):621-6. doi:
10.1097/jcp.0b013e31829a8284. [PMID: 23963054] - Philipp Homan, Simona Grob, Gabriella Milos, Ulrich Schnyder, Gregor Hasler. Reduction in total plasma ghrelin levels following catecholamine depletion: relation to bulimic and depressive symptoms.
Psychoneuroendocrinology.
2013 Sep; 38(9):1545-52. doi:
10.1016/j.psyneuen.2012.12.024. [PMID: 23333252] - Yu-Shang Lee, Ching-Yi Lin, Hai-Hong Jiang, Marc Depaul, Vernon W Lin, Jerry Silver. Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Jun; 33(26):10591-606. doi:
10.1523/jneurosci.1116-12.2013. [PMID: 23804083] - Marguerite Matthews, Corina Bondi, Gonzalo Torres, Bita Moghaddam. Reduced presynaptic dopamine activity in adolescent dorsal striatum.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 Jun; 38(7):1344-51. doi:
10.1038/npp.2013.32. [PMID: 23358239] - Oswald J N Bloemen, Mariken B de Koning, Tobias Gleich, Julia Meijer, Lieuwe de Haan, Don H Linszen, Jan Booij, Thérèse A M J van Amelsvoort. Striatal dopamine D2/3 receptor binding following dopamine depletion in subjects at Ultra High Risk for psychosis.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2013 Feb; 23(2):126-32. doi:
10.1016/j.euroneuro.2012.04.015. [PMID: 22591910] - Murat Yigiter, Abdullah Yildiz, Beyzagul Polat, Hamit Hakan Alp, Osman Nuri Keles, Ahmet Bedii Salman, Halis Suleyman. The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Surgery today.
2012 Nov; 42(11):1051-60. doi:
10.1007/s00595-011-0074-8. [PMID: 22202971] - Dubravka Švob Štrac, Dorotea Muck-Šeler, Nela Pivac. The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Croatian medical journal.
2012 Jun; 53(3):214-23. doi:
10.3325/cmj.2012.53.214. [PMID: 22661134] - Radha Chaube, Rahul K Singh, Keerikkattil P Joy. Estrogen regulation of brain vasotocin secretion in the catfish Heteropneustes fossilis: an interaction with catecholaminergic system.
General and comparative endocrinology.
2012 Jan; 175(1):206-13. doi:
10.1016/j.ygcen.2011.11.012. [PMID: 22138221] - Giselle Charron, Evelyne Doudnikoff, Alexis Laux, Amandine Berthet, Gregory Porras, Marie-Hélène Canron, Pedro Barroso-Chinea, Qin Li, Chuan Qin, Marika Nosten-Bertrand, Bruno Giros, François Delalande, Alain Van Dorsselaer, Anne Vital, Yannick Goumon, Erwan Bezard. Endogenous morphine-like compound immunoreactivity increases in parkinsonism.
Brain : a journal of neurology.
2011 Aug; 134(Pt 8):2321-38. doi:
10.1093/brain/awr166. [PMID: 21742735] - Kinuyo Iwata, Mika Kinoshita, Naoki Susaki, Yoshihisa Uenoyama, Hiroko Tsukamura, Kei-ichiro Maeda. Central injection of ketone body suppresses luteinizing hormone release via the catecholaminergic pathway in female rats.
The Journal of reproduction and development.
2011 Jun; 57(3):379-84. doi:
10.1262/jrd.11-001s. [PMID: 21358145] - Jessica Deslauriers, Marilou Lefrançois, Annie Larouche, Philippe Sarret, Sylvain Grignon. Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells.
Synapse (New York, N.Y.).
2011 Apr; 65(4):321-31. doi:
10.1002/syn.20851. [PMID: 20730801] - Fabiana da Silva Alves, Nicole Schmitz, Martijn Figee, Nico Abeling, Gregor Hasler, Johan van der Meer, Aart Nederveen, Lieuwe de Haan, Don Linszen, Therese van Amelsvoort. Dopaminergic modulation of the human reward system: a placebo-controlled dopamine depletion fMRI study.
Journal of psychopharmacology (Oxford, England).
2011 Apr; 25(4):538-49. doi:
10.1177/0269881110367731. [PMID: 20530591] - Pálma Fehér, Márk Oláh, Ibolya Bodnár, Dániel Hechtl, Ildikó Bácskay, Béla Juhász, György M Nagy, Miklós Vecsernyés. Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses.
Brain research bulletin.
2010 Apr; 82(1-2):141-5. doi:
10.1016/j.brainresbull.2010.02.006. [PMID: 20170714] - Sunoh Kwon, Bombi Lee, Myunghwan Kim, Hyejung Lee, Hi-Joon Park, Dae-Hyun Hahm. Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Mar; 34(2):265-70. doi:
10.1016/j.pnpbp.2009.11.015. [PMID: 19932727] - Ryan Woodman, Warren Lockette. Alpha-methyltyrosine inhibits formation of reactive oxygen species and diminishes apoptosis in PC12 cells.
Brain research.
2009 Nov; 1296(?):137-47. doi:
10.1016/j.brainres.2009.07.084. [PMID: 19647721] - Allison M Benoit, Jose R Molina, Sender Lkhagvadorj, Lloyd L Anderson. Prolactin secretion after hypothalamic deafferentation in beef calves: response to haloperidol, alpha-methyl-rho-tyrosine, thyrotropin-releasing hormone and ovariectomy.
Animal reproduction science.
2009 Mar; 111(1):54-68. doi:
10.1016/j.anireprosci.2008.02.003. [PMID: 18359173] - Márk Oláh, Pálma Fehér, Zsófia Ihm, Ildikó Bácskay, Timea Kiss, Marc E Freeman, Gyorgy M Nagy, Miklós Vecsernyés. Dopamine-regulated adrenocorticotropic hormone secretion in lactating rats: functional plasticity of melanotropes.
Neuroendocrinology.
2009; 90(4):391-401. doi:
10.1159/000232313. [PMID: 19641299] - Valentina Ghisi, Amy J Ramsey, Bernard Masri, Raul R Gainetdinov, Marc G Caron, Ali Salahpour. Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.
Cellular signalling.
2009 Jan; 21(1):87-94. doi:
10.1016/j.cellsig.2008.09.011. [PMID: 18929645] - Costin N Ionescu, Olga V Sakharova, Mark D Harwood, Eugene A Caracciolo, Mark H Schoenfeld, Thomas J Donohue. Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.
Journal of clinical hypertension (Greenwich, Conn.).
2008 Dec; 10(12):936-40. doi:
10.1111/j.1751-7176.2008.00046.x. [PMID: 19120720] - Zaorui Zhao, Alicia M Baros, Han-Ting Zhang, M Danet S Lapiz, Corina O Bondi, David A Morilak, James M O'Donnell. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2008 Dec; 33(13):3190-200. doi:
10.1038/npp.2008.45. [PMID: 18418364] - Daniele G Machado, Luis E B Bettio, Mauricio P Cunha, Adair R S Santos, Moacir G Pizzolatti, Inês M C Brighente, Ana Lúcia S Rodrigues. Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.
European journal of pharmacology.
2008 Jun; 587(1-3):163-8. doi:
10.1016/j.ejphar.2008.03.021. [PMID: 18457827] - Zhidong Zhou, Szeyen Kerk, Tit Meng Lim. Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132.
Free radical research.
2008 May; 42(5):456-66. doi:
10.1080/10715760802005177. [PMID: 18484277] - Denise L Bellinger, Dorian Silva, Ashley Brooke Millar, Christine Molinaro, Mark Ghamsary, Jeff Carter, Sam Perez, Dianne Lorton, Cheri Lubahn, Gerson Araujoa, Srinivasan Thyagarajan. Sympathetic nervous system and lymphocyte proliferation in the Fischer 344 rat spleen: a longitudinal study.
Neuroimmunomodulation.
2008; 15(4-6):260-71. doi:
10.1159/000156469. [PMID: 19047803] - Halis Suleyman, Zekai Halici, Elif Cadirci, Ahmet Hacimuftuoglu, Sait Keles, Fatma Gocer. Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2007 May; 375(3):189-98. doi:
10.1007/s00210-007-0151-0. [PMID: 17372719] - Ibolya Bodnár, Dániel Hechtl, Dániel Székács, Márk Oláh, György M Nagy. Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release.
Ideggyogyaszati szemle.
2007 Mar; 60(3-4):177-81. doi:
. [PMID: 17451064] - Leonid Yavich, Mari Oksman, Heikki Tanila, Petri Kerokoski, Mikko Hiltunen, Thomas van Groen, Jukka Puoliväli, Pekka T Männistö, Arturo García-Horsman, Ewen MacDonald, Konrad Beyreuther, Tobias Hartmann, Pekka Jäkälä. Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.
Neurobiology of disease.
2005 Nov; 20(2):303-13. doi:
10.1016/j.nbd.2005.03.010. [PMID: 16242637] - Tatyana D Sotnikova, Jean-Martin Beaulieu, Larry S Barak, William C Wetsel, Marc G Caron, Raul R Gainetdinov. Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.
PLoS biology.
2005 Aug; 3(8):e271. doi:
10.1371/journal.pbio.0030271. [PMID: 16050778] - David Humphries, Kenneth Ruterbories, Clark Chan, Rangaraj Narayanan. Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of alpha-methyltyrosine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 810(2):229-34. doi:
10.1016/j.jchromb.2004.08.004. [PMID: 15380719] - Andreas Leng, Anna Mura, Bastian Hengerer, Joram Feldon, Boris Ferger. Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice.
Behavioural brain research.
2004 Oct; 154(2):375-83. doi:
10.1016/j.bbr.2004.03.004. [PMID: 15313025] - Den'etsu Sutoo, Kayo Akiyama. Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation.
Brain research.
2004 Aug; 1016(2):255-62. doi:
10.1016/j.brainres.2004.05.018. [PMID: 15246862] - A Heinz, D W Jones, K Zajicek, J G Gorey, G Juckel, J D Higley, D R Weinberger. Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates.
Journal of neural transmission. Supplementum.
2004; ?(68):29-38. doi:
10.1007/978-3-7091-0579-5_4. [PMID: 15354387] - Nicolaas P L G Verhoeff, Bruce K Christensen, Doug Hussey, Maggie Lee, George Papatheodorou, Lili Kopala, Qing Rui, Robert B Zipursky, Shitij Kapur. Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study.
Pharmacology, biochemistry, and behavior.
2003 Jan; 74(2):425-32. doi:
10.1016/s0091-3057(02)01028-6. [PMID: 12479964] - M P Johnson, M Chamberlain. Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268.
Neuropharmacology.
2002 Oct; 43(5):799-808. doi:
10.1016/s0028-3908(02)00142-9. [PMID: 12384165] - Dong-Yih Kuo, Juei-Tang Cheng. Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine.
Neuroscience research.
2002 Sep; 44(1):63-9. doi:
10.1016/s0168-0102(02)00086-x. [PMID: 12204294] - Den'etsu Sutoo, Kayo Akiyama. Neurochemical changes in mice following physical or psychological stress exposures.
Behavioural brain research.
2002 Aug; 134(1-2):347-54. doi:
10.1016/s0166-4328(02)00049-9. [PMID: 12191822] - Shuang Zheng, Alice H Chou, Amie L Jimenez, Omid Khodadadi, Sarah Son, William P Melega, Bruce D Howard. The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult.
Brain research. Developmental brain research.
2002 Jun; 136(2):101-10. doi:
10.1016/s0165-3806(02)00348-6. [PMID: 12101027] - Yumiko Tozawa, Kouji Matsushima. Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
European journal of pharmacology.
2002 Apr; 440(1):37-44. doi:
10.1016/s0014-2999(02)01310-9. [PMID: 11959086] - Ann Caplea, Darcie Seachrist, Hamid Daneshvar, Gail Dunphy, Daniel Ely. Noradrenergic content and turnover rate in kidney and heart shows gender and strain differences.
Journal of applied physiology (Bethesda, Md. : 1985).
2002 Feb; 92(2):567-71. doi:
10.1152/japplphysiol.00557.2001. [PMID: 11796665] - N P L G Verhoeff, D Hussey, M Lee, J Tauscher, G Papatheodorou, A A Wilson, S Houle, S Kapur. Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans.
Molecular psychiatry.
2002; 7(3):233, 322-8. doi:
10.1038/sj.mp.4001062. [PMID: 11920160] - R W Lam, E M Tam, A Grewal, L N Yatham. Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2001 Nov; 25(5 Suppl):S97-101. doi:
10.1016/s0893-133x(01)00337-2. [PMID: 11682283] - N Adachi, B Lei, G Deshpande, F J Seyfried, I Shimizu, T Nagaro, T Arai. Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.
Intensive care medicine.
2001 Oct; 27(10):1655-60. doi:
10.1007/s001340101067. [PMID: 11685308] - X G Xia, N Schmidt, P Teismann, B Ferger, J B Schulz. Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.
Journal of neurochemistry.
2001 Oct; 79(1):63-70. doi:
10.1046/j.1471-4159.2001.00525.x. [PMID: 11595758] - I Bodnár, P Göõz, H Okamura, B E Tóth, M Vecsernyé, B Halász, G M Nagy. Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats.
Brain research bulletin.
2001 Aug; 55(6):767-74. doi:
10.1016/s0361-9230(01)00584-6. [PMID: 11595361] - N P Verhoeff, S Kapur, D Hussey, M Lee, B Christensen, C Psych, G Papatheodorou, R B Zipursky. A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2001 Aug; 25(2):213-23. doi:
10.1016/s0893-133x(01)00231-7. [PMID: 11425505] - H Shimizu, T Kumai, S Kobayashi. Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension.
Japanese journal of pharmacology.
2001 Mar; 85(3):306-12. doi:
10.1254/jjp.85.306. [PMID: 11325024] - A Tohei, M Matsuzaki, H Kogo. Antagonist of pituitary adenylate cyclase activating polypeptide suppresses prolactin secretion without changing the activity of dopamine neurons in lactating rats.
Neuroendocrinology.
2001 Jan; 73(1):68-74. doi:
10.1159/000054622. [PMID: 11174019] - T Kumai, K Asoh, T Tateishi, M Tanaka, M Watanabe, H Shimizu, S Kobayashi. Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
Life sciences.
2000 Sep; 67(16):1993-9. doi:
10.1016/s0024-3205(00)00787-6. [PMID: 11072875] - J Yamada, Y Sugimoto, T Noma. Involvement of adrenaline in diazepam-induced hyperglycemia in mice.
Life sciences.
2000 Feb; 66(13):1213-21. doi:
10.1016/s0024-3205(00)00426-4. [PMID: 10737416] - L N Markova, N Iu Sakharova, V V Bezuglov. [The action of catecholamine-synthesis inhibitors and of spiperone on sea urchin and mouse embryos].
Ontogenez.
2000 Jan; 31(1):32-9. doi:
NULL. [PMID: 10732361] - V Olivier, A Gobert, B Guibert, V Leviel. The in vivo modulation of dopamine synthesis by calcium ions: influences on the calcium independent release.
Neurochemistry international.
1999 Dec; 35(6):431-8. doi:
10.1016/s0197-0186(99)00094-7. [PMID: 10524710] - K L Hermayer, M Szpiech. Diagnosis and management of pheochromocytoma during pregnancy: a case report.
The American journal of the medical sciences.
1999 Sep; 318(3):186-9. doi:
10.1097/00000441-199909000-00014. [PMID: 10487409] - W Zhang, V Klimek, J T Farley, M Y Zhu, G A Ordway. alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine.
The Journal of pharmacology and experimental therapeutics.
1999 Jun; 289(3):1286-92. doi:
NULL. [PMID: 10336518] - R M Berman, M Narasimhan, H L Miller, A Anand, A Cappiello, D A Oren, G R Heninger, D S Charney. Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker?.
Archives of general psychiatry.
1999 May; 56(5):395-403. doi:
10.1001/archpsyc.56.5.395. [PMID: 10232292] - A Anand, A Darnell, H L Miller, R M Berman, A Cappiello, D A Oren, S W Woods, D S Charney. Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder.
Biological psychiatry.
1999 Apr; 45(8):972-8. doi:
10.1016/s0006-3223(98)00293-5. [PMID: 10386179] - K Akiyama, D Sutoo. Rectifying effect of exercise on hypertension in spontaneously hypertensive rats via a calcium-dependent dopamine synthesizing system in the brain.
Brain research.
1999 Mar; 823(1-2):154-60. doi:
10.1016/s0006-8993(99)01171-3. [PMID: 10095021] - K Tomiyoshi, T Inoue, T Higuchi, K Ahmed, M Sarwar, S Alyafei, H Zhang, K Matsubara, K Endo, D Yang. Metabolic studies of [18F-alpha-methyl]tyrosine in mice bearing colorectal carcinoma LS-180.
Anti-cancer drugs.
1999 Mar; 10(3):329-36. doi:
10.1097/00001813-199903000-00013. [PMID: 10327041] - T Inoue, T Shibasaki, N Oriuchi, K Aoyagi, K Tomiyoshi, S Amano, M Mikuni, I Ida, J Aoki, K Endo. 18F alpha-methyl tyrosine PET studies in patients with brain tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999 Mar; 40(3):399-405. doi:
NULL. [PMID: 10086702] - L E Krahn, S C Lin, G G Klee, P Y Lu, S J Ory, R C Zimmermann. The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
1999 Jan; 9(1-2):61-6. doi:
10.1016/s0924-977x(98)00006-6. [PMID: 10082229] - S Han, P P Rowell, L A Carr. D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine.
Research communications in molecular pathology and pharmacology.
1999; 104(3):331-8. doi:
. [PMID: 10741383] - R M Moresco, C Loc'h, M Ottaviani, B Guibert, V Leviel, M Maziere, F Fazio, B Maziere. Effects of dopamine on the in vivo binding of dopamine D2 receptor radioligands in rat striatum.
Nuclear medicine and biology.
1999 Jan; 26(1):91-8. doi:
10.1016/s0969-8051(98)00048-1. [PMID: 10096507] - Y Tozawa, A Ueki, S Manabe, K Matsushima. Stress-induced increase in urinary isatin excretion in rats: reversal by both dexamethasone and alpha-methyl-P-tyrosine.
Biochemical pharmacology.
1998 Oct; 56(8):1041-6. doi:
10.1016/s0006-2952(98)00199-3. [PMID: 9776316] - D V Rayner, E Simón, J S Duncan, P Trayhurn. Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine.
FEBS letters.
1998 Jun; 429(3):395-8. doi:
10.1016/s0014-5793(98)00642-5. [PMID: 9662456] - D Sutoo, K Akiyama, A Matsui. Gastric ulcer formation in cold-stressed mice related to a central calcium-dependent-dopamine synthesizing system.
Neuroscience letters.
1998 Jun; 249(1):9-12. doi:
10.1016/s0304-3940(98)00309-7. [PMID: 9672376] - A Neumeister, E H Turner, J R Matthews, T T Postolache, R L Barnett, M Rauh, R G Vetticad, S Kasper, N E Rosenthal. Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy.
Archives of general psychiatry.
1998 Jun; 55(6):524-30. doi:
10.1001/archpsyc.55.6.524. [PMID: 9633671] - A L Sawaya, P G Lunn. Lowering of plasma triiodothyronine level and sympathetic activity does not alter hypoalbuminaemia in rats fed on a diet of low protein concentration.
The British journal of nutrition.
1998 May; 79(5):455-62. doi:
10.1079/bjn19980076. [PMID: 9682665] - L Pinilla, M Tena-Sempere, R Aguilar, E Aguilar. Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions.
European journal of endocrinology.
1998 Apr; 138(4):460-6. doi:
10.1530/eje.0.1380460. [PMID: 9578517] - R C Zimmermann, L Krahn, N Rahmanie, M V Sauer. Prolonged inhibition of presynaptic catecholamine synthesis does not alter leptin secretion in normal-weight men and women.
Human reproduction (Oxford, England).
1998 Apr; 13(4):822-5. doi:
10.1093/humrep/13.4.822. [PMID: 9619531] - S M Stine, J H Krystal, I L Petrakis, P I Jatlow, G R Heninger, T R Kosten, D S Charney. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge.
Biological psychiatry.
1997 Aug; 42(3):181-90. doi:
10.1016/s0006-3223(96)00331-9. [PMID: 9232210] - K Tomiyoshi, K Amed, S Muhammad, T Higuchi, T Inoue, K Endo, D Yang. Synthesis of isomers of 18F-labelled amino acid radiopharmaceutical: position 2- and 3-L-18F-alpha-methyltyrosine using a separation and purification system.
Nuclear medicine communications.
1997 Feb; 18(2):169-75. doi:
10.1097/00006231-199702000-00013. [PMID: 9076774] - T D Gbadebo, J S Althaus, N Narasimhachari, J K Stewart. Impaired distribution of alpha-methyl-L-p-tyrosine in diabetic rats.
Brain research.
1996 Nov; 739(1-2):210-4. doi:
10.1016/s0006-8993(96)00827-x. [PMID: 8955941] - A L López de Pablo, M J Moreno, E J Marco. In vivo tryptophan hydroxylase activity in rat major cerebral arteries is decreased by dorsal raphe nucleus lesions.
Journal of neurochemistry.
1996 Nov; 67(5):2060-5. doi:
10.1046/j.1471-4159.1996.67052060.x. [PMID: 8863514] - C A Moody, J G Granneman, M J Bannon. Dopamine transporter binding in rat striatum and nucleus accumbens is unaltered following chronic changes in dopamine levels.
Neuroscience letters.
1996 Oct; 217(1):55-7. doi:
10.1016/0304-3940(96)13048-2. [PMID: 8905738] - N R Musso, S Brenci, M Setti, F Indiveri, G Lotti. Catecholamine content and in vitro catecholamine synthesis in peripheral human lymphocytes.
The Journal of clinical endocrinology and metabolism.
1996 Oct; 81(10):3553-7. doi:
10.1210/jcem.81.10.8855800. [PMID: 8855800] - T Yanase, K Nishizawa, O Inoue, T Sukamoto, Y Saito. [Antinociceptive effects of Kami-kihi-to in mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1996 Aug; 108(2):77-83. doi:
10.1254/fpj.108.77. [PMID: 8827725] - R C Zimmermann, L Krahn, G Klee, P Y Lu, S J Ory, S C Lin. The impact of gender on alpha-methyl-para-tyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion.
Psychoneuroendocrinology.
1996 Jul; 21(5):469-78. doi:
10.1016/0306-4530(95)00049-6. [PMID: 8888369] - M T Hsieh, Y F Ho, W H Peng, C R Wu, C F Chen. Effects of Hemerocallis flava on motor activity and the concentration of central monoamines and its metabolites in rats.
Journal of ethnopharmacology.
1996 Jun; 52(2):71-6. doi:
10.1016/0378-8741(96)01388-8. [PMID: 8735450] - H L Miller, P L Delgado, R M Salomon, G R Heninger, D S Charney. Effects of alpha-methyl-para-tyrosine (AMPT) in drug-free depressed patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1996 Mar; 14(3):151-7. doi:
10.1016/0893-133x(95)00072-l. [PMID: 8866698] - M Kurashima, M Domae, T Inoue, M Nagashima, K Yamada, K Shirakawa, T Furukawa. Inhibitory effects of putative dopamine D3 receptor agonists, 7-OH-DPAT and quinpirole, on prolactin secretion in rats.
Pharmacology, biochemistry, and behavior.
1996 Feb; 53(2):379-83. doi:
10.1016/0091-3057(95)02037-3. [PMID: 8808147] - B Senthilkumaran, K P Joy. Effects of administration of some monoamine-synthesis blockers and precursors on ovariectomy-induced rise in plasma gonadotropin II in the catfish Heteropneustes fossilis.
General and comparative endocrinology.
1996 Feb; 101(2):220-6. doi:
10.1006/gcen.1996.0024. [PMID: 8812379] - T Watanabe, T Noshiro, H Akama, T Kusakari, S Shibukawa, W Miura, K Abe, Y Miura. Effect of dexamethasone on plasma free dopamine: dopaminergic modulation in hypertensive patients.
Hypertension research : official journal of the Japanese Society of Hypertension.
1995 Jun; 18 Suppl 1(?):S197-8. doi:
10.1291/hypres.18.supplementi_s197. [PMID: 8529061]