3-Amino-4-methylpentanoic acid (BioDeep_00000173854)

Main id: BioDeep_00000003463

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


3-Amino-4-methylpentanoic acid

化学式: C6H13NO2 (131.0946)
中文名称: 3-氨基-4-甲基戊酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(CC(=O)O)N
InChI: InChI=1S/C6H13NO2/c1-4(2)5(7)3-6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)

描述信息

3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.

同义名列表

4 个代谢物同义名

3-Amino-4-methylpentanoic acid; 3-Amino-4-methylpentanoate; Beta-Leucine; 3-Amino-4-methylpentanoic acid



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 EIF4EBP1, LARS1, MTR, RPS6
Nucleus 4 EIF4EBP1, PCNA, RPS6, SPI1
cytosol 4 EIF4EBP1, LARS1, MTR, RPS6
dendrite 1 RPS6
nuclear body 2 LARS1, PCNA
centrosome 1 PCNA
nucleoplasm 3 PCNA, RPS6, SPI1
Cell membrane 1 TNF
cell surface 1 TNF
Golgi apparatus 1 IGFBP1
Golgi membrane 1 INS
neuronal cell body 1 TNF
Lysosome 1 LARS1
plasma membrane 1 TNF
Membrane 2 RPS6, SPI1
extracellular exosome 1 PCNA
endoplasmic reticulum 2 LARS1, RPS6
extracellular space 7 COL2A1, CXCL8, IGFBP1, IL10, INS, TCN1, TNF
perinuclear region of cytoplasm 1 RPS6
Secreted 5 COL2A1, CXCL8, IGFBP1, IL10, INS
extracellular region 7 COL2A1, CXCL8, IGFBP1, IL10, INS, TCN1, TNF
transcription regulator complex 1 SPI1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 COL2A1
nucleolus 1 RPS6
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
basement membrane 1 COL2A1
collagen trimer 1 COL2A1
collagen-containing extracellular matrix 1 COL2A1
chromatin 2 PCNA, SPI1
phagocytic cup 1 TNF
cytoplasmic ribonucleoprotein granule 1 RPS6
Nucleus, nucleolus 1 RPS6
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Endomembrane system 1 LARS1
endosome lumen 1 INS
cell body 1 RPS6
replication fork 1 PCNA
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 COL2A1, IGFBP1, INS
male germ cell nucleus 1 PCNA
specific granule lumen 1 TCN1
tertiary granule lumen 1 TCN1
transport vesicle 1 INS
small-subunit processome 1 RPS6
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear lamina 1 PCNA
ribonucleoprotein complex 1 RPS6
aminoacyl-tRNA synthetase multienzyme complex 1 LARS1
cytosolic ribosome 1 RPS6
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
ribosome 1 RPS6
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
collagen type II trimer 1 COL2A1
collagen type XI trimer 1 COL2A1
cytosolic small ribosomal subunit 1 RPS6
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
small ribosomal subunit 1 RPS6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Neeraj Kumar Verma, Rikeshwer Prasad Dewangan, Munesh Kumar Harioudh, Jimut Kanti Ghosh. Introduction of a β-leucine residue instead of leucine9 and glycine10 residues in Temporin L for improved cell selectivity, stability and activity against planktonic and biofilm of methicillin resistant S. aureus. Bioorganic chemistry. 2023 Feb; 134(?):106440. doi: 10.1016/j.bioorg.2023.106440. [PMID: 36870201]
  • S P Stabler, J Lindenbaum, R H Allen. Failure to detect beta-leucine in human blood or leucine 2,3-aminomutase in rat liver using capillary gas chromatography-mass spectrometry. The Journal of biological chemistry. 1988 Apr; 263(12):5581-8. doi: . [PMID: 3356699]
  • N E Ward, J Jones, D V Maurice. Essential role of adenosylcobalamin in leucine synthesis from beta-leucine in the domestic chicken. The Journal of nutrition. 1988 Feb; 118(2):159-64. doi: 10.1093/jn/118.2.159. [PMID: 3339472]